KEGG   PATHWAY: pgig05165
Entry
pgig05165                   Pathway                                
Name
Human papillomavirus infection - Pteropus giganteus (Indian flying fox)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
pgig05165  Human papillomavirus infection
pgig05165

Organism
Pteropus giganteus (Indian flying fox) [GN:pgig]
Gene
120618559  WNT1; proto-oncogene Wnt-1 [KO:K03209]
120585033  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
120601108  WNT2; protein Wnt-2 [KO:K00182]
120616644  WNT3A; protein Wnt-3a [KO:K00312]
120589261  WNT3; proto-oncogene Wnt-3 [KO:K00312]
120596198  WNT4; protein Wnt-4 [KO:K00408]
120606289  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
120607346  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
120587668  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
120602874  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
120613810  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
120581156  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
120608938  WNT8B; protein Wnt-8b [KO:K00714]
120616643  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
120589260  WNT9B; protein Wnt-9b [KO:K01064]
120618208  WNT10B; protein Wnt-10b [KO:K01357]
120587739  WNT10A; protein Wnt-10a [KO:K01357]
120590369  WNT11; protein Wnt-11 [KO:K01384]
120601159  WNT16; protein Wnt-16 [KO:K01558]
120615046  FZD1; frizzled-1 [KO:K02432]
120587540  FZD7; frizzled-7 [KO:K02432]
120589224  FZD2; frizzled-2 [KO:K02235]
120613253  FZD3; frizzled-3 isoform X1 [KO:K02329]
120590461  FZD4; frizzled-4 [KO:K02354]
120593264  FZD8; frizzled-8 [KO:K02375]
120587587  FZD5; frizzled-5 [KO:K02375]
120595684  FZD6; frizzled-6 [KO:K02376]
120591641  FZD9; frizzled-9 [KO:K02842]
120615989  FZD10; frizzled-10 [KO:K02842]
120614091  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
120593039  DVL3; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
120589630  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
120586669  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120620161  AXIN1; axin-1 isoform X1 [KO:K02157]
120600021  AXIN2; LOW QUALITY PROTEIN: axin-2 [KO:K04385]
120590819  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
120583698  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
120582202  CTNNB1; catenin beta-1 [KO:K02105]
120581532  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
120586142  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
120581289  TCF7; transcription factor 7 isoform X1 [KO:K02620]
120594603  TCF7L1; transcription factor 7-like 1 [KO:K04490]
120609085  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
120595315  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
120618460  TLR3; toll-like receptor 3 [KO:K05401]
120615407  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
120619723  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
120617936  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
120605013  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
120615538  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
120605473  IFNB1; interferon beta [KO:K05415]
120602971  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
120620322  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
120621440  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
120589680  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120593799  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
120609356  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120584128  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
120603813  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
120593945  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
120583394  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
120604376  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
120614115  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
120596202  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120588792  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
120592931  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
120590423  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
120585407  DLG3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
120600192  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
120589851  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
120615449  CRB3; protein crumbs homolog 3 [KO:K06090]
120621982  PATJ; inaD-like protein isoform X1 [KO:K06092]
120612757  PALS1; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
120611627  VWF; von Willebrand factor isoform X1 [KO:K03900]
120587198  THBS1; thrombospondin-1 [KO:K16857]
120592221  THBS3; thrombospondin-3 [KO:K04659]
120606573  cartilage oligomeric matrix protein [KO:K04659]
120617968  THBS2; thrombospondin-2 [KO:K04659]
120612479  THBS4; thrombospondin-4 [KO:K04659]
120587617  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
120615011  COL1A2; collagen alpha-2(I) chain [KO:K06236]
120588945  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
120618230  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
120616365  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
120616381  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
120605335  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
120605336  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
120597091  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
120597092  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
120582065  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
120582066  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
120582067  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
120616395  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
120616409  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
120601689  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
120614012  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
120603980  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
120594914  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
120592323  LAMA2; laminin subunit alpha-2 [KO:K05637]
120588351  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
120603402  LAMA5; laminin subunit alpha-5 [KO:K06240]
120587525  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
120608707  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
120591582  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
120582328  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
120608483  LAMB3; laminin subunit beta-3 [KO:K06244]
120591580  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
120617578  LAMC1; laminin subunit gamma-1 [KO:K05635]
120617572  LAMC2; laminin subunit gamma-2 [KO:K06246]
120602714  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
120588954  CHAD; chondroadherin [KO:K06248]
120591725  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
120588302  SPP1; osteopontin [KO:K06250]
120620949  VTN; vitronectin [KO:K06251]
120605792  TNC; tenascin isoform X1 [KO:K06252]
120617487  TNN; tenascin-N [KO:K06252]
120617638  TNR; tenascin-R [KO:K06252]
120618893  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
120588299  bone sialoprotein 2 [KO:K06253]
120608161  ITGA1; integrin alpha-1 [KO:K06480]
120608166  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
120589223  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
120588938  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
120596787  ITGA4; integrin alpha-4 [KO:K06483]
120602233  ITGA5; integrin alpha-5 [KO:K06484]
120597205  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
120604874  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
120614631  ITGA8; integrin alpha-8 [KO:K06584]
120586757  ITGA9; integrin alpha-9 [KO:K06585]
120585154  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
120604629  ITGA11; integrin alpha-11 [KO:K06587]
120584269  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
120584124  ITGB1; integrin beta-1 [KO:K05719]
120589273  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
120600356  ITGB4; integrin beta-4 [KO:K06525]
120586723  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
120597015  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
120602246  ITGB7; integrin beta-7 [KO:K06590]
120602322  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
120588751  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
120606782  PXN; paxillin isoform X1 [KO:K05760]
120618944  TNF; tumor necrosis factor [KO:K03156]
120611633  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
120623059  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
120617668  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120609345  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
120584707  FADD; FAS-associated death domain protein [KO:K02373]
120587528  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
120618435  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
120600237  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
120581292  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
120589049  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
120583980  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
120621983  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
120581501  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
120613401  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
120582867  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
120582112  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
120620761  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
120610948  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
120603778  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
120617516  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
120596143  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
120619709  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
120600686  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
120602738  TSC1; hamartin isoform X1 [KO:K07206]
120620251  TSC2; tuberin isoform X1 [KO:K07207]
120601454  RHEB; GTP-binding protein Rheb [KO:K07208]
120585826  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
120595621  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
120584753  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
120620825  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
120597665  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
120600645  BAD; bcl2-associated agonist of cell death [KO:K02158]
120581545  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
120582132  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120596984  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120585845  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120606549  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120608247  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120620206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
120613959  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120595669  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120619079  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120583890  FOXO1; forkhead box protein O1 [KO:K07201]
120613734  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
120597553  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
120584714  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120607308  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
120596338  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
120604974  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
120615024  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
120605475  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
120617212  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
120604889  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
120583848  RB1; retinoblastoma-associated protein [KO:K06618]
120603629  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
120617273  RBL2; retinoblastoma-like protein 2 [KO:K16332]
120619604  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
120603555  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
120616219  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
120610618  CCNA1; cyclin-A1 [KO:K06627]
120619030  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
120613812  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
120596132  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
120609204  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120595665  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
120605919  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120591230  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120584840  RELA; transcription factor p65 [KO:K04735]
120605043  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
120612914  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
120581992  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
120608742  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
120611635  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
120616518  IRF1; interferon regulatory factor 1 [KO:K09444]
120615800  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
120605605  TBPL2; TATA box-binding protein-like 2 isoform X1 [KO:K03120]
120618243  TATA-box-binding protein [KO:K03120]
120613145  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
120592308  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
120592320  saoe class I histocompatibility antigen, C alpha chain-like [KO:K06751]
120592626  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
120615897  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
120616337  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
120616593  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
120606422  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
120618951  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
120599497  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
120589178  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
120589505  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
120605929  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
120586637  ATP6V1A; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
120594507  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
120606610  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
120595414  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
120621961  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
120612760  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
120607358  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
120622103  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
120601220  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
120605797  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
120618948  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
120619228  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
120607248  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
120616118  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
120584738  TCIRG1; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154]
120611080  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
120600989  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
120585571  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
120623071  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
120615065  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
120601482  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
120620277  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
120619469  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
120605892  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
120591156  EGF; pro-epidermal growth factor [KO:K04357]
120602477  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
120600272  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
120604448  SOS2; son of sevenless homolog 2 [KO:K03099]
120621751  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120584662  HRAS; GTPase HRas isoform X1 [KO:K02833]
120618351  KRAS; GTPase KRas isoform X1 [KO:K07827]
120585069  NRAS; GTPase NRas isoform X1 [KO:K07828]
120621476  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120604492  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
120615382  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
120606851  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120620121  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120617547  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
120586164  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
120603881  neuroendocrine secretory protein 55-like [KO:K04632]
120603882  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
120583269  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120618485  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120606950  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
120587583  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
120592160  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
120615385  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
120606645  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
120601151  CREB3L2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
120612863  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
120602391  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
120585731  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
120611084  TUBG2; tubulin gamma-2 chain isoform X1 [KO:K10389]
120611086  tubulin gamma-1 chain [KO:K10389]
120597892  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
120605312  interferon alpha-4-like [KO:K05414]
120617124  interferon alpha-1-like [KO:K05414]
120606426  interferon alpha-1-like [KO:K05414]
120589528  interferon alpha-1-like [KO:K05414]
120589531  interferon alpha-5-like [KO:K05414]
120598793  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
120598866  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
120583126  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
120610872  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
120587473  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
120604905  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
120608511  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
120621778  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
120606799  OASL; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
120606808  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
120598747  MX1; interferon-induced GTP-binding protein Mx1 isoform X1 [KO:K14754]
120598748  MX2; interferon-induced GTP-binding protein Mx2 isoform X1 [KO:K14754]
120614075  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
120611906  JAG1; protein jagged-1 isoform X1 [KO:K06052]
120599821  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
120585122  neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
120606474  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
120618878  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
120619472  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
120614843  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
120615783  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
120600325  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
120613222  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
120616624  MAML1; mastermind-like protein 1 isoform X1 [KO:K06061]
120618100  MAML2; mastermind-like protein 2 [KO:K06061]
120591185  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
120603717  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
120592866  HES1; transcription factor HES-1 [KO:K06054]
120585875  HES2; transcription factor HES-2 [KO:K09087]
120589699  HES7; LOW QUALITY PROTEIN: transcription factor HES-7 [KO:K09087]
120601067  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
120585727  HES3; transcription factor HES-3 [KO:K09088]
120614071  HES4; transcription factor HES-4 [KO:K09089]
120614125  HES5; transcription factor HES-5 isoform X1 [KO:K06055]
120614000  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
120596100  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
120585532  hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Pathogens 5:E8 (2016)
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
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PDZ domains: the building blocks regulating tumorigenesis.
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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Reference
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Reference
PMID:23536685
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Related
pathway
pgig04064  NF-kappa B signaling pathway
pgig04110  Cell cycle
pgig04115  p53 signaling pathway
pgig04150  mTOR signaling pathway
pgig04151  PI3K-Akt signaling pathway
pgig04210  Apoptosis
pgig04310  Wnt signaling pathway
pgig04330  Notch signaling pathway
pgig04510  Focal adhesion
pgig04520  Adherens junction
pgig04530  Tight junction
pgig04612  Antigen processing and presentation
pgig04620  Toll-like receptor signaling pathway
pgig04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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