Entry Name Wnt signaling pathway - Callorhinchus milii (elephant shark)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Callorhinchus milii (elephant shark) [GN:
cmk ]
Gene 103185034 wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572 ]
103180565 serpinf1; pigment epithelium-derived factor precursor [KO:K19614 ]
103174981 lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309 ]
103185324 leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308 ]
103179094 leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399 ]
103174935 lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068 ]
103179330 lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068 ]
103186420 bambia; BMP and activin membrane-bound inhibitor homolog precursor [KO:K10162 ]
103174308 LOW QUALITY PROTEIN: glycogen synthase kinase binding protein [KO:K03096 ]
103176318 nkd2b; protein naked cuticle homolog 2-like isoform X1 [KO:K03213 ]
103181147 apc; LOW QUALITY PROTEIN: adenomatous polyposis coli protein [KO:K02085 ]
103182088 apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085 ]
103175772 tbl1xr1a; F-box-like/WD repeat-containing protein TBL1XR1a [KO:K04508 ]
103179386 prickle1b; LOW QUALITY PROTEIN: prickle-like protein 1b [KO:K04511 ]
103178516 daam1a; LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 1 [KO:K04512 ]
103190354 daam2; disheveled-associated activator of morphogenesis 2-like [KO:K04512 ]
103191021 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
103187499 LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
103181591 camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
121852068 LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515 ] [EC:2.7.11.17 ]
103185841 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348 ] [EC:3.1.3.16 ]
103186967 ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
103183227 nfatc1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
103191018 nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
103176110 nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway LinkDB All DBs
