KEGG   PATHWAY: leri04814
Entry
leri04814                   Pathway                                
Name
Motor proteins - Leucoraja erinacea (little skate)
Class
Cellular Processes; Cell motility
Pathway map
leri04814  Motor proteins
leri04814

Organism
Leucoraja erinacea (little skate) [GN:leri]
Gene
129700543  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
129698145  LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
129713338  cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
129698755  cytoplasmic dynein 1 intermediate chain 2-like [KO:K10415]
129714671  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
129705302  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
129709709  cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]
129699645  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
129709128  dynein light chain LC6, flagellar outer arm [KO:K10418]
129710512  dynll2b; dynein, light chain, LC8-type 2b [KO:K10418]
129705331  dynein light chain roadblock-type 2 [KO:K10419]
129707299  dynein light chain roadblock-type 1-like [KO:K10419]
129709906  LOW QUALITY PROTEIN: dynein light chain Tctex-type 1-like [KO:K10420]
129702684  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
129699583  dynein light chain Tctex-type 1-like [KO:K10420]
129699446  dynein light chain Tctex-type protein 2-like [KO:K25419]
129700857  dynein light chain Tctex-type 4 isoform X1 [KO:K25420]
129701024  dynlt5; dynein light chain Tctex-type 5 isoform X1 [KO:K25421]
129695437  LOW QUALITY PROTEIN: dynein axonemal heavy chain 6-like [KO:K10408]
129705497  dynein axonemal heavy chain 5-like [KO:K10408]
129709236  dnah10; dynein axonemal heavy chain 10 [KO:K10408]
129709750  LOW QUALITY PROTEIN: dynein axonemal heavy chain 5-like [KO:K10408]
129697508  LOW QUALITY PROTEIN: dynein axonemal heavy chain 8-like [KO:K10408]
129697686  dynein axonemal heavy chain 6-like [KO:K10408]
129697689  dynein axonemal heavy chain 8-like [KO:K10408]
129698651  dnah7; dynein axonemal heavy chain 7 [KO:K10408]
129707093  dnah3; dynein axonemal heavy chain 3 [KO:K10408]
129711542  dnah5; dynein axonemal heavy chain 5 [KO:K10408]
129693998  dnah2; LOW QUALITY PROTEIN: dynein axonemal heavy chain 2 [KO:K10408]
129704455  dnah12; dynein axonemal heavy chain 12 [KO:K10408]
129708029  dynein axonemal heavy chain 3-like [KO:K10408]
129708122  dynein axonemal heavy chain 9-like [KO:K10408]
129708244  dynein axonemal heavy chain 17-like [KO:K10408]
129704585  dnah1; dynein axonemal heavy chain 1 [KO:K10408]
129712715  dynein axonemal heavy chain 11-like [KO:K10408]
129695402  dnai1.2; dynein, axonemal, intermediate chain 1, paralog 2 [KO:K10409]
129708419  dnai2b; dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
129694050  dnai3; dynein axonemal intermediate chain 3 [KO:K24722]
129701022  dnai4; dynein axonemal intermediate chain 4 [KO:K24723]
129709597  dnali1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
129697277  axonemal dynein light intermediate polypeptide 1-like [KO:K10410]
129700420  dnal1; dynein axonemal light chain 1 [KO:K10411]
129713807  dynein axonemal light chain 4-like [KO:K10412]
129715569  LOW QUALITY PROTEIN: dynactin subunit 1-like [KO:K04648]
129695193  dctn2; LOW QUALITY PROTEIN: dynactin subunit 2 [KO:K10424]
129695355  dctn3; dynactin subunit 3 [KO:K10425]
129701561  dctn4; LOW QUALITY PROTEIN: dynactin subunit 4 [KO:K10426]
129706805  dctn5; dynactin subunit 5 [KO:K10427]
129704072  dynactin subunit 6-like [KO:K10428]
129713300  beta-centractin-like [KO:K16575]
129704110  alpha-centractin [KO:K16575]
129700203  actr10; actin-related protein 10 [KO:K16576]
129706510  F-actin-capping protein subunit alpha-2 [KO:K10364]
129704546  F-actin-capping protein subunit alpha-2-like [KO:K10364]
129708589  F-actin-capping protein subunit alpha-2-like [KO:K10364]
129711513  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
129709108  BICD family-like cargo adapter 1 [KO:K16756]
129710761  BICD family-like cargo adapter 1 [KO:K16756]
129701459  hook3; protein Hook homolog 3 isoform X1 [KO:K16536]
129694804  tubulin alpha-1 chain-like [KO:K07374]
129694859  tubulin alpha-1B chain-like [KO:K07374]
129694861  tubulin alpha chain-like [KO:K07374]
129694862  tubulin alpha-1B chain-like [KO:K07374]
129694863  tubulin alpha-1B chain-like [KO:K07374]
129694864  tubulin alpha-1D chain-like [KO:K07374]
129694883  tubulin alpha chain-like [KO:K07374]
129695002  tubulin alpha chain-like [KO:K07374]
129695084  tubulin alpha chain-like [KO:K07374]
129695124  tubulin alpha chain-like [KO:K07374]
129701393  tubulin alpha chain-like isoform X1 [KO:K07374]
129701394  tubulin alpha chain-like [KO:K07374]
129701396  tubulin alpha chain-like [KO:K07374]
129701397  tubulin alpha chain-like isoform X1 [KO:K07374]
129708774  tubulin alpha-8 chain-like [KO:K07374]
129693456  tubulin alpha chain-like [KO:K07374]
129693457  tubulin alpha chain-like [KO:K07374]
129693707  tubulin alpha-1B chain-like [KO:K07374]
129693708  tubulin alpha chain-like [KO:K07374]
129693717  tubulin alpha-8 chain-like [KO:K07374]
129693718  tubulin alpha-1B chain-like [KO:K07374]
129694227  tubulin alpha-1D chain-like [KO:K07374]
129694230  tubulin alpha chain-like [KO:K07374]
129694354  tubulin alpha-1 chain-like [KO:K07374]
129694407  tubulin alpha chain-like [KO:K07374]
129714767  tubulin alpha chain [KO:K07374]
129714773  tubulin alpha-1C chain [KO:K07374]
129714785  tubulin alpha chain-like [KO:K07374]
129715292  tubulin alpha chain-like [KO:K07374]
129715293  tubulin alpha-1C chain-like [KO:K07374]
129715377  tubulin alpha chain-like [KO:K07374]
129715553  tubulin alpha-1 chain-like [KO:K07374]
129715554  tubulin alpha-1C chain-like [KO:K07374]
129715555  tubulin alpha-1 chain-like [KO:K07374]
129715583  tubulin alpha chain-like [KO:K07374]
129715825  tubulin alpha-1D chain-like [KO:K07374]
129715826  tubulin alpha-1C chain-like [KO:K07374]
129715828  tubulin alpha-1D chain isoform X1 [KO:K07374]
129715830  tubulin alpha-8 chain-like [KO:K07374]
129715832  tubulin alpha-8 chain-like [KO:K07374]
129715918  tubulin alpha chain-like [KO:K07374]
129716116  tubulin alpha-1B chain-like [KO:K07374]
129716329  tubulin alpha-1B chain-like [KO:K07374]
129695212  tubulin beta-4B chain-like [KO:K07375]
129705445  tubulin beta-3 chain [KO:K07375]
129696463  tubb5; tubulin beta-5 chain isoform X1 [KO:K07375]
129707184  tubulin beta chain-like isoform X1 [KO:K07375]
129707208  tubulin beta chain-like [KO:K07375]
129711937  tubulin beta chain [KO:K07375]
129711939  tubulin beta chain-like [KO:K07375]
129712180  tubulin beta-4B chain-like isoform X1 [KO:K07375]
129712181  tubulin beta chain-like [KO:K07375]
129710053  tubg1; tubulin gamma-1 chain [KO:K10389]
129707175  tubd1; tubulin delta chain isoform X1 [KO:K10390]
129697323  tube1; tubulin epsilon chain [KO:K10391]
129699067  kinesin heavy chain [KO:K10396]
129715239  kinesin-1 heavy chain [KO:K10396]
129697676  kinesin light chain 2-like [KO:K10407]
129700268  klc1a; kinesin light chain 1 isoform X1 [KO:K10407]
129714103  kinesin light chain 1-like isoform X1 [KO:K10407]
129701484  kif3a; kinesin-like protein KIF3A isoform X1 [KO:K10394]
129707540  kif3b; LOW QUALITY PROTEIN: kinesin-like protein KIF3B [KO:K20196]
129701119  kifap3a; kinesin-associated protein 3a [KO:K25388]
129697171  kinesin-like protein KIF3C isoform X1 [KO:K20197]
129711629  kif17; kinesin-like protein KIF17 [KO:K20198]
129703529  kif1aa; kinesin-like protein KIF1A isoform X1 [KO:K10392]
129711740  kif1b; kinesin-like protein KIF1B isoform X1 [KO:K10392]
129699434  kinesin-like protein KIF13B isoform X1 [KO:K17914]
129708689  kif13a; kinesin-like protein KIF13A isoform X1 [KO:K17914]
129701282  kif14; kinesin-like protein KIF14 isoform X1 [KO:K17915]
129699222  kif16ba; kinesin-like protein KIF16B [KO:K17916]
129702094  LOW QUALITY PROTEIN: chromosome-associated kinesin KIF4-like [KO:K10395]
129693963  chromosome-associated kinesin KIF4-like [KO:K10395]
129712807  kif7; kinesin-like protein kif7 [KO:K18806]
129707994  kif21a; kinesin-like protein KIF21A isoform X1 [KO:K24185]
129708695  kif21b; kinesin-like protein KIF21B [KO:K24185]
129695741  kinesin-like protein KIF27 [KO:K24186]
129703912  kif11; kinesin-like protein KIF11 [KO:K10398]
129701862  kif20a; kinesin-like protein KIF20A [KO:K10402]
129696041  zgc:56231; kinesin-like protein KIF20A [KO:K10402]
129703887  kinesin-like protein KIF20B isoform X1 [KO:K10402]
129712730  kif23; kinesin-like protein KIF23 [KO:K17387]
129695585  LOW QUALITY PROTEIN: centromere-associated protein E-like [KO:K11498]
129705560  kif18a; kinesin-like protein KIF18A [KO:K10401]
129714004  kinesin-like protein KIF18A [KO:K10401]
129706712  si:dkey-26i13.8; kinesin-like protein KIF19 isoform X1 [KO:K26157]
129708420  kif19; kinesin-like protein KIF19 isoform X1 [KO:K26157]
129697628  kinesin-like protein KIF6 isoform X1 [KO:K10397]
129714866  kif9; kinesin-like protein KIF9 [KO:K10397]
129699464  kif26ba; kinesin-like protein KIF26B [KO:K10404]
129700281  kif26ab; kinesin-like protein KIF26A isoform X1 [KO:K10404]
129707835  kif15; kinesin-like protein KIF15-A [KO:K10400]
129695589  kinesin-like protein KIF24 [KO:K10393]
129696763  kif2a; kinesin-like protein KIF2A isoform X1 [KO:K10393]
129700852  kif2c; kinesin-like protein KIF2C isoform X1 [KO:K10393]
129701766  carboxy-terminal kinesin 2-like [KO:K10405]
129693927  carboxy-terminal kinesin 2-like [KO:K10405]
129715253  LOW QUALITY PROTEIN: carboxy-terminal kinesin 2-like [KO:K10405]
129705184  kifc3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
129699867  kif25; kinesin-like protein KIF25 [KO:K18627]
129709191  myo1ha; unconventional myosin-Ih isoform X1 [KO:K10356]
129710206  myo1d; unconventional myosin-Id isoform X1 [KO:K10356]
129710629  LOW QUALITY PROTEIN: unconventional myosin-Ic-like [KO:K10356]
129698645  myo1b; unconventional myosin-Ib isoform X1 [KO:K10356]
129711185  unconventional myosin-If-like [KO:K10356]
129712631  myo1ea; unconventional myosin-Ie isoform X1 [KO:K10356]
129714740  unconventional myosin-Ib-like [KO:K10356]
129715042  LOW QUALITY PROTEIN: unconventional myosin-Id-like [KO:K10356]
129698772  myo3b; myosin-IIIb isoform X1 [KO:K08834] [EC:2.7.11.1]
129712060  myo5b; unconventional myosin-Vb [KO:K10357]
129712575  LOW QUALITY PROTEIN: unconventional myosin-Va-like [KO:K10357]
129712576  unconventional myosin-Vc-like isoform X1 [KO:K10357]
129699560  myo6a; LOW QUALITY PROTEIN: myosin VIa [KO:K10358]
129693418  unconventional myosin-VIIa-like [KO:K10359]
129714993  myo7aa; myosin VIIAa [KO:K10359]
129703149  unconventional myosin-VIIa-like [KO:K21868]
129713650  myo9aa; unconventional myosin-IXAa isoform X1 [KO:K10360]
129711044  LOW QUALITY PROTEIN: unconventional myosin-IXb-like [KO:K10360]
129694899  LOW QUALITY PROTEIN: unconventional myosin-X-like [KO:K12559]
129705356  LOW QUALITY PROTEIN: unconventional myosin-X-like [KO:K12559]
129707113  myo15aa; unconventional myosin-XV [KO:K10361]
129698327  myo16; unconventional myosin-XVI [KO:K17481]
129709196  unconventional myosin-XVIIIb-like [KO:K10362]
129710473  myo18ab; unconventional myosin-XVIIIa [KO:K10362]
129710812  unconventional myosin-XIX isoform X1 [KO:K25838]
129707171  myosin heavy chain, cardiac muscle isoform-like [KO:K24220]
129707173  myosin-7-like [KO:K24220]
129708130  myosin-4-like [KO:K24220]
129708131  myosin-4-like [KO:K24220]
129708132  myosin-4-like [KO:K24220]
129708133  myosin-4 [KO:K24220]
129708136  myosin-4-like [KO:K24220]
129713774  myosin-9-like isoform X1 [KO:K10352]
129707084  myh11b; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
129708089  myosin-10 isoform X1 [KO:K10352]
129698855  myosin light chain 1, skeletal muscle isoform-like isoform X1 [KO:K05738]
129714856  myosin light chain 1, cardiac muscle-like [KO:K12749]
129710247  myl4; myosin light chain 4 [KO:K12750]
129714790  myosin light polypeptide 6-like [KO:K12751]
129709423  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
129701298  myosin light chain 5-like [KO:K12753]
129713177  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
129707561  myosin regulatory light polypeptide 9 [KO:K12755]
129710640  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K12756]
129696367  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
129704264  acta2; actin, aortic smooth muscle [KO:K12313]
129703278  uncharacterized protein LOC129703278 [KO:K12314]
129700313  actin, alpha cardiac muscle 1 [KO:K12314]
129715185  actin, alpha cardiac muscle 1-like [KO:K12314]
129696389  actin, non-muscle 6.2-like [KO:K05692]
129696393  actin, non-muscle 6.2-like isoform X1 [KO:K05692]
129696398  actin, non-muscle 6.2-like [KO:K05692]
129696400  actin, non-muscle 6.2-like [KO:K05692]
129696402  actin, non-muscle 6.2-like [KO:K05692]
129706670  actin, cytoplasmic 2 [KO:K05692]
129708303  actin, cytoplasmic type 5 [KO:K05692]
129694224  actin-2-like [KO:K05692]
129711033  uncharacterized protein LOC129711033 [KO:K10355]
129704884  troponin C, slow skeletal and cardiac muscles [KO:K05865]
129707708  troponin I, slow skeletal muscle-like [KO:K10371]
129707709  troponin I, slow skeletal muscle-like [KO:K10371]
129708653  tnni1b; troponin I type 1b (skeletal, slow) isoform X1 [KO:K10371]
129714000  troponin T, slow skeletal muscle-like isoform X1 [KO:K10372]
129707389  troponin C, skeletal muscle-like isoform X1 [KO:K12042]
129705748  troponin I, fast skeletal muscle-like [KO:K12043]
129705757  troponin T, fast skeletal muscle isoforms-like [KO:K12046]
129707705  troponin T, fast skeletal muscle-like isoform X1 [KO:K12046]
129708533  troponin T, cardiac muscle-like [KO:K12045]
129713584  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
129695715  tropomyosin alpha-4 chain-like isoform X1 [KO:K09290]
129716190  LOW QUALITY PROTEIN: tropomyosin alpha-3 chain-like [KO:K09290]
129711219  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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