KEGG   PATHWAY: cuca04145
Entry
cuca04145                   Pathway                                
Name
Phagosome - Cuculus canorus (common cuckoo)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
cuca04145  Phagosome
cuca04145

Other DBs
GO: 0045335
Organism
Cuculus canorus (common cuckoo) [GN:cuca]
Gene
104060584  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
104063565  STX12; syntaxin-12 [KO:K13813]
104058224  STX7; syntaxin-7 [KO:K08488]
104059446  ACTG1; actin, cytoplasmic 2 [KO:K05692]
104066279  actin, cytoplasmic type 5 isoform X1 [KO:K05692]
104062514  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
104059821  STX18; syntaxin-18 [KO:K08492]
104063322  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
104060504  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
104062472  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
104058596  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
104054867  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
104054230  class II histocompatibility antigen, M alpha chain [KO:K06752]
104067570  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
104065505  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
104054406  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
104058436  EEA1; early endosome antigen 1 [KO:K12478]
104067509  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
104063180  TFRC; transferrin receptor protein 1 [KO:K06503]
104057608  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
104058994  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
104055826  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104068560  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104056607  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
104056712  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104058172  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
104062631  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104055896  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
104061370  ATP6V1F; V-type proton ATPase subunit F isoform X1 [KO:K02151]
104054734  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
104055887  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104065583  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
104068412  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
104058936  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 [KO:K02154]
104054401  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [KO:K02154]
104064427  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 [KO:K02154]
104068329  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
104056761  ATP6V0D2; LOW QUALITY PROTEIN: V-type proton ATPase subunit d 2 [KO:K02146]
104067663  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
104068213  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
104057546  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
104061618  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
104068183  RAB7A; ras-related protein Rab-7a [KO:K07897]
104061867  RAB7B; ras-related protein Rab-7b [KO:K07898]
104058695  RILP; rab-interacting lysosomal protein [KO:K13883]
104057788  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
104064704  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
104054560  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
104057490  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
104067252  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
104067637  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
104058988  tubulin alpha-8 chain [KO:K07374]
104054507  tubulin alpha-5 chain [KO:K07374]
104054509  tubulin alpha-5 chain-like [KO:K07374]
104055024  tubulin alpha-1A chain [KO:K07374]
104065251  tubulin alpha-3 chain [KO:K07374]
104055892  TUBA8; tubulin alpha-8 chain [KO:K07374]
104061444  tubulin alpha-3 chain [KO:K07374]
104061446  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
104057653  tubulin alpha-1A chain-like [KO:K07374]
104068758  tubulin beta-7 chain [KO:K07375]
104059948  tubulin beta chain [KO:K07375]
104065509  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
104061250  TUBB3; tubulin beta-3 chain [KO:K07375]
104066605  tubulin beta-1 chain isoform X1 [KO:K07375]
104067524  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
104064035  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
104056668  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
104058266  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
104060628  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
104056123  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
104057358  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
104057361  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
104059907  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
104060939  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
104066019  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
104066024  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
104068402  SEC61A1; protein transport protein Sec61 subunit alpha isoform 1 [KO:K10956]
104066466  SEC61A2; protein transport protein Sec61 subunit alpha isoform 2 [KO:K10956]
104062198  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
104065932  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
104065978  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
104059377  CANX; calnexin isoform X1 [KO:K08054]
104064392  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
104064540  ITGB2; integrin beta-2 [KO:K06464]
104063122  C3; complement C3 [KO:K03990]
104057907  COLEC11; collectin-11 isoform X1 [KO:K10066]
104063003  COLEC12; collectin-12 [KO:K10062]
104063054  SFTPA1; pulmonary surfactant-associated protein A1 [KO:K10067]
104064547  ITGAV; integrin alpha-V [KO:K06487]
104054794  ITGA2; integrin alpha-2 [KO:K06481]
104066646  ITGB1; integrin beta-1 [KO:K05719]
104054370  ITGB3; integrin beta-3 [KO:K06493]
104068623  ITGB5; integrin beta-5 [KO:K06588]
104062852  THBS1; thrombospondin-1 [KO:K16857]
104058869  THBS3; thrombospondin-3 [KO:K04659]
104064019  THBS4; thrombospondin-4 [KO:K04659]
104064717  THBS2; thrombospondin-2 [KO:K04659]
104065774  COMP; cartilage oligomeric matrix protein [KO:K04659]
104064767  TLR2; toll-like receptor 2 [KO:K10159]
104064776  toll-like receptor 2 type-2 [KO:K10159]
104054217  toll-like receptor 2 type-2 [KO:K10159]
104064267  toll-like receptor 1 [KO:K10169]
104066770  TLR4; toll-like receptor 4 [KO:K10160]
104054440  MRC2; LOW QUALITY PROTEIN: C-type mannose receptor 2 [KO:K06560]
104054611  PLA2R1; LOW QUALITY PROTEIN: secretory phospholipase A2 receptor [KO:K06560]
104057663  macrophage mannose receptor 1-like [KO:K06560]
104057694  macrophage mannose receptor 1-like [KO:K06560]
104057695  macrophage mannose receptor 1-like [KO:K06560]
104057696  macrophage mannose receptor 1-like [KO:K06560]
104057697  macrophage mannose receptor 1-like [KO:K06560]
104063254  hepatic lectin-like [KO:K06563]
104068610  MARCO; macrophage receptor MARCO [KO:K13884]
104054707  SCARB1; scavenger receptor class B member 1 [KO:K13885]
104066033  CD36; platelet glycoprotein 4 [KO:K06259]
104061258  cytochrome b-245 light chain [KO:K08009]
104057240  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
104063796  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104060044  NCF1; neutrophil cytosol factor 1 [KO:K08011]
104058576  NCF2; neutrophil cytosol factor 2 [KO:K08010]
104065858  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
cuca04142  Lysosome
cuca04144  Endocytosis
cuca04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
LinkDB

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