KEGG   PATHWAY: ecb04390
Entry
ecb04390                    Pathway                                
Name
Hippo signaling pathway - Equus caballus (horse)
Description
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
ecb04390  Hippo signaling pathway
ecb04390

Other DBs
GO: 0035329
Organism
Equus caballus (horse) [GN:ecb]
Gene
100061068  CRB1; protein crumbs homolog 1 [KO:K16681]
100146515  CRB2; protein crumbs homolog 2 isoform X1 [KO:K16681]
100060218  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100065587  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
100053411  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100052187  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
100064240  PRKCZ; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
100063737  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
100070486  PATJ; inaD-like protein isoform X6 [KO:K06092]
100052602  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
100054069  AMOT; angiomotin isoform X1 [KO:K16819]
100068834  YAP1; transcriptional coactivator YAP1 isoform X1 [KO:K16687]
100050661  WWTR1; WW domain-containing transcription regulator protein 1 [KO:K16820]
100066844  CDH1; cadherin-1 [KO:K05689]
100057361  WTIP; Wilms tumor protein 1-interacting protein isoform X1 [KO:K16682]
100056024  AJUBA; LIM domain-containing protein ajuba [KO:K16682]
100065624  LIMD1; LIM domain-containing protein 1 isoform X1 [KO:K16682]
100058977  NF2; merlin isoform X1 [KO:K16684]
100070535  WWC1; protein KIBRA [KO:K16685]
100054660  FRMD1; FERM domain-containing protein 1 [KO:K16821]
100051800  FRMD6; FERM domain-containing protein 6 isoform X1 [KO:K16822]
100066557  SAV1; protein salvador homolog 1 isoform X1 [KO:K16686]
100060508  STK3; serine/threonine-protein kinase 3 [KO:K04412]
100055761  RASSF6; ras association domain-containing protein 6 isoform X1 [KO:K09854]
100061779  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
100062224  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100062627  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100070408  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100070133  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
100060957  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X5 [KO:K04354]
100059955  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
100051737  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100050150  LATS2; serine/threonine-protein kinase LATS2 isoform X1 [KO:K08791] [EC:2.7.11.1]
100060397  LATS1; serine/threonine-protein kinase LATS1 [KO:K08791] [EC:2.7.11.1]
100054658  MOB1B; MOB kinase activator 1B [KO:K06685]
100058183  MOB1A; MOB kinase activator 1A isoform X1 [KO:K06685]
100071067  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100058160  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100059233  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100055278  TP53BP2; apoptosis-stimulating of p53 protein 2 isoform X1 [KO:K16823]
100051856  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
100059704  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
100063454  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
100060094  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
100050929  DLG2; disks large homolog 2 isoform X14 [KO:K12075]
100146394  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
100061544  DLG4; disks large homolog 4 isoform X8 [KO:K11828]
100072996  DLG5; disks large homolog 5 isoform X1 [KO:K24050]
100057193  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
100055155  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
100069972  FBXW11; F-box/WD repeat-containing protein 11 isoform X3 [KO:K03362]
100070200  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
100052597  TP73; tumor protein p73 [KO:K10148]
100146714  BBC3; bcl-2-binding component 3 [KO:K10132]
100057619  TEAD4; transcriptional enhancer factor TEF-3 [KO:K09448]
100071493  TEAD1; transcriptional enhancer factor TEF-1 isoform X1 [KO:K09448]
100063075  TEAD3; transcriptional enhancer factor TEF-5 isoform X1 [KO:K09448]
100051732  TEAD2; transcriptional enhancer factor TEF-4 isoform X1 [KO:K09448]
100073098  CTGF; connective tissue growth factor [KO:K06827]
100067420  GLI2; zinc finger protein GLI2 [KO:K16798]
100050528  AREG; amphiregulin [KO:K09782]
100050808  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
100034185  AFP; alpha-fetoprotein precursor [KO:K16144]
100056128  ITGB2; integrin beta-2 [KO:K06464]
100056049  integrin beta-2 [KO:K06464]
100033960  FGF1; fibroblast growth factor 1 [KO:K18496]
100033900  TGFB1; transforming growth factor beta-1 precursor [KO:K13375]
100050377  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
111771316  transforming growth factor beta-2-like isoform X1 [KO:K13376]
100051765  TGFB3; transforming growth factor beta-3 [KO:K13377]
100034117  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100033860  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100033853  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
100033843  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100033845  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100033846  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100033931  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
100051701  BMP2; bone morphogenetic protein 2 isoform X1 [KO:K21283]
100034048  BMP4; bone morphogenetic protein 4 precursor [KO:K04662]
100056806  BMP5; bone morphogenetic protein 5 [KO:K04663]
100033934  BMP6; bone morphogenetic protein 6 [KO:K16620]
100050299  BMP7; bone morphogenetic protein 7 precursor [KO:K16621]
102150286  BMP8B; bone morphogenetic protein 8B [KO:K16622]
100068680  bone morphogenetic protein 8B [KO:K16622]
100034228  GDF5; growth/differentiation factor 5 precursor [KO:K04664]
100059475  GDF6; growth/differentiation factor 6 [KO:K20012]
100147101  GDF7; growth/differentiation factor 7 [KO:K20013]
102148318  AMH; muellerian-inhibiting factor precursor [KO:K04665]
100064367  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
100053554  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
100067195  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
100033850  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
100068419  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
100057240  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
100058859  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100063931  WNT2B; protein Wnt-2b [KO:K00182]
100056092  WNT2; protein Wnt-2 precursor [KO:K00182]
100049880  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100061145  WNT3A; protein Wnt-3a [KO:K00312]
100071678  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
100056017  WNT5B; protein Wnt-5b [KO:K00444]
100059157  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100058824  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
100053027  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
100055450  WNT7A; protein Wnt-7a [KO:K00572]
111768287  protein Wnt-7a [KO:K00572]
100070360  WNT8B; protein Wnt-8b [KO:K00714]
100072609  WNT8A; protein Wnt-8a isoform X3 [KO:K00714]
100061110  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
100063730  WNT9B; protein Wnt-9b [KO:K01064]
100051649  WNT10B; protein Wnt-10b [KO:K01357]
111773843  WNT10A; protein Wnt-10a [KO:K01357]
100064184  WNT11; protein Wnt-11 [KO:K01384]
100071393  WNT16; protein Wnt-16 [KO:K01558]
102147960  FZD7; frizzled-7 [KO:K02432]
106783041  FZD1; frizzled-1 [KO:K02432]
100050809  FZD2; frizzled-2 [KO:K02235]
100054732  FZD3; frizzled-3 [KO:K02329]
100050465  FZD4; frizzled-4 [KO:K02354]
100146215  FZD5; frizzled-5 [KO:K02375]
111771171  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
100056351  FZD6; frizzled-6 [KO:K02376]
100062909  FZD10; frizzled-10 [KO:K02842]
100061635  FZD9; frizzled-9 [KO:K02842]
100061612  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100147200  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100147654  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100056060  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100056084  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100057123  YWHAQ; 14-3-3 protein theta [KO:K16197]
100059962  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100062878  YWHAH; 14-3-3 protein eta [KO:K16198]
100059731  YWHAG; 14-3-3 protein gamma [KO:K16198]
100061033  GSK3B; glycogen synthase kinase-3 beta isoform X6 [KO:K03083] [EC:2.7.11.26]
100055241  CTNNB1; catenin beta-1 [KO:K02105]
100064431  APC; adenomatous polyposis coli protein [KO:K02085]
100147102  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100065116  AXIN1; axin-1 isoform X1 [KO:K02157]
100630049  AXIN2; axin-2 [KO:K04385]
100057994  NKD2; protein naked cuticle homolog 2 isoform X1 [KO:K03213]
100059048  NKD1; protein naked cuticle homolog 1 [KO:K03213]
100072786  TCF7; transcription factor 7 isoform X1 [KO:K02620]
100067427  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100059146  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
100072938  LEF1; lymphoid enhancer-binding factor 1 isoform X6 [KO:K04492]
100068097  MYC; myc proto-oncogene protein [KO:K04377]
102149114  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100051150  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100066590  CCND3; G1/S-specific cyclin-D3 isoform X3 [KO:K10152]
100146979  SOX2; transcription factor SOX-2 [KO:K16796]
100050060  SNAI2; zinc finger protein SNAI2 [KO:K05706]
100061273  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
100068894  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
100050139  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100033878  ACTB; actin, cytoplasmic 1 [KO:K05692]
100072548  CTNNA1; catenin alpha-1 [KO:K05691]
100053393  CTNNA2; catenin alpha-2 isoform X10 [KO:K05691]
100062915  CTNNA3; catenin alpha-3 isoform X4 [KO:K05691]
Reference
PMID:22750148
  Authors
Schroeder MC, Halder G
  Title
Regulation of the Hippo pathway by cell architecture and mechanical signals.
  Journal
Semin Cell Dev Biol 23:803-11 (2012)
DOI:10.1016/j.semcdb.2012.06.001
Reference
PMID:21808241
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
PMID:21874053
  Authors
Mauviel A, Nallet-Staub F, Varelas X
  Title
Integrating developmental signals: a Hippo in the (path)way.
  Journal
Oncogene 31:1743-56 (2012)
DOI:10.1038/onc.2011.363
Reference
PMID:21084559
  Authors
Zhao B, Li L, Guan KL
  Title
Hippo signaling at a glance.
  Journal
J Cell Sci 123:4001-6 (2010)
DOI:10.1242/jcs.069070
Reference
PMID:20439427
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
PMID:23034192
  Authors
Tremblay AM, Camargo FD
  Title
Hippo signaling in mammalian stem cells.
  Journal
Semin Cell Dev Biol 23:818-26 (2012)
DOI:10.1016/j.semcdb.2012.08.001
Reference
PMID:21138973
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
PMID:22658639
  Authors
Ramos A, Camargo FD
  Title
The Hippo signaling pathway and stem cell biology.
  Journal
Trends Cell Biol 22:339-46 (2012)
DOI:10.1016/j.tcb.2012.04.006
Reference
PMID:20951342
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
PMID:21324984
  Authors
Bao Y, Hata Y, Ikeda M, Withanage K
  Title
Mammalian Hippo pathway: from development to cancer and beyond.
  Journal
J Biochem 149:361-79 (2011)
DOI:10.1093/jb/mvr021
Reference
PMID:18955139
  Authors
Zhao B, Lei QY, Guan KL
  Title
The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
  Journal
Curr Opin Cell Biol 20:638-46 (2008)
DOI:10.1016/j.ceb.2008.10.001
Reference
PMID:20945341
  Authors
Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W
  Title
The Hippo pathway in biological control and cancer development.
  Journal
J Cell Physiol 226:928-39 (2011)
DOI:10.1002/jcp.22435
Reference
PMID:18328423
  Authors
Zeng Q, Hong W
  Title
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.
  Journal
Cancer Cell 13:188-92 (2008)
DOI:10.1016/j.ccr.2008.02.011
Reference
PMID:19846288
  Authors
Badouel C, Garg A, McNeill H
  Title
Herding Hippos: regulating growth in flies and man.
  Journal
Curr Opin Cell Biol 21:837-43 (2009)
DOI:10.1016/j.ceb.2009.09.010
Reference
PMID:17975546
  Authors
Buttitta LA, Edgar BA
  Title
How size is controlled: from Hippos to Yorkies.
  Journal
Nat Cell Biol 9:1225-7 (2007)
DOI:10.1038/ncb1107-1225
Reference
PMID:22683405
  Authors
Liu AM, Wong KF, Jiang X, Qiao Y, Luk JM
  Title
Regulators of mammalian Hippo pathway in cancer.
  Journal
Biochim Biophys Acta 1826:357-64 (2012)
DOI:10.1016/j.bbcan.2012.05.006
Reference
PMID:22830020
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
PMID:22895435
  Authors
Halder G, Dupont S, Piccolo S
  Title
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
  Journal
Nat Rev Mol Cell Biol 13:591-600 (2012)
DOI:10.1038/nrm3416
Reference
PMID:22153608
  Authors
Varelas X, Wrana JL
  Title
Coordinating developmental signaling: novel roles for the Hippo pathway.
  Journal
Trends Cell Biol 22:88-96 (2012)
DOI:10.1016/j.tcb.2011.10.002
Reference
PMID:21376238
  Authors
Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD
  Title
Yap1 acts downstream of alpha-catenin to control epidermal proliferation.
  Journal
Cell 144:782-95 (2011)
DOI:10.1016/j.cell.2011.02.031
Related
pathway
ecb04120  Ubiquitin mediated proteolysis
ecb04310  Wnt signaling pathway
ecb04350  TGF-beta signaling pathway
ecb04520  Adherens junction
ecb04530  Tight junction
KO pathway
ko04390   
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