KEGG   PATHWAY: mnp05163
Entry
mnp05163                    Pathway                                
Name
Human cytomegalovirus infection - Mustela nigripes (black-footed ferret)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
mnp05163  Human cytomegalovirus infection
mnp05163

Organism
Mustela nigripes (black-footed ferret) [GN:mnp]
Gene
132006175  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
132001008  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132010495  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
132012033  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
132000809  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
132011173  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
132028693  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
132000311  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132025379  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132005674  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132024295  TSC1; hamartin isoform X1 [KO:K07206]
132027018  TSC2; tuberin isoform X1 [KO:K07207]
132015553  RHEB; GTP-binding protein Rheb [KO:K07208]
132001170  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
132006605  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
132017832  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
132004290  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
132016695  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
132006530  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
132006829  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
132001757  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
132018657  RELA; transcription factor p65 [KO:K04735]
132016105  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
132003151  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
132021307  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
131999927  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
132016391  HRAS; GTPase HRas isoform X1 [KO:K02833]
132027717  LOW QUALITY PROTEIN: ras protein let-60-like [KO:K02833]
132019561  KRAS; GTPase KRas isoform X1 [KO:K07827]
132001334  NRAS; GTPase NRas [KO:K07828]
132002077  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
132011570  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131999543  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132010799  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
132008541  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
132023779  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132026755  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132007431  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
132019731  SP1; transcription factor Sp1 [KO:K04684]
132013895  ITGAV; integrin alpha-V [KO:K06487]
132004398  ITGB3; integrin beta-3 [KO:K06493]
132021907  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
132026481  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
132019253  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132004336  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
132011318  RHOA; transforming protein RhoA [KO:K04513]
132017214  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
132028569  STING1; stimulator of interferon genes protein [KO:K12654]
132028570  stimulator of interferon genes protein-like [KO:K12654]
132019462  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
132005020  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
132008962  interferon alpha-1/2-like [KO:K05414]
132009102  interferon alpha-1/2-like [KO:K05414]
132009158  interferon alpha-3-like [KO:K05414]
132009205  interferon alpha-1/2-like [KO:K05414]
132009311  interferon alpha-1/2-like [KO:K05414]
132024131  interferon alpha-1/2-like [KO:K05414]
132024132  interferon alpha-1/2-like [KO:K05414]
132024134  interferon alpha-1/2-like [KO:K05414]
132025116  interferon alpha-1/2-like [KO:K05414]
132025119  interferon alpha-1/2-like [KO:K05414]
132025120  interferon alpha-1/2-like [KO:K05414]
132025121  interferon alpha-1/2-like [KO:K05414]
132025122  interferon alpha-1/2-like [KO:K05414]
132025123  interferon alpha-1/2-like [KO:K05414]
132025124  interferon alpha-14-like [KO:K05414]
132025125  IFNB1; interferon beta [KO:K05415]
132017188  TNF; tumor necrosis factor isoform X1 [KO:K03156]
132019939  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
132018518  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
132006073  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
132025400  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
132024227  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
132022474  IL1B; interleukin-1 beta [KO:K04519]
132021637  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
131999888  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
132003436  C-C motif chemokine 2 [KO:K14624]
132003361  CCL5; C-C motif chemokine 5 [KO:K12499]
132007064  CXCL8; interleukin-8 [KO:K10030]
132015023  IL6; interleukin-6 [KO:K05405]
132001826  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
132026562  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
132019915  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
132012030  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
131999766  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
131999942  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
132019950  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
132016147  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
132001069  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
132017487  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
132012969  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
132010751  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
132005567  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
132024511  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
132018736  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
132015082  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
132000997  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
132020499  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
132027069  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
132015083  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
132003975  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
132024788  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
132010764  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
132019538  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
131999626  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
132021732  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
132021734  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
132011514  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
132019550  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
132017890  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
132015160  calmodulin-1-like [KO:K02183]
132002170  CALML6; calmodulin-like protein 6 [KO:K02183]
132005201  CALM3; calmodulin-3 [KO:K02183]
132020019  calmodulin-like protein 3 [KO:K02183]
132020856  calmodulin-like [KO:K02183]
131999557  CALML4; calmodulin-like protein 4 [KO:K02183]
132021617  CALM2; calmodulin-2 [KO:K02183]
132000098  CALM1; calmodulin-1 [KO:K02183]
132001718  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
132016503  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131999012  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132025071  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
132023704  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
132022031  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
132005175  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
132012169  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
131999851  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
132025471  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
132001262  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
132015994  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
132011347  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
132005670  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
132016088  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
132028199  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
132021183  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
131999850  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
132011863  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
132019632  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
132005324  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
132014306  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
132026955  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
132001064  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
132011072  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
132003142  C-C motif chemokine 3 [KO:K05408]
132003486  C-C motif chemokine 3-like [KO:K05408]
132003519  regakine-1-like [KO:K05408]
132003201  CCL4; C-C motif chemokine 4 [KO:K12964]
132005205  CX3CL1; fractalkine [KO:K05508]
132026441  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
132004175  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
132004999  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
132025833  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
132026896  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
131999066  AKAP13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
132023518  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
132021141  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
132011705  CTNNB1; catenin beta-1 [KO:K02105]
132011082  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
131999946  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
132001012  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
132028268  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
132022829  neuroendocrine secretory protein 55 [KO:K04632]
132022063  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
132022064  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
132012195  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
132017399  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
132014301  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
132025933  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
132000969  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
132004114  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
132018637  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
132004478  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
132017920  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
132017921  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
132019083  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
132019085  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
132013496  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
132013851  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
132009003  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
132019205  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
132008271  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
132008517  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
132015669  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
132009653  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
132024618  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
132025947  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
132015844  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
132017831  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
132016597  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
132013919  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
132003742  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
132026832  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132004993  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
131999727  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
132014328  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
132005689  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
132023406  CRKL; crk-like protein [KO:K04438]
132004503  CRK; adapter molecule crk isoform X1 [KO:K04438]
132023227  PXN; paxillin isoform X1 [KO:K05760]
132027593  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
132012880  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
132011249  C-C chemokine receptor type 1-like [KO:K04176]
132009778  C-C chemokine receptor type 3-like [KO:K04178]
132011251  C-C chemokine receptor type 5 [KO:K04180]
132017858  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
132017855  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
132017880  TAPBP; tapasin [KO:K08058]
131999694  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
132011043  CALR; calreticulin [KO:K08057]
132009006  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
132017771  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
132017773  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
132017774  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
132018094  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
132018566  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
132027438  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
131999710  B2M; beta-2-microglobulin [KO:K08055]
132019435  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
132003790  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
132018107  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
132019857  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
132015946  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
132002924  RB1; retinoblastoma-associated protein [KO:K06618]
132021842  E2F1; transcription factor E2F1 [KO:K17454]
132001761  E2F2; transcription factor E2F2 [KO:K09389]
132017636  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
132026045  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
132016209  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
132017355  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
132013450  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
132019997  BID; BH3-interacting domain death agonist [KO:K04726]
132006078  BAX; apoptosis regulator BAX [KO:K02159]
132017889  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
132015876  cytochrome c [KO:K08738]
132013022  cytochrome c, testis-specific [KO:K08738]
132001514  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
132006389  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
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Related
pathway
mnp00590  Arachidonic acid metabolism
mnp03050  Proteasome
mnp04010  MAPK signaling pathway
mnp04064  NF-kappa B signaling pathway
mnp04110  Cell cycle
mnp04150  mTOR signaling pathway
mnp04151  PI3K-Akt signaling pathway
mnp04210  Apoptosis
mnp04612  Antigen processing and presentation
mnp04623  Cytosolic DNA-sensing pathway
mnp04630  JAK-STAT signaling pathway
mnp04668  TNF signaling pathway
mnp04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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