KEGG   PATHWAY: nle04728
Entry
nle04728                    Pathway                                
Name
Dopaminergic synapse - Nomascus leucogenys (northern white-cheeked gibbon)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
nle04728  Dopaminergic synapse
nle04728

Other DBs
GO: 0001963
Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100591963  TH; tyrosine 3-monooxygenase isoform X1 [KO:K00501] [EC:1.14.16.2]
100597933  DDC; aromatic-L-amino-acid decarboxylase isoform X2 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
100586312  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
100592997  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
100582870  DRD1; D(1A) dopamine receptor [KO:K04144]
100605841  DRD5; D(1B) dopamine receptor [KO:K05840]
100582157  CALY; neuron-specific vesicular protein calcyon [KO:K15493]
100594473  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100597115  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100600507  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
100606558  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100600865  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100587159  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100599135  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
100585914  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100586234  calmodulin-like [KO:K02183]
100582584  CALM2; calmodulin-2 [KO:K02183]
100584686  CALML6; calmodulin-like protein 6 [KO:K02183]
100595594  CALM1; calmodulin-1 [KO:K02183]
100607765  CALML3; calmodulin-like protein 3 [KO:K02183]
100602246  CALM3; calmodulin-3 [KO:K02183]
100588287  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100603253  CALML5; calmodulin-like protein 5 [KO:K02183]
100597007  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100600165  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100591995  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100580290  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X30 [KO:K04515] [EC:2.7.11.17]
100598029  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100607264  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100583664  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100591651  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100590939  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100601464  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100585899  FOS; proto-oncogene c-Fos [KO:K04379]
101176289  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X7 [KO:K04632]
115830355  neuroendocrine secretory protein 55 [KO:K04632]
100597944  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
100580455  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100583577  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X8 [KO:K04345] [EC:2.7.11.11]
100579779  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100607741  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100586647  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100582751  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100588160  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100603387  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100595943  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100594080  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100597876  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100592170  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100600059  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100598020  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
100595369  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
100600225  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100580599  MAPK11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
100581677  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100605285  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100602081  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
100600218  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
100603005  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100605408  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
100587142  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100582833  SCN1A; sodium channel protein type 1 subunit alpha isoform X3 [KO:K04833]
100580437  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100600997  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100602682  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100584807  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100600637  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
100601844  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
100595119  KCNJ9; G protein-activated inward rectifier potassium channel 3 isoform X1 [KO:K05002]
100581187  KCNJ5; G protein-activated inward rectifier potassium channel 4 isoform X1 [KO:K04999]
100594342  DRD3; D(3) dopamine receptor isoform X1 [KO:K04146]
100605969  DRD4; D(4) dopamine receptor [KO:K04147]
100588993  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100583621  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
100604896  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2 [KO:K04630]
100599912  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100583137  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100590367  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
100596905  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100589215  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100594371  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
100579945  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100579986  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100591313  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100586578  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115837666  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115830866  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
115833531  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
115834702  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
100581702  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100593358  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100584569  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115836971  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
115831194  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
115834220  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100592009  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
115833576  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100589985  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
100598721  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
100599882  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100596525  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100585393  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100605248  PPP2R1B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
100598916  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100584267  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
100585667  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100583131  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X5 [KO:K04354]
100583311  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
100597427  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100600043  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
115833850  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
100592661  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
100602668  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
100605694  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100600164  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
100600883  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
100604331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587864  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587109  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100601486  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
100606885  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100584731  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100594244  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100604936  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
100587219  GRIA2; glutamate receptor 2 isoform X4 [KO:K05198]
100596839  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
100590437  GRIA4; glutamate receptor 4 isoform X3 [KO:K05200]
100589788  KIF5B; kinesin-1 heavy chain [KO:K10396]
100579859  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100591941  KIF5C; kinesin heavy chain [KO:K10396]
100606130  CLOCK; circadian locomoter output cycles protein kaput isoform X1 [KO:K02223] [EC:2.3.1.48]
100601785  ARNTL; aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1 [KO:K02296]
100596846  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
100589976  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
100590311  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
100593311  COMT; catechol O-methyltransferase isoform X1 [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
nle00350  Tyrosine metabolism
nle04020  Calcium signaling pathway
nle04721  Synaptic vesicle cycle
nle04724  Glutamatergic synapse
nle05012  Parkinson disease
KO pathway
ko04728   
LinkDB

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