KEGG   PATHWAY: mcal05161
Entry
mcal05161                   Pathway                                
Name
Hepatitis B - Mus caroli (Ryukyu mouse)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcal05161  Hepatitis B
mcal05161

Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110292307  Hspg2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
110307357  Slc10a1; sodium/bile acid cotransporter isoform X1 [KO:K14341]
110298438  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
110292955  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
110306834  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
110292408  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110301725  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110301346  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
110283679  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
110294148  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110308920  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110304169  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110310583  Myc; myc proto-oncogene protein [KO:K04377]
110303857  Egr2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
110309534  Egr3; early growth response protein 3 isoform X1 [KO:K12497]
110310313  Ep300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110311224  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
110300709  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
110285966  Ddb1; DNA damage-binding protein 1 [KO:K10610]
110290093  Ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
110307741  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
110310210  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
110306902  Ywhaq; 14-3-3 protein theta [KO:K16197]
110312563  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
110304803  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
110290798  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110292183  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110301355  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110308009  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110299855  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110292624  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110297609  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110294471  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110307022  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110285285  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110300158  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110287188  Ikbkg; NF-kappa-B essential modulator isoform X4 [KO:K07210]
110306864  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
110291231  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110285703  Rela; transcription factor p65 [KO:K04735]
110290048  Mmp9; matrix metalloproteinase-9 isoform X1 [KO:K01403] [EC:3.4.24.35]
110302433  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
110285481  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110285655  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
110298222  Fadd; FAS-associated death domain protein [KO:K02373]
110291975  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
110297919  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
110302801  Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
110303728  cytochrome c, somatic-like [KO:K08738]
110309371  cytochrome c, testis-specific [KO:K08738]
110296815  cytochrome c, somatic [KO:K08738]
110293440  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
110299851  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110302047  caspase-12 isoform X2 [KO:K04741] [EC:3.4.22.-]
110305684  Birc5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
110305297  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110291693  Ccna1; cyclin-A1 isoform X1 [KO:K06627]
110291472  Ccna2; cyclin-A2 [KO:K06627]
110303221  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110292124  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110298604  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
110309179  Rb1; retinoblastoma-associated protein [KO:K06618]
110289983  E2f1; transcription factor E2F1 [KO:K17454]
110293508  E2f2; transcription factor E2F2 isoform X1 [KO:K09389]
110308034  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
110286977  Atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
110304357  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110297826  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110297763  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110284760  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
110308382  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110299723  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110309052  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
110284110  Tnf; tumor necrosis factor [KO:K03156]
110292243  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110285435  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
110299617  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110302481  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
110306201  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
110304843  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
110302854  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
110293862  Stat4; signal transducer and activator of transcription 4 [KO:K11222]
110304461  signal transducer and activator of transcription 5A [KO:K11223]
110306026  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
110303914  Stat6; signal transducer and activator of transcription 6 [KO:K11225]
110300156  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
110308944  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
110310031  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110304772  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110306968  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110312423  Sos1; son of sevenless homolog 1 [KO:K03099]
110297313  Hras; GTPase HRas isoform X2 [KO:K02833]
110296194  Kras; GTPase KRas isoform X1 [KO:K07827]
110290873  Nras; GTPase NRas [KO:K07828]
110292423  Jun; transcription factor AP-1 [KO:K04448]
110284933  Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
110286367  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110285614  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
110291408  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
110303337  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
110292754  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
110289497  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
110296066  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
110310868  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110296203  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
110312537  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
110310774  proliferating cell nuclear antigen-like [KO:K04802]
110285987  Pcna; proliferating cell nuclear antigen [KO:K04802]
110287540  Araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
110295945  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
110296919  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110301502  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110303196  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110297836  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110311382  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110307063  Fos; proto-oncogene c-Fos [KO:K04379]
110286681  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
110291353  Tlr2; toll-like receptor 2 [KO:K10159]
110301084  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
110301823  Tirap; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
110293229  Tlr4; toll-like receptor 4 [KO:K10160]
110310638  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
110286819  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
110290132  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
110310212  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
110303600  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
110292293  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
110295330  Il6; interleukin-6 [KO:K05405]
110304977  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
110304684  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
110312562  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110310902  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
110310903  Mapk11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
110312437  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110299603  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110284753  Ticam2; TIR domain-containing adapter molecule 2 [KO:K05409]
110300361  Tlr3; toll-like receptor 3 [KO:K05401]
110283813  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
110292323  Ddx58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
110289518  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
110307081  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
110306954  Traf3; TNF receptor-associated factor 3 [KO:K03174]
110301565  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
110303265  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
110302889  putative ATP-dependent RNA helicase Pl10 [KO:K11594] [EC:5.6.2.7]
110287553  Ddx3x; ATP-dependent RNA helicase DDX3X [KO:K11594] [EC:5.6.2.7]
110298322  Irf3; interferon regulatory factor 3 [KO:K05411]
110297922  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
110293074  interferon alpha-12 [KO:K05414]
110288626  interferon alpha-7 [KO:K05414]
110288627  interferon alpha-4 [KO:K05414]
110288628  interferon alpha-5-like [KO:K05414]
110292605  interferon alpha-11 [KO:K05414]
110293011  interferon alpha-12-like [KO:K05414]
110293017  interferon alpha-9 [KO:K05414]
110293025  interferon alpha-1-like [KO:K05414]
110292939  interferon alpha-9-like [KO:K05414]
110292945  interferon alpha-1-like [KO:K05414]
110292969  interferon alpha-9-like [KO:K05414]
110292975  interferon alpha-1 [KO:K05414]
110292981  interferon alpha-2-like [KO:K05414]
110293791  Ifnb1; interferon beta [KO:K05415]
110311756  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
mcal04010  MAPK signaling pathway
mcal04064  NF-kappa B signaling pathway
mcal04110  Cell cycle
mcal04115  p53 signaling pathway
mcal04151  PI3K-Akt signaling pathway
mcal04210  Apoptosis
mcal04620  Toll-like receptor signaling pathway
mcal04622  RIG-I-like receptor signaling pathway
mcal04630  JAK-STAT signaling pathway
KO pathway
ko05161   
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