KEGG   PATHWAY: pcan00983
Entry
pcan00983                   Pathway                                
Name
Drug metabolism - other enzymes - Pomacea canaliculata (golden apple snail)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
pcan00983  Drug metabolism - other enzymes
pcan00983

Organism
Pomacea canaliculata (golden apple snail) [GN:pcan]
Gene
112563983  hypoxanthine-guanine phosphoribosyltransferase-like isoform X1 [KO:K00760] [EC:2.4.2.8]
112571939  inosine-5'-monophosphate dehydrogenase 1b-like isoform X1 [KO:K00088] [EC:1.1.1.205]
112556668  GMP synthase [glutamine-hydrolyzing]-like isoform X1 [KO:K01951] [EC:6.3.5.2]
112573593  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
112558481  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558482  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558485  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558486  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558487  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112560812  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558498  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558796  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558798  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558805  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558811  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112560136  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112570981  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112571030  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112570128  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112570129  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112574044  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
112573738  uncharacterized protein LOC112573738 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
112562471  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
112576958  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
112571694  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
112569585  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112577342  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
112575339  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
112567634  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
112567635  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
112567637  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112567638  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112567639  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112567640  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112567642  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112567644  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112567645  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
112567646  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112567647  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
112567651  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112567652  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112567655  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
112567658  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112573335  UDP-glucuronosyltransferase 2B9-like [KO:K00699] [EC:2.4.1.17]
112564439  UDP-glucuronosyltransferase 1-5-like [KO:K00699] [EC:2.4.1.17]
112564447  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
112567643  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
112561259  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
112561260  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
112561261  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
112557151  LOW QUALITY PROTEIN: cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
112566066  LOW QUALITY PROTEIN: thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
112573163  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
112559110  dihydropyrimidinase-like isoform X1 [KO:K01464] [EC:3.5.2.2]
112559420  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
112561022  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
112557040  LOW QUALITY PROTEIN: uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
112556038  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
112573843  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
112574943  uridine-cytidine kinase 2-B-like [KO:K00876] [EC:2.7.1.48]
112553502  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
112556529  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
112569529  deoxynucleoside kinase-like [KO:K00857] [EC:2.7.1.21]
112556370  deoxynucleoside kinase-like isoform X1 [KO:K00857] [EC:2.7.1.21]
112558861  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
112573380  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
112560420  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
112573879  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
112574364  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
112559300  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
112555258  nucleoside diphosphate kinase 7-like isoform X1 [KO:K00940] [EC:2.7.4.6]
112553866  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
112574787  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
112560111  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
112562146  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
112561564  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
112560787  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
112567268  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
112567352  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
112567358  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
112567360  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
112567368  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
112577330  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
112572009  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
112572010  LOW QUALITY PROTEIN: glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
112565003  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

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