KEGG   PATHWAY: mmyo05168
Entry
mmyo05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Myotis myotis (greater mouse-eared bat)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
mmyo05168  Herpes simplex virus 1 infection
mmyo05168

Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118659261  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
118655594  TNFRSF14; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 14 [KO:K05152]
118655263  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118672932  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
118650776  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118669852  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118653690  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118677878  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118671867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118665292  RELA; transcription factor p65 [KO:K04735]
118677457  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2-like [KO:K16060]
118664470  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
118664472  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
118672334  C-C motif chemokine 2-like [KO:K14624]
118657359  NECTIN1; nectin-1 [KO:K06081]
118674230  NECTIN2; nectin-2 isoform X1 [KO:K06531]
118656877  paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411]
118656894  paired immunoglobulin-like type 2 receptor beta isoform X1 [KO:K15411]
118678341  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
118650963  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
118671715  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
118662917  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
118652511  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
118655259  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
118655420  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
118666805  IFNB1; interferon beta [KO:K05415]
118672084  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118658864  C3; LOW QUALITY PROTEIN: complement C3 [KO:K03990]
118667117  C5; complement C5 isoform X1 [KO:K03994]
118654456  properdin [KO:K15412]
118658736  TLR2; toll-like receptor 2 [KO:K10159]
118668416  toll-like receptor 9 isoform X1 [KO:K10161]
118668344  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
118648972  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
118651795  TLR3; toll-like receptor 3 [KO:K05401]
118658886  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
118649743  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118654047  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118665127  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118659996  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118650066  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
118659738  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
118657544  IL1B; interleukin-1 beta [KO:K04519]
118671844  CCL5; C-C motif chemokine 5 [KO:K12499]
118666134  IL6; interleukin-6 [KO:K05405]
118679652  tumor necrosis factor-like isoform X1 [KO:K03156]
118675787  IL12A; interleukin-12 subunit alpha [KO:K05406]
118659025  IL12B; interleukin-12 subunit beta [KO:K05425]
118667402  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
118661739  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
118663001  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
118655021  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
118672786  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
118651925  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
118667586  interferon omega-1-like [KO:K05414]
118660304  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
118659024  STING1; stimulator of interferon genes protein [KO:K12654]
118678222  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
118666814  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A-like [KO:K06269] [EC:3.1.3.16]
118669147  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
118665223  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
118658079  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
118669450  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
118675238  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
118649629  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
118656765  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 isoform X1 [KO:K03237]
118655490  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
118658148  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
118676502  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
118669166  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
118676274  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
118673356  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
118678496  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
118678600  OAS3; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
118673060  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
118653808  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
118650112  HCFC2; host cell factor 2 isoform X1 [KO:K27390]
118672894  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
118674565  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
118657360  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
118676057  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
118676213  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
118671119  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
118675339  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
118658254  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
118661220  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118651142  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
118678839  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
118651453  zinc finger protein 547-like isoform X1 [KO:K09228]
118649136  oocyte zinc finger protein XlCOF6-like [KO:K09228]
118649146  LOW QUALITY PROTEIN: zinc finger protein 649-like [KO:K09228]
118649167  zinc finger protein 91-like [KO:K09228]
118649168  zinc finger protein 11-like isoform X1 [KO:K09228]
118649169  LOW QUALITY PROTEIN: zinc finger protein 271-like [KO:K09228]
118649170  zinc finger protein 708-like isoform X1 [KO:K09228]
118649172  zinc finger protein 665-like [KO:K09228]
118649173  zinc finger protein 708-like isoform X1 [KO:K09228]
118649174  zinc finger protein 420-like isoform X1 [KO:K09228]
118649175  LOW QUALITY PROTEIN: zinc finger protein 615-like [KO:K09228]
118649176  zinc finger protein 420-like isoform X1 [KO:K09228]
118649179  zinc finger protein 271-like [KO:K09228]
118649180  zinc finger protein 420-like [KO:K09228]
118649181  zinc finger protein 345-like isoform X1 [KO:K09228]
118649182  zinc finger protein 432-like [KO:K09228]
118649183  zinc finger protein 615-like [KO:K09228]
118649184  zinc finger protein 615-like isoform X1 [KO:K09228]
118649187  zinc finger protein 883-like [KO:K09228]
118649188  zinc finger protein 883-like isoform X1 [KO:K09228]
118649189  zinc finger protein 883-like isoform X1 [KO:K09228]
118649190  zinc finger protein 345-like [KO:K09228]
118649192  zinc finger protein 883-like isoform X1 [KO:K09228]
118649193  zinc finger protein 345-like [KO:K09228]
118649194  zinc finger protein 883-like [KO:K09228]
118649195  zinc finger protein 420-like [KO:K09228]
118649196  ZNF613; zinc finger protein 613 [KO:K09228]
118649197  zinc finger protein 883-like isoform X1 [KO:K09228]
118649198  zinc finger protein 883-like isoform X1 [KO:K09228]
118649199  zinc finger protein 883-like isoform X1 [KO:K09228]
118649200  zinc finger protein 615-like isoform X1 [KO:K09228]
118649202  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
118649203  zinc finger protein 43-like [KO:K09228]
118649204  ZNF614; zinc finger protein 614 isoform X1 [KO:K09228]
118649205  zinc finger protein 256-like [KO:K09228]
118649208  zinc finger protein 737-like isoform X1 [KO:K09228]
118649209  zinc finger protein 724-like isoform X1 [KO:K09228]
118649210  zinc finger protein 737-like [KO:K09228]
118649211  zinc finger protein OZF-like isoform X1 [KO:K09228]
118649212  zinc finger protein OZF-like [KO:K09228]
118649213  zinc finger protein 420-like [KO:K09228]
118649214  zinc finger protein 660-like [KO:K09228]
118649215  zinc finger protein 211-like [KO:K09228]
118649216  ZNF350; zinc finger protein 350 isoform X1 [KO:K09228]
118649219  zinc finger protein 501-like [KO:K09228]
118649220  LOW QUALITY PROTEIN: zinc finger protein 615-like [KO:K09228]
118649221  zinc finger protein 420-like isoform X1 [KO:K09228]
118649222  ZNF331; zinc finger protein 331 isoform X1 [KO:K09228]
118649223  zinc finger protein 211-like [KO:K09228]
118649225  zinc finger protein 211-like isoform X1 [KO:K09228]
118649228  zinc finger protein 418-like [KO:K09228]
118649242  zinc finger protein 501-like [KO:K09228]
118649247  LOW QUALITY PROTEIN: zinc finger protein 615-like [KO:K09228]
118649260  zinc finger protein 84-like [KO:K09228]
118649735  zinc finger protein 239-like [KO:K09228]
118651061  zinc finger protein 596-like [KO:K09228]
118651362  ZNF596; zinc finger protein 596 isoform X1 [KO:K09228]
118657990  ZNF300; zinc finger protein 300 isoform X1 [KO:K09228]
118658314  zinc finger protein 555-like isoform X1 [KO:K09228]
118658315  ZNF77; zinc finger protein 77 isoform X1 [KO:K09228]
118658379  RB-associated KRAB zinc finger protein isoform X1 [KO:K09228]
118658399  ZNF316; zinc finger protein 316 isoform X1 [KO:K09228]
118658413  ZNF12; zinc finger protein 12 isoform X1 [KO:K09228]
118658415  ZNF317; zinc finger protein 317 isoform X1 [KO:K09228]
118658507  ZNF425; LOW QUALITY PROTEIN: zinc finger protein 425 [KO:K09228]
118658523  ZNF554; LOW QUALITY PROTEIN: zinc finger protein 554 [KO:K09228]
118666279  ZNF746; zinc finger protein 746 isoform X1 [KO:K09228]
118666280  ZNF777; zinc finger protein 777 isoform X1 [KO:K09228]
118666282  ZNF398; zinc finger protein 398 [KO:K09228]
118666283  ZNF212; zinc finger protein 212 isoform X1 [KO:K09228]
118666284  ZNF783; protein ZNF783 isoform X1 [KO:K09228]
118666285  ZNF282; zinc finger protein 282 [KO:K09228]
118666286  ZNF786; zinc finger protein 786 isoform X1 [KO:K09228]
118678396  ZNF74; zinc finger protein 74 isoform X1 [KO:K09228]
118658693  zinc finger protein 709-like isoform X1 [KO:K09228]
118658705  ZNF454; zinc finger protein 454 [KO:K09228]
118658726  zinc finger protein 709-like isoform X1 [KO:K09228]
118658765  zinc finger protein 709-like isoform X1 [KO:K09228]
118658771  zinc finger protein 14-like [KO:K09228]
118658795  ZNF558; zinc finger protein 558 isoform X1 [KO:K09228]
118658812  zinc finger protein 177-like [KO:K09228]
118658841  ZNF266; zinc finger protein 266 isoform X1 [KO:K09228]
118658843  zinc finger protein 14-like [KO:K09228]
118667043  ZNF79; zinc finger protein 79 [KO:K09228]
118673715  ZNF184; zinc finger protein 184 isoform X1 [KO:K09228]
118674043  ZNF569; zinc finger protein 569 isoform X1 [KO:K09228]
118674044  zinc finger protein 420 [KO:K09228]
118674045  ZNF382; zinc finger protein 382 isoform X1 [KO:K09228]
118674048  zinc finger protein 527-like [KO:K09228]
118674049  zinc finger protein 568-like [KO:K09228]
118674050  ZFP14; zinc finger protein 14 homolog isoform X1 [KO:K09228]
118674051  zinc finger protein 30 homolog isoform X1 [KO:K09228]
118674052  ZFP82; zinc finger protein 82 homolog isoform X1 [KO:K09228]
118674053  zinc finger protein 383 [KO:K09228]
118674054  ZNF566; zinc finger protein 566 isoform X1 [KO:K09228]
118674083  zinc finger protein 226-like isoform X1 [KO:K09228]
118674084  zinc finger protein 234-like [KO:K09228]
118674085  ZNF45; zinc finger protein 45 isoform X1 [KO:K09228]
118674086  zinc finger protein 234-like isoform X1 [KO:K09228]
118674100  ZNF23; zinc finger protein 23 isoform X1 [KO:K09228]
118674102  ZNF19; zinc finger protein 19 isoform X1 [KO:K09228]
118674125  ZNF567; zinc finger protein 567 [KO:K09228]
118674126  ZNF565; zinc finger protein 565 [KO:K09228]
118659222  zinc finger protein 14-like [KO:K09228]
118659311  zinc finger protein 709-like [KO:K09228]
118659312  zinc finger protein 14-like isoform X1 [KO:K09228]
118659313  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
118659314  zinc finger protein 709-like [KO:K09228]
118659316  zinc finger protein 709-like [KO:K09228]
118659317  zinc finger protein 14-like [KO:K09228]
118659318  zinc finger protein 136-like [KO:K09228]
118659319  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
118659320  LOW QUALITY PROTEIN: putative zinc finger protein 833 [KO:K09228]
118659326  zinc finger protein 709-like [KO:K09228]
118667170  ZFP37; zinc finger protein 37 homolog isoform X1 [KO:K09228]
118667242  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
118674305  zinc finger protein 235-like isoform X1 [KO:K09228]
118674306  zinc finger protein 233-like isoform X1 [KO:K09228]
118674470  ZNF283; LOW QUALITY PROTEIN: zinc finger protein 283 [KO:K09228]
118674513  zinc finger protein 227-like isoform X1 [KO:K09228]
118674539  ZNF180; zinc finger protein 180 isoform X1 [KO:K09228]
118659338  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
118659631  zinc finger protein 501-like isoform X1 [KO:K09228]
118659677  zinc finger protein 345-like [KO:K09228]
118659683  ZNF624; zinc finger protein 624 [KO:K09228]
118659684  ZNF286A; zinc finger protein 286A isoform X1 [KO:K09228]
118667622  zinc finger protein 658-like isoform X1 [KO:K09228]
118667625  zinc finger protein 658-like [KO:K09228]
118667633  ZNF169; zinc finger protein 169 isoform X1 [KO:K09228]
118679600  ZFP57; zinc finger protein 57 homolog [KO:K09228]
118652545  zinc finger protein 14-like [KO:K09228]
118652649  zinc finger protein 791-like [KO:K09228]
118652675  zinc finger protein 14-like [KO:K09228]
118652676  zinc finger protein 709-like [KO:K09228]
118652693  ZNF333; zinc finger protein 333 isoform X1 [KO:K09228]
118652723  zinc finger protein 791-like isoform X1 [KO:K09228]
118652724  zinc finger protein 709-like [KO:K09228]
118652726  zinc finger protein 791-like [KO:K09228]
118652736  zinc finger protein 564-like isoform X1 [KO:K09228]
118652744  zinc finger protein 14-like [KO:K09228]
118652831  zinc finger protein 211-like isoform X1 [KO:K09228]
118652976  ZNF268; LOW QUALITY PROTEIN: zinc finger protein 268 [KO:K09228]
118652979  ZNF84; zinc finger protein 84 isoform X1 [KO:K09228]
118652983  ZNF26; zinc finger protein 26 [KO:K09228]
118652984  ZNF605; zinc finger protein 605 isoform X1 [KO:K09228]
118652986  ZNF10; zinc finger protein 10 isoform X1 [KO:K09228]
118652988  ZNF140; zinc finger protein 140 isoform X1 [KO:K09228]
118653058  ZNF7; LOW QUALITY PROTEIN: zinc finger protein 7 [KO:K09228]
118653059  zinc finger protein 250-like isoform X1 [KO:K09228]
118653108  ZNF251; zinc finger protein 251 isoform X1 [KO:K09228]
118653121  ZNF623; zinc finger protein 623 [KO:K09228]
118660971  ZNF2; zinc finger protein 2 [KO:K09228]
118660978  zinc finger protein 416-like [KO:K09228]
118668368  ZNF621; zinc finger protein 621 [KO:K09228]
118668369  ZNF620; zinc finger protein 620 [KO:K09228]
118668389  ZNF662; LOW QUALITY PROTEIN: zinc finger protein 662 [KO:K09228]
118653950  ZNF275; zinc finger protein 275 [KO:K09228]
118654044  ZNF81; zinc finger protein 81 isoform X1 [KO:K09228]
118654045  zinc finger protein 182 isoform X1 [KO:K09228]
118654647  ZNF674; zinc finger protein 674 [KO:K09228]
118654670  ZNF41; zinc finger protein 41 [KO:K09228]
118654680  ZFP92; zinc finger protein 92 homolog [KO:K09228]
118654956  zinc finger protein 420-like [KO:K09228]
118654958  zinc finger protein 260-like [KO:K09228]
118654959  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
118654961  zinc finger protein 551-like isoform X1 [KO:K09228]
118654962  zinc finger protein 501-like isoform X1 [KO:K09228]
118654963  zinc finger protein OZF-like isoform X1 [KO:K09228]
118654964  LOW QUALITY PROTEIN: zinc finger protein 530-like [KO:K09228]
118654977  zinc finger protein 211-like [KO:K09228]
118654984  zinc finger protein 772-like isoform X1 [KO:K09228]
118654985  zinc finger protein 501-like [KO:K09228]
118654986  zinc finger protein 260-like isoform X1 [KO:K09228]
118654992  zinc finger protein interacting with ribonucleoprotein K-like [KO:K09228]
118654993  zinc finger protein OZF-like isoform X1 [KO:K09228]
118654999  zinc finger protein 551-like [KO:K09228]
118655084  zinc finger protein 551-like [KO:K09228]
118655085  zinc finger protein 416-like [KO:K09228]
118655086  ZNF772; zinc finger protein 772 [KO:K09228]
118655115  zinc finger protein 470-like isoform X1 [KO:K09228]
118655116  ZNF667; zinc finger protein 667 isoform X1 [KO:K09228]
118655117  zinc finger protein 805-like isoform X1 [KO:K09228]
118655118  zinc finger protein 304-like isoform X1 [KO:K09228]
118655119  ZNF583; zinc finger protein 583 isoform X1 [KO:K09228]
118655120  ZNF582; LOW QUALITY PROTEIN: zinc finger protein 582 [KO:K09228]
118655133  zinc finger protein 883-like [KO:K09228]
118655135  zinc finger protein OZF-like [KO:K09228]
118655137  zinc finger protein 551-like [KO:K09228]
118655138  zinc finger protein 883-like [KO:K09228]
118655139  zinc finger protein 773-like [KO:K09228]
118655140  zinc finger protein interacting with ribonucleoprotein K-like [KO:K09228]
118655143  zinc finger protein 548-like isoform X1 [KO:K09228]
118655232  zinc finger protein 501-like [KO:K09228]
118655394  ZNF473; zinc finger protein 473 isoform X1 [KO:K09228]
118663085  zinc finger protein 420-like isoform X1 [KO:K09228]
118663088  zinc finger protein 682-like isoform X1 [KO:K09228]
118663099  ZNF343; zinc finger protein 343 [KO:K09228]
118663243  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
118663281  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
118670207  ZNF33B; LOW QUALITY PROTEIN: zinc finger protein 33B [KO:K09228]
118670208  ZNF25; zinc finger protein 25 [KO:K09228]
118670210  ZNF248; zinc finger protein 248 [KO:K09228]
118674544  ZNF112; zinc finger protein 112 isoform X1 [KO:K09228]
118674562  zinc finger protein 233-like [KO:K09228]
118674581  ZFP90; zinc finger protein 90 homolog isoform X1 [KO:K09228]
118674602  LOW QUALITY PROTEIN: zinc finger protein 181-like [KO:K09228]
118674730  ZNF570; zinc finger protein 570 [KO:K09228]
118663672  ZNF133; zinc finger protein 133 [KO:K09228]
118675878  ZFP69; zinc finger protein 69 homolog isoform X1 [KO:K09228]
118675880  ZNF684; zinc finger protein 684 isoform X1 [KO:K09228]
118656490  ZNF3; zinc finger protein 3 isoform X1 [KO:K09228]
118656845  ZNF205; zinc finger protein 205 [KO:K09228]
118656852  ZNF200; zinc finger protein 200 isoform X1 [KO:K09228]
118656922  zinc finger protein 665-like [KO:K09228]
118657058  ZNF768; zinc finger protein 768 [KO:K09228]
118657059  ZNF689; zinc finger protein 689 isoform X1 [KO:K09228]
118657060  zinc finger protein 764-like isoform X1 [KO:K09228]
118657061  ZNF688; zinc finger protein 688 isoform X1 [KO:K09228]
118657093  ZNF713; zinc finger protein 713 [KO:K09228]
118664727  zinc finger protein 883-like [KO:K09228]
118676574  ZNF436; zinc finger protein 436 isoform X1 [KO:K09228]
118657415  ZNF606; zinc finger protein 606 isoform X1 [KO:K09228]
118657416  ZNF132; LOW QUALITY PROTEIN: zinc finger protein 132 [KO:K09228]
118657418  ZNF544; zinc finger protein 544 isoform X1 [KO:K09228]
118657419  zinc finger protein 324A-like isoform X1 [KO:K09228]
118657420  ZNF135; zinc finger protein 135 [KO:K09228]
118657429  ZNF584; zinc finger protein 584 [KO:K09228]
118657437  zinc finger protein 271-like [KO:K09228]
118657438  zinc finger protein 345-like isoform X1 [KO:K09228]
118657440  zinc finger protein 256-like isoform X1 [KO:K09228]
118657441  zinc finger protein 883-like [KO:K09228]
118657442  zinc finger protein OZF-like [KO:K09228]
118657443  zinc finger protein 501-like [KO:K09228]
118657451  zinc finger protein 260-like isoform X1 [KO:K09228]
118657453  zinc finger protein 883-like isoform X1 [KO:K09228]
118657454  zinc finger protein 154-like isoform X1 [KO:K09228]
118657455  zinc finger protein 154-like isoform X1 [KO:K09228]
118657457  zinc finger protein OZF-like isoform X1 [KO:K09228]
118657458  zinc finger protein OZF-like [KO:K09228]
118657459  zinc finger protein 154-like [KO:K09228]
118657464  LOW QUALITY PROTEIN: zinc finger protein 2-like [KO:K09228]
118657468  zinc finger protein 345-like [KO:K09228]
118657496  ZNF114; zinc finger protein 114 [KO:K09228]
118657512  zinc finger protein 724-like isoform X1 [KO:K09228]
118657513  zinc finger protein 595-like isoform X1 [KO:K09228]
118657626  ZNF853; zinc finger protein 853 [KO:K09228]
118652630  BST2; bone marrow stromal antigen 2 isoform X1 [KO:K06731]
118651276  IFNG; interferon gamma [KO:K04687]
118659706  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
118675501  IFNGR2; interferon gamma receptor 2 [KO:K05133]
118667512  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
118679513  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
118661407  SP100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
118675706  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
118679553  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
118679593  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
118679520  tapasin [KO:K08058]
118650961  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
118652589  CALR; calreticulin [KO:K08057]
118658369  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
118679578  patr class I histocompatibility antigen, B-1 alpha chain-like isoform X1 [KO:K06751]
118652788  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
118659954  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118659955  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118659956  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
118659957  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118662409  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118655123  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
118655161  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
118655171  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
118651123  B2M; beta-2-microglobulin [KO:K08055]
118679500  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
118679523  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
118679525  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
118679591  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118679613  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
118679614  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752]
118679619  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
118679624  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
118679625  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
118679626  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
118679627  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
118679628  boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X1 [KO:K06752]
118679633  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
118679640  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
118660487  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118657706  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
118677590  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118668125  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675045  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675217  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118656203  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118657573  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118678909  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118655031  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118674834  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118666926  TSC1; hamartin isoform X1 [KO:K07206]
118656215  TSC2; tuberin isoform X1 [KO:K07207]
118651521  GTP-binding protein Rheb [KO:K07208]
118679434  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
118675322  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118651220  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
118659765  SRPK1; LOW QUALITY PROTEIN: SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
118667227  serine/arginine-rich splicing factor 1-like [KO:K12890]
118656669  serine/arginine-rich splicing factor 1-like [KO:K12890]
118671733  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
118653578  serine/arginine-rich splicing factor 2-like [KO:K12891]
118671134  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
118651555  serine/arginine-rich splicing factor 3-like [KO:K12892]
118660016  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
118663133  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
118675050  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
118657356  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
118669446  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
118670239  serine/arginine-rich splicing factor 7-like [KO:K12896]
118657461  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
118678115  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
118649015  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
118653413  nuclear RNA export factor 2-like [KO:K14284]
118653414  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
118653416  nuclear RNA export factor 2-like [KO:K14284]
118653418  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
118653419  nuclear RNA export factor 2-like [KO:K14284]
118649944  THO complex subunit 4-like [KO:K12881]
118649945  THO complex subunit 4-like [KO:K12881]
118649951  THO complex subunit 4-like [KO:K12881]
118667190  LOW QUALITY PROTEIN: THO complex subunit 4-like [KO:K12881]
118671810  ALYREF; THO complex subunit 4 [KO:K12881]
118657486  THO complex subunit 4-like [KO:K12881]
118657487  THO complex subunit 4-like [KO:K12881]
118673639  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118669989  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118649937  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118674287  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118665178  FADD; FAS-associated death domain protein [KO:K02373]
118661495  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118652071  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118655437  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118679638  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
118665363  BAD; bcl2-associated agonist of cell death [KO:K02158]
118663765  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118663066  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
118666111  cytochrome c [KO:K08738]
118679308  cytochrome c-like [KO:K08738]
118654943  cytochrome c-like [KO:K08738]
118650180  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
118677148  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118650210  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
mmyo03040  Spliceosome
mmyo03050  Proteasome
mmyo04115  p53 signaling pathway
mmyo04151  PI3K-Akt signaling pathway
mmyo04210  Apoptosis
mmyo04610  Complement and coagulation cascades
mmyo04612  Antigen processing and presentation
mmyo04620  Toll-like receptor signaling pathway
mmyo04622  RIG-I-like receptor signaling pathway
mmyo04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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