PATHWAY: ko00280 Help Entry ko00280                     Pathway                                 Name Valine, leucine and isoleucine degradation Class Metabolism; Amino acid metabolism BRITE hierarchy Pathway map ko00280   Valine, leucine and isoleucine degradation Ortholog table Module M00036   Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:ko00280] M00741   Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:ko00280] Other DBs GO:  0006550 0006552 0006574 Orthology K00826   branched-chain amino acid aminotransferase [EC:2.6.1.42] K03334   L-amino-acid oxidase [EC:1.4.3.2] K00271   valine dehydrogenase (NAD+) [EC:1.4.1.23] K00263   leucine dehydrogenase [EC:1.4.1.9] K00166   2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4] K00167   2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4] K11381   2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4] K09699   2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168] K00382   dihydrolipoyl dehydrogenase [EC:1.8.1.4] K00186   2-oxoisovalerate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.7] K00187   2-oxoisovalerate ferredoxin oxidoreductase beta subunit [EC:1.2.7.7] K00189   2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1] K00188   2-oxoisovalerate ferredoxin oxidoreductase delta subunit [EC:1.2.7.7] K00248   butyryl-CoA dehydrogenase [EC:1.3.8.1] K00249   acyl-CoA dehydrogenase [EC:1.3.8.7] K00253   isovaleryl-CoA dehydrogenase [EC:1.3.8.4] K11410   short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5] K09478   short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5] K11538   isobutyryl-CoA dehydrogenase [EC:1.3.99.-] K01692   enoyl-CoA hydratase [EC:4.2.1.17] K01825   3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8] K01782   3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3] K07515   enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211] K07514   enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8] K07511   enoyl-CoA hydratase [EC:4.2.1.17] K00022   3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] K08683   3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178] K00632   acetyl-CoA acyltransferase [EC:2.3.1.16] K07513   acetyl-CoA acyltransferase 1 [EC:2.3.1.16] K07508   acetyl-CoA acyltransferase 2 [EC:2.3.1.16] K07509   acetyl-CoA acyltransferase [EC:2.3.1.16] K01965   propionyl-CoA carboxylase alpha subunit [EC:6.4.1.3] K01966   propionyl-CoA carboxylase beta subunit [EC:6.4.1.3 2.1.3.15] K11263   acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14] K27094   propionyl-/long chain acyl-CoA carboxylase carboxyl transferase subunit beta 5 [EC:6.4.1.3 6.4.1.- 2.1.3.15] K27095   acyl-CoA carboxylase epsilon subunit K18472   acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] K19312   acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] K22568   acetyl-CoA/propionyl-CoA carboxylase, PccX subunit [EC:6.4.1.2 6.4.1.3] K01964   acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] K15036   acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15] K15037   biotin carboxyl carrier protein K05606   methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] K01847   methylmalonyl-CoA mutase [EC:5.4.99.2] K01849   methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2] K01848   methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2] K05605   3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4] K00020   3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] K23146   3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase [EC:1.1.1.31 1.1.1.59] K00140   malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27] K00128   aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] K14085   aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] K00149   aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3] K00157   aldehyde oxidase [EC:1.2.3.1] K18660   malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-] K18661   malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-] K00822   beta-alanine--pyruvate transaminase [EC:2.6.1.18] K07250   4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase / 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48] K13524   4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22] K00827   alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase [EC:2.6.1.44 2.6.1.40] K01968   3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4] K01969   3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4] K05607   methylglutaconyl-CoA hydratase [EC:4.2.1.18] K13766   methylglutaconyl-CoA hydratase [EC:4.2.1.18] K01640   hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] K01027   3-oxoacid CoA-transferase [EC:2.8.3.5] K01028   3-oxoacid CoA-transferase subunit A [EC:2.8.3.5] K01029   3-oxoacid CoA-transferase subunit B [EC:2.8.3.5] K01907   acetoacetyl-CoA synthetase [EC:6.2.1.16] K00626   acetyl-CoA C-acetyltransferase [EC:2.3.1.9] K01641   hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] Compound C00024   Acetyl-CoA C00068   Thiamin diphosphate C00091   Succinyl-CoA C00100   Propanoyl-CoA C00123   L-Leucine C00141   3-Methyl-2-oxobutanoic acid C00164   Acetoacetate C00183   L-Valine C00233   4-Methyl-2-oxopentanoate C00332   Acetoacetyl-CoA C00349   2-Methyl-3-oxopropanoate C00356   (S)-3-Hydroxy-3-methylglutaryl-CoA C00407   L-Isoleucine C00630   2-Methylpropanoyl-CoA C00671   (S)-3-Methyl-2-oxopentanoic acid C00683   (S)-Methylmalonyl-CoA C01205   (R)-3-Amino-2-methylpropanoate C01213   (R)-Methylmalonyl-CoA C02170   Methylmalonate C02939   3-Methylbutanoyl-CoA C03069   3-Methylcrotonyl-CoA C03231   3-Methylglutaconyl-CoA C03284   L-3-Aminoisobutanoate C03344   2-Methylacetoacetyl-CoA C03345   2-Methylbut-2-enoyl-CoA C03460   2-Methylprop-2-enoyl-CoA C04405   (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA C05996   Branched chain fatty acid C05998   3-Hydroxyisovaleryl-CoA C06000   (S)-3-Hydroxyisobutyryl-CoA C06001   (S)-3-Hydroxyisobutyrate C06002   (S)-Methylmalonate semialdehyde C15972   Enzyme N6-(lipoyl)lysine C15973   Enzyme N6-(dihydrolipoyl)lysine C15974   3-Methyl-1-hydroxybutyl-ThPP C15975   [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine C15976   2-Methyl-1-hydroxypropyl-ThPP C15977   [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine C15978   2-Methyl-1-hydroxybutyl-ThPP C15979   [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine C15980   (S)-2-Methylbutanoyl-CoA C20827   3-Hydroxyisovalerate Related pathway ko00020   Citrate cycle (TCA cycle) ko00240   Pyrimidine metabolism ko00290   Valine, leucine and isoleucine biosynthesis ko00522   Biosynthesis of 12-, 14- and 16-membered macrolides ko00640   Propanoate metabolism ko00900   Terpenoid backbone biosynthesis ko01056   Biosynthesis of type II polyketide backbone LinkDB All DBs

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