KEGG   PATHWAY: dse00983
Entry
dse00983                    Pathway                                
Name
Drug metabolism - other enzymes - Drosophila sechellia
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
dse00983  Drug metabolism - other enzymes
dse00983

Organism
Drosophila sechellia [GN:dse]
Gene
6617580  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
6618256  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
6606230  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6606231  abscisic-aldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6606232  indole-3-acetaldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6606233  indole-3-acetaldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6606582  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6613418  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
6605412  esterase 6 [KO:K01044] [EC:3.1.1.1]
6605413  esterase P [KO:K01044] [EC:3.1.1.1]
6611498  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
6612980  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
6613263  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
6614348  UDP-glucuronosyltransferase 2B15 [KO:K00699] [EC:2.4.1.17]
6614428  UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
6614430  UDP-glucuronosyltransferase 2B15 [KO:K00699] [EC:2.4.1.17]
6614556  UDP-glucuronosyltransferase 2B13 [KO:K00699] [EC:2.4.1.17]
6615332  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
6615333  UDP-glucuronosyltransferase 2B13 [KO:K00699] [EC:2.4.1.17]
6615559  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
6618381  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
6606870  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
6606873  UDP-glucuronosyltransferase 2A2 [KO:K00699] [EC:2.4.1.17]
6606875  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B20 [KO:K00699] [EC:2.4.1.17]
6606886  UDP-glucuronosyltransferase 2B10 [KO:K00699] [EC:2.4.1.17]
6609502  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
6614592  UDP-glucuronosyltransferase 1-3 [KO:K00699] [EC:2.4.1.17]
6609892  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
6611638  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
6611639  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
6611637  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
6619786  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
6613969  dihydropyrimidinase 1 isoform X1 [KO:K01464] [EC:3.5.2.2]
6614278  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
6613187  uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
6615627  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
6617103  uridine phosphorylase 1 isoform X2 [KO:K00757] [EC:2.4.2.3]
6609588  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
6620065  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
6617018  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
6611964  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
6608739  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
6618544  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
6619521  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
6607067  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
6612103  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
6609781  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6609787  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6609788  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6609789  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6609790  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6609791  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6609804  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6615137  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
6615180  microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
6618678  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
6619589  microsomal glutathione S-transferase 1 isoform X2 [KO:K00799] [EC:2.5.1.18]
6621820  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
6606682  glutathione S-transferase D7 isoform X1 [KO:K00799] [EC:2.5.1.18]
6606685  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
6606686  LOW QUALITY PROTEIN: glutathione S-transferase D7 [KO:K00799] [EC:2.5.1.18]
6606689  uncharacterized protein LOC6606689 [KO:K00799] [EC:2.5.1.18]
6606692  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
6606693  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
6606694  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
6608303  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6608384  glutathione S-transferase theta-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
6608385  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
116800563  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
6608972  glutathione S-transferase E14 isoform X2 [KO:K00799] [EC:2.5.1.18]
6618874  glutathione S-transferase 1 isoform X2 [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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