Entry Name Wnt signaling pathway - Manis javanica (Malayan pangolin)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Manis javanica (Malayan pangolin) [GN:
mjv ]
Gene 108393336 LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309 ]
108402381 LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1 [KO:K04308 ]
108405411 LGR6; LOW QUALITY PROTEIN: leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399 ]
108392097 LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068 ]
108403486 LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068 ]
108399312 BAMBI; BMP and activin membrane-bound inhibitor homolog isoform X1 [KO:K10162 ]
108401217 segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
118973512 segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353 ]
118974014 segment polarity protein dishevelled homolog DVL-2-like [KO:K02353 ]
108408942 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
108404758 APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085 ]
108390366 CTNNBIP1; beta-catenin-interacting protein 1 isoform X1 [KO:K04493 ]
108383966 CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494 ] [EC:5.6.2.-]
108393200 CCAR2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816 ]
108394195 SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
108404778 SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605 ]
108402235 PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504 ]
108408735 TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508 ]
108394519 LOW QUALITY PROTEIN: F-box-like/WD repeat-containing protein TBL1X [KO:K04508 ]
108408519 BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362 ]
108383975 FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362 ]
108404210 PRICKLE3; prickle planar cell polarity protein 3 isoform X1 [KO:K04511 ]
108404667 DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512 ]
108396805 DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512 ]
108407595 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
108392664 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
108394257 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X3 [KO:K05858 ] [EC:3.1.4.11 ]
108394259 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
108401653 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
108385398 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
108394027 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
108398760 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
108400883 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
108393196 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
108398753 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
108391436 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
108386668 PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268 ]
108385943 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
108391749 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
108402601 NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway LinkDB All DBs
