KEGG   PATHWAY: pale04310
Entry
pale04310                   Pathway                                
Name
Wnt signaling pathway - Pteropus alecto (black flying fox)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
pale04310  Wnt signaling pathway
pale04310

Other DBs
GO: 0016055
Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102890685  PORCN; protein-serine O-palmitoleoyltransferase porcupine isoform X1 [KO:K00181] [EC:2.3.1.250]
102888016  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102880959  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
102885080  WNT2; protein Wnt-2 [KO:K00182]
102895795  WNT3A; protein Wnt-3a [KO:K00312]
102877979  WNT3; proto-oncogene Wnt-3 [KO:K00312]
102888866  WNT4; protein Wnt-4 [KO:K00408]
102890342  WNT5A; protein Wnt-5a isoform X5 [KO:K00444]
102881682  WNT5B; protein Wnt-5b isoform X2 [KO:K00444]
102882368  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
102888597  WNT7A; protein Wnt-7a [KO:K00572]
102898026  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
102896480  WNT8A; protein Wnt-8a [KO:K00714]
102878209  WNT8B; protein Wnt-8b [KO:K00714]
102885223  protein Wnt-9b [KO:K01064]
102884543  WNT9A; protein Wnt-9a [KO:K01064]
102882121  WNT10A; protein Wnt-10a [KO:K01357]
102888263  WNT10B; protein Wnt-10b [KO:K01357]
102877879  WNT11; protein Wnt-11 [KO:K01384]
102882050  WNT16; LOW QUALITY PROTEIN: protein Wnt-16 [KO:K01558]
102884178  CER1; cerberus [KO:K01645]
102888165  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
102880126  WIF1; wnt inhibitory factor 1 [KO:K01691]
102884991  SOST; sclerostin [KO:K16834]
102885148  DKK1; dickkopf-related protein 1 [KO:K02165]
102885949  DKK2; dickkopf-related protein 2 [KO:K02165]
102892774  DKK4; dickkopf-related protein 4 [KO:K02165]
102889116  SERPINF1; pigment epithelium-derived factor [KO:K19614]
102877912  SFRP1; secreted frizzled-related protein 1 [KO:K02166]
102892812  SFRP2; secreted frizzled-related protein 2 [KO:K02176]
102878180  FRZB; secreted frizzled-related protein 3 [KO:K25481]
102896589  SFRP4; secreted frizzled-related protein 4 [KO:K02185]
102883884  SFRP5; secreted frizzled-related protein 5 [KO:K02222]
102896655  RSPO1; R-spondin-1 [KO:K19471]
102886430  RSPO2; LOW QUALITY PROTEIN: R-spondin-2 [KO:K23097]
102892821  RSPO3; R-spondin-3 [KO:K23098]
102888614  RSPO4; R-spondin-4 isoform X1 [KO:K23099]
102895571  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309]
102889362  LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308]
102882458  LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
102883877  RNF43; E3 ubiquitin-protein ligase RNF43 isoform X1 [KO:K15694] [EC:2.3.2.27]
102883100  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [KO:K16273] [EC:2.3.2.27]
102880538  FZD7; frizzled-7 [KO:K02432]
102895634  FZD1; frizzled-1 [KO:K02432]
102884150  FZD2; frizzled-2 [KO:K02235]
102890038  FZD3; frizzled-3 isoform X1 [KO:K02329]
102892989  FZD4; LOW QUALITY PROTEIN: frizzled-4 [KO:K02354]
102877864  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
102883426  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
102890002  FZD6; frizzled-6 [KO:K02376]
102894135  FZD10; frizzled-10 [KO:K02842]
102878169  FZD9; frizzled-9 [KO:K02842]
102894479  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
102878233  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
102896142  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
102891642  APCDD1; protein APCDD1 [KO:K25812]
102889272  APCDD1L; LOW QUALITY PROTEIN: protein APCDD1-like [KO:K25812]
102879920  CSNK1E; casein kinase I isoform X2 [KO:K08960] [EC:2.7.11.1]
102886550  CCDC88C; protein Daple [KO:K25811]
102895469  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
102880039  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
102881158  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
102896339  LOW QUALITY PROTEIN: proto-oncogene FRAT1 [KO:K03069]
102883511  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
102893812  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
102884366  CSNK2B; casein kinase II subunit beta [KO:K03115]
102881791  NKD1; protein naked cuticle homolog 1 [KO:K03213]
102883326  CXXC4; CXXC-type zinc finger protein 4 [KO:K03344]
102881618  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
102882441  GSK3B; glycogen synthase kinase-3 beta isoform X4 [KO:K03083] [EC:2.7.11.26]
102880017  CTNNB1; LOW QUALITY PROTEIN: catenin beta-1 [KO:K02105]
102878657  AXIN1; axin-1 isoform X1 [KO:K02157]
102885831  AXIN2; axin-2 [KO:K04385]
102880260  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
102891886  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
102884974  CSNK1A1; casein kinase I isoform X3 [KO:K08957] [EC:2.7.11.1]
102885788  TCF7; transcription factor 7 isoform X4 [KO:K02620]
102886093  TCF7L1; transcription factor 7-like 1 [KO:K04490]
102880370  TCF7L2; transcription factor 7-like 2 isoform X2 [KO:K04491]
102886933  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
102896497  LZTS2; leucine zipper putative tumor suppressor 2 [KO:K26471]
102889327  CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493]
102878568  CBY1; protein chibby homolog 1 isoform X1 [KO:K23402]
102883323  CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X2 [KO:K04494] [EC:5.6.2.-]
102897926  MCC; colorectal mutant cancer protein [KO:K26734]
102878607  CCAR2; cell cycle and apoptosis regulator protein 2 [KO:K25816]
102880351  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
102883268  SOX17; LOW QUALITY PROTEIN: transcription factor SOX-17 [KO:K04495]
102899024  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
102879836  CTBP2; C-terminal-binding protein 2 isoform X3 [KO:K04496] [EC:1.1.1.428]
112478148  transducin-like enhancer protein 7 [KO:K04497]
102888042  TLE2; transducin-like enhancer protein 2 isoform X1 [KO:K04497]
102881591  TLE3; transducin-like enhancer protein 3 isoform X1 [KO:K04497]
102878423  TLE4; transducin-like enhancer protein 4 isoform X1 [KO:K04497]
102894321  TLE1; transducin-like enhancer protein 1 isoform X1 [KO:K04497]
102896642  TLE6; LOW QUALITY PROTEIN: transducin-like enhancer protein 6 [KO:K04497]
102886759  CTNND2; catenin delta-2 isoform X1 [KO:K23491]
102886172  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102881042  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
102896512  RUVBL1; ruvB-like 1 isoform X1 [KO:K04499] [EC:5.6.2.4]
102886521  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
102895268  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
102882452  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102890853  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
102895524  MYC; myc proto-oncogene protein [KO:K04377]
102896121  JUN; transcription factor AP-1 [KO:K04448]
102884316  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
102885330  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102892640  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102881884  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
102898503  WISP1; WNT1-inducible-signaling pathway protein 1 [KO:K22471]
102898485  PPARD; peroxisome proliferator-activated receptor delta isoform X2 [KO:K04504]
102884900  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
102883360  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
102886679  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102877853  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102889604  TP53; cellular tumor antigen p53 [KO:K04451]
102879482  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
102880139  CACYBP; calcyclin-binding protein [KO:K04507]
102885538  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
102888322  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
102878089  TBL1X; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
102893556  FBXW11; F-box/WD repeat-containing protein 11 isoform X6 [KO:K03362]
102895058  BTRC; F-box/WD repeat-containing protein 1A isoform X3 [KO:K03362]
102887109  CUL1; cullin-1 [KO:K03347]
102893437  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
102886856  GPC4; glypican-4 [KO:K08110]
102888022  ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
102889823  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 [KO:K05123] [EC:2.7.10.1]
102882125  RYK; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
102882434  VANGL2; vang-like protein 2 [KO:K04510]
102887360  VANGL1; vang-like protein 1 [KO:K04510]
102882072  PRICKLE1; prickle-like protein 1 [KO:K04511]
102885107  PRICKLE2; prickle-like protein 2 [KO:K04511]
102882619  PRICKLE4; prickle-like protein 4 isoform X3 [KO:K04511]
102883599  PRICKLE3; prickle planar cell polarity protein 3 isoform X1 [KO:K04511]
102878310  INVS; inversin isoform X2 [KO:K19626]
102888145  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X2 [KO:K04512]
102892871  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X2 [KO:K04512]
102891515  RHOA; transforming protein RhoA [KO:K04513]
102897424  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102897644  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102885507  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102887421  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102885064  MAPK10; mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
102890689  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102892777  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102879238  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102885207  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102885781  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102885953  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102888982  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
102888385  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102880869  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
102896030  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
102880029  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102883156  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102898473  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102894471  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102895490  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102887078  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102880663  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102888961  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102880857  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102886274  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
102884312  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
102888827  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
Compound
C00076  Calcium cation
Reference
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
pale04010  MAPK signaling pathway
pale04110  Cell cycle
pale04115  p53 signaling pathway
pale04120  Ubiquitin mediated proteolysis
pale04350  TGF-beta signaling pathway
pale04510  Focal adhesion
pale04520  Adherens junction
pale05010  Alzheimer disease
KO pathway
ko04310   
LinkDB

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