KEGG   PATHWAY: cge04625
Entry
cge04625                    Pathway                                
Name
C-type lectin receptor signaling pathway - Cricetulus griseus (Chinese hamster)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
cge04625  C-type lectin receptor signaling pathway
cge04625

Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100772766  C-type lectin domain family 7 member A isoform X2 [KO:K10074]
100767209  Lsp1; lymphocyte-specific protein 1 [KO:K14957]
100773737  Hras; GTPase HRas isoform X2 [KO:K02833]
100763178  Kras; GTPase KRas isoform X4 [KO:K07827]
113839127  GTPase KRas-like [KO:K07827]
113837935  GTPase KRas-like isoform X2 [KO:K07827]
113837956  GTPase KRas-like [KO:K07827]
113838653  GTPase KRas-like isoform X2 [KO:K07827]
113838692  GTPase KRas-like [KO:K07827]
113838722  GTPase KRas-like isoform X1 [KO:K07827]
113838818  GTPase KRas-like [KO:K07827]
113837633  GTPase KRas-like isoform X1 [KO:K07827]
113838146  GTPase KRas-like isoform X1 [KO:K07827]
113838876  GTPase KRas-like [KO:K07827]
113838228  GTPase KRas-like isoform X1 [KO:K07827]
113839011  GTPase KRas-like [KO:K07827]
100771078  GTPase KRas-like isoform X2 [KO:K07827]
113837960  GTPase KRas-like [KO:K07827]
113838098  GTPase KRas-like [KO:K07827]
113838326  GTPase KRas-like [KO:K07827]
113838417  GTPase KRas-like isoform X1 [KO:K07827]
113838488  GTPase KRas-like [KO:K07827]
113838583  GTPase KRas-like isoform X1 [KO:K07827]
113838676  GTPase KRas-like [KO:K07827]
113838679  GTPase KRas-like isoform X1 [KO:K07827]
113838746  GTPase KRas-like [KO:K07827]
113838796  GTPase KRas-like isoform X1 [KO:K07827]
113838871  GTPase KRas-like [KO:K07827]
113838872  GTPase KRas-like [KO:K07827]
113838892  GTPase KRas-like [KO:K07827]
113838898  GTPase KRas-like [KO:K07827]
113838914  GTPase KRas-like [KO:K07827]
113838921  GTPase KRas-like [KO:K07827]
113838942  GTPase KRas-like isoform X1 [KO:K07827]
113838943  GTPase KRas-like isoform X1 [KO:K07827]
113839007  GTPase HRas-like isoform X1 [KO:K07827]
118239746  GTPase KRas-like isoform X1 [KO:K07827]
118239767  GTPase KRas-like isoform X1 [KO:K07827]
118239768  GTPase KRas-like [KO:K07827]
118239770  GTPase KRas-like [KO:K07827]
118239801  GTPase KRas-like [KO:K07827]
118239825  GTPase KRas-like isoform X1 [KO:K07827]
100757614  Nras; GTPase NRas [KO:K07828]
100767950  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
100766263  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
100771410  Rras2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
100769018  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100763542  Rela; transcription factor p65 isoform X4 [KO:K04735]
100752828  Relb; transcription factor RelB isoform X3 [KO:K09253]
113837283  transcription factor RelB-like isoform X1 [KO:K09253]
100760602  Il12a; interleukin-12 subunit alpha [KO:K05406]
100764758  Il12b; interleukin-12 subunit beta [KO:K05425]
100775079  Il1b; interleukin-1 beta [KO:K04519]
100758656  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
100771077  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
100766459  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X3 [KO:K04466] [EC:2.7.11.25]
100754432  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X5 [KO:K04467] [EC:2.7.11.10]
100774604  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X2 [KO:K04469]
100752475  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100764450  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X9 [KO:K04958]
100758965  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
100751775  inositol 1,4,5-trisphosphate receptor type 3 isoform X3 [KO:K04960]
100766751  Calml3; calmodulin-like protein 3 [KO:K02183]
100767046  Calml5; calmodulin-like protein 5 isoform X1 [KO:K02183]
100762749  Calm3; calmodulin-3 isoform X2 [KO:K02183]
100765281  Calm2; calmodulin-2 isoform X2 [KO:K02183]
100771772  Calm1; calmodulin-1 isoform X2 [KO:K02183]
100757500  Calml4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
100751814  calmodulin-like isoform X2 [KO:K02183]
100751412  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X6 [KO:K04348] [EC:3.1.3.16]
100752571  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
100764987  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100754314  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
100773706  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100764851  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100762227  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100760989  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100768420  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100755773  Il2; interleukin-2 [KO:K05429]
100759320  Il10; interleukin-10 isoform X1 [KO:K05443]
100770422  Egr2; E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
100751220  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100774348  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100759809  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 isoform X2 [KO:K12800]
100757158  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
100759171  caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
100759255  Card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
100750466  Bcl10; B-cell lymphoma/leukemia 10 [KO:K07368]
100770557  Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X3 [KO:K07369] [EC:3.4.22.-]
100689369  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100759762  Ikbkg; NF-kappa-B essential modulator isoform X6 [KO:K07210]
100750488  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100754153  Nfkbia; NF-kappa-B inhibitor alpha isoform X2 [KO:K04734]
100770607  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100764780  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
100689186  Il6; interleukin-6 [KO:K05405]
100765061  Il23a; interleukin-23 subunit alpha [KO:K05426]
100689104  Mapk14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
100759172  Mapk11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
100754042  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100763519  Mapk13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
100771734  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100754361  mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
100764964  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113834001  transcription factor AP-1 [KO:K04448]
100774600  Cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
100772671  Clec6a; C-type lectin domain family 6 member A isoform X1 [KO:K17514]
100768356  Fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
100770076  CD209 antigen-like protein A [KO:K06563]
100756903  CD209 antigen-like protein A isoform X2 [KO:K06563]
100773817  CD209 antigen-like protein C [KO:K06563]
100755286  LOW QUALITY PROTEIN: CD209 antigen-like protein 2 [KO:K06563]
100772951  CD209 antigen-like protein E [KO:K06563]
100773244  CD209 antigen-like protein D [KO:K06563]
100773525  CD209 antigen-like protein B isoform X1 [KO:K06563]
100755579  LOW QUALITY PROTEIN: CD209 antigen-like protein C isoform X2 [KO:K06563]
100765006  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X3 [KO:K07532]
100762797  Rhoa; transforming protein RhoA [KO:K04513]
100757042  transforming protein RhoA isoform X1 [KO:K04513]
100767503  Pak1; serine/threonine-protein kinase PAK 1 isoform X4 [KO:K04409] [EC:2.7.11.1]
100769629  Ksr1; kinase suppressor of Ras 1 isoform X2 [KO:K14958]
100762491  Plk3; serine/threonine-protein kinase PLK3 isoform X2 [KO:K08862] [EC:2.7.11.21]
100757188  Src; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
100761646  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X11 [KO:K07211] [EC:2.7.11.10]
100755609  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
100760392  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
100764772  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100763580  Il17d; LOW QUALITY PROTEIN: interleukin-17D isoform X2 [KO:K05492]
100758070  Cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
100751077  Bcl3; B-cell lymphoma 3 protein isoform X2 [KO:K09258]
100764062  Ccl17; C-C motif chemokine 17 [KO:K21083]
100760298  Ccl22; C-C motif chemokine 22 [KO:K21095]
100762218  Mapkapk2; MAP kinase-activated protein kinase 2 isoform X2 [KO:K04443] [EC:2.7.11.1]
100773355  Clec4e; C-type lectin domain family 4 member E [KO:K10059]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100768351  Akt2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100752454  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100769460  Akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100770120  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X3 [KO:K06643] [EC:2.3.2.27]
100756092  Irf1; interferon regulatory factor 1 isoform X2 [KO:K09444]
100775089  Clec4d; C-type lectin domain family 4 member D [KO:K10058]
100770085  C-type lectin domain family 1 member B isoform X1 [KO:K10070]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
Related
pathway
cge04658  Th1 and Th2 cell differentiation
cge04659  Th17 cell differentiation
KO pathway
ko04625   
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