KEGG   PATHWAY: fex04013
Entry
fex04013                    Pathway                                
Name
MAPK signaling pathway - fly - Formica exsecta (narrow-headed ant)
Description
The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Class
Environmental Information Processing; Signal transduction
Pathway map
fex04013  MAPK signaling pathway - fly
fex04013

Other DBs
GO: 0000165
Organism
Formica exsecta (narrow-headed ant) [GN:fex]
Gene
115239086  torso-like protein [KO:K12377]
115242654  uncharacterized protein LOC115242654 [KO:K20227]
115239185  uncharacterized protein LOC115239185 [KO:K20228]
115244178  tyrosine-protein kinase receptor torso-like isoform X1 [KO:K12378] [EC:2.7.10.1]
115238403  protein giant-lens [KO:K02104]
115235495  protein vein [KO:K16690]
115233448  uncharacterized protein LOC115233448 [KO:K16691]
115245656  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
115239962  protein bride of sevenless [KO:K04623]
115245820  proto-oncogene tyrosine-protein kinase ROS-like isoform X1 [KO:K05088] [EC:2.7.10.1]
115238146  proto-oncogene tyrosine-protein kinase ROS-like [KO:K05088] [EC:2.7.10.1]
115233105  proto-oncogene tyrosine-protein kinase ROS-like isoform X1 [KO:K05088] [EC:2.7.10.1]
115233534  LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS-like [KO:K05088] [EC:2.7.10.1]
115244724  LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS-like [KO:K05088] [EC:2.7.10.1]
115237281  LOW QUALITY PROTEIN: protein sevenless-like [KO:K05088] [EC:2.7.10.1]
115245349  LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS-like [KO:K05088] [EC:2.7.10.1]
115245358  proto-oncogene tyrosine-protein kinase ROS-like [KO:K05088] [EC:2.7.10.1]
115245360  proto-oncogene tyrosine-protein kinase ROS-like isoform X1 [KO:K05088] [EC:2.7.10.1]
115243693  SHC-transforming protein 3 [KO:K06279]
115236298  protein enhancer of sevenless 2B isoform X1 [KO:K04364]
115240153  GRB2-associated-binding protein 2 [KO:K20231]
115236536  tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
115240543  protein son of sevenless isoform X1 [KO:K03099]
115234834  flocculation protein FLO11 [KO:K17383]
115234907  GTPase HRas [KO:K07827]
115234885  ras GTPase-activating protein 1 [KO:K04352]
115239552  ras GTPase-activating protein 3 isoform X1 [KO:K12380]
115243616  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
115239813  14-3-3 protein zeta isoform X1 [KO:K16197]
115245178  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
115245431  kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
115240360  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
115236103  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115239816  importin-7 isoform X1 [KO:K20223]
115242485  protein capicua homolog isoform X1 [KO:K20225]
115236074  nuclear receptor subfamily 2 group E member 1 [KO:K08545]
115237531  protein groucho-like [KO:K04497]
115237566  protein groucho-like isoform X1 [KO:K04497]
115235418  LOW QUALITY PROTEIN: protein groucho-like [KO:K04497]
115239636  ETS-like protein pointed isoform X1 [KO:K02678]
115235061  ets DNA-binding protein pokkuri [KO:K03211]
115238368  exportin-1 [KO:K14290]
115233565  protein bric-a-brac 1-like isoform X1 [KO:K09237]
115233617  uncharacterized protein LOC115233617 [KO:K04506] [EC:2.3.2.27]
115240629  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
115237598  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
115246170  protein lozenge-like [KO:K20214]
115234259  homeobox protein prospero-like isoform X1 [KO:K20211]
115241564  protein eiger isoform X1 [KO:K16678]
115243533  tumor necrosis factor receptor superfamily member wengen [KO:K16679]
115242765  docking protein 3 [KO:K20234]
115235891  LOW QUALITY PROTEIN: tyrosine-protein kinase Src42A [KO:K08892] [EC:2.7.10.2]
115240812  tyrosine-protein kinase Src64B isoform X1 [KO:K05704] [EC:2.7.10.2]
115239653  tyrosine-protein kinase Btk29A-like isoform X1 [KO:K07364] [EC:2.7.10.2]
115244633  serine/threonine-protein kinase mig-15 isoform X1 [KO:K08840] [EC:2.7.11.1]
115235667  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
115236267  ras-related protein Rac1 [KO:K04392]
115245065  ras-like GTP-binding protein RhoL [KO:K04392]
115238130  TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
115238518  ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
115239920  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K04404]
115245076  uncharacterized protein LOC115245076 isoform X1 [KO:K04417] [EC:2.7.11.25]
115245292  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
115235092  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
115240135  dual specificity mitogen-activated protein kinase kinase hemipterous-like isoform X1 [KO:K04431] [EC:2.7.12.2]
115235990  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
115235148  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
115233298  striatin-3 [KO:K17608]
115236485  transcription factor AP-1 [KO:K04448]
115241779  transcription factor kayak isoform X1 [KO:K09031]
115243411  LOW QUALITY PROTEIN: uncharacterized protein LOC115243411 [KO:K20210]
115243907  uncharacterized protein LOC115243907 isoform X1 [KO:K20235]
115240280  protein decapentaplegic-like [KO:K04662]
115244986  profilin [KO:K05759]
115242855  uncharacterized protein LOC115242855 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
115239944  bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
115244021  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
115233363  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
115235985  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04432] [EC:2.7.12.2]
115240435  mitogen-activated protein kinase p38b-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115239013  cyclic AMP-dependent transcription factor ATF-2-like isoform X1 [KO:K04450]
115244371  cyclic AMP-dependent transcription factor ATF-2-like isoform X1 [KO:K04450]
115238324  dual oxidase 2-like [KO:K13411] [EC:1.6.3.1 1.11.1.-]
115238334  dual oxidase 2-like [KO:K13411] [EC:1.6.3.1 1.11.1.-]
115243603  dual oxidase [KO:K13411] [EC:1.6.3.1 1.11.1.-]
115238453  optomotor-blind protein [KO:K10176]
115242600  myocyte-specific enhancer factor 2 isoform X1 [KO:K09260]
115243455  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
Reference
PMID:23732470
  Authors
Sopko R, Perrimon N
  Title
Receptor tyrosine kinases in Drosophila development.
  Journal
Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050
Reference
PMID:15704136
  Authors
Li WX
  Title
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
  Journal
Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295
Reference
PMID:12648473
  Authors
Shilo BZ
  Title
Signaling by the Drosophila epidermal growth factor receptor pathway during development.
  Journal
Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0
Reference
PMID:10771085
  Authors
Raabe T
  Title
The sevenless signaling pathway: variations of a common theme.
  Journal
Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3
Reference
PMID:23109363
  Authors
Rios-Barrera LD, Riesgo-Escovar JR
  Title
Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
  Journal
Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354
Reference
PMID:24981286
  Authors
Igaki T, Miura M
  Title
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
  Journal
Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003
Reference
PMID:16014325
  Authors
Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
  Title
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
  Journal
Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013
Reference
PMID:10557109
  Authors
Stronach BE, Perrimon N
  Title
Stress signaling in Drosophila.
  Journal
Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125
Related
pathway
fex04214  Apoptosis - fly
KO pathway
ko04013   
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