KEGG PATHWAY: pbar04013

KEGG

PATHWAY: pbar04013

Entry

pbar04013                   Pathway

Name

MAPK signaling pathway - fly - Pogonomyrmex barbatus (red harvester ant)

Description

The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.

Class

Environmental Information Processing; Signal transduction

Pathway map

MAPK signaling pathway - fly

Other DBs

GO:

Organism

Pogonomyrmex barbatus (red harvester ant) [GN:pbar]

Gene

torso-like protein [KO:K12377]

LOW QUALITY PROTEIN: uncharacterized protein LOC105427878 [KO:K20227]

LOW QUALITY PROTEIN: uncharacterized protein LOC105431077 [KO:K20228]

LOW QUALITY PROTEIN: uncharacterized protein LOC105425647 [KO:K12378] [EC:2.7.10.1]

protein giant-lens [KO:K02104]

uncharacterized protein LOC105422780 [KO:K16690]

uncharacterized protein LOC105430466 [KO:K16691]

epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]

leucine-rich repeat-containing protein 24 [KO:K20230]

protein bride of sevenless [KO:K04623]

proto-oncogene tyrosine-protein kinase ROS isoform X1 [KO:K05088] [EC:2.7.10.1]

SHC-transforming protein 1 [KO:K06279]

protein enhancer of sevenless 2B [KO:K04364]

proteoglycan 4 isoform X1 [KO:K20231]

tyrosine-protein phosphatase corkscrew isoform X1 [KO:K07293] [EC:3.1.3.48]

LOW QUALITY PROTEIN: protein son of sevenless [KO:K03099]

protein sprouty homolog 2 [KO:K17383]

GTPase HRas [KO:K07827]

ras GTPase-activating protein 1 [KO:K04352]

ras GTPase-activating protein 3 isoform X1 [KO:K12380]

raf homolog serine/threonine-protein kinase phl-like [KO:K04365] [EC:2.7.11.1]

serine/threonine-protein kinase A-Raf-like [KO:K04365] [EC:2.7.11.1]

14-3-3 protein zeta [KO:K16197]

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]

LOW QUALITY PROTEIN: kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]

LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]

mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]

importin-7 [KO:K20223]

putative transcription factor capicua isoform X1 [KO:K20225]

nuclear receptor subfamily 2 group E member 1 [KO:K08545]

protein groucho-1 [KO:K04497]

protein groucho-1-like [KO:K04497]

LOW QUALITY PROTEIN: protein groucho-1-like [KO:K04497]

zinc finger protein Xfin [KO:K12379]

ETS-like protein pointed, isoform P2/D isoform X1 [KO:K02678]

ets DNA-binding protein pokkuri [KO:K03211]

exportin-1 [KO:K14290]

protein tramtrack, alpha isoform isoform X1 [KO:K09237]

F-box-like/WD repeat-containing protein ebi [KO:K04508]

ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]

protein lozenge [KO:K20214]

homeobox protein prospero-like isoform X1 [KO:K20211]

LOW QUALITY PROTEIN: uncharacterized protein LOC105434179 [KO:K16678]

uncharacterized protein LOC105432788 [KO:K16679]

uncharacterized protein LOC105432930 [KO:K20234]

tyrosine-protein kinase Src42A isoform X1 [KO:K08892] [EC:2.7.10.2]

tyrosine-protein kinase Src64B [KO:K05704] [EC:2.7.10.2]

serine/threonine-protein kinase mig-15 isoform X1 [KO:K08840] [EC:2.7.11.1]

ras-related C3 botulinum toxin substrate 1 [KO:K04392]

ras-related protein Rac1 [KO:K04392]

ras-like GTP-binding protein RhoL [KO:K04392]

TNF receptor-associated factor 6-A-like isoform X1 [KO:K03175] [EC:2.3.2.27]

ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]

LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K04404]

mitogen-activated protein kinase kinase kinase 11-like isoform X1 [KO:K04417] [EC:2.7.11.25]

mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]

protein phosphatase 1A-like isoform X1 [KO:K04461] [EC:3.1.3.16]

dual specificity mitogen-activated protein kinase kinase hemipterous-like isoform X1 [KO:K04431] [EC:2.7.12.2]

dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]

stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]

striatin-3 [KO:K17608]

transcription factor AP-1 [KO:K04448]

transcription factor kayak isoform X1 [KO:K09031]

ras-responsive element-binding protein 1-like [KO:K20210]

uncharacterized protein LOC105423820 [KO:K20235]

protein decapentaplegic [KO:K04662]

profilin [KO:K05759]

uncharacterized protein LOC105424205 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]

bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]

LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]

mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]

dual specificity mitogen-activated protein kinase kinase 6 [KO:K04432] [EC:2.7.12.2]

mitogen-activated protein kinase 14B-like isoform X1 [KO:K04441] [EC:2.7.11.24]

LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2-like [KO:K04450]

LOW QUALITY PROTEIN: dual oxidase 2-like [KO:K13411] [EC:1.6.3.1 1.11.1.-]

LOW QUALITY PROTEIN: dual oxidase [KO:K13411] [EC:1.6.3.1 1.11.1.-]

optomotor-blind protein-like [KO:K10176]

myocyte-specific enhancer factor 2 isoform X1 [KO:K09260]

superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]

Reference

Authors

Sopko R, Perrimon N

Title

Receptor tyrosine kinases in Drosophila development.

Journal

Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050

Reference

Authors

Li WX

Title

Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.

Journal

Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295

Reference

Authors

Shilo BZ

Title

Signaling by the Drosophila epidermal growth factor receptor pathway during development.

Journal

Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0

Reference

Authors

Raabe T

Title

The sevenless signaling pathway: variations of a common theme.

Journal

Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3

Reference

Authors

Rios-Barrera LD, Riesgo-Escovar JR

Title

Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.

Journal

Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354

Reference

Authors

Igaki T, Miura M

Title

The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.

Journal

Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003

Reference

Authors

Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX

Title

Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.

Journal

Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013

Reference

Authors

Stronach BE, Perrimon N

Title

Stress signaling in Drosophila.

Journal

Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125

Related
pathway

Apoptosis - fly

KO pathway

LinkDB

DBGET integrated database retrieval system