KEGG   PATHWAY: els05168
Entry
els05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Esox lucius (northern pike)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
els05168  Herpes simplex virus 1 infection
els05168

Organism
Esox lucius (northern pike) [GN:els]
Gene
105012342  tumor necrosis factor [KO:K05468]
105013080  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
106023899  tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
105023882  tumor necrosis factor receptor superfamily member 14-like precursor [KO:K05152]
105023790  tumor necrosis factor receptor superfamily member 14 [KO:K05152]
105023791  tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
105023793  tumor necrosis factor receptor superfamily member 5 [KO:K05152]
105023794  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
105023888  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
105023802  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
105023883  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
105023886  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
105023887  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
105015142  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105014393  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105015035  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105026840  TNF receptor-associated factor 5 isoform X1 [KO:K09849]
105014298  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105006906  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105010696  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105030753  ikbkg; NF-kappa-B essential modulator [KO:K07210]
105015478  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
105015312  NF-kappa-B inhibitor alpha [KO:K04734]
105029910  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105020694  putative transcription factor p65 homolog [KO:K04735]
105006427  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
105012979  nectin1; nectin-1 isoform X1 [KO:K06081]
105009232  nectin-1-like isoform X1 [KO:K06081]
105027893  nectin-4-like isoform X1 [KO:K06081]
105006124  nectin2; nectin-2 isoform X1 [KO:K06531]
105028598  poliovirus receptor isoform X1 [KO:K06531]
105013921  tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
105007638  ptpn11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
105022289  integrin alpha-5 [KO:K06484]
105024782  integrin alpha-5 isoform X1 [KO:K06484]
105006835  integrin beta-3 [KO:K06493]
105013321  integrin beta-3 [KO:K06493]
105013575  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105016680  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105020452  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
105014418  card9; caspase recruitment domain-containing protein 9 [KO:K12794]
105026239  interferon regulatory factor 3 isoform X1 [KO:K05411]
105008589  cellular tumor antigen p53-like isoform X1 [KO:K04451]
105020676  cellular tumor antigen p53 [KO:K04451]
105009354  complement C3-like [KO:K03990]
105009355  complement C3-like [KO:K03990]
105019308  complement C3-like [KO:K03990]
105030204  c5; complement C5 isoform X1 [KO:K03994]
105026928  cfp; properdin [KO:K15412]
105030906  tlr2; toll-like receptor 2 isoform X1 [KO:K10159]
105028681  toll-like receptor 2 type-1 isoform X1 [KO:K10159]
105013993  toll-like receptor 9 isoform X1 [KO:K10161]
105007691  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105018339  irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
105022862  tlr3; toll-like receptor 3 [KO:K05401]
105018625  TIR domain-containing adapter molecule 1 [KO:K05842]
105026619  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105028326  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105025313  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
105017873  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105015746  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105031193  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
105017897  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
105007339  interleukin-1 beta [KO:K04519]
105009489  interleukin-1 beta isoform X1 [KO:K04519]
105012469  LOW QUALITY PROTEIN: interleukin-6-like [KO:K05405]
105031348  tumor necrosis factor-like [KO:K03156]
109616205  uncharacterized protein LOC109616205 [KO:K05406]
105009140  interleukin-12 subunit beta isoform X1 [KO:K05425]
105011273  il12b; interleukin-12 subunit beta [KO:K05425]
105006256  interleukin-12 subunit beta-like [KO:K05425]
105006239  ddx58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
105022448  ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
105023593  traf3; TNF receptor-associated factor 3 [KO:K03174]
105017402  inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
105026533  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105023401  interferon beta-like [KO:K05414]
106024123  interferon a3 [KO:K05414]
106024529  interferon beta-like [KO:K05414]
105023354  interferon alpha-13-like [KO:K05414]
109616238  interferon alpha-7-like [KO:K05414]
105023355  interferon beta-like [KO:K05414]
105008644  interferon a3 [KO:K05414]
114828768  interferon a3-like [KO:K05414]
114840176  interferon alpha-1-like [KO:K05414]
114840178  interferon beta-like [KO:K05414]
114840421  interferon beta-like [KO:K05414]
114840426  interferon beta-like [KO:K05414]
105008645  interferon a3-like [KO:K05414]
105023252  cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
105027914  cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
105026749  tmem173; stimulator of interferon genes protein [KO:K12654]
105012949  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
105020693  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105024808  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105014191  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105024386  serine/threonine-protein phosphatase alpha-2 isoform isoform X1 [KO:K06269] [EC:3.1.3.16]
105031427  eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X2 [KO:K16194] [EC:2.7.11.1]
105008364  interferon-induced, double-stranded RNA-activated protein kinase-like isoform X1 [KO:K16195] [EC:2.7.11.1]
105015862  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
105015665  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
105026061  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105017697  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105026093  eif2b1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
105007639  translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
105005943  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
105022689  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
105028624  eif2b4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
105023052  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
105028333  hcfc1; host cell factor 1 isoform X1 [KO:K14966]
105017367  host cell factor 1 isoform X1 [KO:K14966]
105007492  hcfc2; host cell factor 2 [KO:K27390]
105010752  pou2f3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
105019697  POU domain, class 2, transcription factor 1 isoform X2 [KO:K09364]
105029967  POU domain, class 2, transcription factor 2 isoform X8 [KO:K09364]
105016564  POU domain, class 2, transcription factor 1 isoform X6 [KO:K09364]
105028601  POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
105031504  interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
105013055  suppressor of cytokine signaling 3 [KO:K04696]
105021322  suppressor of cytokine signaling 3 [KO:K04696]
105024705  tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105011918  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105027793  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
105022492  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
105022417  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
105022527  signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
105017162  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11221]
105008779  zinc finger protein OZF-like isoform X2 [KO:K09228]
105005698  zinc finger protein 501-like [KO:K09228]
105005701  zinc finger protein 501-like isoform X1 [KO:K09228]
105006306  zinc finger protein 883-like [KO:K09228]
105006310  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
105006312  zinc finger protein 431-like isoform X1 [KO:K09228]
105006315  zinc finger protein 135-like isoform X2 [KO:K09228]
105006771  zinc finger protein OZF [KO:K09228]
105007651  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
105009211  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
105007861  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
105008178  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
105011940  zinc finger protein 345 [KO:K09228]
105012666  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
105009203  zinc finger protein 883-like isoform X1 [KO:K09228]
105009719  zinc finger protein 845-like [KO:K09228]
109614657  zinc finger protein 501-like [KO:K09228]
105009546  oocyte zinc finger protein XlCOF6-like [KO:K09228]
105005641  zinc finger protein 436-like [KO:K09228]
105025854  uncharacterized protein LOC105025854 [KO:K09228]
105031592  zinc finger protein 501-like [KO:K09228]
106023922  oocyte zinc finger protein XlCOF6-like [KO:K09228]
106023923  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
106023924  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
105030073  zinc finger protein 239-like [KO:K09228]
105030075  gastrula zinc finger protein XlCGF28.1-like [KO:K09228]
105030077  zinc finger protein 501-like [KO:K09228]
105030083  zinc finger protein 501-like isoform X1 [KO:K09228]
105006070  uncharacterized protein LOC105006070 [KO:K09228]
109614774  LOW QUALITY PROTEIN: gastrula zinc finger protein XlCGF28.1-like [KO:K09228]
105027982  zinc finger protein 664-like isoform X3 [KO:K09228]
105027483  zinc finger protein 436-like [KO:K09228]
109616100  zinc finger protein OZF-like [KO:K09228]
105030086  zinc finger protein 2 homolog isoform X1 [KO:K09228]
105005643  zinc finger protein OZF-like [KO:K09228]
114828681  zinc finger protein 883-like isoform X1 [KO:K09228]
105007165  zinc finger protein 345-like [KO:K09228]
105006314  zinc finger protein 883-like isoform X1 [KO:K09228]
114839780  zinc finger protein 345-like [KO:K09228]
105030249  zinc finger protein 2 isoform X1 [KO:K09228]
114839782  zinc finger protein 501-like [KO:K09228]
106023780  zinc finger protein 180-like [KO:K09228]
106023902  zinc finger protein OZF-like [KO:K09228]
114839784  zinc finger protein 544-like isoform X1 [KO:K09228]
114839785  zinc finger protein 239-like [KO:K09228]
105017660  zinc finger protein 180-like [KO:K09228]
105020319  zinc finger protein 2 homolog [KO:K09228]
105021761  oocyte zinc finger protein XlCOF6-like [KO:K09228]
105021764  zinc finger protein 708-like isoform X2 [KO:K09228]
109616258  zinc finger protein 501-like isoform X1 [KO:K09228]
109616260  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
105017578  zinc finger protein 770 [KO:K09228]
105031301  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
105008742  zinc finger protein OZF-like [KO:K09228]
105027458  zinc finger protein 664 isoform X1 [KO:K09228]
105027432  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
105030089  zinc finger protein 2 homolog [KO:K09228]
114828650  zinc finger protein 664-like [KO:K09228]
105018040  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K09228]
105027624  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
105027633  zinc finger protein Xfin-like isoform X1 [KO:K09228]
105023315  zinc finger protein 585A isoform X1 [KO:K09228]
105015516  zinc finger protein 770 [KO:K09228]
105029841  zinc finger protein 721 [KO:K09228]
105029846  zinc finger protein 729 isoform X1 [KO:K09228]
105029848  zinc finger protein 585A-like [KO:K09228]
105028126  zinc finger protein 709-like [KO:K09228]
105027455  zinc finger protein OZF-like [KO:K09228]
105027454  zinc finger protein OZF-like [KO:K09228]
105007860  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
109615482  zinc finger protein 501-like [KO:K09228]
105009206  zinc finger protein 436-like [KO:K09228]
105029854  zinc finger protein 91 isoform X2 [KO:K09228]
105029853  zinc finger protein 585A-like isoform X1 [KO:K09228]
106023921  zinc finger protein 665 isoform X1 [KO:K09228]
105023266  zinc finger protein OZF-like isoform X1 [KO:K09228]
105020312  uncharacterized protein LOC105020312 [KO:K09228]
105025908  zinc finger protein 2 isoform X1 [KO:K09228]
105020700  putative zinc finger protein 735 isoform X3 [KO:K09228]
105025061  zinc finger protein 624-like isoform X1 [KO:K09228]
105031158  zinc finger protein 665-like [KO:K09228]
106023681  gastrula zinc finger protein XlCGF57.1 isoform X1 [KO:K09228]
109615749  zinc finger protein OZF isoform X1 [KO:K09228]
114840359  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
114840363  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
105021039  zinc finger protein 79-like [KO:K09228]
105025517  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K09228]
105027476  zinc finger protein 2-like isoform X1 [KO:K09228]
105027481  zinc finger protein 883-like [KO:K09228]
109615240  zinc finger protein 436-like [KO:K09228]
105006319  zinc finger protein 436-like [KO:K09228]
105031392  zinc finger protein 271-like isoform X1 [KO:K09228]
105031399  zinc finger protein 431 isoform X1 [KO:K09228]
106023909  zinc finger protein 345-like [KO:K09228]
105008401  zinc finger protein 436-like [KO:K09228]
106024466  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
109616932  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
105031049  zinc finger protein 436-like [KO:K09228]
105031046  zinc finger protein 436 isoform X1 [KO:K09228]
105027972  gastrula zinc finger protein XlCGF17.1-like isoform X2 [KO:K09228]
105019980  zinc finger protein 420 [KO:K09228]
105006945  zinc finger protein 271 isoform X1 [KO:K09228]
105007459  zinc finger protein 260-like isoform X1 [KO:K09228]
105012528  zinc finger protein 136-like [KO:K09228]
105005925  zinc finger protein 420 isoform X1 [KO:K09228]
105005699  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K09228]
105006768  zinc finger protein 32-like isoform X1 [KO:K09228]
105006769  zinc finger and SCAN domain-containing protein 2-like isoform X1 [KO:K09228]
105006780  zinc finger protein 431-like [KO:K09228]
105007029  zinc finger protein OZF-like [KO:K09228]
105016977  gastrula zinc finger protein XlCGF58.1 isoform X2 [KO:K09228]
105025064  zinc finger protein 420-like [KO:K09228]
106024821  zinc finger protein OZF isoform X1 [KO:K09228]
109616752  zinc finger protein 559 [KO:K09228]
114830696  zinc finger protein 16-like [KO:K09228]
109615438  zinc finger protein OZF-like isoform X1 [KO:K09228]
105019728  gastrula zinc finger protein XlCGF8.2DB-like isoform X2 [KO:K09228]
105027973  oocyte zinc finger protein XlCOF20-like [KO:K09228]
105031269  zinc finger protein 501-like [KO:K09228]
105027441  zinc finger protein 420-like isoform X1 [KO:K09228]
114828713  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
106023774  zinc finger protein OZF-like isoform X1 [KO:K09228]
105027438  zinc finger protein OZF-like [KO:K09228]
105027444  zinc finger protein 271-like [KO:K09228]
114828696  zinc finger protein 239-like [KO:K09228]
109614777  zinc finger protein 239-like [KO:K09228]
105031293  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
106024460  zinc finger protein OZF-like [KO:K09228]
105028942  zinc finger protein 16-like isoform X1 [KO:K09228]
114840470  oocyte zinc finger protein XlCOF6-like [KO:K09228]
105031390  zinc finger protein 883-like isoform X1 [KO:K09228]
105031391  zinc finger protein 431-like isoform X1 [KO:K09228]
105031394  zinc finger protein 2 homolog [KO:K09228]
105031396  zinc finger protein 260-like [KO:K09228]
105031397  zinc finger protein 883-like isoform X2 [KO:K09228]
105031401  zinc finger protein 391-like [KO:K09228]
105031403  zinc finger protein 883 [KO:K09228]
105031404  zinc finger protein 2-like isoform X1 [KO:K09228]
105031409  zinc finger protein 883-like isoform X1 [KO:K09228]
105018624  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
105019982  zinc finger protein 271 [KO:K09228]
105028249  zinc finger protein 391-like [KO:K09228]
105029865  oocyte zinc finger protein XlCOF22-like [KO:K09228]
105029866  zinc finger protein 568-like isoform X1 [KO:K09228]
105031523  zinc finger protein 184-like isoform X1 [KO:K09228]
105030904  putative zinc finger protein 730 isoform X1 [KO:K09228]
106024249  zinc finger protein ZFMSA12A-like isoform X1 [KO:K09228]
105021546  zinc finger protein 32 [KO:K09228]
105025905  zinc finger protein 2 isoform X1 [KO:K09228]
114830122  zinc finger protein 436-like isoform X1 [KO:K09228]
105021582  zinc finger protein 568-like [KO:K09228]
105025549  oocyte zinc finger protein XlCOF6 [KO:K09228]
105025550  gastrula zinc finger protein XlCGF46.1-like [KO:K09228]
105027445  zinc finger protein 271-like [KO:K09228]
105027450  zinc finger protein 286A-like isoform X1 [KO:K09228]
105027983  zinc finger protein 501-like [KO:K09228]
105031295  zinc finger protein 664-like isoform X1 [KO:K09228]
105008744  gastrula zinc finger protein XlCGF17.1-like isoform X1 [KO:K09228]
109616099  oocyte zinc finger protein XlCOF6-like [KO:K09228]
114830141  zinc finger protein 184-like [KO:K09228]
105022826  zinc finger protein 420-like [KO:K09228]
106024268  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
114839777  zinc finger protein 883-like [KO:K09228]
114839778  zinc finger protein 345-like isoform X1 [KO:K09228]
105009685  zinc finger protein 883-like [KO:K09228]
114839783  zinc finger protein OZF-like [KO:K09228]
105031398  zinc finger protein 135-like [KO:K09228]
105021637  zinc finger protein OZF-like [KO:K09228]
105024305  uncharacterized protein LOC105024305 isoform X1 [KO:K09228]
105027977  oocyte zinc finger protein XlCOF6.1-like isoform X2 [KO:K09228]
106023693  zinc finger protein 239-like isoform X2 [KO:K09228]
105023635  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
114830150  zinc finger protein 14-like [KO:K09228]
105007786  uncharacterized protein LOC105007786 isoform X1 [KO:K09228]
105015029  zinc finger protein 436-like [KO:K09228]
105021760  zinc finger protein 708-like [KO:K09228]
105021762  zinc finger protein 708-like isoform X1 [KO:K09228]
105028713  zinc finger protein 154 isoform X1 [KO:K09228]
105030248  zinc finger protein OZF-like [KO:K09228]
105006046  zinc finger protein OZF-like [KO:K09228]
106023801  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
105031393  zinc finger protein 345-like [KO:K09228]
109614644  zinc finger protein Xfin [KO:K09228]
105020417  zinc finger protein ZFMSA12A-like isoform X5 [KO:K09228]
105028757  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
105030440  zinc finger protein OZF [KO:K09228]
105031600  zinc finger protein 501-like isoform X1 [KO:K09228]
105029850  zinc finger protein 658B-like isoform X2 [KO:K09228]
105030257  zinc finger protein 883-like isoform X1 [KO:K09228]
105030828  zinc finger protein 570 isoform X1 [KO:K09228]
105007460  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
105029480  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K09228]
114830301  gastrula zinc finger protein XlCGF46.1-like [KO:K09228]
105031528  gastrula zinc finger protein XlCGF57.1 isoform X1 [KO:K09228]
114840978  zinc finger protein 436-like isoform X1 [KO:K09228]
105025976  zinc finger protein 501-like [KO:K09228]
105027431  zinc finger protein OZF-like isoform X1 [KO:K09228]
105027436  zinc finger protein OZF-like [KO:K09228]
105028944  zinc finger protein 501-like isoform X1 [KO:K09228]
105028945  zinc finger protein 184-like [KO:K09228]
105028953  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
109615123  zinc finger protein 708-like isoform X1 [KO:K09228]
105029700  zinc finger protein 239-like isoform X1 [KO:K09228]
105027448  zinc finger protein 501-like isoform X2 [KO:K09228]
105027451  zinc finger protein OZF-like [KO:K09228]
105014214  zinc finger protein 22-like [KO:K09228]
105018038  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K09228]
106024288  zinc finger protein OZF [KO:K09228]
105029404  zinc finger protein 135-like [KO:K09228]
105009207  oocyte zinc finger protein XlCOF6.1-like isoform X1 [KO:K09228]
105029856  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
114828641  oocyte zinc finger protein XlCOF6-like [KO:K09228]
114840310  znf551; zinc finger protein 551 [KO:K09228]
114840313  zinc finger protein 883-like [KO:K09228]
105008075  zinc finger protein 501-like [KO:K09228]
106024827  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
105017796  ifng1; interferon gamma 1 precursor [KO:K04687]
105021221  ifngr1l; interferon gamma receptor 1-like precursor [KO:K05132]
105021504  interferon gamma receptor 1-like isoform X1 [KO:K05132]
105014676  tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
105023553  jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105028589  daxx; death domain-associated protein 6 [KO:K02308]
105021865  antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
105006976  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105009100  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105028587  tapasin [KO:K08058]
105012685  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105028549  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105019162  protein disulfide-isomerase A3 isoform X1 [KO:K08056] [EC:5.3.4.1]
105011462  calr3; calreticulin-3 [KO:K08057]
105026372  calreticulin [KO:K08057]
105009518  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
105010034  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
105028584  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X2 [KO:K06751]
114839964  major histocompatibility complex class I-related gene protein-like [KO:K06751]
105028062  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
114839965  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
105028052  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
105009516  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
114828637  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
105023574  major histocompatibility complex class I-related gene protein-like [KO:K06751]
105017803  beta-2-microglobulin-like precursor [KO:K08055]
105009874  beta-2-microglobulin isoform X1 [KO:K08055]
105010407  beta-2-microglobulin-like precursor [KO:K08055]
114828636  beta-2-microglobulin-like [KO:K08055]
105025121  SLA class II histocompatibility antigen, DQ haplotype D beta chain-like [KO:K06752]
105025122  H-2 class II histocompatibility antigen, A-U alpha chain-like precursor [KO:K06752]
105018934  H-2 class II histocompatibility antigen, E-S beta chain-like precursor [KO:K06752]
105012011  H-2 class II histocompatibility antigen, A-F alpha chain-like isoform X2 [KO:K06752]
105012013  H-2 class II histocompatibility antigen, A-Q alpha chain [KO:K06752]
105012014  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
105012016  H-2 class II histocompatibility antigen, E-S beta chain isoform X1 [KO:K06752]
105007472  H-2 class II histocompatibility antigen, I-E alpha chain-like [KO:K06752]
105009474  class II histocompatibility antigen, B-L beta chain [KO:K06752]
106023666  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
105012008  H-2 class II histocompatibility antigen, A-Q alpha chain-like isoform X1 [KO:K06752]
114828682  H-2 class II histocompatibility antigen, A-Q alpha chain-like isoform X1 [KO:K06752]
105012009  HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
105012007  H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752]
105018935  H-2 class II histocompatibility antigen, A-U alpha chain isoform X1 [KO:K06752]
105018946  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
105018952  beta-2-microglobulin-like [KO:K06752]
105018931  H-2 class II histocompatibility antigen, A-U alpha chain isoform X1 [KO:K06752]
105018933  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
105025465  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
105010382  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
105025834  cd74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
105026926  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105025897  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105028918  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105009929  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
105029118  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
105024545  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105026229  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105015144  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105021974  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109614581  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
105025378  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
105023568  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105017614  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105015651  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105024916  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105021234  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105021541  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105027820  hamartin isoform X1 [KO:K07206]
105024185  tsc1; hamartin isoform X1 [KO:K07206]
105031540  tsc2; tuberin isoform X1 [KO:K07207]
105025720  rheb; GTP-binding protein Rheb [KO:K07208]
105030778  GTP-binding protein Rheb [KO:K07208]
105017211  rhebl1; GTPase RhebL1 [KO:K07208]
105013925  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105027007  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
105027118  SRSF protein kinase 1 isoform X1 [KO:K15409] [EC:2.7.11.1]
105023763  SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
105006947  serine/arginine-rich splicing factor 1B-like [KO:K12890]
105023489  serine/arginine-rich splicing factor 1B isoform X1 [KO:K12890]
105012916  serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
105017130  serine/arginine-rich splicing factor 3 [KO:K12892]
105026480  serine/arginine-rich splicing factor 3 [KO:K12892]
105009000  serine/arginine-rich splicing factor 6 [KO:K12893]
105008066  serine/arginine-rich splicing factor 6-like isoform X1 [KO:K12893]
105026339  serine/arginine-rich splicing factor 6 [KO:K12893]
105024333  serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
105025531  srsf5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
105006373  serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
105026808  serine/arginine-rich splicing factor 7 isoform X2 [KO:K12896]
105026824  srsf7; serine/arginine-rich splicing factor 7 [KO:K12896]
105025588  serine/arginine-rich splicing factor 9-like isoform X2 [KO:K21123]
105027059  serine/arginine-rich splicing factor 9 [KO:K21123]
105010949  nxf1; nuclear RNA export factor 1 [KO:K14284]
105026736  nuclear RNA export factor 1 isoform X1 [KO:K14284]
105012898  THO complex subunit 4 [KO:K12881]
105021606  THO complex subunit 4-A [KO:K12881]
105011736  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105014159  tumor necrosis factor [KO:K04389]
105022722  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105013803  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105019071  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105016269  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105017350  fadd; FAS-associated death domain protein [KO:K02373]
105006190  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
105009870  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
105021271  caspase-7 [KO:K04398] [EC:3.4.22.61]
105021259  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
105024762  caspase-8 [KO:K04398] [EC:3.4.22.61]
105018117  BH3-interacting domain death agonist-like [KO:K04726]
105013211  bax; apoptosis regulator BAX [KO:K02159]
105017307  apoptosis regulator BAX [KO:K02159]
105031446  apoptosis regulator BAX-like isoform X2 [KO:K02159]
105031447  apoptosis regulator BAX-like isoform X1 [KO:K02159]
114839466  bad; bcl2-associated agonist of cell death [KO:K02158]
105018981  apoptosis regulator Bcl-2 [KO:K02161]
105027305  apoptosis regulator Bcl-2 [KO:K02161]
105013756  bcl-2-like protein 1 [KO:K04570]
105017364  bcl-2-like protein 1 [KO:K04570]
105009094  cyc; cytochrome c [KO:K08738]
105024767  cytochrome c [KO:K08738]
105023666  cytochrome c iso-1/iso-2 [KO:K08738]
105020401  apaf1; apoptotic protease-activating factor 1 isoform X2 [KO:K02084]
105028691  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105029385  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105006735  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
els03040  Spliceosome
els03050  Proteasome
els04115  p53 signaling pathway
els04210  Apoptosis
els04620  Toll-like receptor signaling pathway
els04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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