KEGG   PATHWAY: lco04060
Entry
lco04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Larimichthys crocea (large yellow croaker)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
lco04060  Cytokine-cytokine receptor interaction
lco04060

Organism
Larimichthys crocea (large yellow croaker) [GN:lco]
Gene
104931435  C-C motif chemokine 25 [KO:K13072]
104930476  C-C motif chemokine 21 [KO:K13072]
104928552  C-C motif chemokine 19-like precursor [KO:K05512]
109139007  C-C motif chemokine 20-like [KO:K05512]
109138316  C-C motif chemokine 3 [KO:K05408]
104921094  ccl28; C-C motif chemokine 28 [KO:K05513]
104935099  C-C motif chemokine 20 [KO:K14625]
104929633  C-C motif chemokine 19 isoform X1 [KO:K14625]
104928757  C-C motif chemokine 20 [KO:K14625]
104938000  interleukin-8 [KO:K10030]
104938003  growth-regulated alpha protein [KO:K10030]
104924350  interleukin-8 [KO:K10030]
104924349  interleukin-8-like precursor [KO:K10030]
109138668  uncharacterized protein LOC109138668 [KO:K05416]
109136981  C-X-C motif chemokine 9-like [KO:K12671]
104939600  C-X-C motif chemokine 9 [KO:K12671]
104935022  cxcl13; C-X-C motif chemokine 13 precursor [KO:K10032]
109138674  stromal cell-derived factor 1 [KO:K10031]
109136722  stromal cell-derived factor 1-like isoform X1 [KO:K10031]
104928610  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
104917905  interleukin-15 isoform X1 [KO:K05433]
104932935  epo; erythropoietin isoform X1 [KO:K05437]
104940493  somatolactin isoform X1 [KO:K05438]
104931893  somatotropin precursor [KO:K05438]
104922938  prolactin [KO:K05439]
104933293  prolactin [KO:K05439]
104931899  csf3; granulocyte colony-stimulating factor [KO:K05423]
104934640  uncharacterized protein LOC104934640 [KO:K05417]
104936631  interleukin-12 subunit alpha [KO:K05406]
104922998  interleukin-12 subunit beta [KO:K05425]
104938187  interleukin-12 subunit beta [KO:K05425]
104924236  il12b; interleukin-12 subunit beta isoform X1 [KO:K05425]
104919725  uncharacterized protein LOC104919725 isoform X2 [KO:K22629]
104926591  ebi3; interleukin-27 subunit beta [KO:K24476]
104922670  clcf1; cardiotrophin-like cytokine factor 1 [KO:K05421]
104924550  uncharacterized protein LOC104924550 [KO:K05420]
104925242  il10; interleukin-10 [KO:K05443]
104925249  interleukin-20 [KO:K22667]
104935811  uncharacterized protein LOC104935811 [KO:K05445]
109139382  interferon a3 [KO:K05414]
109138476  interferon a3-like [KO:K05414]
104923462  interleukin-1 beta [KO:K04519]
104927225  interleukin-17F [KO:K05494]
104938420  interleukin-17F [KO:K05494]
104936509  interleukin-17B [KO:K05491]
104934846  il17d; interleukin-17D [KO:K05492]
104933284  il16; pro-interleukin-16 isoform X1 [KO:K22628]
104934466  uncharacterized protein LOC104934466 isoform X1 [KO:K22628]
104929131  il34; interleukin-34 [KO:K22633]
104931067  tumor necrosis factor [KO:K03156]
104931068  tumor necrosis factor-like [KO:K03156]
104933337  tumor necrosis factor-like [KO:K03156]
104925387  tumor necrosis factor ligand superfamily member 14 [KO:K05477]
104918586  tumor necrosis factor ligand superfamily member 14 [KO:K05477]
104917990  tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
104926008  tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
104934258  lymphotoxin-alpha isoform X1 [KO:K05478]
104920041  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104939189  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104923179  eda; ectodysplasin-A isoform X1 [KO:K05480]
104931860  nerve growth factor [KO:K02582]
109136629  nerve growth factor-like [KO:K02582]
104927602  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
104923178  tumor necrosis factor ligand superfamily member 13B [KO:K05476]
104928453  tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
109141681  transforming growth factor beta-1 proprotein [KO:K13375]
104925539  transforming growth factor beta-2 proprotein [KO:K13376]
104936633  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
104922426  transforming growth factor beta-3 proprotein [KO:K13377]
104921351  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
104920968  gdf15; growth/differentiation factor 15 [KO:K05504]
104928589  growth/differentiation factor 2 [KO:K05503]
104924996  bone morphogenetic protein 10 [KO:K22670]
104924743  bone morphogenetic protein 10 [KO:K22670]
104928327  inha; inhibin alpha chain [KO:K05500]
104929950  bmp3; bone morphogenetic protein 3 [KO:K05496]
104924293  growth/differentiation factor 10 [KO:K22674]
104928588  growth/differentiation factor 10 [KO:K22674]
104937251  growth/differentiation factor 11 isoform X1 [KO:K22679]
104926238  growth/differentiation factor 8-like precursor [KO:K05497]
104920787  mstn; growth/differentiation factor 8 [KO:K05497]
104932675  inhba; inhibin beta A chain [KO:K04667]
104934797  inhibin beta A chain [KO:K04667]
104919974  inhibin beta B chain [KO:K22687]
104940378  inhibin beta B chain isoform X1 [KO:K22687]
104931304  inhibin beta B chain [KO:K22687]
104923597  gdf3; growth/differentiation factor 3 [KO:K22672]
104920316  nodal homolog [KO:K04666]
104929310  nodal; nodal homolog [KO:K04666]
104920104  nodal homolog 2-A [KO:K04666]
104938380  gdf9; growth/differentiation factor 9 [KO:K22673]
104918414  amh; muellerian-inhibiting factor isoform X1 [KO:K04665]
104936815  bone morphogenetic protein 4 isoform X2 [KO:K21283]
104920857  bmp2; bone morphogenetic protein 2 [KO:K21283]
104928596  bone morphogenetic protein 2 [KO:K21283]
104931444  bone morphogenetic protein 2 [KO:K21283]
104922404  bmp4; bone morphogenetic protein 4 [KO:K04662]
104938314  gdf5; growth/differentiation factor 5 [KO:K04664]
104931979  gdf6; growth/differentiation factor 6 [KO:K20012]
104929251  growth/differentiation factor 6-B [KO:K20012]
109142805  growth/differentiation factor 6-A [KO:K20013]
104935018  bmp15; bone morphogenetic protein 15 [KO:K05498]
104939831  bmp5; bone morphogenetic protein 5 [KO:K04663]
104927526  bmp6; bone morphogenetic protein 6 [KO:K16620]
104939054  bone morphogenetic protein 7 isoform X1 [KO:K16621]
104919617  bone morphogenetic protein 7 isoform X1 [KO:K16621]
104931596  bmp8a; bone morphogenetic protein 8A [KO:K16622]
104932191  C-C chemokine receptor type 9 [KO:K04184]
104932659  C-C chemokine receptor type 9 [KO:K04184]
104937348  ackr4; atypical chemokine receptor 4 [KO:K04186]
104926171  atypical chemokine receptor 4 [KO:K04186]
104929216  C-C chemokine receptor type 7 [KO:K04182]
104920376  ccr7; C-C chemokine receptor type 7 [KO:K04182]
104940418  C-C chemokine receptor type 5 isoform X1 [KO:K04179]
104934761  C-C chemokine receptor type 4-like [KO:K04179]
104938034  C-C chemokine receptor type 3 [KO:K04179]
109140802  C-C chemokine receptor type 3 [KO:K04179]
104934762  C-C chemokine receptor type 2-like [KO:K04177]
104933182  ccr6; C-C chemokine receptor type 6 isoform X1 [KO:K04181]
104929313  C-C chemokine receptor type 6 [KO:K04181]
104935054  C-X-C chemokine receptor type 2 [KO:K05050]
104925870  C-X-C chemokine receptor type 1 isoform X1 [KO:K05050]
104925881  C-X-C chemokine receptor type 1 [KO:K05050]
109140398  C-X-C chemokine receptor type 3-2-like [KO:K04188]
104922270  C-X-C chemokine receptor type 3 [KO:K04188]
104922271  cxcr3; C-X-C chemokine receptor type 3 [KO:K04188]
104925951  cxcr5; C-X-C chemokine receptor type 5 [KO:K04190]
104926341  C-X-C chemokine receptor type 4 [KO:K04189]
104938220  C-X-C chemokine receptor type 4 [KO:K04189]
104934108  atypical chemokine receptor 3 [KO:K04304]
104934004  atypical chemokine receptor 3 isoform X2 [KO:K04304]
104917733  chemokine XC receptor 1 [KO:K04193]
104917755  chemokine XC receptor 1 isoform X2 [KO:K04193]
104918453  chemokine XC receptor 1-like isoform X1 [KO:K04193]
104936154  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
104938889  cytokine receptor common subunit gamma [KO:K05070]
104936386  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
104933240  il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
104934035  uncharacterized protein LOC104934035 [KO:K05075]
109143089  interleukin-2 receptor subunit beta [KO:K05075]
104922917  interleukin-3 receptor class 2 subunit beta [KO:K04738]
104924051  uncharacterized protein LOC104924051 isoform X1 [KO:K05076]
104935298  interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077]
104934504  epor; erythropoietin receptor isoform X2 [KO:K05079]
104920655  ghr; growth hormone receptor [KO:K05080]
104928485  growth hormone receptor isoform X1 [KO:K05080]
104928231  prlr; prolactin receptor [KO:K05081]
104919040  mpl; thrombopoietin receptor [KO:K05082]
104919598  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
104929466  lepr; leptin receptor isoform X2 [KO:K05062]
104934469  interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
104933784  interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
104935192  interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
104933465  interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
104927707  ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05056]
104920404  leukemia inhibitory factor receptor [KO:K05063]
104930794  interleukin-12 receptor subunit beta-2-like [KO:K05064]
104930800  interleukin-12 receptor subunit beta-2-like isoform X1 [KO:K05064]
104934385  interleukin-31 receptor subunit alpha [KO:K22630]
104929836  ciliary neurotrophic factor receptor subunit alpha-like isoform X1 [KO:K05059]
104937030  leukemia inhibitory factor receptor isoform X1 [KO:K05058]
104920813  leukemia inhibitory factor receptor [KO:K05058]
104918008  uncharacterized protein LOC104918008 isoform X1 [KO:K05134]
104932500  interleukin-10 receptor subunit beta [KO:K05135]
104938392  interferon alpha/beta receptor 1b [KO:K05135]
104938393  ifngr2; interferon gamma receptor 2 precursor [KO:K05135]
104927387  uncharacterized protein LOC104927387 [KO:K05136]
104937176  il20rb; interleukin-20 receptor subunit beta [KO:K05137]
104932498  uncharacterized protein LOC104932498 [KO:K05131]
104931539  ifngr1l; interferon gamma receptor 1-like precursor [KO:K05132]
104918512  interferon gamma receptor 1-like isoform X1 [KO:K05132]
104928679  interleukin-1 receptor type 1 [KO:K04386]
104939698  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
104918238  interleukin-1 receptor type 2 isoform X1 [KO:K04387]
104918267  interleukin-1 receptor accessory protein isoform X1 [KO:K05173]
109139280  interleukin-18 receptor 1 isoform X1 [KO:K05173]
104918246  interleukin-18 receptor accessory protein [KO:K05174]
104928671  interleukin-1 receptor-like 1 [KO:K05171]
104934026  il17ra; interleukin-17 receptor A [KO:K05164]
104940657  interleukin-17 receptor A [KO:K05164]
104940236  interleukin-17 receptor C isoform X1 [KO:K05166]
104925128  uncharacterized protein LOC104925128 [KO:K05166]
109137939  il17rb; interleukin-17 receptor B [KO:K05165]
104940235  uncharacterized protein LOC104940235 [KO:K05168]
104922282  T-cell surface glycoprotein CD4 [KO:K06454]
104927057  macrophage colony-stimulating factor 1 receptor 1 isoform X1 [KO:K05090] [EC:2.7.10.1]
104919443  macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
104929001  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104919357  tumor necrosis factor receptor superfamily member 1B [KO:K05141]
109136699  tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K05152]
104939379  tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K05152]
104939381  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
104935365  tumor necrosis factor receptor superfamily member 6B [KO:K05143]
104920199  tumor necrosis factor receptor superfamily member 6B [KO:K05143]
104929632  tumor necrosis factor receptor superfamily member 26 isoform X1 [KO:K04390]
104936786  tumor necrosis factor receptor superfamily member 10B-like precursor [KO:K04722]
104939559  tumor necrosis factor receptor superfamily member 10B isoform X3 [KO:K04722]
104930893  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
104923838  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
104930398  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104926051  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104940332  death domain-containing membrane protein NRADD [KO:K02583]
104920198  tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
104922590  tumor necrosis factor receptor superfamily member 11A [KO:K05147]
104929029  cd27; CD27 antigen [KO:K05144]
104932110  tumor necrosis factor receptor superfamily member 5 [KO:K03160]
104932548  tumor necrosis factor receptor superfamily member 5 [KO:K03160]
104924674  tumor necrosis factor receptor superfamily member 9 [KO:K05146]
104920529  tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146]
104929158  tnfrsf13b; tumor necrosis factor receptor superfamily member 13B isoform X2 [KO:K05150]
104921132  tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
104928511  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
104934875  nascent polypeptide-associated complex subunit alpha, muscle-specific form [KO:K26541]
104936801  rell1; RELT-like protein 1 [KO:K26541]
104931778  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104923102  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104922506  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104932540  activin receptor type-1 [KO:K13594] [EC:2.7.11.30]
104935816  activin receptor type-2A isoform X4 [KO:K04670] [EC:2.7.11.30]
104926240  acvr2a; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
104931750  bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
104926387  bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
104932045  activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
104932530  activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
104938405  activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
104920074  acvr1c; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
104920073  acvr1; activin receptor type-1 isoform X2 [KO:K04675] [EC:2.7.11.30]
104926585  activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
104934248  bmpr1a; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
104924706  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
104920273  bmpr1b; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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