KEGG   PATHWAY: cns04013
Entry
cns04013                    Pathway                                
Name
MAPK signaling pathway - fly - Contarinia nasturtii (swede midge)
Description
The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Class
Environmental Information Processing; Signal transduction
Pathway map
cns04013  MAPK signaling pathway - fly
cns04013

Other DBs
GO: 0000165
Organism
Contarinia nasturtii (swede midge) [GN:cns]
Gene
116344966  torso-like protein [KO:K12377]
116340865  protein trunk-like [KO:K20226]
116342257  protein trunk-like [KO:K20226]
116350528  uncharacterized protein LOC116350528 [KO:K20227]
116342472  uncharacterized protein LOC116342472 [KO:K20228]
116345728  tyrosine-protein kinase receptor torso-like isoform X1 [KO:K12378] [EC:2.7.10.1]
116342743  protein giant-lens [KO:K02104]
116338640  protein vein isoform X1 [KO:K16690]
116342894  protein spitz-like [KO:K16691]
116340995  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116340841  uncharacterized protein LOC116340841 [KO:K20230]
116348110  proto-oncogene tyrosine-protein kinase ROS-like [KO:K05088] [EC:2.7.10.1]
116350943  proto-oncogene tyrosine-protein kinase ROS-like [KO:K05088] [EC:2.7.10.1]
116343521  proto-oncogene tyrosine-protein kinase ROS-like isoform X1 [KO:K05088] [EC:2.7.10.1]
116350900  SHC-transforming protein 1 [KO:K06279]
116352612  protein enhancer of sevenless 2B [KO:K04364]
116351945  protein daughter of sevenless [KO:K20231]
116340555  tyrosine-protein phosphatase corkscrew isoform X1 [KO:K07293] [EC:3.1.3.48]
116341426  protein son of sevenless isoform X1 [KO:K03099]
116345661  protein sprouty [KO:K17383]
116342755  ras GTPase-activating protein 1 isoform X1 [KO:K04352]
116342566  GTPase-activating protein [KO:K12380]
116342361  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
116338505  14-3-3 protein zeta isoform X1 [KO:K16197]
116340678  serine/threonine-protein phosphatase PP2A [KO:K04382] [EC:3.1.3.16]
116343032  uncharacterized protein LOC116343032 [KO:K17536]
116349855  kinase suppressor of Ras 2-like [KO:K18529] [EC:2.7.11.1]
116349943  kinase suppressor of Ras 2-like isoform X1 [KO:K18529] [EC:2.7.11.1]
116347451  dual specificity mitogen-activated protein kinase kinase dSOR1-like [KO:K04368] [EC:2.7.12.2]
116340771  dual specificity mitogen-activated protein kinase kinase dSOR1-like [KO:K04368] [EC:2.7.12.2]
116348270  dual specificity mitogen-activated protein kinase kinase dSOR1-like [KO:K04368] [EC:2.7.12.2]
116342246  dual specificity mitogen-activated protein kinase kinase dSOR1-like [KO:K04368] [EC:2.7.12.2]
116343982  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116340348  uncharacterized protein LOC116340348 isoform X1 [KO:K20220] [EC:3.1.3.48]
116339065  importin-7 [KO:K20223]
116349074  putative transcription factor capicua isoform X1 [KO:K20225]
116336620  protein tailless [KO:K08545]
116340510  protein groucho-like [KO:K04497]
116348923  protein groucho isoform X1 [KO:K04497]
116345887  Krueppel-like factor 4 [KO:K12379]
116339304  ETS-like protein pointed isoform X1 [KO:K02678]
116336930  ets DNA-binding protein pokkuri [KO:K03211]
116337222  exportin-1 [KO:K14290]
116342488  protein tramtrack, alpha isoform-like isoform X1 [KO:K09237]
116352081  protein phyllopod [KO:K20233]
116346899  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:2.3.2.27]
116341552  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
116346810  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
116344766  protein lozenge [KO:K20214]
116336737  homeobox protein prospero isoform X1 [KO:K20211]
116339551  tumor necrosis factor receptor superfamily member wengen [KO:K16679]
116343946  uncharacterized protein LOC116343946 [KO:K20234]
116336575  tyrosine-protein kinase Src64B isoform X1 [KO:K05704] [EC:2.7.10.2]
116341451  tyrosine-protein kinase Btk29A isoform X1 [KO:K07364] [EC:2.7.10.2]
116349442  tyrosine-protein kinase Shark isoform X1 [KO:K17512] [EC:2.7.10.2]
116338413  serine/threonine-protein kinase mig-15 isoform X1 [KO:K08840] [EC:2.7.11.1]
116341118  ras-like GTP-binding protein RhoL [KO:K04392]
116341682  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116350186  ras-related protein Rac1 [KO:K04392]
116343003  ras-like GTP-binding protein RhoL [KO:K04392]
116336910  ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
116344694  probable basic-leucine zipper transcription factor N isoform X1 [KO:K04404]
116342759  mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04417] [EC:2.7.11.25]
116344782  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116346422  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
116345496  stress-activated protein kinase JNK-like [KO:K04440] [EC:2.7.11.24]
116341527  striatin [KO:K17608]
116350146  transcription factor AP-1 [KO:K04448]
116343773  ras-responsive element-binding protein 1 [KO:K20210]
116340766  uncharacterized protein LOC116340766 isoform X1 [KO:K20235]
116350486  uncharacterized protein LOC116350486 isoform X1 [KO:K20235]
116340869  protein decapentaplegic [KO:K04662]
116352615  profilin [KO:K05759]
116341326  uncharacterized protein LOC116341326 [KO:K20016]
116337061  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
116352343  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
116339144  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
116343518  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
116338437  mitogen-activated protein kinase p38b-like [KO:K04441] [EC:2.7.11.24]
116349554  cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
116343935  dual oxidase [KO:K13411] [EC:1.6.3.1 1.11.1.-]
116348990  optomotor-blind protein isoform X1 [KO:K10176]
116345988  myocyte-specific enhancer factor 2 isoform X1 [KO:K09260]
116342484  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
Reference
PMID:23732470
  Authors
Sopko R, Perrimon N
  Title
Receptor tyrosine kinases in Drosophila development.
  Journal
Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050
Reference
PMID:15704136
  Authors
Li WX
  Title
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
  Journal
Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295
Reference
PMID:12648473
  Authors
Shilo BZ
  Title
Signaling by the Drosophila epidermal growth factor receptor pathway during development.
  Journal
Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0
Reference
PMID:10771085
  Authors
Raabe T
  Title
The sevenless signaling pathway: variations of a common theme.
  Journal
Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3
Reference
PMID:23109363
  Authors
Rios-Barrera LD, Riesgo-Escovar JR
  Title
Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
  Journal
Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354
Reference
PMID:24981286
  Authors
Igaki T, Miura M
  Title
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
  Journal
Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003
Reference
PMID:16014325
  Authors
Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
  Title
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
  Journal
Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013
Reference
PMID:10557109
  Authors
Stronach BE, Perrimon N
  Title
Stress signaling in Drosophila.
  Journal
Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125
Related
pathway
cns04214  Apoptosis - fly
KO pathway
ko04013   
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