KEGG   PATHWAY: chx05161
Entry
chx05161                    Pathway                                
Name
Hepatitis B - Capra hircus (goat)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
chx05161  Hepatitis B
chx05161

Organism
Capra hircus (goat) [GN:chx]
Gene
102188640  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
102177168  SLC10A1; sodium/bile acid cotransporter [KO:K14341]
102191364  TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
100861228  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
102189962  TGFB3; transforming growth factor beta-3 [KO:K13377]
102187767  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100861300  TGFBR2; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102169293  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
102179898  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102171262  MYC; myc proto-oncogene protein [KO:K04377]
102174905  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
106501825  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
102187824  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102187383  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
102178753  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102173071  DDB1; DNA damage-binding protein 1 [KO:K10610]
102171356  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
102187530  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
102186877  YWHAQ; 14-3-3 protein theta [KO:K16197]
102175223  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
102172459  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
102175799  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102181262  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102177406  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102171591  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102169137  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102175660  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102174096  RELA; transcription factor p65 [KO:K04735]
102168469  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
100861254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102189930  BAD; bcl2-associated agonist of cell death [KO:K02158]
102180451  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
102170760  FADD; FAS-associated death domain protein [KO:K02373]
102169919  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102176106  BID; BH3-interacting domain death agonist [KO:K04726]
100846984  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
102188830  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
106501717  cytochrome c 2 [KO:K08738]
102173997  cytochrome c [KO:K08738]
102174681  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102177031  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102180077  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
102169621  TP53; cellular tumor antigen p53 [KO:K04451]
102176051  CCNA1; cyclin-A1 [KO:K06627]
102190390  CCNA2; cyclin-A2 [KO:K06627]
100860751  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102185672  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
102184185  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
102183886  RB1; retinoblastoma-associated protein [KO:K06618]
102173018  E2F1; transcription factor E2F1 [KO:K17454]
102186169  E2F2; transcription factor E2F2 [KO:K09389]
102169535  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
108635054  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
106502862  V-type proton ATPase subunit S1 [KO:K03662]
102180890  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102172114  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
102175984  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102188180  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102180958  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102184725  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100861232  TNF; tumor necrosis factor [KO:K03156]
102182846  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102180670  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
102171504  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
102188492  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
102186154  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
102189170  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
102190301  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102189443  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
102185866  signal transducer and activator of transcription 5A [KO:K11223]
102176415  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
102180571  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
102176666  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102184810  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
102182890  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102170356  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102185660  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102184154  SOS2; son of sevenless homolog 2 [KO:K03099]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102187180  NRAS; GTPase NRas [KO:K07828]
102185423  JUN; transcription factor AP-1 [KO:K04448]
100861019  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
102180634  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
102186065  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102180221  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
102174829  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102183745  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
102183893  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102170199  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102185072  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102190378  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
102171671  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
102178438  CXCL8; interleukin-8 [KO:K10030]
102172276  PCNA; proliferating cell nuclear antigen [KO:K04802]
102169370  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102174360  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102175285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102171520  FOS; proto-oncogene c-Fos [KO:K04379]
102170129  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100860747  TLR2; toll-like receptor 2 precursor [KO:K10159]
102174883  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102184789  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
100860955  TLR4; toll-like receptor 4 precursor [KO:K10160]
102171575  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102177432  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102172830  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
102185161  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102187405  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102172719  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
100860785  IL6; interleukin-6 precursor [KO:K05405]
102173967  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102169516  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
102180926  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100860996  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102189174  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102184510  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102173178  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108636847  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
102182757  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
102170774  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102183788  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
102183188  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
102178286  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
102171742  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
102183809  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102181474  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
102171588  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
108634620  ATP-dependent RNA helicase DDX3X-like [KO:K11594] [EC:5.6.2.7]
102171811  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
106503773  IRF7; interferon regulatory factor 7 [KO:K09447]
108635529  interferon alpha-H-like [KO:K05414]
108633160  interferon alpha-1-like [KO:K05414]
100860850  IFNA; interferon-alpha precursor [KO:K05414]
102174842  interferon alpha-1-like [KO:K05414]
102179943  interferon alpha-H-like [KO:K05414]
102180761  interferon alpha-H [KO:K05414]
102181299  interferon alpha-H-like [KO:K05414]
108636621  interferon alpha-H-like [KO:K05414]
108636627  interferon alpha-H-like [KO:K05414]
102181867  interferon beta-2 [KO:K05415]
102189208  LOW QUALITY PROTEIN: interferon beta-2 [KO:K05415]
102181595  interferon beta-2-like [KO:K05415]
108636544  interferon beta-2-like [KO:K05415]
108636629  interferon beta-2-like [KO:K05415]
108636632  interferon beta-2-like [KO:K05415]
108636634  interferon beta-2 [KO:K05415]
108633243  interferon beta-2-like [KO:K05415]
102191552  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
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PMID:25550115
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Zhang E, Lu M
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Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
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Med Microbiol Immunol 204:11-20 (2015)
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PMID:20375222
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Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
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J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
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PMID:23363957
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Revill P, Yuan Z
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New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
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Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
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PMID:28893934
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Hopcraft SE, Damania B
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Tumour viruses and innate immunity.
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Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
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PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
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Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
chx04010  MAPK signaling pathway
chx04064  NF-kappa B signaling pathway
chx04110  Cell cycle
chx04115  p53 signaling pathway
chx04151  PI3K-Akt signaling pathway
chx04210  Apoptosis
chx04620  Toll-like receptor signaling pathway
chx04622  RIG-I-like receptor signaling pathway
chx04630  JAK-STAT signaling pathway
KO pathway
ko05161   
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