KEGG   PATHWAY: mun05163
Entry
mun05163                    Pathway                                
Name
Human cytomegalovirus infection - Meriones unguiculatus (Mongolian gerbil)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
mun05163  Human cytomegalovirus infection
mun05163

Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110558105  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110565112  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110556252  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110548394  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110553683  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110549145  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110563512  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110556719  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110558966  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110564898  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110550703  Tsc1; hamartin isoform X1 [KO:K07206]
110553023  Tsc2; tuberin isoform X1 [KO:K07207]
110565714  Rheb; GTP-binding protein Rheb [KO:K07208]
110548161  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110550200  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
110553742  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110560360  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
110552966  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110544653  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
110556613  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110562528  Ikbkg; NF-kappa-B essential modulator isoform X3 [KO:K07210]
110558602  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
110549347  Rela; transcription factor p65 isoform X1 [KO:K04735]
110539539  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110547825  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
110547073  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110556913  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110553931  Hras; GTPase HRas isoform X1 [KO:K02833]
110558913  Kras; GTPase KRas isoform X1 [KO:K07827]
110544642  GTPase NRas [KO:K07828]
110544765  Nras; GTPase NRas [KO:K07828]
110550814  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110559000  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110555605  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110553796  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
110547978  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110543001  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
110552322  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
110559159  Itgav; integrin alpha-V [KO:K06487]
110545659  Itgb3; integrin beta-3 [KO:K06493]
110566227  Src; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
110557417  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110548466  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110548820  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
110540728  transforming protein RhoA-like isoform X1 [KO:K04513]
110565123  Rhoa; transforming protein RhoA isoform X2 [KO:K04513]
110560519  Cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
110549049  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
110546826  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
110544130  interferon alpha-1-like [KO:K05414]
110543198  interferon alpha-1-like [KO:K05414]
110543200  interferon alpha-1-like [KO:K05414]
110544870  interferon alpha-2-like [KO:K05414]
110544619  interferon alpha-1-like [KO:K05414]
132646742  interferon alpha-1-like [KO:K05414]
132646744  interferon alpha-11-like [KO:K05414]
132646745  interferon alpha-1-like [KO:K05414]
132646746  interferon alpha-1-like [KO:K05414]
132646775  interferon alpha-11-like [KO:K05414]
110541303  Ifnb1; interferon beta [KO:K05415]
110560136  Tnf; LOW QUALITY PROTEIN: tumor necrosis factor [KO:K03156]
110548604  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
110561376  Ripk1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
110545551  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
110566223  Traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
110557003  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110551400  Il1b; interleukin-1 beta [KO:K04519]
110559960  Il1r1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
110562401  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
110564365  C-C motif chemokine 2-like [KO:K14624]
110555684  Ccl5; C-C motif chemokine 5 [KO:K12499]
110539463  Il6; interleukin-6 [KO:K05405]
110559917  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110556769  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
110548560  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
110556251  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
110545481  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
110557636  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
110557460  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
110558140  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
110540240  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
110555606  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110552633  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
110557441  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
110565823  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
110545821  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
110558424  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110548730  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
110565822  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
110553430  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
110562511  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
110548534  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
110563159  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110555720  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110551595  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
110550598  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
110552142  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
110558908  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
110543748  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
110561484  Calm1; calmodulin-1 [KO:K02183]
110562918  Calm2; calmodulin-2 [KO:K02183]
110552646  Calm3; calmodulin-3 [KO:K02183]
110550527  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
110560701  Calml3; calmodulin-like protein 3 [KO:K02183]
110560702  calmodulin-4-like [KO:K02183]
110555973  Ppp3ca; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
110551992  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
110551668  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
110558957  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
110561325  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
110550273  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110547352  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110545902  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110543951  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
110553489  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
110539607  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
110545517  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
110564775  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
110561150  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
110555169  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110550962  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
110555185  Adcy3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
110556521  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
110547229  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110559444  Adcy6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
110560723  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110561696  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110545944  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110545842  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110555016  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110555679  C-C motif chemokine 3 [KO:K05408]
110555685  C-C motif chemokine 4-like [KO:K12964]
110559526  Cx3cl1; fractalkine [KO:K05508]
110554732  Gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X2 [KO:K04346]
110560037  Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
110566357  Arhgef1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
110564974  Arhgef11; rho guanine nucleotide exchange factor 11 isoform X3 [KO:K12331]
110548553  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
110566614  Akap13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
110564211  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
110541556  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
110561755  Ctnnb1; catenin beta-1 [KO:K02105]
110545849  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
110563956  Ptger2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
110563508  Ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
110563125  Ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
110563608  neuroendocrine secretory protein 55-like [KO:K04632]
110555390  Gsk3b; glycogen synthase kinase-3 beta isoform X4 [KO:K03083] [EC:2.7.11.26]
110546940  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
110560064  Myc; myc proto-oncogene protein [KO:K04377]
110555551  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110550916  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
110550366  Vegfa; vascular endothelial growth factor A, long form isoform X3 [KO:K05448]
110563015  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
110546562  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110546585  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110549680  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110549673  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
110551437  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
110556579  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110564629  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110549859  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
110555614  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
110549233  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
110554250  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
110561882  Creb3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
110554970  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
110565383  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
110565182  Cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
110555409  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
110555335  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110559612  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110556016  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110559230  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
110542391  Ptk2; focal adhesion kinase 1 isoform X4 [KO:K05725] [EC:2.7.10.2]
110554744  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
110547367  Crk; adapter molecule crk isoform X1 [KO:K04438]
110559213  Crkl; crk-like protein [KO:K04438]
110545583  Pxn; paxillin isoform X1 [KO:K05760]
110549113  Il10ra; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
110541906  Il10rb; interleukin-10 receptor subunit beta [KO:K05135]
110554125  C-C chemokine receptor 1-like protein 1 [KO:K04176]
110554126  C-C chemokine receptor type 1 [KO:K04176]
110566890  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
110566894  C-C chemokine receptor type 5 [KO:K04180]
110543126  Tap1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
110543246  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
110543537  Tapbp; tapasin [KO:K08058]
110556211  Pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
110545829  Calr; calreticulin [KO:K08057]
110563573  calreticulin-like [KO:K08057]
110557144  H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751]
110557146  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
110562341  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X3 [KO:K06751]
110563045  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
110563046  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110563052  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
110543171  H-2 class I histocompatibility antigen, K-D alpha chain-like [KO:K06751]
110543428  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
110544579  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
132648276  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
110543095  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
110557135  RT1 class I histocompatibility antigen, AA alpha chain [KO:K06751]
132648299  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
110553258  B2m; beta-2-microglobulin [KO:K08055]
110554386  cyclin-dependent kinase 4 inhibitor B-like [KO:K06621]
110562241  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
110555127  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110546586  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
110561245  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110558380  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
110553592  Rb1; retinoblastoma-associated protein [KO:K06618]
110554547  E2f1; transcription factor E2F1 isoform X1 [KO:K17454]
110545385  E2f2; transcription factor E2F2 [KO:K09389]
110561800  E2f3; transcription factor E2F3 isoform X3 [KO:K06620]
110556827  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
110561521  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
110546885  Fadd; FAS-associated death domain protein [KO:K02373]
110557662  Casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
110546065  Bid; BH3-interacting domain death agonist isoform X2 [KO:K04726]
110560658  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
110543676  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
110545164  cytochrome c, somatic [KO:K08738]
110555979  cytochrome c, testis-specific [KO:K08738]
110563439  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
110559601  cytochrome c, somatic-like [KO:K08738]
110549868  LOW QUALITY PROTEIN: cytochrome c, somatic-like [KO:K08738]
110552819  cytochrome c, somatic-like [KO:K08738]
110545060  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
132653623  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
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Related
pathway
mun00590  Arachidonic acid metabolism
mun03050  Proteasome
mun04010  MAPK signaling pathway
mun04064  NF-kappa B signaling pathway
mun04110  Cell cycle
mun04150  mTOR signaling pathway
mun04151  PI3K-Akt signaling pathway
mun04210  Apoptosis
mun04612  Antigen processing and presentation
mun04623  Cytosolic DNA-sensing pathway
mun04630  JAK-STAT signaling pathway
mun04668  TNF signaling pathway
mun04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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