KEGG   PATHWAY: opi05225
Entry
opi05225                    Pathway                                
Name
Hepatocellular carcinoma - Ochotona princeps (American pika)
Description
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class
Human Diseases; Cancer: specific types
Pathway map
opi05225  Hepatocellular carcinoma
opi05225

Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101534278  IGF2; insulin-like growth factor II [KO:K13769]
101535483  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101520175  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101526399  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101523549  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101523439  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101534827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101530378  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101529134  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
101522080  SHC2; SHC-transforming protein 2 [KO:K17447]
101522287  SHC3; SHC-transforming protein 3 [KO:K17448]
101535980  SHC4; SHC-transforming protein 4 [KO:K17449]
101531037  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101534610  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101525349  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101531636  HRAS; GTPase HRas [KO:K02833]
101534080  KRAS; GTPase KRas isoform X1 [KO:K07827]
101524465  NRAS; GTPase NRas [KO:K07828]
101529871  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101526188  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
101534290  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101533612  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105942099  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
101529486  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101530701  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101525427  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101519449  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101533851  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101533024  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101532354  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101517982  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101528030  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101529935  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101525384  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101526118  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101528246  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101534340  BAD; bcl2-associated agonist of cell death [KO:K02158]
101518143  BCL2L1; bcl-2-like protein 1 [KO:K04570]
101522285  MYC; myc proto-oncogene protein [KO:K04377]
101517612  RB1; retinoblastoma-associated protein [KO:K06618]
101529862  E2F1; transcription factor E2F1 [KO:K17454]
101528728  E2F2; transcription factor E2F2 [KO:K09389]
101536117  E2F3; transcription factor E2F3 [KO:K06620]
101516388  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
101528346  TP53; cellular tumor antigen p53 [KO:K04451]
101522490  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101516300  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101519285  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
101521693  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101517703  BAX; apoptosis regulator BAX [KO:K02159]
101516199  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101527969  DDB2; DNA damage-binding protein 2 [KO:K10140]
101528874  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
101531644  cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
101530437  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101530682  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101531631  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
101533379  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101529904  transforming growth factor beta-1 proprotein-like [KO:K13375]
101516556  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
101525102  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101533160  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101534968  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
101529841  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
101532983  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101525575  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
101526533  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101519545  WNT2; protein Wnt-2 [KO:K00182]
101535993  WNT2B; protein Wnt-2b [KO:K00182]
101531097  WNT3A; protein Wnt-3a [KO:K00312]
101519718  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101532229  WNT4; protein Wnt-4 [KO:K00408]
101533147  WNT5B; protein Wnt-5b [KO:K00444]
101526139  WNT5A; protein Wnt-5a [KO:K00444]
101518428  WNT6; protein Wnt-6 [KO:K00445]
101525411  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
101527317  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
101535038  WNT8A; protein Wnt-8a [KO:K00714]
101530831  WNT8B; protein Wnt-8b [KO:K00714]
101535462  WNT9A; protein Wnt-9a [KO:K01064]
101519468  WNT9B; protein Wnt-9b [KO:K01064]
101526780  WNT10B; protein Wnt-10b [KO:K01357]
101518185  WNT10A; protein Wnt-10a [KO:K01357]
101530628  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
101521646  WNT16; protein Wnt-16 [KO:K01558]
101528861  FZD1; frizzled-1 [KO:K02432]
101519819  FZD7; frizzled-7 [KO:K02432]
101520542  FZD2; frizzled-2 [KO:K02235]
101528374  FZD3; frizzled-3 [KO:K02329]
101518239  FZD4; frizzled-4 [KO:K02354]
101532093  FZD5; frizzled-5 [KO:K02375]
101517741  FZD8; frizzled-8 [KO:K02375]
101524151  FZD6; frizzled-6 [KO:K02376]
101519524  FZD9; frizzled-9 [KO:K02842]
101520287  FZD10; frizzled-10 [KO:K02842]
101517031  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101517587  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
101522688  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
101528918  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
101516456  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
101520075  FRAT1; proto-oncogene FRAT1 [KO:K03069]
101533693  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101533051  AXIN1; axin-1 isoform X1 [KO:K02157]
101522655  AXIN2; axin-2 isoform X1 [KO:K04385]
101516222  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
101526321  APC; adenomatous polyposis coli protein [KO:K02085]
101528934  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101535269  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101516751  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101520021  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101532141  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101519529  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101530782  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101530428  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101516511  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101519787  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101522229  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101518228  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
101534687  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101526730  TCF7; transcription factor 7 isoform X2 [KO:K02620]
101522406  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101521047  TCF7L2; transcription factor 7-like 2 isoform X4 [KO:K04491]
101525298  LEF1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492]
101521346  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
101522597  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
101516673  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
101517642  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
101522707  glutathione S-transferase Mu 3 isoform X2 [KO:K00799] [EC:2.5.1.18]
101522940  glutathione S-transferase Mu 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
101523672  glutathione S-transferase Mu 2-like isoform X4 [KO:K00799] [EC:2.5.1.18]
101524307  glutathione S-transferase Mu 1 isoform X3 [KO:K00799] [EC:2.5.1.18]
101532277  glutathione S-transferase Mu 1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
101532518  glutathione S-transferase Mu 1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
101520678  glutathione S-transferase alpha I-like [KO:K00799] [EC:2.5.1.18]
101531637  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101531866  glutathione S-transferase alpha I [KO:K00799] [EC:2.5.1.18]
101532588  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
101533070  glutathione S-transferase A6-like [KO:K00799] [EC:2.5.1.18]
101531950  glutathione S-transferase Yc-like [KO:K00799] [EC:2.5.1.18]
101531527  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
101531328  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
105941642  glutathione S-transferase Mu 2-like isoform X3 [KO:K00799] [EC:2.5.1.18]
101527080  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101534648  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
101531952  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101531717  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
101516998  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
101524017  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101536139  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
101521251  TXNRD2; thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
101524181  TXNRD1; thioredoxin reductase 1, cytoplasmic [KO:K22182] [EC:1.8.1.9]
101520978  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
101536351  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101535058  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101535368  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
101525072  ACTB; actin, cytoplasmic 1 [KO:K05692]
101518086  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101518318  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
101529370  ACTL6B; actin-like protein 6B [KO:K11652]
101517872  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
101536701  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
101530733  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
101523395  PHF10; PHD finger protein 10 isoform X2 [KO:K22197]
101534613  DPF3; zinc finger protein DPF3 isoform X1 [KO:K22198]
101516458  DPF1; zinc finger protein neuro-d4 isoform X3 [KO:K22198]
101518008  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
101527927  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
101531149  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
101530636  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
101531723  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
101519290  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
101526342  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
101516138  SMARCA4; transcription activator BRG1 [KO:K11647] [EC:5.6.2.-]
101525472  ARID2; AT-rich interactive domain-containing protein 2 [KO:K11765]
101521214  PBRM1; protein polybromo-1 isoform X1 [KO:K11757]
101519678  BRD7; bromodomain-containing protein 7 [KO:K11723]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06793  Vinyl chloride
C06800  Aflatoxin B1
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:26099527
  Authors
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
  Title
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
  Journal
Gastroenterology 149:1226-1239.e4 (2015)
DOI:10.1053/j.gastro.2015.05.061
Reference
PMID:17295177
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Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
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Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
PMID:16799620
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Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
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Oncogene 25:3787-800 (2006)
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Reference
PMID:19387255
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Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
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Pathogenesis of hepatocellular carcinoma and molecular therapies.
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Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
PMID:21829020
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Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
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Dig Dis 29:289-302 (2011)
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Reference
PMID:23994386
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Nault JC, Zucman-Rossi J
  Title
Genetics of hepatocellular carcinoma: the next generation.
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J Hepatol 60:224-6 (2014)
DOI:10.1016/j.jhep.2013.08.019
Reference
PMID:11935086
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Rocken C, Carl-McGrath S.
  Title
Pathology and pathogenesis of hepatocellular carcinoma.
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Dig Dis 19:269-78 (2001)
DOI:10.1159/000050693
Reference
PMID:21303380
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Cornella H, Alsinet C, Villanueva A
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Molecular pathogenesis of hepatocellular carcinoma.
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Alcohol Clin Exp Res 35:821-5 (2011)
DOI:10.1111/j.1530-0277.2010.01406.x
Reference
PMID:27895396
  Authors
Niu ZS, Niu XJ, Wang WH
  Title
Genetic alterations in hepatocellular carcinoma: An update.
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World J Gastroenterol 22:9069-9095 (2016)
DOI:10.3748/wjg.v22.i41.9069
Reference
PMID:11956813
  Authors
Tannapfel A, Wittekind C
  Title
Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
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Virchows Arch 440:345-52 (2002)
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Reference
PMID:23426905
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Shiraha H, Yamamoto K, Namba M
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Human hepatocyte carcinogenesis (review).
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Int J Oncol 42:1133-8 (2013)
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Reference
PMID:23887712
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Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
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High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
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Nat Commun 4:2218 (2013)
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Reference
PMID:22561517
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Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
  Title
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
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Nat Genet 44:694-8 (2012)
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Reference
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Praslicka BJ, Kerins MJ, Ooi A
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The complex role of NRF2 in cancer: a genomic view
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Curr Opin Toxicol 1:37-45 (2016)
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Reference
PMID:24024136
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Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
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Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
PMID:21251164
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Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
PMID:20019356
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Klaunig JE, Kamendulis LM, Hocevar BA
  Title
Oxidative stress and oxidative damage in carcinogenesis.
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Toxicol Pathol 38:96-109 (2010)
DOI:10.1177/0192623309356453
Reference
PMID:11193292
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Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
PMID:27323951
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
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Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
PMID:27029895
  Authors
Shay JW
  Title
Role of Telomeres and Telomerase in Aging and Cancer.
  Journal
Cancer Discov 6:584-93 (2016)
DOI:10.1158/2159-8290.CD-16-0062
Reference
PMID:27508192
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
PMID:16934487
  Authors
Vita M, Henriksson M
  Title
The Myc oncoprotein as a therapeutic target for human cancer.
  Journal
Semin Cancer Biol 16:318-30 (2006)
DOI:10.1016/j.semcancer.2006.07.015
Reference
PMID:24096051
  Authors
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
  Title
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
  Journal
J Hepatol 60:331-8 (2014)
DOI:10.1016/j.jhep.2013.09.024
Related
pathway
opi04010  MAPK signaling pathway
opi04020  Calcium signaling pathway
opi04110  Cell cycle
opi04115  p53 signaling pathway
opi04151  PI3K-Akt signaling pathway
opi04310  Wnt signaling pathway
opi04350  TGF-beta signaling pathway
opi04932  Non-alcoholic fatty liver disease
opi04936  Alcoholic liver disease
opi05160  Hepatitis C
opi05161  Hepatitis B
KO pathway
ko05225   
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