KEGG   PATHWAY: mthb05165
Entry
mthb05165                   Pathway                                
Name
Human papillomavirus infection - Macaca thibetana thibetana (Pere David's macaque)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
mthb05165  Human papillomavirus infection
mthb05165

Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126930178  proto-oncogene Wnt-1 [KO:K03209]
126930501  protein Wnt-2b [KO:K00182]
126951195  protein Wnt-2 [KO:K00182]
126936033  protein Wnt-3a [KO:K00312]
126938314  proto-oncogene Wnt-3 [KO:K00312]
126956796  protein Wnt-4 [KO:K00408]
126930247  protein Wnt-5b [KO:K00444]
126947624  protein Wnt-5a isoform X1 [KO:K00444]
126933008  protein Wnt-6 isoform X1 [KO:K00445]
126949140  protein Wnt-7a [KO:K00572]
126963624  protein Wnt-7b isoform X1 [KO:K00572]
126963076  protein Wnt-8b [KO:K00714]
126957556  protein Wnt-8a [KO:K00714]
126938932  protein Wnt-9b isoform X1 [KO:K01064]
126935947  protein Wnt-9a isoform X1 [KO:K01064]
126930177  protein Wnt-10b [KO:K01357]
126933003  protein Wnt-10a [KO:K01357]
126935098  protein Wnt-11 isoform X1 [KO:K01384]
126950813  protein Wnt-16 [KO:K01558]
126932182  frizzled-7 [KO:K02432]
126949919  frizzled-1 [KO:K02432]
126938678  frizzled-2 [KO:K02235]
126961767  frizzled-3 isoform X1 [KO:K02329]
126934903  frizzled-4 isoform X1 [KO:K02354]
126962319  LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
126933089  frizzled-5 [KO:K02375]
126960879  frizzled-6 isoform X1 [KO:K02376]
126930546  frizzled-10 [KO:K02842]
126950358  frizzled-9 [KO:K02842]
126939681  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
126951679  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
126948407  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
126949239  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
126944825  axin-1 isoform X1 [KO:K02157]
126938336  axin-2 isoform X1 [KO:K04385]
126942456  LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
126956213  adenomatous polyposis coli protein isoform X1 [KO:K02085]
126948505  catenin beta-1 isoform X1 [KO:K02105]
126956791  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
126940310  casein kinase I [KO:K08957] [EC:2.7.11.1]
126957402  telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
126955989  transcription factor 7 isoform X1 [KO:K02620]
126933391  transcription factor 7-like 1 isoform X1 [KO:K04490]
126962827  transcription factor 7-like 2 isoform X1 [KO:K04491]
126959062  ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
126954496  toll-like receptor 3 [KO:K05401]
126942532  TIR domain-containing adapter molecule 1 [KO:K05842]
126959960  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
126938771  inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
126930857  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
126943112  interferon regulatory factor 3 isoform X1 [KO:K05411]
126937702  interferon beta [KO:K05415]
126963565  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
126944569  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
126947716  transcriptional adapter 3 [KO:K11315]
126939707  cellular tumor antigen p53 isoform X1 [KO:K04451]
126947634  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
126963336  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
126962979  partitioning defective 3 homolog isoform X1 [KO:K04237]
126944023  partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
126964388  partitioning defective 6 homolog beta [KO:K06093]
126941471  LOW QUALITY PROTEIN: partitioning defective 6 homolog gamma-like [KO:K06093]
126947535  protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
126951757  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
126956242  cell division control protein 42 homolog isoform X1 [KO:K04393]
126953277  cell division control protein 42 homolog [KO:K04393]
126960933  protein scribble homolog isoform X1 [KO:K16175]
126947952  disks large homolog 1 isoform X1 [KO:K12076]
126934894  disks large homolog 2 isoform X1 [KO:K12075]
126946175  disks large homolog 3 isoform X1 [KO:K21098]
126938781  lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
126939167  LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
126942846  protein crumbs homolog 3 [KO:K06090]
126933063  inaD-like protein isoform X1 [KO:K06092]
126958648  protein PALS1 isoform X1 [KO:K06091]
126930424  von Willebrand factor isoform X1 [KO:K03900]
126957930  thrombospondin-1 [KO:K16857]
126933159  thrombospondin-3 isoform X1 [KO:K04659]
126957575  thrombospondin-4 isoform X1 [KO:K04659]
126952464  thrombospondin-2 [KO:K04659]
126942208  cartilage oligomeric matrix protein [KO:K04659]
126932417  fibronectin isoform X1 [KO:K05717]
126949926  collagen alpha-2(I) chain isoform X1 [KO:K06236]
126939864  collagen alpha-1(I) chain isoform X1 [KO:K06236]
126930148  collagen alpha-1(II) chain isoform X1 [KO:K19719]
126932884  collagen alpha-4(IV) chain isoform X1 [KO:K06237]
126932960  collagen alpha-3(IV) chain isoform X1 [KO:K06237]
126946614  collagen alpha-6(IV) chain isoform X1 [KO:K06237]
126946615  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
126940592  collagen alpha-1(IV) chain [KO:K06237]
126940593  collagen alpha-2(IV) chain [KO:K06237]
126932624  collagen alpha-3(VI) chain [KO:K06238]
126950596  collagen alpha-2(VI) chain isoform X1 [KO:K06238]
126951507  collagen alpha-1(VI) chain [KO:K06238]
126947062  collagen alpha-5(VI) chain [KO:K06238]
126947078  collagen alpha-6(VI) chain [KO:K06238]
126947094  collagen alpha-4(VI) chain-like [KO:K06238]
126953938  collagen alpha-1(IX) chain isoform X1 [KO:K08131]
126964093  collagen alpha-3(IX) chain [KO:K08131]
126959408  collagen alpha-2(IX) chain [KO:K08131]
126940995  laminin subunit alpha-1 isoform X1 [KO:K05637]
126953024  laminin subunit alpha-2 isoform X1 [KO:K05637]
126941333  laminin subunit alpha-3 isoform X1 [KO:K06240]
126929064  laminin subunit alpha-5 [KO:K06240]
126953585  laminin subunit alpha-4 isoform X1 [KO:K06241]
126951221  laminin subunit beta-1 [KO:K05636]
126948619  laminin subunit beta-2 [KO:K06243]
126949026  laminin subunit beta-3 [KO:K06244]
126951219  laminin subunit beta-4 isoform X1 [KO:K06245]
126950143  laminin subunit gamma-1 isoform X1 [KO:K05635]
126940264  laminin subunit gamma-2 [KO:K06246]
126936881  laminin subunit gamma-3 [KO:K06247]
126939616  chondroadherin [KO:K06248]
126949834  reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
126954703  osteopontin [KO:K06250]
126938724  vitronectin [KO:K06251]
126938007  tenascin isoform X1 [KO:K06252]
126956954  tenascin-N [KO:K06252]
126940803  tenascin-R isoform X1 [KO:K06252]
126953208  LOW QUALITY PROTEIN: tenascin-X-like [KO:K06252]
126954719  bone sialoprotein 2 [KO:K06253]
126956843  integrin alpha-1 [KO:K06480]
126956842  integrin alpha-2 [KO:K06481]
126938666  integrin alpha-IIb [KO:K06476]
126939866  integrin alpha-3 isoform X1 [KO:K06482]
126932061  integrin alpha-4 [KO:K06483]
126931101  integrin alpha-5 [KO:K06484]
126932479  integrin alpha-6 isoform X1 [KO:K06485]
126931100  integrin alpha-7 isoform X1 [KO:K06583]
126962394  LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
126948472  integrin alpha-9 isoform X1 [KO:K06585]
126931423  integrin alpha-10 isoform X1 [KO:K06586]
126958133  LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
126933042  integrin alpha-V isoform X1 [KO:K06487]
126962945  integrin beta-1 isoform X1 [KO:K05719]
126939509  integrin beta-3 [KO:K06493]
126939156  integrin beta-4 isoform X1 [KO:K06525]
126949108  integrin beta-5 [KO:K06588]
126932940  integrin beta-6 isoform X1 [KO:K06589]
126931103  integrin beta-7 isoform X1 [KO:K06590]
126951352  integrin beta-8 [KO:K06591]
126961367  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
126930628  paxillin isoform X1 [KO:K05760]
126953141  tumor necrosis factor isoform X1 [KO:K03156]
126930443  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
126945020  tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
126941397  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
126963192  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
126935972  FAS-associated death domain protein [KO:K02373]
126932110  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
126954341  caspase-3 [KO:K02187] [EC:3.4.22.56]
126939247  Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
126961792  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
126955999  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
126943032  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
126935784  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
126961827  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
126955498  protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
126963299  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
126956781  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
126946849  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
126947137  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
126959165  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
126948134  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
126936807  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
126958423  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
126952394  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
126959744  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
126935580  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
126948635  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
126936889  hamartin isoform X1 [KO:K07206]
126944570  tuberin isoform X1 [KO:K07207]
126951632  GTP-binding protein Rheb [KO:K07208]
126952739  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
126961225  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
126939388  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
126935360  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
126952802  bcl-2 homologous antagonist/killer [KO:K14021]
126935617  bcl2-associated agonist of cell death [KO:K02158]
126956582  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126940335  forkhead box protein O1 [KO:K07201]
126930782  cyclin-dependent kinase inhibitor 1B [KO:K06624]
126952813  cyclin-dependent kinase inhibitor 1 [KO:K06625]
126935963  G1/S-specific cyclin-D1 [KO:K04503]
126931745  G1/S-specific cyclin-D2 [KO:K10151]
126953804  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
126930400  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
126951304  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
126943618  G1/S-specific cyclin-E1 [KO:K06626]
126960826  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
126931216  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
126940411  retinoblastoma-associated protein isoform X1 [KO:K06618]
126964175  retinoblastoma-like protein 1 isoform X1 [KO:K04681]
126944978  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
126949685  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
126959662  26S proteasome regulatory subunit 4 [KO:K03062]
126964352  transcription factor E2F1 [KO:K17454]
126955746  cyclin-A2 [KO:K06627]
126940304  cyclin-A1 isoform X1 [KO:K06627]
126936196  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
126947465  serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
126952424  vascular endothelial growth factor A isoform X1 [KO:K05448]
126963067  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
126960750  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126945470  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126955390  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
126935358  transcription factor p65 isoform X1 [KO:K04735]
126931704  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
126937380  transcriptional repressor NF-X1 isoform X1 [KO:K12236]
126957492  histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
126952258  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
126930425  chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
126956002  interferon regulatory factor 1 [KO:K09444]
126952481  TATA-box-binding protein [KO:K03120]
126959340  TATA box-binding protein-like 2 [KO:K03120]
126952889  TATA box-binding protein-like 1 [KO:K03120]
126947251  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
126947252  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
126953081  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
126953085  mamu class I histocompatibility antigen, alpha chain F-like isoform X1 [KO:K06751]
126953093  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
126953095  patr class I histocompatibility antigen, B-1 alpha chain-like isoform X1 [KO:K06751]
126953097  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
126953098  popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
126953131  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
126953169  patr class I histocompatibility antigen, A-5 alpha chain-like [KO:K06751]
126945412  B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
126955010  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
126947782  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
126961447  V-type proton ATPase subunit B, brain isoform [KO:K02147]
126934029  V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
126933787  V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
126960887  V-type proton ATPase subunit C 1 [KO:K02148]
126958659  V-type proton ATPase subunit D [KO:K02149]
126933977  V-type proton ATPase subunit E 2 [KO:K02150]
126935228  LOW QUALITY PROTEIN: V-type proton ATPase subunit E 1-like [KO:K02150]
126929711  V-type proton ATPase subunit E 1 [KO:K02150]
126930200  V-type proton ATPase subunit F [KO:K02151]
126951162  V-type proton ATPase subunit F [KO:K02151]
126929766  V-type proton ATPase subunit G 1-like [KO:K02152]
126937541  V-type proton ATPase subunit G 1 [KO:K02152]
126958612  V-type proton ATPase subunit G 1-like [KO:K02152]
126958613  V-type proton ATPase subunit G 1-like [KO:K02152]
126939740  V-type proton ATPase subunit G 3 [KO:K02152]
126952322  V-type proton ATPase subunit G 1-like [KO:K02152]
126953173  V-type proton ATPase subunit G 2 [KO:K02152]
126961417  V-type proton ATPase subunit H isoform X1 [KO:K02144]
126930608  V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
126938425  V-type proton ATPase 116 kDa subunit a 1 [KO:K02154]
126951135  V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
126935338  V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
126944029  V-type proton ATPase subunit d 1 [KO:K02146]
126961171  V-type proton ATPase subunit d 2 [KO:K02146]
126956386  V-type proton ATPase subunit e 1 [KO:K02153]
126951639  V-type proton ATPase subunit e 2 isoform X1 [KO:K02153]
126947683  V-type proton ATPase subunit e 1-like [KO:K02153]
126948546  V-type proton ATPase subunit e 1-like [KO:K02153]
126944767  V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
126952430  V-type proton ATPase 16 kDa proteolipid subunit c-like [KO:K02155]
126960748  V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X1 [KO:K03661]
126945464  V-type proton ATPase subunit S1 [KO:K03662]
126954925  pro-epidermal growth factor isoform X1 [KO:K04357]
126950202  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
126939255  growth factor receptor-bound protein 2 [KO:K04364]
126933534  son of sevenless homolog 1 isoform X1 [KO:K03099]
126958499  son of sevenless homolog 2 isoform X1 [KO:K03099]
126935869  GTPase HRas isoform X1 [KO:K02833]
126931572  GTPase KRas [KO:K07827]
126930824  GTPase NRas [KO:K07828]
126949054  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126957976  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126942673  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126944456  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
126929669  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126950108  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
126956451  prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
126929358  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
126929369  neuroendocrine secretory protein 55 [KO:K04632]
126942437  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
126937647  cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
126963591  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126943600  apoptosis regulator BAX isoform X1 [KO:K02159]
126933094  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
126942639  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
126938066  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
126951142  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
126934237  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
126935751  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
126950050  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
126953936  E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
126938484  tubulin gamma-1 chain [KO:K10389]
126938485  tubulin gamma-2 chain [KO:K10389]
126932236  pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
126958146  pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
126937598  interferon alpha-14 [KO:K05414]
126937600  interferon alpha-4-like [KO:K05414]
126937601  interferon alpha-17 [KO:K05414]
126937602  interferon alpha-17-like [KO:K05414]
126937603  interferon alpha-17-like [KO:K05414]
126937604  interferon alpha-17-like [KO:K05414]
126937605  LOW QUALITY PROTEIN: interferon alpha-10-like [KO:K05414]
126937606  interferon alpha-10-like [KO:K05414]
126937607  interferon alpha-1/13-like [KO:K05414]
126937608  interferon alpha-1/13 [KO:K05414]
126937609  interferon alpha-1/13-like [KO:K05414]
126937610  interferon alpha-6 [KO:K05414]
126937611  interferon alpha-4 [KO:K05414]
126937612  interferon alpha-8 [KO:K05414]
126937613  interferon alpha-2 [KO:K05414]
126937615  interferon alpha-21 [KO:K05414]
126947451  interferon alpha-10-like [KO:K05414]
126951662  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
126951665  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
126935739  tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
126942474  non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
126932637  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
126931203  signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
126958809  interferon regulatory factor 9 isoform X1 [KO:K04693]
126933547  interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
126930638  2'-5'-oligoadenylate synthase-like protein [KO:K14608]
126950684  interferon-induced GTP-binding protein Mx2 [KO:K14754]
126950685  interferon-induced GTP-binding protein Mx1 [KO:K14754]
126952266  ubiquitin-like protein ISG15 [KO:K12159]
126964413  protein jagged-1 isoform X1 [KO:K06052]
126936867  neurogenic locus notch homolog protein 1 [KO:K02599]
126931272  neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
126942169  neurogenic locus notch homolog protein 3 [KO:K20995]
126953209  neurogenic locus notch homolog protein 4 [KO:K20996]
126959532  presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
126963749  beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
126939112  beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
126951486  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
126954601  mastermind-like protein 3 [KO:K06061]
126956890  mastermind-like protein 1 [KO:K06061]
126935893  mastermind-like protein 2 isoform X1 [KO:K06061]
126954808  recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
126963822  recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
126947977  transcription factor HES-1 [KO:K06054]
126933052  transcription cofactor HES-6 isoform X1 [KO:K09087]
126939775  transcription factor HES-7 isoform X1 [KO:K09087]
126952617  transcription factor HES-2 [KO:K09087]
126952624  transcription factor HES-3 [KO:K09088]
126952154  transcription factor HES-4 [KO:K09089]
126961434  transcription factor HES-5 [KO:K06055]
126961663  hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
126953267  hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
126960300  hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Sci Rep 5:13446 (2015)
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Pathogens 5:E8 (2016)
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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PDZ domains: the building blocks regulating tumorigenesis.
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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  Title
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Related
pathway
mthb04064  NF-kappa B signaling pathway
mthb04110  Cell cycle
mthb04115  p53 signaling pathway
mthb04150  mTOR signaling pathway
mthb04151  PI3K-Akt signaling pathway
mthb04210  Apoptosis
mthb04310  Wnt signaling pathway
mthb04330  Notch signaling pathway
mthb04510  Focal adhesion
mthb04520  Adherens junction
mthb04530  Tight junction
mthb04612  Antigen processing and presentation
mthb04620  Toll-like receptor signaling pathway
mthb04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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