KEGG   PATHWAY: csyr04540
Entry
csyr04540                   Pathway                                
Name
Gap junction - Carlito syrichta (Philippine tarsier)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
csyr04540  Gap junction
csyr04540

Other DBs
GO: 0005921
Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103272272  gap junction alpha-1 protein [KO:K07372]
103268330  GJD2; gap junction delta-2 protein [KO:K07373]
103272585  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103263431  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
103255466  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
103264772  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
103255351  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103250983  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
103267441  PDGFD; platelet-derived growth factor D [KO:K05450]
103265612  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
103267942  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
103249185  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103263367  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103268107  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103275922  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103270607  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103276422  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
103250130  HRAS; GTPase HRas isoform X1 [KO:K02833]
103263630  KRAS; GTPase KRas isoform X2 [KO:K07827]
103259236  NRAS; GTPase NRas [KO:K07828]
103263745  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
103277453  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103251709  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103265435  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103274188  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103273857  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103276598  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
103267084  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
103273099  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
103261248  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
103261588  tubulin alpha-1 chain-like [KO:K07374]
103262680  TUBA8; tubulin alpha-8 chain [KO:K07374]
103271714  tubulin alpha-3 chain [KO:K07374]
103253635  tubulin alpha-1 chain-like [KO:K07374]
103261884  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
103273447  TUBA1B; tubulin alpha-1B chain isoform X1 [KO:K07374]
103271353  tubulin alpha-3 chain [KO:K07374]
103269656  tubulin beta-4A chain isoform X1 [KO:K07375]
103270010  TUBB1; tubulin beta-1 chain isoform X2 [KO:K07375]
103250978  tubulin beta-4B chain-like isoform X1 [KO:K07375]
103261319  TUBB; tubulin beta chain isoform X1 [KO:K07375]
103253258  tubulin beta-6 chain [KO:K07375]
103253520  tubulin beta chain-like isoform X1 [KO:K07375]
103272009  tubulin beta-2A chain isoform X3 [KO:K07375]
103272010  tubulin beta-2B chain isoform X2 [KO:K07375]
103251324  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
103267344  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
103258785  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
103254801  DRD1; D(1A) dopamine receptor [KO:K04144]
103251768  neuroendocrine secretory protein 55 [KO:K04632]
103255823  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
103276000  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
103252919  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103262642  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103272228  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
103254816  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103273462  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103259338  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103267869  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103273680  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103253311  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
103266092  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103254749  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
103265332  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
103257339  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
103269071  LOW QUALITY PROTEIN: metabotropic glutamate receptor 1-like [KO:K04603]
103268803  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
103252789  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
103258399  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103261218  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
103257479  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103272341  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103275147  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
103256992  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103261167  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103269243  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103269994  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103251444  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103276479  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103250785  guanylate cyclase soluble subunit alpha-2-like [KO:K12318] [EC:4.6.1.2]
103253703  GUCY1A3; guanylate cyclase soluble subunit alpha-3 isoform X1 [KO:K12318] [EC:4.6.1.2]
103253702  GUCY1B3; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
103268507  guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
103275000  cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
103272881  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
csyr04010  MAPK signaling pathway
csyr04020  Calcium signaling pathway
csyr04060  Cytokine-cytokine receptor interaction
csyr04070  Phosphatidylinositol signaling system
csyr04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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