KEGG   PATHWAY: mmyo05165
Entry
mmyo05165                   Pathway                                
Name
Human papillomavirus infection - Myotis myotis (greater mouse-eared bat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
mmyo05165  Human papillomavirus infection
mmyo05165

Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118650977  WNT1; proto-oncogene Wnt-1 [KO:K03209]
118672911  WNT2B; protein Wnt-2b [KO:K00182]
118666478  WNT2; protein Wnt-2 [KO:K00182]
118658755  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
118672219  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
118676694  WNT4; protein Wnt-4 [KO:K00408]
118650248  WNT5B; protein Wnt-5b [KO:K00444]
118667971  WNT5A; protein Wnt-5a [KO:K00444]
118662211  WNT6; protein Wnt-6 [KO:K00445]
118650243  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
118677354  WNT7A; protein Wnt-7a [KO:K00572]
118658912  WNT8A; protein Wnt-8a [KO:K00714]
118669850  WNT8B; protein Wnt-8b [KO:K00714]
118658374  WNT9A; protein Wnt-9a [KO:K01064]
118671436  WNT9B; protein Wnt-9b [KO:K01064]
118651671  WNT10B; protein Wnt-10b [KO:K01357]
118661959  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
118664619  WNT11; protein Wnt-11 [KO:K01384]
118666468  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
118666245  FZD1; frizzled-1 [KO:K02432]
118661773  FZD7; frizzled-7 [KO:K02432]
118672294  FZD2; frizzled-2 [KO:K02235]
118658774  FZD3; frizzled-3 isoform X1 [KO:K02329]
118664546  FZD4; frizzled-4 [KO:K02354]
118661425  FZD5; frizzled-5 [KO:K02375]
118676314  FZD8; frizzled-8 [KO:K02375]
118670703  FZD6; frizzled-6 [KO:K02376]
118653033  FZD10; LOW QUALITY PROTEIN: frizzled-10 [KO:K02842]
118656623  FZD9; frizzled-9 [KO:K02842]
118677642  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
118655561  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
118672041  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
118675932  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118652848  AXIN1; axin-1 isoform X1 [KO:K02157]
118654322  LOW QUALITY PROTEIN: axin-1-like [KO:K02157]
118671617  AXIN2; axin-2 isoform X1 [KO:K04385]
118658707  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
118655759  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
118668371  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
118657973  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
118665504  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118653594  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118654184  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118662055  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118656828  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
118657631  TCF7; transcription factor 7 isoform X1 [KO:K02620]
118668800  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
118669739  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
118653049  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
118651795  TLR3; toll-like receptor 3 [KO:K05401]
118658886  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
118655021  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
118672786  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
118651925  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
118655420  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
118666805  IFNB1; interferon beta [KO:K05415]
118651024  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118656434  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
118668035  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
118672084  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118667913  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
118677363  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118670001  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118676463  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
118674364  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
118662903  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
118663118  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
118675320  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
118655597  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
118675144  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118653067  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
118677032  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
118664568  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
118654099  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
118649344  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
118671285  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
118658003  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
118677647  PATJ; inaD-like protein isoform X1 [KO:K06092]
118656732  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
118650211  VWF; von Willebrand factor [KO:K03900]
118649603  THBS1; thrombospondin-1 [KO:K16857]
118660255  THBS2; thrombospondin-2 [KO:K04659]
118656424  THBS4; thrombospondin-4 [KO:K04659]
118657572  cartilage oligomeric matrix protein [KO:K04659]
118672802  THBS3; thrombospondin-3 [KO:K04659]
118661269  FN1; fibronectin isoform X1 [KO:K05717]
118666213  COL1A2; collagen alpha-2(I) chain [KO:K06236]
118671908  COL1A1; collagen alpha-1(I) chain [KO:K06236]
118651665  COL2A1; collagen alpha-1(II) chain [KO:K19719]
118651398  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
118651399  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
118654149  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
118654373  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
118661805  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
118661915  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
118668193  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
118668194  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
118668195  collagen alpha-4(VI) chain-like [KO:K06238]
118661519  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
118676403  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
118676671  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
118677314  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
118660173  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
118663693  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
118659861  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
118663257  LAMA1; laminin subunit alpha-1 [KO:K05637]
118662808  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
118663687  LAMA5; laminin subunit alpha-5 [KO:K06240]
118660060  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
118665985  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
118668489  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
118672717  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
118665984  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
118672671  LAMC1; laminin subunit gamma-1 [KO:K05635]
118672978  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
118666951  LAMC3; laminin subunit gamma-3 [KO:K06247]
118672321  CHAD; chondroadherin [KO:K06248]
118666027  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
118671281  SPP1; osteopontin [KO:K06250]
118672342  VTN; vitronectin [KO:K06251]
118673566  TNN; tenascin-N [KO:K06252]
118673756  TNR; tenascin-R isoform X1 [KO:K06252]
118667101  TNC; tenascin isoform X1 [KO:K06252]
118679562  TNXB; tenascin-X [KO:K06252]
118654608  bone sialoprotein 2 [KO:K06253]
118655725  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
118655743  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
118671403  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
118671288  ITGA3; integrin alpha-3 [KO:K06482]
118661108  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
118650963  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
118661789  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
118650215  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
118677239  ITGA8; integrin alpha-8 [KO:K06584]
118668336  ITGA9; integrin alpha-9 [KO:K06585]
118672990  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
118654530  ITGA11; integrin alpha-11 [KO:K06587]
118661050  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
118676628  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118671715  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
118671145  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
118675382  ITGB5; integrin beta-5 [KO:K06588]
118661965  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
118650229  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
118666144  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
118670566  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118678208  PXN; paxillin isoform X1 [KO:K05760]
118679652  tumor necrosis factor-like isoform X1 [KO:K03156]
118649937  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118674287  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118673639  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118669989  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118665178  FADD; FAS-associated death domain protein [KO:K02373]
118661495  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118650210  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118671166  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X1 [KO:K13365]
118650809  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
118658020  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118649206  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
118664327  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
118658359  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
118666309  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
118659262  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
118669650  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
118677985  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
118668147  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
118657301  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
118672968  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
118659834  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
118659943  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
118656278  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
118665341  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
118666926  TSC1; hamartin isoform X1 [KO:K07206]
118656215  TSC2; tuberin isoform X1 [KO:K07207]
118651521  GTP-binding protein Rheb [KO:K07208]
118679434  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
118675322  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118651220  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
118649569  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
118649570  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
118671643  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118665219  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
118679638  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
118665363  BAD; bcl2-associated agonist of cell death [KO:K02158]
118658697  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
118677590  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118668125  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675045  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675217  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118656203  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118657573  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118678909  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118655031  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118674834  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118649960  FOXO1; forkhead box protein O1 [KO:K07201]
118650327  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
118659964  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118665181  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
118650032  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118660354  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118651037  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118666224  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118653038  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
118670629  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
118651193  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118651068  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
118663055  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
118674330  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
118659186  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
118663841  E2F1; transcription factor E2F1 [KO:K17454]
118651324  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
118658224  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
118664416  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
118677681  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
118660010  VEGFA; vascular endothelial growth factor A [KO:K05448]
118669852  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118650776  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118653690  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118671867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118665292  RELA; transcription factor p65 [KO:K04735]
118650326  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118667392  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
118665982  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
118660079  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
118676336  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
118664991  histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
118649768  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
118658441  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
118659721  TATA-box-binding protein isoform X1 [KO:K03120]
118660696  TBPL1; TATA box-binding protein-like 1 isoform X1 [KO:K03120]
118669552  TATA box-binding protein-like 1 [KO:K03120]
118655762  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
118658369  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
118679578  patr class I histocompatibility antigen, B-1 alpha chain-like isoform X1 [KO:K06751]
118652788  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
118659954  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118659955  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118659956  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
118659957  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118662409  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118655123  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
118655161  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
118655171  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
118653904  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
118676142  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
118657996  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
118668877  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
118669278  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
118670702  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
118656775  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
118650310  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
118669485  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
118666428  ATP6V1F; V-type proton ATPase subunit F isoform X1 [KO:K02151]
118666304  V-type proton ATPase subunit G 1-like [KO:K02152]
118678759  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
118667098  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
118667222  V-type proton ATPase subunit G 1-like [KO:K02152]
118679590  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
118670820  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
118666617  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
118655501  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
118671503  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
118665201  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
118670455  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
118674875  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
118658031  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
118665948  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
118662111  V-type proton ATPase subunit e 1-like [KO:K02153]
118655969  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
118676845  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
118654072  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
118672981  EGF; pro-epidermal growth factor [KO:K04357]
118665909  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
118671153  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
118669078  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118654741  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118648965  HRAS; GTPase HRas isoform X1 [KO:K02833]
118649554  KRAS; GTPase KRas isoform X1 [KO:K07827]
118672986  NRAS; GTPase NRas [KO:K07828]
118668076  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118654213  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118657986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
118678650  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118656605  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118673371  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
118656159  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
118662565  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
118663143  neuroendocrine secretory protein 55-like [KO:K04632]
118652717  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118675444  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118655437  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118661646  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
118673054  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
118666355  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
118658839  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
118667339  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
118665089  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
118666077  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
118676008  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
118671493  tubulin gamma-1 chain [KO:K10389]
118672409  TUBG2; tubulin gamma-2 chain [KO:K10389]
118675415  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
118667586  interferon omega-1-like [KO:K05414]
118676057  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
118676213  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
118675339  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
118658254  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
118661220  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118651142  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
118678839  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
118669450  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
118678281  OASL; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
118675907  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
118676391  MX1; interferon-induced GTP-binding protein Mx1 isoform X1 [KO:K14754]
118655585  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
118663641  JAG1; protein jagged-1 isoform X1 [KO:K06052]
118655240  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
118673433  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
118652571  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
118679629  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
118657710  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
118651215  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
118658757  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
118671602  RFNG; LOW QUALITY PROTEIN: beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
118657847  MAML1; mastermind-like protein 1 isoform X1 [KO:K06061]
118658247  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
118664486  MAML2; mastermind-like protein 2 [KO:K06061]
118667398  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
118663233  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
118676420  HES1; transcription factor HES-1 [KO:K06054]
118661963  HES6; transcription cofactor HES-6 [KO:K09087]
118676609  HES2; transcription factor HES-2 [KO:K09087]
118672392  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
118675160  HES3; transcription factor HES-3 [KO:K09088]
118655584  HES4; transcription factor HES-4 isoform X1 [KO:K09089]
118655604  HES5; transcription factor HES-5 [KO:K06055]
118660302  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
118671024  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
118677027  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Reference
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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Reference
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Reference
PMID:23536685
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Related
pathway
mmyo04064  NF-kappa B signaling pathway
mmyo04110  Cell cycle
mmyo04115  p53 signaling pathway
mmyo04150  mTOR signaling pathway
mmyo04151  PI3K-Akt signaling pathway
mmyo04210  Apoptosis
mmyo04310  Wnt signaling pathway
mmyo04330  Notch signaling pathway
mmyo04510  Focal adhesion
mmyo04520  Adherens junction
mmyo04530  Tight junction
mmyo04612  Antigen processing and presentation
mmyo04620  Toll-like receptor signaling pathway
mmyo04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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