KEGG   PATHWAY: mlx04914
Entry
mlx04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Mirounga leonina (Southern elephant seal)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
mlx04914  Progesterone-mediated oocyte maturation
mlx04914

Other DBs
GO: 0001556
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118013416  PGR; progesterone receptor [KO:K08556]
118016863  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118019468  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118006042  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118004424  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118020028  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118006556  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118022776  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118010368  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118026506  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118001095  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118001265  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117997742  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
117997743  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118019030  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
118005775  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118020679  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
118024512  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118006264  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
118007652  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
118003693  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
118007016  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
118008901  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
118023800  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118015219  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118021775  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
118005070  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118019227  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118023985  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
118023095  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
118023712  CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
118016905  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
118010699  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
118007724  SPDYA; speedy protein A [KO:K08694]
118015637  SPDYC; speedy protein C [KO:K08694]
117999231  speedy protein E4-like [KO:K08694]
118008734  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118025943  LOW QUALITY PROTEIN: cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
118019514  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
118019992  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
118022359  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
118009187  CCNA1; cyclin-A1 [KO:K06627]
118026164  cyclin-A2 isoform X1 [KO:K06627]
118026166  cyclin-A2 isoform X1 [KO:K06627]
118026996  LOW QUALITY PROTEIN: cyclin-A1-like [KO:K06627]
118014837  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
118014942  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118001625  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
118002022  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
118003336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
117999637  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999826  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118001843  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
118001950  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
118026062  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
118019834  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
118007563  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118021743  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
118002147  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
118016867  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
118003405  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
118010424  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
118016665  STK10; serine/threonine-protein kinase 10 isoform X1 [KO:K08837] [EC:2.7.11.1]
117999124  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
118005263  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
118010280  LOW QUALITY PROTEIN: M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
118011286  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
118016681  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
118015656  INS; insulin [KO:K04526]
117998812  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118023006  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118022658  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118002024  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118014553  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118004181  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
118025572  KRAS; GTPase KRas isoform X1 [KO:K07827]
118009801  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118021159  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118005431  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118007842  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
117999286  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
118000543  mitotic spindle assembly checkpoint protein MAD2A-like isoform X1 [KO:K02537]
118019231  mitotic spindle assembly checkpoint protein MAD2A isoform X1 [KO:K02537]
118019243  mitotic spindle assembly checkpoint protein MAD2A isoform X1 [KO:K02537]
118013863  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
118014011  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
118020004  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
118005527  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
118007847  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
118017491  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
118027181  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
118010649  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
118018444  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
118009208  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
118018452  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
118016679  CDC23; cell division cycle protein 23 homolog [KO:K03355]
118022281  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
118024162  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
118017792  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
118017798  anaphase-promoting complex subunit CDC26-like [KO:K03359]
118003983  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
117999502  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 13-like [KO:K12456]
118003900  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
118021187  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
117999614  KIF22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
mlx04010  MAPK signaling pathway
mlx04110  Cell cycle
KO pathway
ko04914   
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