Entry
Name
Platelet activation - Macaca mulatta (rhesus monkey)
Description
Platelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by adhesion to adhesive macromolecules, such as collagen and von Willebrand factor (vWF), or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A2. Different receptors are stimulated by various agonists, almost converging in increasing intracellular Ca2+ concentration that stimulate platelet shape change and granule secretion and ultimately induce the "inside-out" signaling process leading to activation of the ligand-binding function of integrin alpha IIb beta 3. Binding of alpha IIb beta 3 to its ligands, mainly fibrinogen, mediates platelet adhesion and aggregation and triggers "outside-in" signaling, resulting in platelet spreading, additional granule secretion, stabilization of platelet adhesion and aggregation, and clot retraction.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene
718144 GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639 ]
722198 ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X2 [KO:K12330 ]
712096 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532 ]
703302 PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
709935 PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
721735 PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
695735 PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270 ]
694957 MYL12B; myosin regulatory light chain 12B [KO:K12757 ]
695077 MYL12A; myosin, light chain 12A, regulatory, non-sarcomeric isoform X1 [KO:K12757 ]
700190 ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056 ]
703669 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
708714 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
718040 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
717963 STIM1; stromal interaction molecule 1 precursor [KO:K16059 ]
705680 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
701951 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
718418 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858 ] [EC:3.1.4.11 ]
718387 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
717764 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
703838 RASGRP1; RAS guanyl-releasing protein 1 isoform X3 [KO:K04350 ]
693750 LOW QUALITY PROTEIN: ras-related protein Rap-1b [KO:K07836 ]
707383 amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X1 [KO:K17704 ]
699310 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
703780 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
708940 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630 ]
694289 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632 ]
698857 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
722027 PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290 ]
722023 PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290 ]
718632 PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345 ] [EC:2.7.11.11 ]
716022 VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274 ]
716936 ARHGAP35; rho GTPase-activating protein 35 [KO:K05732 ]
719996 FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a precursor [KO:K06472 ]
574201 COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236 ]
700359 COL1A2; collagen alpha-2(I) chain precursor [KO:K06236 ]
574131 COL3A1; collagen alpha-1(III) chain precursor [KO:K19720 ]
720291 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma precursor [KO:K07983 ]
716098 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
709959 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
710552 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
707310 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
719367 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
698996 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
714173 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
721584 GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261 ]
712129 GP1BB; platelet glycoprotein Ib beta chain [KO:K06262 ]
708225 SNAP23; synaptosomal-associated protein 23 [KO:K08508 ]
695851 VAMP8; vesicle-associated membrane protein 8 [KO:K08512 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Li Z, Delaney MK, O'Brien KA, Du X
Title
Signaling during platelet adhesion and activation.
Journal
Reference
Authors
Broos K, De Meyer SF, Feys HB, Vanhoorelbeke K, Deckmyn H
Title
Blood platelet biochemistry.
Journal
Reference
Authors
Jurk K, Kehrel BE
Title
Platelets: physiology and biochemistry.
Journal
Reference
Authors
Offermanns S
Title
Activation of platelet function through G protein-coupled receptors.
Journal
Reference
Authors
Varga-Szabo D, Pleines I, Nieswandt B
Title
Cell adhesion mechanisms in platelets.
Journal
Reference
Authors
Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X
Title
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
Journal
Reference
Authors
Bergmeier W, Stefanini L
Title
Novel molecules in calcium signaling in platelets.
Journal
Reference
Authors
Cifuni SM, Wagner DD, Bergmeier W
Title
CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.
Journal
Reference
Authors
Heemskerk JW, Mattheij NJ, Cosemans JM
Title
Platelet-based coagulation: different populations, different functions.
Journal
Reference
Authors
Rivera J, Lozano ML, Navarro-Nunez L, Vicente V
Title
Platelet receptors and signaling in the dynamics of thrombus formation.
Journal
Reference
Authors
Banno A, Ginsberg MH
Title
Integrin activation.
Journal
Reference
Authors
Angiolillo DJ, Ferreiro JL
Title
Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions.
Journal
Reference
Authors
Joo SJ
Title
Mechanisms of Platelet Activation and Integrin alphaIIbeta3.
Journal
Reference
Authors
Harper MT, Poole AW
Title
Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.
Journal
Reference
Authors
Fitch-Tewfik JL, Flaumenhaft R
Title
Platelet granule exocytosis: a comparison with chromaffin cells.
Journal
Reference
Authors
Boylan B, Gao C, Rathore V, Gill JC, Newman DK, Newman PJ
Title
Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets.
Journal
Related pathway
mcc04610 Complement and coagulation cascades
KO pathway
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