KEGG   PATHWAY: mnp04728
Entry
mnp04728                    Pathway                                
Name
Dopaminergic synapse - Mustela nigripes (black-footed ferret)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
mnp04728  Dopaminergic synapse
mnp04728

Other DBs
GO: 0001963
Organism
Mustela nigripes (black-footed ferret) [GN:mnp]
Gene
132016827  TH; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
132016099  DDC; aromatic-L-amino-acid decarboxylase isoform X1 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
132016810  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
132022054  SLC18A1; chromaffin granule amine transporter [KO:K08155]
132027843  DRD1; D(1A) dopamine receptor [KO:K04144]
132015124  DRD5; D(1B) dopamine receptor [KO:K05840]
132016903  CALY; neuron-specific vesicular protein calcyon [KO:K15493]
132024788  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
132019538  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
131999626  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
132021732  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
132021734  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
132011514  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
132019550  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
132017890  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
132015160  calmodulin-1-like [KO:K02183]
132002170  CALML6; calmodulin-like protein 6 [KO:K02183]
132005201  CALM3; calmodulin-3 [KO:K02183]
132020019  calmodulin-like protein 3 [KO:K02183]
132020856  calmodulin-like [KO:K02183]
131999557  CALML4; calmodulin-like protein 4 [KO:K02183]
132021617  CALM2; calmodulin-2 [KO:K02183]
132000098  CALM1; calmodulin-1 [KO:K02183]
132016071  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
132016520  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
132002521  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
132028323  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
132001718  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
132016503  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131999012  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132003742  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
132026832  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132004993  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
132000157  FOS; protein c-Fos [KO:K04379]
132022829  neuroendocrine secretory protein 55 [KO:K04632]
132022063  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
132022064  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
132023466  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
132011863  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
132001064  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
132011072  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
132013496  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
132013851  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
132009003  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
132019205  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
132008271  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
132008517  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
132015669  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
132009653  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
132024618  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
132025947  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
132015844  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
132017831  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
132017920  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
132017921  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
132019083  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
132019085  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
132001060  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132016577  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132027429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132003482  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
132023151  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
132017911  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
132021249  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
132013801  sodium channel protein type 1 subunit alpha isoform X1 [KO:K04833]
132019988  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
132011423  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
132011054  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
132024930  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
132013755  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
132012398  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
132025794  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
132012254  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
132010189  DRD3; D(3) dopamine receptor isoform X1 [KO:K04146]
132016443  DRD4; D(4) dopamine receptor [KO:K04147]
132001262  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
132015994  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
132011347  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
132005670  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
132001826  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
132026562  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
132019915  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
132012030  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
131999766  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
131999942  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
132019950  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
132016147  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
132001069  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
132017487  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
132012969  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
132010751  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
132005567  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
132024511  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
132018736  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
132015082  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
132000997  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
132020499  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
132027069  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
132015083  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
132003975  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
132013000  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
132024474  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
132003138  ARRB2; beta-arrestin-2 [KO:K04439]
132006351  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
132005478  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
132028487  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
132016884  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
132004258  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
131999245  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
132028637  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
132007618  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
132011814  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
131999885  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
132000267  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
132018044  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
132025408  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
132019210  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
132000016  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
132000311  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132025379  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132005674  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132004779  GSK3A; glycogen synthase kinase-3 alpha isoform X1 [KO:K08822] [EC:2.7.11.26]
132012195  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
132026908  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
132020616  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
132028345  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
132000814  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
132006667  glutamate receptor 3 [KO:K05199]
132028857  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
132019844  KIF5A; kinesin heavy chain [KO:K10396]
132020192  KIF5B; kinesin-1 heavy chain [KO:K10396]
132013898  KIF5C; kinesin heavy chain [KO:K10396]
132006408  CLOCK; circadian locomoter output cycles protein kaput isoform X1 [KO:K02223] [EC:2.3.1.48]
132022770  BMAL1; basic helix-loop-helix ARNT-like protein 1 isoform X1 [KO:K02296]
132027708  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
132007773  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
132006741  LOW QUALITY PROTEIN: amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
132023436  COMT; catechol O-methyltransferase [KO:K00545] [EC:2.1.1.6]
132023803  TOMT; transmembrane O-methyltransferase isoform X1 [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
mnp00350  Tyrosine metabolism
mnp04020  Calcium signaling pathway
mnp04721  Synaptic vesicle cycle
mnp04724  Glutamatergic synapse
mnp05012  Parkinson disease
KO pathway
ko04728   
LinkDB

DBGET integrated database retrieval system