KEGG   PATHWAY: mlx05165
Entry
mlx05165                    Pathway                                
Name
Human papillomavirus infection - Mirounga leonina (Southern elephant seal)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
mlx05165  Human papillomavirus infection
mlx05165

Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118008496  WNT1; proto-oncogene Wnt-1 [KO:K03209]
118018995  WNT2B; protein Wnt-2b [KO:K00182]
118021014  WNT2; protein Wnt-2 [KO:K00182]
118026858  WNT3A; protein Wnt-3a [KO:K00312]
118027173  WNT3; proto-oncogene Wnt-3 [KO:K00312]
118019912  WNT4; protein Wnt-4 [KO:K00408]
118025802  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
118005025  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
118011751  WNT6; protein Wnt-6 [KO:K00445]
118005134  WNT7A; protein Wnt-7a [KO:K00572]
117998566  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
118017183  WNT8A; protein Wnt-8a [KO:K00714]
118024994  WNT8B; protein Wnt-8b [KO:K00714]
118026884  WNT9A; protein Wnt-9a [KO:K01064]
118027171  WNT9B; protein Wnt-9b [KO:K01064]
118008893  WNT10B; protein Wnt-10b [KO:K01357]
118011750  WNT10A; protein Wnt-10a [KO:K01357]
118004067  WNT11; protein Wnt-11 [KO:K01384]
118021382  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
118012141  FZD7; frizzled-7 [KO:K02432]
118020735  FZD1; frizzled-1 [KO:K02432]
118024980  FZD2; frizzled-2 isoform X1 [KO:K02235]
118022125  FZD3; frizzled-3 [KO:K02329]
118003939  FZD4; frizzled-4 [KO:K02354]
118026631  FZD8; frizzled-8 [KO:K02375]
118012097  FZD5; frizzled-5 [KO:K02375]
118015096  FZD6; frizzled-6 [KO:K02376]
118018686  FZD10; frizzled-10 [KO:K02842]
117999200  FZD9; frizzled-9 [KO:K02842]
117999990  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
118020123  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
118006887  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
118007057  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118021650  AXIN1; axin-1 isoform X1 [KO:K02157]
118024344  AXIN2; axin-2 isoform X1 [KO:K04385]
118017527  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
118005119  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
118002288  CTNNB1; catenin beta-1 [KO:K02105]
118006658  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
118006792  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
118006196  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
118016638  TCF7; transcription factor 7 isoform X1 [KO:K02620]
118007920  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
118026323  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
118022960  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
118010049  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
118005289  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
118002595  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
118014127  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
118008624  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
117998287  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
117998994  IFNB1; interferon beta [KO:K05415]
117998639  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118021774  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
118006019  TADA3; transcriptional adapter 3 [KO:K11315]
118000034  TP53; cellular tumor antigen p53 [KO:K04451]
118005981  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
118012969  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118026623  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
118023665  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
118023971  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
118004760  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
118006199  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
118020095  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
118011345  cell division control protein 42 homolog [KO:K04393]
118004774  cell division control protein 42 homolog [KO:K04393]
118019913  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118015284  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
118006967  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
118004277  disks large homolog 2 isoform X1 [KO:K12075]
118026012  DLG3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
118000141  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
118024269  LLGL2; LLGL scribble cell polarity complex component 2 [KO:K06094]
118005106  CRB3; protein crumbs homolog 3 [KO:K06090]
118019338  PATJ; inaD-like protein isoform X1 [KO:K06092]
118002126  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
118025754  VWF; von Willebrand factor [KO:K03900]
118003756  THBS1; thrombospondin-1 [KO:K16857]
118001778  thrombospondin-2 isoform X1 [KO:K04659]
118001902  thrombospondin-2 isoform X1 [KO:K04659]
118016945  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
118005658  COMP; cartilage oligomeric matrix protein [KO:K04659]
118013877  THBS3; thrombospondin-3 [KO:K04659]
118012071  FN1; fibronectin isoform X1 [KO:K05717]
118024771  COL1A1; collagen alpha-1(I) chain [KO:K06236]
118020776  COL1A2; collagen alpha-2(I) chain [KO:K06236]
118008509  COL2A1; collagen alpha-1(II) chain [KO:K19719]
118009236  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
118009237  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
118011976  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
118011978  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
118011980  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
118011987  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
118003458  collagen alpha-4(VI) chain-like [KO:K06238]
118003466  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
118003477  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
118026936  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
118026938  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
118011895  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
118000978  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
118024036  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
118019571  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
118000741  LAMA2; laminin subunit alpha-2 [KO:K05637]
118004427  LAMA1; laminin subunit alpha-1 [KO:K05637]
118024031  LAMA5; laminin subunit alpha-5 [KO:K06240]
118004707  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
118001619  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
118020609  LAMB1; laminin subunit beta-1 [KO:K05636]
118005984  LAMB2; laminin subunit beta-2 [KO:K06243]
118014280  LAMB3; laminin subunit beta-3 [KO:K06244]
118020611  LAMB4; laminin subunit beta-4 [KO:K06245]
118014371  LAMC1; laminin subunit gamma-1 [KO:K05635]
118014372  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
118018107  LAMC3; laminin subunit gamma-3 [KO:K06247]
118024764  CHAD; chondroadherin [KO:K06248]
118020651  RELN; reelin [KO:K06249] [EC:3.4.21.-]
118010349  SPP1; osteopontin isoform X1 [KO:K06250]
118025294  VTN; vitronectin [KO:K06251]
118017766  TNC; tenascin isoform X1 [KO:K06252]
118027196  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
118014437  TNR; tenascin-R [KO:K06252]
118014453  TNN; tenascin-N [KO:K06252]
118010352  IBSP; bone sialoprotein 2 [KO:K06253]
118006650  integrin alpha-1 isoform X1 [KO:K06480]
118006776  integrin alpha-1-like isoform X1 [KO:K06480]
118006689  integrin alpha-2 [KO:K06481]
118006810  integrin alpha-2 [KO:K06481]
118024979  ITGA2B; integrin alpha-IIb [KO:K06476]
118024776  ITGA3; integrin alpha-3 [KO:K06482]
118012261  ITGA4; integrin alpha-4 [KO:K06483]
118008757  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
118012328  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
118008748  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
118021548  ITGA8; integrin alpha-8 [KO:K06584]
118001833  ITGA9; integrin alpha-9 [KO:K06585]
118000263  ITGA10; integrin alpha-10 [KO:K06586]
118003019  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
118012237  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
118026614  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118027184  ITGB3; integrin beta-3 [KO:K06493]
118024262  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
118007005  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
118012407  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
118008801  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
118020850  ITGB8; integrin beta-8 [KO:K06591]
118015244  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118018538  PXN; paxillin isoform X1 [KO:K05760]
118027255  TNF; tumor necrosis factor [KO:K03156]
118025746  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
118023691  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118014469  FASLG; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118012958  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118016168  FADD; FAS-associated death domain protein [KO:K02373]
118012152  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118010074  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118024297  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
118016640  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118009990  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117998379  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
118013220  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
118022103  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
118016779  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
118010733  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
117997823  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
118002828  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
118002870  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
118004050  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
118026663  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
118001186  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
118016017  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
118002322  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
118002344  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
118014309  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
118017558  TSC1; hamartin isoform X1 [KO:K07206]
118021717  TSC2; tuberin isoform X1 [KO:K07207]
118026819  RHEB; GTP-binding protein Rheb [KO:K07208]
118020008  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118009966  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
118016129  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
118024673  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118000738  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
118016000  BAD; bcl2-associated agonist of cell death [KO:K02158]
118006692  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
118006827  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
118004424  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118020028  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118006556  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118016863  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118019468  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118006042  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118022658  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118002024  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118014553  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118009481  FOXO1; forkhead box protein O1 [KO:K07201]
118025649  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
118000822  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118016166  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118025766  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118001139  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
118008659  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
118020759  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118015032  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
118022752  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
118008734  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118009434  RB1; retinoblastoma-associated protein [KO:K06618]
118011456  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
118023785  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
118002372  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
118011049  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
118022359  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
118009187  CCNA1; cyclin-A1 [KO:K06627]
118026164  cyclin-A2 isoform X1 [KO:K06627]
118026166  cyclin-A2 isoform X1 [KO:K06627]
118026996  LOW QUALITY PROTEIN: cyclin-A1-like [KO:K06627]
118013186  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
118004694  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
118001628  VEGFA; vascular endothelial growth factor A [KO:K05448]
118024839  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118009921  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118014480  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118027047  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118016059  RELA; transcription factor p65 [KO:K04735]
118008591  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118018021  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
118014995  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
118000550  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
118019746  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
118025738  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
118016621  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
118000803  TBPL1; TATA box-binding protein-like protein 1 isoform X1 [KO:K03120]
118001851  TATA-box-binding protein [KO:K03120]
118001974  TBP; TATA-box-binding protein [KO:K03120]
118002165  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
118000898  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
118026501  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
118026743  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
118027349  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
118027378  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G [KO:K06751]
118014922  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
118007092  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
118022062  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
118007993  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
118015094  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
118007592  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
118002129  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
118025820  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
118007470  ATP6V1E2; V-type proton ATPase subunit E 2 isoform X1 [KO:K02150]
118021064  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
118017772  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
118004112  V-type proton ATPase subunit G 1-like [KO:K02152]
118027347  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
118013687  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
118014820  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
118016148  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
118024916  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
118018379  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
118021138  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
118014982  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
118023671  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
118016796  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
117998192  V-type proton ATPase subunit e 1-like [KO:K02153]
118020597  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
118021734  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
118019515  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
118014535  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
118027092  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118024535  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118024273  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118007794  SOS1; son of sevenless homolog 1 [KO:K03099]
118002069  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118016228  HRAS; GTPase HRas isoform X1 [KO:K02833]
118025572  KRAS; GTPase KRas isoform X1 [KO:K07827]
118000495  NRAS; GTPase NRas [KO:K07828]
118005431  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118003336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118004882  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117999637  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999826  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118013715  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
118006386  prostaglandin E2 receptor EP4 subtype [KO:K04261]
118006517  prostaglandin E2 receptor EP4 subtype [KO:K04261]
118023087  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
118024008  neuroendocrine secretory protein 55 [KO:K04632]
118024010  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
118005070  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118019227  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117998245  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118012101  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
118015807  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
118017967  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
118005189  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
118013832  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
118021134  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
118021299  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
118019939  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
118024924  TUBG1; tubulin gamma-1 chain [KO:K10389]
118024927  tubulin gamma-2 chain isoform X1 [KO:K10389]
118017337  LOW QUALITY PROTEIN: pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
117998991  LOW QUALITY PROTEIN: interferon alpha-4-like [KO:K05414]
117998992  interferon alpha-1/2-like [KO:K05414]
117998993  interferon alpha-14-like [KO:K05414]
117999009  interferon alpha-2-like [KO:K05414]
118018831  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
118018829  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
118019316  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
118004956  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
118012204  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
118008707  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
118003729  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
118007769  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
118018561  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
118018562  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
118026150  MX2; interferon-induced GTP-binding protein Mx2 isoform X1 [KO:K14754]
118026151  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
118020366  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
118011235  JAG1; protein jagged-1 [KO:K06052]
118017516  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
118000453  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
118006072  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
118027299  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
118002427  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
118024152  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
117998712  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
117999295  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
118022302  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
118026513  MAML1; mastermind-like protein 1 [KO:K06061]
118013425  MAML2; mastermind-like protein 2 [KO:K06061]
118010644  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
118011528  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
118000498  HES1; transcription factor HES-1 [KO:K06054]
118000186  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
118011713  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
118020348  HES2; transcription factor HES-2 [KO:K09087]
118020070  HES3; transcription factor HES-3 [KO:K09088]
118020138  HES4; transcription factor HES-4 isoform X1 [KO:K09089]
118020360  HES5; transcription factor HES-5 [KO:K06055]
118014950  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
118000692  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
118019582  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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The molecular biology of cervical cancer.
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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Human papillomaviruses and cell signaling.
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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Pathogens 5:E8 (2016)
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
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PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Reference
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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Related
pathway
mlx04064  NF-kappa B signaling pathway
mlx04110  Cell cycle
mlx04115  p53 signaling pathway
mlx04150  mTOR signaling pathway
mlx04151  PI3K-Akt signaling pathway
mlx04210  Apoptosis
mlx04310  Wnt signaling pathway
mlx04330  Notch signaling pathway
mlx04510  Focal adhesion
mlx04520  Adherens junction
mlx04530  Tight junction
mlx04612  Antigen processing and presentation
mlx04620  Toll-like receptor signaling pathway
mlx04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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