KEGG   PATHWAY: pcoq05167
Entry
pcoq05167                   Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Propithecus coquereli (Coquerel's sifaka)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
pcoq05167  Kaposi sarcoma-associated herpesvirus infection
pcoq05167

Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105811847  C3; LOW QUALITY PROTEIN: complement C3 [KO:K03990]
105810089  TLR3; toll-like receptor 3 [KO:K05401]
105811926  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
105812625  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
105821217  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
105824183  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105816570  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
105827001  interferon alpha-5-like [KO:K05414]
105809375  IRF3; interferon regulatory factor 3 [KO:K05411]
105813122  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
105805288  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
105827006  IFNB1; interferon beta [KO:K05415]
105820771  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105820833  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105806352  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105807810  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
105813290  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105817095  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
105812737  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
105818017  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
105812191  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
105812227  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105813949  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105813961  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105805879  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
105824710  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105820542  ZFP36; tristetraprolin [KO:K15308]
105822445  IL6; interleukin-6 [KO:K05405]
105821018  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
105817505  CCR3; C-C chemokine receptor type 3 [KO:K04178]
105805826  CCR5; C-C chemokine receptor type 5 [KO:K04180]
105804907  CCR1; C-C chemokine receptor type 1 [KO:K04176]
105812430  CCR4; C-C chemokine receptor type 4 [KO:K04179]
105816642  CCR8; C-C chemokine receptor type 8 [KO:K04183]
105822691  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105827473  FADD; FAS-associated death domain protein [KO:K02373]
105819477  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105815816  BID; BH3-interacting domain death agonist [KO:K04726]
105809316  BAX; apoptosis regulator BAX [KO:K02159]
105821684  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105812509  cytochrome c-like [KO:K08738]
105807375  cytochrome c, somatic [KO:K08738]
105815609  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
105810555  cytochrome c-like [KO:K08738]
105825008  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105810111  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105805081  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105823400  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105818690  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105824261  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105819687  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105824538  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105821530  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105819191  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
105819395  TP53; cellular tumor antigen p53 [KO:K04451]
105812249  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105816738  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105820132  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105813707  RB1; retinoblastoma-associated protein [KO:K06618]
105804948  E2F1; transcription factor E2F1 [KO:K17454]
105815699  E2F2; transcription factor E2F2 [KO:K09389]
105805737  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
105817846  HLA class I histocompatibility antigen, B-8 alpha chain-like [KO:K06751]
105817910  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
105817268  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
105817288  HLA class I histocompatibility antigen, B-14 alpha chain-like isoform X1 [KO:K06751]
105817290  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
105817294  HLA class I histocompatibility antigen, B-41 alpha chain-like [KO:K06751]
105827142  IFNGR1; interferon gamma receptor 1 [KO:K05132]
105807825  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
105806444  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
105816663  CLEC2B; C-type lectin domain family 2 member B [KO:K10071]
105825561  UBC; polyubiquitin-C [KO:K02927]
105818097  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
105818146  ubiquitin-60S ribosomal protein L40 [KO:K02927]
105814769  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
105820245  BECN1; beclin-1 isoform X1 [KO:K08334]
105825918  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
105827070  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
105816763  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
105821039  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
105810391  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
105804954  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
105820912  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105806018  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105805044  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
105806301  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105821386  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105825893  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105827172  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105823098  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105819816  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105812945  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105807545  KRAS; GTPase KRas [KO:K07827]
105810591  NRAS; GTPase NRas [KO:K07828]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105811965  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105819837  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
105806347  JUN; transcription factor AP-1 [KO:K04448]
105819831  FOS; proto-oncogene c-Fos [KO:K04379]
105815179  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
105819419  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
105819482  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105824883  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105818611  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105815999  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
105816736  CD200R1; cell surface glycoprotein CD200 receptor 1 [KO:K21668]
105817784  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
105822028  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105804972  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
105824094  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
105818077  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
105807933  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105813491  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105816581  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105812706  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
105807599  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105821681  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105820913  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105826829  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105826912  CALML3; calmodulin-like protein 3 [KO:K02183]
105826917  CALML5; calmodulin-like protein 5 [KO:K02183]
105807119  CALM1; calmodulin [KO:K02183]
105805895  CALM2; calmodulin [KO:K02183]
105817634  CALM3; calmodulin [KO:K02183]
105825283  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
105825498  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105821611  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
105812112  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105805391  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105821171  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105820432  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105823351  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105812762  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
105822820  CXCL8; interleukin-8 [KO:K10030]
105813187  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105820828  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
105815256  FGF2; fibroblast growth factor 2 [KO:K18497]
105807498  VEGFA; vascular endothelial growth factor A [KO:K05448]
105805188  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105811628  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105819129  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
105820249  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105806400  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
105825335  CTNNB1; catenin beta-1 [KO:K02105]
105816027  TCF7; transcription factor 7 isoform X1 [KO:K02620]
105810284  TCF7L1; transcription factor 7-like 1 [KO:K04490]
105826013  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
105818969  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
105823945  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
105827423  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
105811323  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
  Journal
J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
Reference
PMID:17166914
  Authors
Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
Reference
PMID:18230726
  Authors
Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
  Journal
Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
Reference
PMID:11413168
  Authors
Coscoy L, Ganem D
  Title
A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
  Journal
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pathway
pcoq04010  MAPK signaling pathway
pcoq04064  NF-kappa B signaling pathway
pcoq04110  Cell cycle
pcoq04115  p53 signaling pathway
pcoq04140  Autophagy - animal
pcoq04144  Endocytosis
pcoq04151  PI3K-Akt signaling pathway
pcoq04210  Apoptosis
pcoq04310  Wnt signaling pathway
pcoq04610  Complement and coagulation cascades
pcoq04620  Toll-like receptor signaling pathway
pcoq04630  JAK-STAT signaling pathway
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KO pathway
ko05167   
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