KEGG   PATHWAY: cjc05163
Entry
cjc05163                    Pathway                                
Name
Human cytomegalovirus infection - Callithrix jacchus (white-tufted-ear marmoset)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
cjc05163  Human cytomegalovirus infection
cjc05163

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100412331  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100407741  TSC1; hamartin isoform X2 [KO:K07206]
100390664  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
100410955  RHEB; GTP-binding protein Rheb isoform X2 [KO:K07208]
100406608  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100386453  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100397180  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100409247  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X3 [KO:K04688] [EC:2.7.11.1]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100390258  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100412158  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100395682  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100414931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100410124  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100406017  HRAS; GTPase HRas [KO:K02833]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
108591807  GTPase NRas-like [KO:K07828]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100393766  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100407824  SP1; transcription factor Sp1 isoform X3 [KO:K04684]
100389906  ITGAV; integrin alpha-V [KO:K06487]
100386042  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100386165  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100404109  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100895294  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100395636  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100400756  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100393236  RHOA; transforming protein RhoA [KO:K04513]
100404129  transforming protein RhoA-like [KO:K04513]
100387233  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
100403981  STING1; stimulator of interferon genes protein [KO:K12654]
100399701  TBK1; serine/threonine-protein kinase TBK1 isoform X6 [KO:K05410] [EC:2.7.11.10]
100414132  IRF3; interferon regulatory factor 3 isoform X4 [KO:K05411]
100414516  interferon alpha-1/13-like [KO:K05414]
100390201  interferon alpha-5-like [KO:K05414]
100406098  interferon alpha-5-like [KO:K05414]
100406466  interferon alpha-14 [KO:K05414]
100387372  interferon alpha-5-like [KO:K05414]
103793369  interferon alpha-5-like [KO:K05414]
128928158  interferon alpha-14-like [KO:K05414]
128932203  interferon alpha-5-like [KO:K05414]
100388391  IFNB1; interferon beta [KO:K05415]
100397484  TNF; tumor necrosis factor [KO:K03156]
100397418  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
100415562  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100401347  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171]
100388423  TRAF5; TNF receptor-associated factor 5 isoform X3 [KO:K09849]
100404226  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100406769  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
100393945  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100402266  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100387612  CCL2; C-C motif chemokine 2 [KO:K14624]
100389780  CCL5; C-C motif chemokine 5 [KO:K12499]
100390587  CXCL8; interleukin-8 [KO:K10030]
100393440  IL6; interleukin-6 precursor [KO:K05405]
100412968  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2 [KO:K04536]
100395033  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100407336  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100395633  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
100415506  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X2 [KO:K04539]
100391372  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100397915  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100411028  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103787193  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
108590740  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
108593490  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118150544  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
128930422  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100411155  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
108589488  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100385281  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
108588980  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
100412160  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100396640  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100394978  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108594009  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100412503  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100394732  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100403006  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
100386734  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
100400803  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100386921  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100409716  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100410075  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
100385763  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
118144170  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100390843  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100390180  CALM1; calmodulin-1 [KO:K02183]
100386819  CALM2; calmodulin-2 isoform X2 [KO:K02183]
100406081  CALM3; calmodulin-3 [KO:K02183]
100408289  CALML3; calmodulin-like protein 3 [KO:K02183]
100392199  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100396690  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
108592443  CALML5; calmodulin-like protein 5 [KO:K02183]
118148021  calmodulin-1-like [KO:K02183]
100386369  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
100387059  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100386452  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100392986  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100388148  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100405187  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100414856  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100406801  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100385008  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100407639  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100404474  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100405745  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630]
100388113  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100389396  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100394265  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100385658  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100415165  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100415141  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100412782  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100406617  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100404620  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100404484  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100405403  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100392123  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100408115  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
100407692  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100400737  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100409206  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
118151333  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
100415219  CCL3L3; C-C motif chemokine 3-like 1 [KO:K05408]
100385441  C-C motif chemokine 4-like isoform X1 [KO:K12964]
100412922  CX3CL1; fractalkine [KO:K05508]
100387912  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100394016  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
100409602  ARHGEF1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
100389507  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X5 [KO:K12331]
100411450  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
100390018  AKAP13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
100394652  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100408337  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100395047  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100396387  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100394168  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
108590441  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
100410649  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100408515  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
103787209  neuroendocrine secretory protein 55 [KO:K04632]
100387683  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103796419  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100407754  MYC; myc proto-oncogene protein [KO:K04377]
100385661  IL6R; interleukin-6 receptor subunit alpha precursor [KO:K05055]
100385835  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100389282  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100389629  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100397389  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
100396611  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100396967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100404377  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100405093  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100407681  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100414156  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
100392193  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100394351  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100408954  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100406635  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100411140  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100409637  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100392579  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X6 [KO:K09047]
100411862  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100402880  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
100406954  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100404210  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
100395283  PTK2; focal adhesion kinase 1 isoform X9 [KO:K05725] [EC:2.7.10.2]
100391559  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X7 [KO:K05726]
100390206  CRKL; crk-like protein [KO:K04438]
100399916  CRK; adapter molecule crk isoform X1 [KO:K04438]
103795442  PXN; paxillin isoform X1 [KO:K05760]
100396693  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
100409946  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
100415726  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
100398059  CCR1; C-C chemokine receptor type 1 [KO:K04176]
100398418  CCR3; C-C chemokine receptor type 3 [KO:K04178]
100399144  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100407051  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100406316  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
100409944  TAPBP; tapasin isoform X1 [KO:K08058]
100395129  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100401971  CALR; calreticulin [KO:K08057]
100406240  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
100398361  patr class I histocompatibility antigen, CH28 alpha chain isoform X3 [KO:K06751]
100405128  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100399078  patr class I histocompatibility antigen, A-126 alpha chain isoform X3 [KO:K06751]
100411069  patr class I histocompatibility antigen, A-126 alpha chain isoform X6 [KO:K06751]
100388209  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100387811  CAJA-E; patr class I histocompatibility antigen, alpha chain E precursor [KO:K06751]
118151094  saoe class I histocompatibility antigen, A alpha chain [KO:K06751]
100404307  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
100394189  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100415620  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100396301  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
100415710  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100894215  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100408304  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100385604  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100397928  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100414261  E2F1; transcription factor E2F1 [KO:K17454]
100414776  E2F2; transcription factor E2F2 [KO:K09389]
100390235  E2F3; transcription factor E2F3 isoform X4 [KO:K06620]
100404850  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100397803  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100410616  FADD; FAS-associated death domain protein [KO:K02373]
100395220  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100403496  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
100391322  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100387945  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
108593648  cytochrome c-like [KO:K08738]
108593819  cytochrome c-like [KO:K08738]
108593835  cytochrome c-like [KO:K08738]
108588095  cytochrome c-like [KO:K08738]
100406761  cytochrome c-like [KO:K08738]
100401718  cytochrome c [KO:K08738]
100413276  cytochrome c-like [KO:K08738]
108591937  cytochrome c-like [KO:K08738]
108592162  cytochrome c-like [KO:K08738]
108591932  cytochrome c, somatic-like [KO:K08738]
100409028  CASP9; caspase-9 isoform X3 [KO:K04399] [EC:3.4.22.62]
100387570  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
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Related
pathway
cjc00590  Arachidonic acid metabolism
cjc03050  Proteasome
cjc04010  MAPK signaling pathway
cjc04064  NF-kappa B signaling pathway
cjc04110  Cell cycle
cjc04150  mTOR signaling pathway
cjc04151  PI3K-Akt signaling pathway
cjc04210  Apoptosis
cjc04612  Antigen processing and presentation
cjc04623  Cytosolic DNA-sensing pathway
cjc04630  JAK-STAT signaling pathway
cjc04668  TNF signaling pathway
cjc04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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