KEGG   PATHWAY: nsu05225
Entry
nsu05225                    Pathway                                
Name
Hepatocellular carcinoma - Neomonachus schauinslandi (Hawaiian monk seal)
Description
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class
Human Diseases; Cancer: specific types
Pathway map
nsu05225  Hepatocellular carcinoma
nsu05225

Organism
Neomonachus schauinslandi (Hawaiian monk seal) [GN:nsu]
Gene
110588715  TGFA; protransforming growth factor alpha [KO:K08774]
110592687  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110576079  IGF2; insulin-like growth factor II [KO:K13769]
110572370  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
110579324  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
110593864  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
110570410  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110577506  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
110573626  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110571415  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
110573574  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
110594105  SHC2; SHC-transforming protein 2 [KO:K17447]
110584374  SHC3; SHC-transforming protein 3 [KO:K17448]
110584023  SHC4; SHC-transforming protein 4 [KO:K17449]
110572604  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
110590530  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110587156  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110582206  HRAS; GTPase HRas isoform X1 [KO:K02833]
123323805  GTPase HRas-like [KO:K02833]
110580861  KRAS; GTPase KRas isoform X1 [KO:K07827]
110580342  NRAS; GTPase NRas [KO:K07828]
110571460  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
110582758  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
110584928  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110584045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110593734  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110589825  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110578336  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110575119  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110582352  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110570825  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110574558  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110575009  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110591287  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110574156  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110590250  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110571694  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110575132  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
110576039  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
110592787  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110575945  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110579449  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
110578930  MYC; myc proto-oncogene protein [KO:K04377]
110579773  RB1; retinoblastoma-associated protein [KO:K06618]
110579642  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
110574749  E2F2; transcription factor E2F2 [KO:K09389]
110586656  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
110577700  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
110584444  TP53; cellular tumor antigen p53 [KO:K04451]
110575681  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
110584301  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
110571814  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
110593844  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [KO:K04402]
110572854  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
110575593  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
110575769  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
110587463  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
110572649  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
110577858  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110579972  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
110576391  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110590084  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
110588122  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
110571461  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
110581718  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110570864  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110583310  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110577095  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
110583782  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
110577109  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
110593633  WNT1; proto-oncogene Wnt-1 [KO:K03209]
110580388  WNT2B; protein Wnt-2b [KO:K00182]
110588994  WNT2; protein Wnt-2 [KO:K00182]
110570451  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
110575377  WNT4; protein Wnt-4 [KO:K00408]
110580933  WNT5B; protein Wnt-5b [KO:K00444]
110584850  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
110592208  WNT6; protein Wnt-6 [KO:K00445]
110584915  WNT7A; protein Wnt-7a [KO:K00572]
110578288  WNT7B; protein Wnt-7b [KO:K00572]
110589521  WNT8B; protein Wnt-8b [KO:K00714]
110591217  WNT8A; protein Wnt-8a [KO:K00714]
110584597  WNT9A; protein Wnt-9a [KO:K01064]
110570486  WNT9B; protein Wnt-9b [KO:K01064]
110591938  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
110593622  WNT10B; protein Wnt-10b [KO:K01357]
110593438  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
110588989  WNT16; protein Wnt-16 [KO:K01558]
110579969  FZD1; frizzled-1 [KO:K02432]
110591883  FZD7; frizzled-7 [KO:K02432]
110573184  FZD2; frizzled-2 [KO:K02235]
110588518  FZD3; frizzled-3 [KO:K02329]
110577197  FZD4; frizzled-4 [KO:K02354]
110578691  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
110592244  FZD5; frizzled-5 [KO:K02375]
110578752  FZD6; frizzled-6 isoform X1 [KO:K02376]
110588325  FZD10; frizzled-10 [KO:K02842]
110589803  FZD9; frizzled-9 [KO:K02842]
110580851  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
110576209  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
110575099  DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
110582453  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
110584453  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
123325104  proto-oncogene FRAT1-like [KO:K03069]
110582720  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110587966  AXIN1; axin-1 isoform X1 [KO:K02157]
110570475  AXIN2; axin-2 isoform X1 [KO:K04385]
110590627  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
110593901  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
110569652  CTNNB1; catenin beta-1 [KO:K02105]
110590044  CSNK1A1; casein kinase I isoform X4 [KO:K08957] [EC:2.7.11.1]
110590995  TCF7; transcription factor 7 isoform X1 [KO:K02620]
110587588  TCF7L1; transcription factor 7-like 1 [KO:K04490]
110589494  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
110575521  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
110593664  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
110592399  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
110578095  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
110594226  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
110580326  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
110580360  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
110588128  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
110580843  MGST1; microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
110589698  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
110589699  glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
110582041  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
110582203  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
110582011  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
110571225  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
110573775  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
110578389  glutathione S-transferase theta-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
110578390  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
110578391  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
110578394  LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
110582361  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
110576049  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
110576050  LOW QUALITY PROTEIN: glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
110571000  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
110570615  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
110584841  TXNRD3; thioredoxin reductase 3 isoform X1 [KO:K22182] [EC:1.8.1.9]
110581139  TXNRD2; thioredoxin reductase 2, mitochondrial [KO:K22182] [EC:1.8.1.9]
110577903  TXNRD1; thioredoxin reductase 1, cytoplasmic isoform X1 [KO:K22182] [EC:1.8.1.9]
110580160  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
110588887  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110571268  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
110572001  ACTB; actin, cytoplasmic 1 [KO:K05692]
110572558  ACTG1; actin, cytoplasmic 2 [KO:K05692]
110582325  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
110571880  ACTL6B; actin-like protein 6B [KO:K11652]
110582856  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
110570463  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
110593652  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
110583694  PHF10; PHD finger protein 10 [KO:K22197]
110590271  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
110571427  DPF3; LOW QUALITY PROTEIN: zinc finger protein DPF3 [KO:K22198]
110575190  ARID1A; LOW QUALITY PROTEIN: AT-rich interactive domain-containing protein 1A [KO:K11653]
110583450  ARID1B; AT-rich interactive domain-containing protein 1B [KO:K11653]
123326181  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-like [KO:K11651]
110592783  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
110578397  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
110577790  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
110577578  SMARCC1; SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
110584333  SMARCA2; probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
110593821  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
110593597  ARID2; AT-rich interactive domain-containing protein 2 [KO:K11765]
110584992  PBRM1; protein polybromo-1 isoform X1 [KO:K11757]
110593499  BRD7; bromodomain-containing protein 7 [KO:K11723]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06793  Vinyl chloride
C06800  Aflatoxin B1
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:26099527
  Authors
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
  Title
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
  Journal
Gastroenterology 149:1226-1239.e4 (2015)
DOI:10.1053/j.gastro.2015.05.061
Reference
PMID:17295177
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:19387255
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
PMID:21829020
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
Reference
PMID:23994386
  Authors
Nault JC, Zucman-Rossi J
  Title
Genetics of hepatocellular carcinoma: the next generation.
  Journal
J Hepatol 60:224-6 (2014)
DOI:10.1016/j.jhep.2013.08.019
Reference
PMID:11935086
  Authors
Rocken C, Carl-McGrath S.
  Title
Pathology and pathogenesis of hepatocellular carcinoma.
  Journal
Dig Dis 19:269-78 (2001)
DOI:10.1159/000050693
Reference
PMID:21303380
  Authors
Cornella H, Alsinet C, Villanueva A
  Title
Molecular pathogenesis of hepatocellular carcinoma.
  Journal
Alcohol Clin Exp Res 35:821-5 (2011)
DOI:10.1111/j.1530-0277.2010.01406.x
Reference
PMID:27895396
  Authors
Niu ZS, Niu XJ, Wang WH
  Title
Genetic alterations in hepatocellular carcinoma: An update.
  Journal
World J Gastroenterol 22:9069-9095 (2016)
DOI:10.3748/wjg.v22.i41.9069
Reference
PMID:11956813
  Authors
Tannapfel A, Wittekind C
  Title
Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
  Journal
Virchows Arch 440:345-52 (2002)
DOI:10.1007/s00428-002-0617-x
Reference
PMID:23426905
  Authors
Shiraha H, Yamamoto K, Namba M
  Title
Human hepatocyte carcinogenesis (review).
  Journal
Int J Oncol 42:1133-8 (2013)
DOI:10.3892/ijo.2013.1829
Reference
PMID:23887712
  Authors
Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
  Title
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
  Journal
Nat Commun 4:2218 (2013)
DOI:10.1038/ncomms3218
Reference
PMID:22561517
  Authors
Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
  Title
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
  Journal
Nat Genet 44:694-8 (2012)
DOI:10.1038/ng.2256
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Curr Opin Toxicol 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
Reference
PMID:24024136
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
PMID:21251164
  Authors
Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
PMID:20019356
  Authors
Klaunig JE, Kamendulis LM, Hocevar BA
  Title
Oxidative stress and oxidative damage in carcinogenesis.
  Journal
Toxicol Pathol 38:96-109 (2010)
DOI:10.1177/0192623309356453
Reference
PMID:11193292
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
PMID:27323951
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
PMID:27029895
  Authors
Shay JW
  Title
Role of Telomeres and Telomerase in Aging and Cancer.
  Journal
Cancer Discov 6:584-93 (2016)
DOI:10.1158/2159-8290.CD-16-0062
Reference
PMID:27508192
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
PMID:16934487
  Authors
Vita M, Henriksson M
  Title
The Myc oncoprotein as a therapeutic target for human cancer.
  Journal
Semin Cancer Biol 16:318-30 (2006)
DOI:10.1016/j.semcancer.2006.07.015
Reference
PMID:24096051
  Authors
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
  Title
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
  Journal
J Hepatol 60:331-8 (2014)
DOI:10.1016/j.jhep.2013.09.024
Related
pathway
nsu04010  MAPK signaling pathway
nsu04020  Calcium signaling pathway
nsu04110  Cell cycle
nsu04115  p53 signaling pathway
nsu04151  PI3K-Akt signaling pathway
nsu04310  Wnt signaling pathway
nsu04350  TGF-beta signaling pathway
nsu04932  Non-alcoholic fatty liver disease
nsu04936  Alcoholic liver disease
nsu05160  Hepatitis C
nsu05161  Hepatitis B
KO pathway
ko05225   
LinkDB

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