KEGG   PATHWAY: mlx00330
Entry
mlx00330                    Pathway                                
Name
Arginine and proline metabolism - Mirounga leonina (Southern elephant seal)
Class
Metabolism; Amino acid metabolism
Pathway map
mlx00330  Arginine and proline metabolism
mlx00330

Module
mlx_M00015  Proline biosynthesis, glutamate => proline [PATH:mlx00330]
mlx_M00047  Creatine pathway [PATH:mlx00330]
mlx_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:mlx00330]
mlx_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:mlx00330]
mlx_M00970  Proline degradation, proline => glutamate [PATH:mlx00330]
mlx_M00972  Proline metabolism [PATH:mlx00330]
Other DBs
GO: 0006525 0006560
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118002936  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
118005113  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
118002176  CKB; creatine kinase B-type [KO:K00933] [EC:2.7.3.2]
118003189  CKMT1A; creatine kinase U-type, mitochondrial isoform X1 [KO:K00933] [EC:2.7.3.2]
118017142  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
117998135  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
118019725  AZIN2; antizyme inhibitor 2 isoform X1 [KO:K01583] [EC:4.1.1.19]
118010221  LOW QUALITY PROTEIN: ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
118010239  LOW QUALITY PROTEIN: ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
118019617  LOW QUALITY PROTEIN: antizyme inhibitor 2-like [KO:K01581] [EC:4.1.1.17]
118007589  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
118020012  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
118007648  SMS; spermine synthase [KO:K00802] [EC:2.5.1.22]
118005364  LOW QUALITY PROTEIN: spermine synthase-like [KO:K00802] [EC:2.5.1.22]
118001603  AMD1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
118026779  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
118011280  SMOX; spermine oxidase isoform X1 [KO:K12259] [EC:1.5.3.16 1.5.3.-]
118000124  ALDH3A2; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
118010107  LOW QUALITY PROTEIN: aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
118017928  ALDH1B1; LOW QUALITY PROTEIN: aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
118018478  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
117998267  ALDH16A1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
118016584  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
118014052  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
118004601  CNDP1; beta-Ala-His dipeptidase [KO:K05604] [EC:3.4.13.20]
118004423  CNDP2; cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
118016128  CARNS1; carnosine synthase 1 isoform X1 [KO:K14755] [EC:6.3.2.11]
118000175  SAT2; diamine acetyltransferase 2 isoform X1 [KO:K00657] [EC:2.3.1.57]
118007749  SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
118009417  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
118009422  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
118019978  AGMAT; agmatinase, mitochondrial [KO:K27001] [EC:3.5.3.- 3.5.3.7 3.5.3.17]
118018518  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
118025303  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
118026800  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
118000773  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
118002534  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
117997414  OAT; ornithine aminotransferase, mitochondrial isoform X1 [KO:K00819] [EC:2.6.1.13]
118015278  PYCR3; pyrroline-5-carboxylate reductase 3 isoform X1 [KO:K00286] [EC:1.5.1.2]
118024157  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial [KO:K00286] [EC:1.5.1.2]
118013013  PYCR2; pyrroline-5-carboxylate reductase 2 isoform X1 [KO:K00286] [EC:1.5.1.2]
117999791  proline dehydrogenase 1, mitochondrial [KO:K00318] [EC:1.5.5.2]
118019944  ALDH4A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
118024183  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
118010677  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
118016615  prolyl 4-hydroxylase subunit alpha-2 isoform X1 [KO:K00472] [EC:1.14.11.2]
118003933  P4HA3; prolyl 4-hydroxylase subunit alpha-3 isoform X1 [KO:K00472] [EC:1.14.11.2]
118021367  P4HA1; prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
118022832  PRODH2; hydroxyproline dehydrogenase [KO:K11394] [EC:1.5.5.3]
118024778  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
118009968  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
118023718  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
118024504  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1 [KO:K18123] [EC:4.1.3.16]
118018696  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
118002357  L3HYPDH; trans-3-hydroxy-L-proline dehydratase [KO:K18384] [EC:4.2.1.77]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
mlx00020  Citrate cycle (TCA cycle)
mlx00220  Arginine biosynthesis
mlx00250  Alanine, aspartate and glutamate metabolism
mlx00260  Glycine, serine and threonine metabolism
mlx00270  Cysteine and methionine metabolism
mlx00310  Lysine degradation
mlx00410  beta-Alanine metabolism
mlx00470  D-Amino acid metabolism
mlx00480  Glutathione metabolism
mlx00630  Glyoxylate and dicarboxylate metabolism
mlx00650  Butanoate metabolism
mlx00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   
LinkDB

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