KEGG   PATHWAY: ctig04060
Entry
ctig04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Crotalus tigris (Tiger rattlesnake)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ctig04060  Cytokine-cytokine receptor interaction
ctig04060

Organism
Crotalus tigris (Tiger rattlesnake) [GN:ctig]
Gene
120309084  C-C motif chemokine 5-like [KO:K12964]
120309204  C-C motif chemokine 4-like [KO:K12964]
120318580  CCL28; C-C motif chemokine 28 [KO:K05513]
120302722  interleukin-8-like [KO:K10030]
120311145  C-X-C motif chemokine 11-6-like [KO:K12672]
120311156  C-X-C motif chemokine 11-like [KO:K12672]
120296751  alveolar macrophage chemotactic factor-like [KO:K10032]
120296745  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
120309933  CXCL12; stromal cell-derived factor 1 [KO:K10031]
120304377  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
120306197  IL15; interleukin-15 isoform X1 [KO:K05433]
120299737  EPO; erythropoietin [KO:K05437]
120302686  somatotropin-like [KO:K05438]
120298694  PRL; prolactin [KO:K05439]
120313987  thrombopoietin-like isoform X1 [KO:K06854]
120315179  myelomonocytic growth factor-like isoform X1 [KO:K05423]
120303713  leptin [KO:K05424]
120307373  IL6; interleukin-6 isoform X1 [KO:K05405]
120304395  IL11; interleukin-11 [KO:K05417]
120311467  interleukin-12 subunit beta-like [KO:K05425]
120304576  uncharacterized protein LOC120304576 isoform X1 [KO:K22629]
120320012  EBI3; interleukin-27 subunit beta [KO:K24476]
120306950  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
120307042  CNTF; ciliary neurotrophic factor [KO:K05420]
120302313  cardiotrophin-2-like [KO:K24382]
120303284  LIF; leukemia inhibitory factor [KO:K05419]
120297448  IL10; interleukin-10 [KO:K05443]
120307680  IL22; interleukin-22 isoform X1 [KO:K05445]
120314223  interferon alpha-21-like [KO:K05414]
120307681  IFNG; interferon gamma [KO:K04687]
120299419  IL1B; interleukin-1 beta [KO:K04519]
120299430  interleukin-1 receptor antagonist protein-like isoform X1 [KO:K05481]
120311261  interleukin-18-like [KO:K05482]
120300342  interleukin-17F-like [KO:K05494]
120312217  IL17B; interleukin-17B [KO:K05490]
120302491  IL17C; interleukin-17C [KO:K05491]
120311690  IL17D; interleukin-17D isoform X1 [KO:K05492]
120315264  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
120298943  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
120313450  TNF; tumor necrosis factor [KO:K03156]
120310465  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
120300257  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
120311448  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
120305867  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
120310190  EDA; ectodysplasin-A isoform X1 [KO:K05480]
120314141  NGF; beta-nerve growth factor [KO:K02582]
120318729  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
120313166  CD40LG; CD40 ligand [KO:K03161]
120300397  TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
120319885  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
120317025  transforming growth factor beta-2 proprotein-like [KO:K13376]
120306706  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
120297457  transforming growth factor beta-2 proprotein [KO:K13376]
120311758  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
120304299  GDF15; growth/differentiation factor 15 [KO:K05504]
120319584  GDF2; growth/differentiation factor 2 [KO:K05503]
120299431  BMP10; bone morphogenetic protein 10 [KO:K22670]
120312953  INHA; inhibin alpha chain [KO:K05500]
120311421  BMP3; bone morphogenetic protein 3 [KO:K05496]
120306144  GDF11; growth/differentiation factor 11 [KO:K22679]
120298378  MSTN; growth/differentiation factor 8 [KO:K05497]
120305243  INHBA; inhibin beta A chain [KO:K04667]
120297117  INHBB; inhibin beta B chain [KO:K22687]
120299790  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
120303437  NODAL; nodal homolog [KO:K04666]
120311397  GDF9; growth/differentiation factor 9 [KO:K22673]
120311316  inhibin beta E chain-like [KO:K22688]
120301359  AMH; muellerian-inhibiting factor [KO:K04665]
120299534  bone morphogenetic protein 2-like [KO:K21283]
120312041  bone morphogenetic protein 2-like [KO:K21283]
120315300  BMP2; bone morphogenetic protein 2 isoform X1 [KO:K21283]
120297875  BMP4; bone morphogenetic protein 4 [KO:K04662]
120297032  GDF5; growth/differentiation factor 5 [KO:K04664]
120301517  GDF6; growth/differentiation factor 6 [KO:K20012]
120317601  GDF7; growth/differentiation factor 7 [KO:K20013]
120313234  BMP15; bone morphogenetic protein 15 isoform X1 [KO:K05498]
120297573  BMP5; bone morphogenetic protein 5 [KO:K04663]
120311109  BMP6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
120307940  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
120301209  BMP8A; bone morphogenetic protein 8A [KO:K16622]
120312793  CCR7; C-C chemokine receptor type 7 [KO:K04182]
120305297  CCR4; C-C chemokine receptor type 4 isoform X1 [KO:K04179]
120304971  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
120304979  C-C chemokine receptor type 1-like [KO:K04180]
120301026  CCR10; C-C chemokine receptor type 10 [KO:K04185]
120307902  C-X-C chemokine receptor type 1-like [KO:K05050]
120307908  C-X-C chemokine receptor type 1-like [KO:K05050]
120312034  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
120301944  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
120307499  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
120300383  ACKR3; atypical chemokine receptor 3 isoform X1 [KO:K04304]
120304973  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
120304972  XCR1; chemokine XC receptor 1 [KO:K04193]
120305298  CX3C chemokine receptor 1-like isoform X1 [KO:K04192]
120312416  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
120310016  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
120310820  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
120314092  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
120312411  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
120297521  interleukin-5 receptor subunit alpha-like [KO:K05066]
120313190  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
120305098  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
120318581  GHR; growth hormone receptor isoform X1 [KO:K05080]
120310015  PRLR; prolactin receptor isoform X1 [KO:K05081]
120299026  MPL; thrombopoietin receptor isoform X1 [KO:K05082]
120301512  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
120310003  LEPR; leptin receptor [KO:K05062]
120313516  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
120316180  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
120305983  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
120301629  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
120301904  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
120313520  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
120316182  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
120310032  LIFR; leukemia inhibitory factor receptor [KO:K05058]
120310034  oncostatin-M-specific receptor subunit beta-like isoform X1 [KO:K05057]
120307257  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
120296989  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
120298917  interleukin-20 receptor subunit alpha-like isoform X1 [KO:K05136]
120300064  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
120316884  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
120296983  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
120297000  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
120298684  IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
120296956  interferon gamma receptor 2-like [KO:K05133]
120313650  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
120313652  interleukin-1 receptor-like 2 [KO:K04386]
120319821  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
120313675  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
120313674  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
120297220  interleukin-18 receptor accessory protein isoform X1 [KO:K05174]
120316688  IL17RA; interleukin-17 receptor A [KO:K05164]
120303688  IL17RC; interleukin-17 receptor C [KO:K05166]
120315891  interleukin-17 receptor B-like [KO:K05165]
120303684  IL17RE; interleukin-17 receptor E isoform X1 [KO:K05168]
120306099  uncharacterized protein LOC120306099 isoform X1 [KO:K06454]
120306868  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
120318665  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
120319215  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
120300659  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
120300387  TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157]
120302833  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
120317644  EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163]
120303484  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
120319704  death domain-containing membrane protein NRADD-like [KO:K02583]
120317963  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
120319516  tumor necrosis factor receptor superfamily member 11B-like [KO:K05148]
120304238  tumor necrosis factor receptor superfamily member 11A-like [KO:K05147]
120302305  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
120315723  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
120313840  TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
120300323  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
120309891  RELL1; RELT-like protein 1 [KO:K26541]
120310061  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
120299217  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
120308137  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
120305449  ACVRL1; serine/threonine-protein kinase receptor R3 isoform X1 [KO:K13594] [EC:2.7.11.30]
120301136  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
120313103  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
120304070  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
120305450  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
120304605  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
120304602  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
120309975  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
120307998  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
120298803  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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