KEGG   PATHWAY: mjv04015
Entry
mjv04015                    Pathway                                
Name
Rap1 signaling pathway - Manis javanica (Malayan pangolin)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
mjv04015  Rap1 signaling pathway
mjv04015

Other DBs
GO: 0007264
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108395546  RAP1A; ras-related protein Rap-1A [KO:K04353]
108407356  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
108392641  LOW QUALITY PROTEIN: ras-related protein Rap-1b-like [KO:K07836]
108406677  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
108403513  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
108408881  DOCK4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
108388298  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
108405840  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
108406616  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108406654  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
108386142  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
108383704  calmodulin-A-like [KO:K02183]
108406136  CALM3; calmodulin-3 [KO:K02183]
108391461  CALM2; calmodulin-2 [KO:K02183]
108389026  CALM1; calmodulin-1 [KO:K02183]
108383641  F2R; proteinase-activated receptor 1 [KO:K03914]
108396895  F2RL3; proteinase-activated receptor 4 [KO:K04236]
108396428  P2RY1; P2Y purinoceptor 1 [KO:K04270]
108408598  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
108401369  lysophosphatidic acid receptor 2 [KO:K04291]
118967966  lysophosphatidic acid receptor 2 [KO:K04291]
108403785  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
108387620  lysophosphatidic acid receptor 5 [KO:K08390]
118966829  lysophosphatidic acid receptor 5-like [KO:K08390]
108398879  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
108403987  ADORA2B; adenosine receptor A2b isoform X1 [KO:K04267]
108406177  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
108406179  neuroendocrine secretory protein 55-like [KO:K04632]
118970338  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
108403511  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
108409724  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
108397345  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108410207  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
108396721  ADCY5; adenylate cyclase type 5 isoform X4 [KO:K08045] [EC:4.6.1.1]
108383520  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
108407296  ADCY7; adenylate cyclase type 7 isoform X2 [KO:K08047] [EC:4.6.1.1]
108397669  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
108388549  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
108392459  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
108395539  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
108397041  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
108407569  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108394257  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X3 [KO:K05858] [EC:3.1.4.11]
108394259  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108401653  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108387321  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
108396371  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
108408073  EGF; pro-epidermal growth factor [KO:K04357]
108405921  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
108393279  FGF20; fibroblast growth factor 20 [KO:K04358]
108402439  FGF16; fibroblast growth factor 16 [KO:K04358]
108397295  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108397792  FGF10; fibroblast growth factor 10 [KO:K04358]
108383974  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
108391342  fibroblast growth factor 6 [KO:K04358]
108393043  FGF9; fibroblast growth factor 9 [KO:K04358]
108396343  FGF5; fibroblast growth factor 5 [KO:K04358]
118970663  FGF6; fibroblast growth factor 6 [KO:K04358]
108389506  FGF4; fibroblast growth factor 4 [KO:K04358]
108394626  FGF3; fibroblast growth factor 3 [KO:K04358]
118973114  FGF7; fibroblast growth factor 7 [KO:K04358]
118971119  FGF19; fibroblast growth factor 19 [KO:K22603]
108400332  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
108391341  FGF23; fibroblast growth factor 23 isoform X2 [KO:K22428]
108386081  NGF; beta-nerve growth factor [KO:K02582]
108402614  INS; insulin [KO:K04526]
108410340  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118970652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108397360  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
108393368  PDGFC; platelet-derived growth factor C isoform X4 [KO:K05450]
108390154  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
108400987  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
108396268  KITLG; kit ligand isoform X1 [KO:K05461]
108407135  VEGFA; vascular endothelial growth factor A [KO:K05448]
108407564  VEGFB; vascular endothelial growth factor B isoform X3 [KO:K16858]
108399226  PGF; placenta growth factor isoform X1 [KO:K16859]
108391501  VEGFC; vascular endothelial growth factor C [KO:K05449]
108384371  VEGFD; vascular endothelial growth factor D [KO:K05449]
108399212  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
108392444  ANGPT1; angiopoietin-1 [KO:K05465]
108410138  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
108386709  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
108405281  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
108407285  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
108397962  EGFR; epidermal growth factor receptor isoform X5 [KO:K04361] [EC:2.7.10.1]
108403050  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108395520  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108383914  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
108398432  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
108391063  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
108404652  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
108403280  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
108385741  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108385397  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108385396  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108391899  KIT; mast/stem cell growth factor receptor Kit isoform X5 [KO:K05091] [EC:2.7.10.1]
108385338  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108408755  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108400781  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
108399322  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
108399089  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
108393890  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
108408988  CRKL; crk-like protein [KO:K04438]
108394533  CRK; adapter molecule crk isoform X1 [KO:K04438]
108406801  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X18 [KO:K06277]
108396170  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
108404941  CDH1; cadherin-1 isoform X1 [KO:K05689]
108387548  CTNNB1; catenin beta-1 [KO:K02105]
108392147  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
108392761  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
108392059  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
108392300  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X10 [KO:K08018]
108398447  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
108407644  LAT; LOW QUALITY PROTEIN: linker for activation of T-cells family member 1 [KO:K07362]
108388561  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
108393851  LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361]
108407838  SKAP1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
108407248  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
108387768  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
108385666  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108395733  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108406135  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
108392230  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
108396782  PRKD1; serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
108409056  DRD2; D(2) dopamine receptor [KO:K04145]
108403157  CNR1; cannabinoid receptor 1 [KO:K04277]
108402874  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
108400984  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
108388509  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
108408793  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
108391527  rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
108391312  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 [KO:K17701]
108397006  SIPA1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
108403350  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
108391279  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
108394269  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
108400147  THBS1; thrombospondin-1 [KO:K16857]
108388220  RALGDS; ral guanine nucleotide dissociation stimulator isoform X2 [KO:K08732]
108393225  RALA; ras-related protein Ral-A [KO:K07834]
108400050  RALB; ras-related protein Ral-B [KO:K07835]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108392664  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
108401717  amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
108406886  TLN1; talin-1 isoform X1 [KO:K06271]
108408578  TLN2; talin-2 isoform X1 [KO:K06271]
108410024  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
108401068  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
108406371  PFN3; profilin-3 [KO:K05759]
108406701  PFN2; profilin-2 isoform X2 [KO:K05759]
108395351  PFN1; profilin-1 [KO:K05759]
108392553  PFN4; profilin-4 [KO:K05759]
108396233  profilin-1-like [KO:K05759]
108392084  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
108403502  ENAH; LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
108400773  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
108399416  ACTB; actin, cytoplasmic 1 [KO:K05692]
108409874  ACTG1; actin, cytoplasmic 2 [KO:K05692]
108405531  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
108383250  transforming protein RhoA [KO:K04513]
108401592  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108391531  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108388194  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
108401794  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
108394631  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
108387898  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
108395882  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
118969461  partitioning defective 6 homolog beta-like [KO:K06093]
118969605  partitioning defective 6 homolog beta-like [KO:K06093]
108387488  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
118973716  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
108386155  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
108393654  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
108386819  AFDN; afadin isoform X1 [KO:K05702]
108402308  CTNND1; catenin delta-1 isoform X2 [KO:K05690]
108386843  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
108406361  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
108390201  RASSF5; ras association domain-containing protein 5 isoform X2 [KO:K08015]
108399261  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
108400695  ITGAM; integrin alpha-M [KO:K06461]
108388833  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
108397161  integrin beta-1 isoform X1 [KO:K05719]
118970953  integrin beta-1-like [KO:K05719]
108387830  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
108394305  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108392139  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108385046  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108400663  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108392844  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
108405137  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
108395598  MAPK12; mitogen-activated protein kinase 12 isoform X9 [KO:K04441] [EC:2.7.11.24]
108394635  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
108394636  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108395975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108393532  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
118967667  GTPase HRas-like isoform X1 [KO:K02833]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108398047  NRAS; GTPase NRas [KO:K07828]
108400295  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
mjv04010  MAPK signaling pathway
mjv04014  Ras signaling pathway
mjv04020  Calcium signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04510  Focal adhesion
mjv04520  Adherens junction
mjv04660  T cell receptor signaling pathway
mjv04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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