KEGG   PATHWAY: panu05165
Entry
panu05165                   Pathway                                
Name
Human papillomavirus infection - Papio anubis (olive baboon)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
panu05165  Human papillomavirus infection
panu05165

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101013629  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101008897  WNT2B; protein Wnt-2b [KO:K00182]
100126674  WNT2; protein Wnt-2 precursor [KO:K00182]
101001727  WNT3; proto-oncogene Wnt-3 isoform X2 [KO:K00312]
101005424  WNT4; protein Wnt-4 [KO:K00408]
100997755  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
101019776  WNT5B; protein Wnt-5b [KO:K00444]
100997506  WNT6; protein Wnt-6 [KO:K00445]
101009898  WNT7B; protein Wnt-7b [KO:K00572]
101002180  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
101014279  WNT8A; protein Wnt-8a [KO:K00714]
101002037  WNT8B; protein Wnt-8b [KO:K00714]
100999626  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
101007522  WNT9B; protein Wnt-9b [KO:K01064]
100997855  WNT10A; protein Wnt-10a [KO:K01357]
101013252  WNT10B; protein Wnt-10b [KO:K01357]
101005798  WNT11; protein Wnt-11 [KO:K01384]
101022538  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
101015632  FZD7; frizzled-7 [KO:K02432]
100137461  FZD1; frizzled-1 [KO:K02432]
101011059  FZD2; frizzled-2 [KO:K02235]
101000744  FZD3; frizzled-3 isoform X1 [KO:K02329]
101013533  FZD4; frizzled-4 isoform X1 [KO:K02354]
101013139  FZD5; frizzled-5 [KO:K02375]
101012990  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
100999712  FZD6; frizzled-6 [KO:K02376]
101004836  FZD10; frizzled-10 [KO:K02842]
101010325  FZD9; frizzled-9 [KO:K02842]
101019485  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101007736  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X6 [KO:K02353]
101007009  DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
100998800  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101012942  AXIN2; axin-2 isoform X1 [KO:K04385]
101015820  APC; adenomatous polyposis coli protein isoform X7 [KO:K02085]
101014712  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101004678  CSNK1A1; casein kinase I isoform X6 [KO:K08957] [EC:2.7.11.1]
101008836  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
101024790  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
101024089  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
101017547  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101026705  TCF7L2; transcription factor 7-like 2 isoform X20 [KO:K04491]
101014661  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
101003041  TLR3; toll-like receptor 3 [KO:K05401]
101015106  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101015482  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101001355  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
100999858  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101013579  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101024523  IFNB1; interferon beta [KO:K05415]
101027061  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101002586  CREBBP; CREB-binding protein isoform X5 [KO:K04498] [EC:2.3.1.48]
101002766  TADA3; transcriptional adapter 3 [KO:K11315]
101006608  TP53; cellular tumor antigen p53 [KO:K04451]
101024164  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101016586  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101007578  PARD3; partitioning defective 3 homolog isoform X9 [KO:K04237]
101003483  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101019858  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
101006674  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101025097  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101020378  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101004833  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101017045  SCRIB; protein scribble homolog isoform X5 [KO:K16175]
101017325  DLG1; disks large homolog 1 isoform X23 [KO:K12076]
101003637  DLG3; disks large homolog 3 isoform X6 [KO:K21098]
101017576  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X4 [KO:K06094]
101004998  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
101005008  CRB3; protein crumbs homolog 3 [KO:K06090]
101018974  PATJ; inaD-like protein isoform X1 [KO:K06092]
101024105  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
101011576  VWF; von Willebrand factor isoform X1 [KO:K03900]
101005612  THBS1; thrombospondin-1 [KO:K16857]
101009359  THBS3; thrombospondin-3 isoform X3 [KO:K04659]
116269767  thrombospondin-3-like isoform X1 [KO:K04659]
100998149  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
101022199  COMP; cartilage oligomeric matrix protein [KO:K04659]
101005587  THBS2; thrombospondin-2 [KO:K04659]
101004025  FN1; fibronectin isoform X9 [KO:K05717]
101005809  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101004530  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
100997603  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
101000665  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
101000307  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101026688  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
101011877  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101024690  COL4A6; collagen alpha-6(IV) chain isoform X2 [KO:K06237]
101011528  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
101012673  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
101012328  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
101014591  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
101006375  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
101007269  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101019435  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101004771  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
101007358  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
101009064  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101005361  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
116272742  laminin subunit alpha-1-like isoform X1 [KO:K05637]
101024356  LAMA5; laminin subunit alpha-5 [KO:K06240]
101009063  LAMA3; laminin subunit alpha-3 isoform X5 [KO:K06240]
101002096  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
101025814  LAMB1; LOW QUALITY PROTEIN: laminin subunit beta-1 [KO:K05636]
101000787  LAMB2; laminin subunit beta-2 [KO:K06243]
101005084  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
101026514  LAMB4; laminin subunit beta-4 [KO:K06245]
101008905  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
101007972  LAMC2; laminin subunit gamma-2 [KO:K06246]
101006376  LAMC3; laminin subunit gamma-3 [KO:K06247]
101008710  CHAD; chondroadherin [KO:K06248]
101007274  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101015689  SPP1; osteopontin isoform X1 [KO:K06250]
101023125  VTN; vitronectin [KO:K06251]
101012923  TNC; tenascin isoform X1 [KO:K06252]
101015643  TNR; tenascin-R isoform X3 [KO:K06252]
101012779  TNN; tenascin-N isoform X1 [KO:K06252]
101015348  IBSP; bone sialoprotein 2 [KO:K06253]
101013799  ITGA1; integrin alpha-1 [KO:K06480]
101014159  ITGA2; integrin alpha-2 [KO:K06481]
101009395  ITGA2B; integrin alpha-IIb [KO:K06476]
116271056  integrin alpha-3-like isoform X1 [KO:K06482]
116271057  integrin alpha-3-like [KO:K06482]
101003243  integrin alpha-3 isoform X2 [KO:K06482]
101006463  ITGA4; integrin alpha-4 [KO:K06483]
101003191  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
100999739  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101016956  ITGA7; integrin alpha-7 isoform X7 [KO:K06583]
101006669  ITGA8; integrin alpha-8 [KO:K06584]
101014480  ITGA9; integrin alpha-9 [KO:K06585]
101021265  ITGA11; integrin alpha-11 [KO:K06587]
101017655  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101005052  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
101012095  ITGB3; integrin beta-3 [KO:K06493]
101010563  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101020640  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
101018133  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101014095  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
101017806  ITGB8; integrin beta-8 [KO:K06591]
101022936  PTK2; focal adhesion kinase 1 isoform X25 [KO:K05725] [EC:2.7.10.2]
101003196  PXN; paxillin isoform X6 [KO:K05760]
101013835  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101006641  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101000210  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101017433  FADD; FAS-associated death domain protein [KO:K02373]
101009470  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101023728  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
101018430  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
101021745  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101011206  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101003925  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101000613  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101020551  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101017040  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
116272968  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
101020796  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6 [KO:K04354]
101011219  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101021204  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101020710  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101011174  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100997528  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
101006765  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101010611  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
100137475  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101007684  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
101024169  TSC1; hamartin isoform X4 [KO:K07206]
101025020  TSC2; tuberin isoform X12 [KO:K07207]
101004763  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
101015041  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
100998866  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101012071  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101024761  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101000115  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
101012551  BAD; bcl2-associated agonist of cell death [KO:K02158]
101008264  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101017109  FOXO1; forkhead box protein O1 [KO:K07201]
101001461  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100999911  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101019923  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101004371  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100137215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
101011004  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101013902  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
101000606  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101025307  CCNE2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
101025892  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101017005  RB1; retinoblastoma-associated protein [KO:K06618]
100998071  RBL1; retinoblastoma-like protein 1 isoform X3 [KO:K04681]
101008150  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101006552  PSMC1; 26S proteasome regulatory subunit 4 isoform X1 [KO:K03062]
101000533  E2F1; transcription factor E2F1 [KO:K17454]
100999197  CCNA2; cyclin-A2 [KO:K06627]
101003474  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
101021695  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
101017442  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
100510872  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100998877  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101016447  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101016712  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101020878  NFX1; transcriptional repressor NF-X1 isoform X4 [KO:K12236]
101024777  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
101010160  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
101017168  CHD4; chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
100137219  IRF1; interferon regulatory factor 1 [KO:K09444]
101018561  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
101006949  TBP; TATA-box-binding protein [KO:K03120]
101003400  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
101021987  HLA class I histocompatibility antigen, B-27 alpha chain isoform X1 [KO:K06751]
101019755  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-38 alpha chain [KO:K06751]
101025045  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
116272574  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100997583  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
116272784  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
101022333  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
101003522  HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
101021633  HLA class I histocompatibility antigen, B-7 alpha chain-like [KO:K06751]
101006198  class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
116268677  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
116272937  HLA class I histocompatibility antigen, Cw-6 alpha chain-like isoform X1 [KO:K06751]
101012738  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain [KO:K06751]
101026217  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
101002482  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X2 [KO:K06751]
116273056  HLA class I histocompatibility antigen, Cw-8 alpha chain-like isoform X1 [KO:K06751]
116273133  HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751]
116273134  HLA class I histocompatibility antigen, B-7 alpha chain-like [KO:K06751]
101020363  HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
101021052  HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
101024059  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, alpha chain E [KO:K06751]
101015220  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-11 alpha chain [KO:K06751]
101009503  popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
100126713  PACA-F; major histocompatibility complex, class I, F precursor [KO:K06751]
101007932  patr class I histocompatibility antigen, A-126 alpha chain-like precursor [KO:K06751]
101014301  BCAP31; LOW QUALITY PROTEIN: B-cell receptor-associated protein 31 [KO:K14009]
101007030  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100997623  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
101016078  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101006580  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
101000859  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101025037  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
101024001  V-type proton ATPase subunit D [KO:K02149]
101010034  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101023443  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
101024652  ATP6V1F; V-type proton ATPase subunit F isoform X1 [KO:K02151]
101004961  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101016141  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101018105  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101014564  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
101002176  TCIRG1; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a [KO:K02154]
101009497  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101001513  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X4 [KO:K02154]
100997943  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
101014644  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
101008111  V-type proton ATPase subunit e 2 [KO:K02153]
116272145  V-type proton ATPase subunit e 1 [KO:K02153]
101000139  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
103883684  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
108582506  LOW QUALITY PROTEIN: V-type proton ATPase 16 kDa proteolipid subunit 2-like [KO:K02155]
101004324  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101011827  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X2 [KO:K03661]
100137266  ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662]
101026665  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101003588  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101002675  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101022024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101003749  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101017528  KRAS; GTPase KRas isoform X2 [KO:K07827]
101026253  NRAS; GTPase NRas isoform X2 [KO:K07828]
101009029  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101004074  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101025796  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101013075  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
103887915  neuroendocrine secretory protein 55 [KO:K04632]
101006785  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
101026251  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X15 [KO:K04345] [EC:2.7.11.11]
101026282  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
101020553  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101017891  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101004296  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101020406  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101004434  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101008452  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101007514  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X4 [KO:K09047]
101008547  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X9 [KO:K10691] [EC:2.3.2.27]
101004062  TUBG1; tubulin gamma-1 chain [KO:K10389]
101008712  tubulin gamma-2 chain isoform X1 [KO:K10389]
101008966  PKM; pyruvate kinase PKM isoform X3 [KO:K00873] [EC:2.7.1.40]
101023828  LOW QUALITY PROTEIN: interferon alpha-21 [KO:K05414]
101016516  interferon alpha-1/13 [KO:K05414]
116270026  interferon alpha-1/13 [KO:K05414]
101019008  LOW QUALITY PROTEIN: interferon alpha-1/13 [KO:K05414]
101018652  LOW QUALITY PROTEIN: interferon alpha-1/13 [KO:K05414]
101017918  interferon alpha-8 [KO:K05414]
101018287  interferon alpha-2 [KO:K05414]
101019380  interferon alpha-6 [KO:K05414]
101021706  interferon alpha-14 [KO:K05414]
101023118  interferon alpha-4 [KO:K05414]
100137245  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100137545  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
101002872  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101020681  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101005886  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101011342  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
101020807  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
101011480  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
101016108  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
101020760  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
101021095  MX2; interferon-induced GTP-binding protein Mx2 isoform X1 [KO:K14754]
101022694  ISG15; ubiquitin-like protein ISG15 isoform X2 [KO:K12159]
101005762  JAG1; protein jagged-1 [KO:K06052]
101007043  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
101024262  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
101007194  NOTCH3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995]
101000508  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
101018492  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X3 [KO:K05948] [EC:2.4.1.222]
101013421  RFNG; LOW QUALITY PROTEIN: beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
101011968  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
101018410  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
101000822  MAML3; mastermind-like protein 3 [KO:K06061]
101023273  MAML1; LOW QUALITY PROTEIN: mastermind-like protein 1 [KO:K06061]
101015927  RBPJ; recombining binding protein suppressor of hairless isoform X4 [KO:K06053]
101025059  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
101006374  HES1; transcription factor HES-1 [KO:K06054]
101010274  HES2; transcription factor HES-2 [KO:K09087]
110740831  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
101015907  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
101009005  HES3; transcription factor HES-3 [KO:K09088]
101022336  HES4; transcription factor HES-4 [KO:K09089]
101024013  HES5; transcription factor HES-5 isoform X2 [KO:K06055]
100998649  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
101023494  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
101005751  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Sci Rep 5:13446 (2015)
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Related
pathway
panu04064  NF-kappa B signaling pathway
panu04110  Cell cycle
panu04115  p53 signaling pathway
panu04150  mTOR signaling pathway
panu04151  PI3K-Akt signaling pathway
panu04210  Apoptosis
panu04310  Wnt signaling pathway
panu04330  Notch signaling pathway
panu04510  Focal adhesion
panu04520  Adherens junction
panu04530  Tight junction
panu04612  Antigen processing and presentation
panu04620  Toll-like receptor signaling pathway
panu04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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