KEGG ORTHOLOGY: K06225

ORTHOLOGY: K06225

Entry

K06225                      KO

Symbol

PTCH1

Name

patched 1

Pathway

map04024

cAMP signaling pathway

map04340

Hedgehog signaling pathway

map04341

Hedgehog signaling pathway - fly

map04360

Axon guidance

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05217

Basal cell carcinoma

Disease

H00039

Basal cell carcinoma

H00267

Holoprosencephaly

H00895

Basal cell nevus syndrome

H01667

Medulloblastoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K06225  PTCH1; patched 1
   04341 Hedgehog signaling pathway - fly
    K06225  PTCH1; patched 1
   04024 cAMP signaling pathway
    K06225  PTCH1; patched 1
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K06225  PTCH1; patched 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06225  PTCH1; patched 1
   05205 Proteoglycans in cancer
    K06225  PTCH1; patched 1
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    K06225  PTCH1; patched 1

Other DBs

GO:	0005119 0008158

TC:	2.A.6.6.2 2.A.6.6.13

Genes

HSA:	5727(PTCH1)

PTR:	465254(PTCH1)

PPS:	100970040(PTCH1)

GGO:	101138988(PTCH1)

NLE:	100581789(PTCH1)

HMH:	116475280(PTCH1)

MCC:	718751(PTCH1)

MCF:	102121818(PTCH1)

MTHB:

126937986

MNI:	105498937(PTCH1)

CSAB:

103219825(PTCH1)

CATY:

105579525(PTCH1)

PANU:

101018770(PTCH1)

TGE:	112608438(PTCH1)

MLEU:

105536603(PTCH1)

RRO:	104669119(PTCH1)

RBB:	108529288(PTCH1)

TFN:	117098271(PTCH1)

PTEH:

111521696(PTCH1)

CANG:

105501521(PTCH1)

CJC:	100410387(PTCH1)

SBQ:	101048276(PTCH1)

CIMI:

108317034(PTCH1)

CSYR:

103260565(PTCH1)

MMUR:

105862135(PTCH1)

LCAT:

123645901(PTCH1)

PCOQ:

105806844(PTCH1)

OGA:	100961156(PTCH1)

MMU:	19206(Ptch1)

MCAL:

110307775(Ptch1)

MPAH:

110333595(Ptch1)

RNO:	89830(Ptch1)

MCOC:

116081424(Ptch1)

ANU:	117713602(Ptch1)

MUN:	110551759(Ptch1)

CGE:	100763926(Ptch1)

MAUA:

101823482(Ptch1)

PROB:

127229131(Ptch1)

PLEU:

114708424(Ptch1)

MORG:

121443344 121453284

MFOT:

126502661

AAMP:

119817589(Ptch1)

NGI:

103751618

HGL:	101711146(Ptch1)

CPOC:

100729719(Ptch1)

CCAN:

109683424(Ptch1)

DORD:

105999815(Ptch1)

DSP:	122113824(Ptch1)

PLOP:

125339795(Ptch1)

NCAR:

124965298

MMMA:

107157623(Ptch1)

OCU:

100345046

OPI:	101521576(PTCH1)

TUP:	102471693(PTCH1)

GVR:	103586051(PTCH1)

CFA:	484137(PTCH1)

CLUD:

112644598(PTCH1)

VVP:	112908731(PTCH1)

VLG:	121484106(PTCH1)

NPO:	129499614(PTCH1)

AML:	100475966(PTCH1)

UMR:	103682234(PTCH1)

UAH:	113269779(PTCH1)

UAR:	123781394(PTCH1)

ELK:

111139086

LLV:

125083161

MPUF:

101680366(PTCH1)

MNP:	132024752(PTCH1)

MLK:	131812048(PTCH1)

NVS:	122917630(PTCH1)

ORO:	101379447(PTCH1)

EJU:	114223388(PTCH1)

ZCA:	113934486(PTCH1)

MLX:	118023339(PTCH1)

NSU:	110569938(PTCH1)

LWW:	102738196(PTCH1)

FCA:	101085077(PTCH1)

PYU:

121014183

PCOO:

112868509(PTCH1)

PBG:	122475073(PTCH1)

PVIV:

125150324(PTCH1)

LRUF:

124529241

PTG:	102972008(PTCH1)

PPAD:

109251660

PUC:

125925310

AJU:

106971452

HHV:	120240837(PTCH1)

BTA:	520994(PTCH1)

BOM:	102283867(PTCH1)

BIU:	109563237(PTCH1)

BBUB:

102389314(PTCH1)

BBIS:

104985743(PTCH1)

CHX:	102187048(PTCH1)

OAS:	101112193(PTCH1)

BTAX:

128052308(PTCH1)

ODA:	120867037(PTCH1)

CCAD:

122432119(PTCH1)

MBEZ:

129556988(PTCH1)

SSC:	100627504(PTCH1)

CFR:	102517641(PTCH1)

CBAI:

105078863(PTCH1)

CDK:	105084688(PTCH1)

VPC:	102525054(PTCH1)

BACU:

103004681(PTCH1)

BMUS:

118897335(PTCH1)

LVE:	103086592(PTCH1)

OOR:	101284461(PTCH1)

DLE:	111166803(PTCH1)

PCAD:

102973233(PTCH1)

PSIU:

116755916(PTCH1)

NASI:

112405448(PTCH1)

ECB:	100033936(PTCH1)

EPZ:	103551335(PTCH1)

EAI:	106841108(PTCH1)

MYB:	102254605(PTCH1)

MYD:	102770033(PTCH1)

MMYO:

118667639(PTCH1)

MLF:	102424447(PTCH1)

PKL:	118732205(PTCH1)

EFUS:

103297886(PTCH1)

MNA:	107532314(PTCH1)

DRO:	112302742(PTCH1)

SHON:

118993710(PTCH1)

AJM:	119046072(PTCH1)

PDIC:

114512586(PTCH1)

PHAS:

123819437(PTCH1)

MMF:	118629803(PTCH1)

PPAM:

129082371(PTCH1)

HAI:	109396730(PTCH1)

RFQ:	117032144(PTCH1)

PALE:

102884350(PTCH1)

PGIG:

120616899(PTCH1)

PVP:	105306915(PTCH1)

RAY:	107518086(PTCH1)

MJV:	108383415(PTCH1)

TOD:	119232087(PTCH1)

SARA:

101552783(PTCH1)

SETR:

126006690(PTCH1)

LAV:	100676123(PTCH1)

TMU:

101346502

ETF:	101661574(PTCH1)

DNM:

101422669

MDO:	100014019(PTCH1)

GAS:	123231296(PTCH1)

SHR:	100934585(PTCH1)

AFZ:

127561700

PCW:	110197646(PTCH1)

OAA:	100079214(PTCH1)

GGA:	395806(PTCH1)

PCOC:

116238484(PTCH1)

CJO:	107306269(PTCH1)

TPAI:

128089577(PTCH1)

LMUT:

125687227(PTCH1)

NMEL:

110389731(PTCH1)

APLA:

101802613(PTCH1)

ACYG:

106047348(PTCH1)

CATA:

118257382(PTCH1)

AFUL:

116500683(PTCH1)

TGU:	100224767(PTCH1)

LSR:	110471014(PTCH1)

SCAN:

103822966(PTCH1)

PMOA:

120511975(PTCH1)

OTC:	121333264(PTCH1)

PRUF:

121360712(PTCH1)

GFR:	102033626(PTCH1)

FAB:	101813866(PTCH1)

OMA:	130265215(PTCH1)

PHI:	102104157(PTCH1)

PMAJ:

107198215(PTCH1)

CCAE:

111941810(PTCH1)

CCW:	104692014(PTCH1)

CBRC:

103619855(PTCH1)

ETL:	114055235(PTCH1) 114071695

ZAB:	102060815(PTCH1)

ACHL:

103801192(PTCH1)

SVG:	106848909(PTCH1)

MMEA:

130575821(PTCH1)

HRT:	120765624(PTCH1)

FPG:	101915344(PTCH1)

FCH:	102054107(PTCH1)

CLV:	102096921(PTCH1)

EGZ:	104125901(PTCH1)

NNI:	104011757(PTCH1) 104022796

PCRI:

104038460(PTCH1)

PLET:

104628516

EHS:	104507849(PTCH1)

PCAO:

104049532(PTCH1)

ACUN:

113490118(PTCH1)

TALA:

104359315(PTCH1)

PADL:

103920407(PTCH1)

AFOR:

103893793(PTCH1)

ACHC:

115336793(PTCH1) 121232936

HALD:

104312912(PTCH1)

HLE:	104832469(PTCH1)

AGEN:

126035435 126036458

GCL:	127027678 127027961

CCRI:

104168152(PTCH1)

CSTI:

104562852

CMAC:

104483781(PTCH1)

MUI:	104533453(PTCH1)

BREG:

104639091(PTCH1)

FGA:	104084285(PTCH1)

LDI:	104344265(PTCH1)

MNB:	103776680(PTCH1)

OHA:	104331154(PTCH1)

NNT:	104413540(PTCH1)

SHAB:

115619911(PTCH1)

DPUB:

104298786(PTCH1)

PGUU:

104463424(PTCH1)

ACAR:

104525590(PTCH1)

CPEA:

104389116(PTCH1)

AVIT:

104267036(PTCH1)

CVF:	104287166(PTCH1) 104292237

RTD:	128901901 128902375(PTCH1)

CUCA:

104059905(PTCH1)

TEO:	104377161(PTCH1)

BRHI:

104497422(PTCH1)

AAM:	106489077(PTCH1) 106492944

AROW:

112976814(PTCH1)

NPD:	112946422(PTCH1)

TGT:	104566507(PTCH1) 104572409

DNE:	112978825(PTCH1)

SCAM:

104146473 104152422

ASN:	102382615(PTCH1)

AMJ:	102570023(PTCH1)

CPOO:

109323424(PTCH1)

GGN:	109297535(PTCH1)

PSS:	102445339(PTCH1)

CMY:	102936563(PTCH1)

CCAY:

125636995(PTCH1)

DCC:	119856055(PTCH1)

CPIC:

101942144(PTCH1)

TST:	117878979(PTCH1)

CABI:

116821162(PTCH1)

MRV:	120408524(PTCH1)

ACS:	100561354(ptch1)

ASAO:

132767298(PTCH1)

PVT:	110084178(PTCH1)

SUND:

121922494(PTCH1)

PBI:	103057988(PTCH1)

PMUR:

107294604(PTCH1)

CTIG:

120308183(PTCH1)

TSR:	106537500(PTCH1)

PGUT:

117661370(PTCH1)

APRI:

131190886(PTCH1)

PTEX:

113438495(PTCH1)

NSS:	113416529(PTCH1)

VKO:	123031396(PTCH1)

PMUA:

114606550(PTCH1)

PRAF:

128423718(PTCH1)

ZVI:	118076713(PTCH1)

HCG:	128346780(PTCH1)

GJA:	107111660(PTCH1)

STOW:

125436183(PTCH1)

EMC:	129334733(PTCH1)

XLA:	108714691(ptch1.L) 398215(ptch1.S)

XTR:	100492061(ptch1)

NPR:	108788147(PTCH1)

RTEM:

120941850(PTCH1)

BBUF:

120989096(PTCH1)

BGAR:

122922751(PTCH1)

MUO:	115463278(PTCH1)

GSH:	117352069(PTCH1)

DRE:	30189(ptch1)

SRX:	107711868 107724865

SANH:

107669660 107689274

SGH:	107594528 107602819(ptch1)

CCAR:

109048512 109095008

CAUA:

113096379 113107504

CGIB:

127963772 128018538

PTET:

122350898(ptch1)

LROH:

127169827(ptch1)

OMC:	131545314(ptch1)

PPRM:

120484655(ptch1)

RKG:	130072459(ptch1)

MAMB:

125279705(ptch1)

CIDE:

127517759

MASI:

127414914 127424328

TROS:

130568269(ptch1)

TDW:	130439905(ptch1)

MANU:

129414094(ptch1)

IPU:

108265905

IFU:	128607840(ptch1)

PHYP:

113526490(ptch1)

SMEO:

124399875(ptch1)

TFD:	113656148(ptch1)

TVC:	132853484(ptch1)

AMEX:

103030480(ptch1)

CMAO:

118813172(ptch1)

EEE:	113591305(ptch1)

CHAR:

105894152 116224733(ptch1)

TRU:	101065775(ptch1)

TFS:	130525821(ptch1)

TNG:	GSTEN00008859G001

LCO:	104920679(ptch1)

NCC:

104961260

TBEN:

117472824(ptch1)

CGOB:

115013236(ptch1)

PGEO:

117453154(ptch1)

GACU:

117558558(ptch1)

EMAC:

134874090(ptch1)

ELY:	117252668(ptch1)

EFO:	125890475(ptch1)

PLEP:

121944402(ptch1)

SLUC:

116054025(ptch1)

ECRA:

117944979(ptch1)

ESP:	116688885(ptch1)

PFLV:

114555949(ptch1)

GAT:	120830892(ptch1)

PPUG:

119225375(ptch1)

AFB:	129101209(ptch1)

CLUM:

117736350(ptch1)

PSWI:

130197089(ptch1)

MSAM:

119891957(ptch1)

SCHU:

122876156(ptch1)

CUD:	121509987(ptch1)

ALAT:

119019829(ptch1)

MZE:	101469910(ptch1)

ONL:	100700194(ptch1)

OAU:	116311163(ptch1)

OLA:	101166055(ptch1)

OML:	112148505(ptch1)

CSAI:

133450601(ptch1)

XMA:	102216370(ptch1)

XCO:	114154713(ptch1)

XHE:	116729898(ptch1)

PRET:

103470155(ptch1)

PFOR:

103135448(ptch1)

PLAI:

106948666(ptch1)

PMEI:

106917880(ptch1)

GAF:	122828383(ptch1)

PPRL:

129366156(ptch1)

CVG:	107098237(ptch1)

CTUL:

119781110(ptch1)

GMU:	124878031(ptch1)

NFU:	107394090(ptch1)

KMR:	108244808(ptch1)

ALIM:

106534574(ptch1)

AOCE:

111576662(ptch1)

MCEP:

125012392(ptch1)

CSEM:

103397246 103398858

POV:	109639307(ptch1)

SSEN:

122769693(ptch1)

HHIP:

117768058(ptch1)

HSP:	118115454(ptch1)

SMAU:

118314237(ptch1)

LCF:

108882648

SDU:	111236154(ptch1)

SLAL:

111644627(ptch1)

XGL:	120805768(ptch1)

HCQ:	109520682(ptch1)

SSCV:

125994286

SBIA:

133499518(ptch1)

PEE:	133399906(ptch1)

PTAO:

133475246(ptch1)

BPEC:

110167016(ptch1)

MALB:

109956558(ptch1)

BSPL:

114862104(ptch1)

SJO:	128365391(ptch1)

SASA:

106580561 106585152(ptch1)

STRU:

115164238(ptch1) 115200404

OTW:	112249515(ptch1) 112262641

OMY:	110525920(ptch1) 110535101

OGO:	124034123(ptch1) 124036525

ONE:	115111823(ptch1) 115140695

OKI:	109894934 116357717(ptch1)

OKE:	118374258(ptch1) 118394092

SALP:

111957566 111974363(ptch1)

SNH:	120044320(ptch1) 120062919

CCLU:

121559464 121585073(ptch1)

ELS:	105014106(ptch1)

SFM:	108938420(ptch1)

PKI:	111836962(ptch2) 111839228(ptch1)

AANG:

118206641(ptch1)

LOC:	102685711(ptch1)

PSPA:

121303042 121314947

ARUT:

117411705 117973031

PSEX:

120532650(ptch1)

LCM:	102356323(PTCH1)

CMK:	103182828(ptch1)

RTP:	109910728(ptch1)

CPLA:

122561596(ptch1)

HOC:	132824157(ptch1)

LERI:

129695718(ptch1)

PMRN:

116950944

LRJ:	133358969(PTCH1)

CIN:

SCLV:

SPU:

APLC:

AJC:

SKO:

DME:	Dmel_CG2411(ptc)

DER:

6542563

DSE:

6608211

DSI:	Dsimw501_GD15378(Dsim_GD15378)

DYA:	Dyak_GE19216

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18803

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119674486 119677537

MDE:	101891704 131800407

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ003243

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100120760(Ptc)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	656155(Ptc)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

NVL:

APLN:

PPYR:

OTU:

BMOR:

MSEX:

DPL:	KGM_215640

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128996885 128997054

PHU:	Phum_PHUM390440

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DPX:	DAPPUDRAFT_40041(PTC)

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:	127003491 127003511

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:	111242949 111245110 111252634

VJA:	111261749 111266823 111270737

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_Y110A2AL.8(ptc-3) CELE_ZK675.1(ptc-1)

CBR:	CBG_03294 CBG_19582(Cbr-ptc-3)

CRQ:	GCK72_005683 GCK72_006798

NAI:	NECAME_13111

BMY:	BM_BM12292(Bma-ptc-3) BM_BM3500(Bm3500)

LOA:	LOAG_05826 LOAG_06459

TSP:

Tsp_05634

LGI:	LOTGIDRAFT_71238

PCAN:

BGT:

HRF:

HRJ:

CRG:

CVN:	111120798 111120833

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_131940

OVI:	T265_04436

EGL:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AAF:	AURANDRAFT_67307

» show all

Reference

PMID:8647801

Authors

Hahn H, Christiansen J, Wicking C, Zaphiropoulos PG, Chidambaram A, Gerrard B, Vorechovsky I, Bale AE, Toftgard R, Dean M, Wainwright B

Title

A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities.

Journal

J Biol Chem 271:12125-8 (1996)
DOI:10.1074/jbc.271.21.12125

Sequence

[hsa:5727] [mmu:19206]

LinkDB

DBGET integrated database retrieval system