KEGG   PATHWAY: ipu00983
Entry
ipu00983                    Pathway                                
Name
Drug metabolism - other enzymes - Ictalurus punctatus (channel catfish)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ipu00983  Drug metabolism - other enzymes
ipu00983

Organism
Ictalurus punctatus (channel catfish) [GN:ipu]
Gene
100528167  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
108274759  hprt1l; hypoxanthine phosphoribosyltransferase 1, like [KO:K00760] [EC:2.4.2.8]
108268988  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
108264359  impdh1a; inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
108265904  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
124628121  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
108257434  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
108269840  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100528635  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
108275184  ces2b; carboxylesterase 1D isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
108259977  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
108259978  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
108259979  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
108259980  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
108255642  UDP-glucuronosyltransferase 2C1 isoform X2 [KO:K00699] [EC:2.4.1.17]
108268336  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 isoform X1 [KO:K00699] [EC:2.4.1.17]
108259975  uncharacterized protein LOC108259975 [KO:K00699] [EC:2.4.1.17]
108259976  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
100304991  ugt; UDP-glucuronosyltransferase precursor [KO:K00699] [EC:2.4.1.17]
108259503  UDP-glucuronosyltransferase 1A5 [KO:K00699] [EC:2.4.1.17]
108259048  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
108259049  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
108264675  UDP glucuronosyltransferase 5 family, polypeptide F1 [KO:K00699] [EC:2.4.1.17]
108275224  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
108265511  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
128629361  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
108259875  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
108267558  zgc:103586 isoform X1 [KO:K01489] [EC:3.5.4.5]
108275845  cdaa; cytidine deaminase a [KO:K01489] [EC:3.5.4.5]
108255155  cdab; cytidine deaminase b [KO:K01489] [EC:3.5.4.5]
108279442  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
108268608  dpyda.1; dihydropyrimidine dehydrogenase a, tandem duplicate 1 isoform X1 [KO:K00207] [EC:1.3.1.2]
108256537  dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
100528125  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
108266824  uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
100528868  uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
108262504  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
108261810  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
108265664  uck2a; uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
108276050  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
108279217  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
108279177  uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
100528309  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
108259222  thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
108266445  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
108267647  cmpk; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
108268039  UMP-CMP kinase isoform X1 [KO:K13800] [EC:2.7.4.14]
108279224  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
108256937  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
100304963  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
100304503  nm23; putative oncoprotein nm23 [KO:K00940] [EC:2.7.4.6]
108276282  nme4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
100528088  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
100528368  nme3; nucleoside diphosphate kinase 3 precursor [KO:K00940] [EC:2.7.4.6]
108257533  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
108264288  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
108259370  arylamine N-acetyltransferase, pineal gland isozyme NAT-10 [KO:K00622] [EC:2.3.1.5]
108259371  arylamine N-acetyltransferase, pineal gland isozyme NAT-10 [KO:K00622] [EC:2.3.1.5]
100528628  ary1; arylamine n-acetyltransferase pineal gland isozyme nat-10 [KO:K00622] [EC:2.3.1.5]
108259233  arylamine N-acetyltransferase, pineal gland isozyme NAT-10 isoform X1 [KO:K00622] [EC:2.3.1.5]
108263214  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
108263647  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100528993  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
108274859  gstr; glutathione S-transferase rho [KO:K00799] [EC:2.5.1.18]
100528347  gstt1b; glutathione S-transferase theta-1b [KO:K00799] [EC:2.5.1.18]
100528338  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
108279760  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108255823  gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
108265745  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
108275325  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system