Entry
Name
Drug metabolism - other enzymes - Drosophila erecta
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
der00983 Drug metabolism - other enzymes
Ortholog table
Organism
Drosophila erecta [GN:
der ]
Gene
Compound
C04242 5-Fluorodeoxyuridine monophosphate
C04646 6-Thioinosine-5'-monophosphate
C12739 5'-Deoxy-5-fluorouridine
C16615 6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616 6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617 6-Mercaptopurine ribonucleoside triphosphate
C16618 6-Thioxanthine 5'-monophosphate
C16619 6-Thioguanosine monophosphate
C16620 6-Methylthioguanosine monophosphate
C16621 1-Methyl-4-nitroimidazole
C16625 Isoniazid alpha-ketoglutaric acid
C16630 5,6-Dihydro-5-fluorouracil
C16631 alpha-Fluoro-beta-ureidopropionic acid
C16632 alpha-Fluoro-beta-alanine
C16634 5-Fluorouridine monophosphate
C16635 5'-Deoxy-5-fluorocytidine
C21748 5-Fluorouridine diphosphate
C21749 5-Fluorouridine triphosphate
C21750 5-Fluorodeoxyuridine diphosphate
C21751 5-Fluorodeoxyuridine triphosphate
C21759 Isonicotinoyl-NAD adduct
C21760 Isonicotinoyl-NADP adduct
D00238 Azathioprine (JP18/USP/INN)
D00346 Isoniazid (JP18/USP/INN)
D00584 Fluorouracil (JP18/USP/INN)
D01223 Capecitabine (JAN/USP/INN)
D01244 Tegafur (JP18/USAN/INN)
D01309 Doxifluridine (JP18/INN)
Reference
Authors
Kato R, Kamatari T (eds).
Title
[Drug Metabolism] (In Japanese)
Journal
Tokyo Kagaku Dojin (2000)
Reference
Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
Journal
Reference
Authors
Gearry RB, Barclay ML.
Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
Journal
Reference
Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
Journal
Reference
Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
Journal
Reference
Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
Journal
Reference
Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
Journal
Reference
Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
Journal
Reference
Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
Journal
Reference
Authors
Wang P, Pradhan K, Zhong XB, Ma X
Title
Isoniazid metabolism and hepatotoxicity.
Journal
Reference
Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
Journal
Reference
Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
Journal
Reference
Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
Title
Mechanisms of catalase activity of heme peroxidases.
Journal
Reference
Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
Journal
Reference
Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
Journal
Reference
Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
Journal
Reference
Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
Journal
Reference
Authors
Argyrou A, Vetting MW, Blanchard JS
Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
Journal
KO pathway
LinkDB
All DBs