KEGG   PATHWAY: oas04814
Entry
oas04814                    Pathway                                
Name
Motor proteins - Ovis aries (sheep)
Class
Cellular Processes; Cell motility
Pathway map
oas04814  Motor proteins
oas04814

Organism
Ovis aries (sheep) [GN:oas]
Gene
101102427  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
101118215  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
101115433  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X5 [KO:K10415]
101118013  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X10 [KO:K10415]
101108246  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
101112428  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
101114180  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X3 [KO:K10417]
101121274  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
101102461  dynein light chain 1, cytoplasmic-like [KO:K10418]
101106977  dynein light chain 1, cytoplasmic-like [KO:K10418]
101118902  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
114113093  dynein light chain 1, cytoplasmic-like [KO:K10418]
101112751  DYNLRB1; dynein light chain roadblock-type 1 isoform X3 [KO:K10419]
101120685  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
443256  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
101110149  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
106990126  DYNLT2; dynein light chain Tctex-type protein 2 [KO:K25419]
105607910  DYNLT4; dynein light chain Tctex-type 4 [KO:K25420]
101113023  DYNLT5; dynein light chain Tctex-type 5 [KO:K25421]
101119280  DNAH7; dynein axonemal heavy chain 7 isoform X1 [KO:K10408]
101104179  DNAH5; dynein axonemal heavy chain 5 isoform X2 [KO:K10408]
101122589  DNAH6; dynein axonemal heavy chain 6 isoform X1 [KO:K10408]
101114286  DNAH9; dynein axonemal heavy chain 9 isoform X1 [KO:K10408]
101120490  DNAH11; dynein axonemal heavy chain 11 isoform X2 [KO:K10408]
101108960  DNAH12; dynein axonemal heavy chain 12 isoform X1 [KO:K10408]
101105194  DNAH8; dynein axonemal heavy chain 8 [KO:K10408]
101121295  DNAH10; dynein axonemal heavy chain 10 [KO:K10408]
101113255  DNAH17; dynein axonemal heavy chain 17 [KO:K10408]
101104330  DNAH14; dynein axonemal heavy chain 14 [KO:K10408]
101113559  DNAH3; dynein axonemal heavy chain 3 isoform X1 [KO:K10408]
101104254  DNAH2; dynein axonemal heavy chain 2 [KO:K10408]
101112094  DNAH1; dynein axonemal heavy chain 1 [KO:K10408]
101122250  DNAI1; dynein axonemal intermediate chain 1 isoform X2 [KO:K10409]
101113084  DNAI2; dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
101112532  DNAI3; dynein axonemal intermediate chain 3 [KO:K24722]
101113544  DNAI4; LOW QUALITY PROTEIN: dynein axonemal intermediate chain 4 [KO:K24723]
101114567  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
101104495  DNAL1; dynein axonemal light chain 1 [KO:K10411]
101106580  DNAL4; dynein axonemal light chain 4 [KO:K10412]
101116037  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
101119807  DCTN2; dynactin subunit 2 isoform X3 [KO:K10424]
101103473  DCTN4; dynactin subunit 4 isoform X2 [KO:K10426]
101105464  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
101104551  DCTN6; dynactin subunit 6 [KO:K10428]
101108440  ACTR1A; alpha-centractin [KO:K16575]
101112894  ACTR1B; beta-centractin isoform X1 [KO:K16575]
101115545  ACTR10; actin-related protein 10 [KO:K16576]
101117461  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
101122590  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
101109168  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
101121938  F-actin-capping protein subunit alpha-2-like [KO:K10364]
101108893  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
101118239  BICDL2; BICD family-like cargo adapter 2 isoform X2 [KO:K16756]
101116936  BICDL1; BICD family-like cargo adapter 1 isoform X2 [KO:K16756]
101123347  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
100302357  TUBA4A; tubulin alpha-4A chain [KO:K07374]
101116286  tubulin alpha-1D chain [KO:K07374]
101118307  tubulin alpha-3 chain isoform X1 [KO:K07374]
101108295  LOW QUALITY PROTEIN: tubulin alpha-3 chain [KO:K07374]
101120326  tubulin alpha-1B chain [KO:K07374]
101107301  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
101118605  TUBA8; tubulin alpha-8 chain [KO:K07374]
114113987  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
105614728  tubulin alpha-1C chain isoform X1 [KO:K07374]
106990101  tubulin alpha-1B chain isoform X1 [KO:K07374]
101119975  tubulin alpha-1A chain isoform X1 [KO:K07374]
101115144  TUBB1; tubulin beta-1 chain [KO:K07375]
101122734  tubulin beta-2A chain [KO:K07375]
101106224  TUBB6; tubulin beta-6 chain [KO:K07375]
101109608  TUBB4B; tubulin beta-4B chain [KO:K07375]
105609865  TUBB4A; tubulin beta-4A chain [KO:K07375]
100303606  TUBB; tubulin beta chain [KO:K07375]
101122475  TUBB2B; tubulin beta-2B chain [KO:K07375]
101111036  tubulin gamma-2 chain [KO:K10389]
101103906  TUBG1; tubulin gamma-1 chain [KO:K10389]
101106182  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
101108660  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
101119383  KIF5A; kinesin heavy chain isoform X2 [KO:K10396]
101113663  KIF5C; kinesin heavy chain [KO:K10396]
100037703  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
101116082  KLC3; kinesin light chain 3 [KO:K10407]
101104701  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
101102677  KLC1; kinesin light chain 1 isoform X3 [KO:K10407]
101113441  KLC4; kinesin light chain 4 isoform X2 [KO:K10407]
101122522  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
101104261  KIF3B; kinesin-like protein KIF3B [KO:K20196]
101102827  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
101109434  KIF3C; kinesin-like protein KIF3C [KO:K20197]
101101877  KIF17; kinesin-like protein KIF17 isoform X1 [KO:K20198]
101115220  KIF1B; kinesin-like protein KIF1B isoform X20 [KO:K10392]
101107535  KIF1C; kinesin-like protein KIF1C [KO:K10392]
101103691  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
101112010  KIF13A; kinesin-like protein KIF13A isoform X3 [KO:K17914]
101109076  KIF13B; kinesin-like protein KIF13B isoform X1 [KO:K17914]
101107720  KIF14; kinesin-like protein KIF14 [KO:K17915]
101111986  KIF16B; kinesin-like protein KIF16B isoform X6 [KO:K17916]
101117936  STARD9; stAR-related lipid transfer protein 9 isoform X2 [KO:K16491]
101123442  KIF4A; chromosome-associated kinesin KIF4A [KO:K10395]
101103926  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
101108506  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
101119971  KIF21A; kinesin-like protein KIF21A isoform X1 [KO:K24185]
101118416  KIF27; kinesin-like protein KIF27 isoform X1 [KO:K24186]
101102946  KIF11; LOW QUALITY PROTEIN: kinesin-like protein KIF11 [KO:K10398]
101122564  KIF20B; kinesin-like protein KIF20B isoform X4 [KO:K10402]
101109352  KIF20A; kinesin-like protein KIF20A [KO:K10402]
101114023  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
101105752  CENPE; centromere-associated protein E isoform X9 [KO:K11498]
101117696  KIF18A; kinesin-like protein KIF18A [KO:K10401]
101118461  KIF18B; kinesin-like protein KIF18B isoform X1 [KO:K26156]
101106188  KIF19; kinesin-like protein KIF19 isoform X3 [KO:K26157]
101112623  kinesin-like protein KIF19 [KO:K26157]
101113963  KIF9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
101106209  KIF6; kinesin-like protein KIF6 isoform X2 [KO:K10397]
101120211  KIF22; kinesin-like protein KIF22 [KO:K10403]
101106609  KIF26B; kinesin-like protein KIF26B isoform X1 [KO:K10404]
106991730  KIF26A; kinesin-like protein KIF26A [KO:K10404]
101119620  KIF12; kinesin-like protein KIF12 isoform X2 [KO:K10399]
101121554  KIF15; kinesin-like protein KIF15 isoform X3 [KO:K10400]
101117942  KIF2B; kinesin-like protein KIF2B [KO:K10393]
101117203  KIF2C; kinesin-like protein KIF2C isoform X2 [KO:K10393]
101123527  KIF24; kinesin-like protein KIF24 isoform X1 [KO:K10393]
101107307  KIF2A; kinesin-like protein KIF2A isoform X2 [KO:K10393]
101113367  KIFC1; kinesin-like protein KIFC1 isoform X5 [KO:K10405]
101103342  KIFC3; kinesin-like protein KIFC3 isoform X6 [KO:K10406]
101107533  KIFC2; kinesin-like protein KIFC2 isoform X1 [KO:K10406]
101117822  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
101115463  MYO1E; unconventional myosin-Ie isoform X2 [KO:K10356]
101102890  MYO1A; unconventional myosin-Ia [KO:K10356]
101102997  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
101115139  MYO1D; unconventional myosin-Id [KO:K10356]
101114605  MYO1G; unconventional myosin-Ig [KO:K10356]
101104826  MYO1F; unconventional myosin-If [KO:K10356]
101114559  MYO1H; unconventional myosin-Ih [KO:K10356]
101114632  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
101118079  MYO3B; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
101105758  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
101106017  MYO5C; unconventional myosin-Vc isoform X1 [KO:K10357]
101112182  MYO5B; unconventional myosin-Vb isoform X1 [KO:K10357]
101110599  MYO6; unconventional myosin-VI [KO:K10358]
101113697  MYO7A; unconventional myosin-VIIa isoform X4 [KO:K10359]
101118339  MYO7B; unconventional myosin-VIIb isoform X1 [KO:K21868]
101108657  MYO9A; unconventional myosin-IXa isoform X1 [KO:K10360]
101115874  MYO9B; unconventional myosin-IXb isoform X5 [KO:K10360]
101102178  MYO10; unconventional myosin-X isoform X2 [KO:K12559]
101111380  MYO15A; unconventional myosin-XV [KO:K10361]
101120179  MYO15B; myosin XVB [KO:K10361]
101115289  MYO16; unconventional myosin-XVI [KO:K17481]
101121529  MYO18A; unconventional myosin-XVIIIa isoform X2 [KO:K10362]
101117620  MYO18B; unconventional myosin-XVIIIb isoform X1 [KO:K10362]
101109982  MYO19; unconventional myosin-XIX isoform X1 [KO:K25838]
442994  MYH1; myosin-1 [KO:K24220]
101111723  MYH8; myosin-8 [KO:K24220]
443471  MYH2; myosin-2 [KO:K24220]
101113252  myosin-3 [KO:K24220]
101119327  MYH7B; myosin-7B isoform X3 [KO:K24220]
101111932  MYH15; myosin-15 isoform X1 [KO:K24220]
101111980  myosin-4 [KO:K24220]
101103165  MYH13; myosin-13 [KO:K24220]
442995  myosin-7 [KO:K17751]
101120580  myosin-6 [KO:K17751]
101108844  MYH10; myosin-10 isoform X1 [KO:K10352]
101114409  MYH11; myosin-11 isoform X1 [KO:K10352]
101115985  MYH14; myosin-14 isoform X1 [KO:K10352]
101106321  MYH9; myosin-9 [KO:K10352]
101101869  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X2 [KO:K05738]
101115408  MYL3; myosin light chain 3 isoform X2 [KO:K12749]
101121691  MYL4; myosin light chain 4 isoform X2 [KO:K12750]
101110925  MYL6B; myosin light chain 6B [KO:K12751]
100135445  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
100196904  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101117156  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
101121534  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101118074  MYL10; myosin regulatory light chain 10 isoform X2 [KO:K12756]
101105123  myosin regulatory light chain 12B [KO:K12757]
100270714  MRCL3; myosin regulatory light chain MRCL3 [KO:K12757]
101118735  myosin regulatory light polypeptide 9-like [KO:K12757]
100270715  MYL11; myosin regulatory light chain 11 [KO:K12758]
101107662  ACTA1; actin, alpha skeletal muscle [KO:K10354]
101121051  ACTA2; actin, aortic smooth muscle [KO:K12313]
101111554  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
101114256  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
443340  ACTG1; actin, cytoplasmic 2 [KO:K05692]
443052  ACTB; actin, cytoplasmic 1 [KO:K05692]
101111132  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101112151  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
101122212  TNNT1; troponin T, slow skeletal muscle isoform X2 [KO:K10372]
100127216  TNNC2; troponin C, skeletal muscle [KO:K12042]
101121135  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
101104467  TNNT3; troponin T, fast skeletal muscle isoform X8 [KO:K12046]
101121961  TNNI3; troponin I, cardiac muscle [KO:K12044]
105610024  TNNT2; troponin T, cardiac muscle [KO:K12045]
100145865  TPM1; tropomyosin alpha-1 chain [KO:K10373]
101114931  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
101118433  tropomyosin alpha-3 chain isoform X2 [KO:K09290]
101108973  TPM3; tropomyosin alpha-3 chain isoform X5 [KO:K09290]
114114091  tropomyosin alpha-3 chain-like [KO:K09290]
101117499  TPM4; tropomyosin alpha-4 chain isoform X3 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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