KEGG   PATHWAY: phas04540
Entry
phas04540                   Pathway                                
Name
Gap junction - Phyllostomus hastatus (greater spear-nosed bat)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
phas04540  Gap junction
phas04540

Other DBs
GO: 0005921
Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123822010  GJA1; gap junction alpha-1 protein [KO:K07372]
123808541  GJD2; gap junction delta-2 protein [KO:K07373]
123820165  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
123804401  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
123811789  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
123830671  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
123810721  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123816209  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
123805628  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123814141  PDGFC; platelet-derived growth factor C [KO:K05450]
123806865  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123815579  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123807517  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123811124  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123817350  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123811120  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123807983  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
123807317  HRAS; GTPase HRas isoform X1 [KO:K02833]
123812406  KRAS; GTPase KRas isoform X1 [KO:K07827]
123804414  NRAS; GTPase NRas [KO:K07828]
123814364  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123808110  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123813640  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123806569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123825523  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123814829  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
123810283  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
123808725  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
123809287  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
123818736  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
123812863  tubulin alpha-1B chain isoform X1 [KO:K07374]
123812864  TUBA1C; tubulin alpha-1C chain [KO:K07374]
123828105  tubulin alpha-4A chain [KO:K07374]
123806560  tubulin alpha-3 chain [KO:K07374]
123822762  TUBA3C; LOW QUALITY PROTEIN: tubulin alpha-3C chain [KO:K07374]
123831161  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
123825961  TUBB6; tubulin beta-6 chain [KO:K07375]
123805754  TUBB3; LOW QUALITY PROTEIN: tubulin beta-3 chain [KO:K07375]
123820805  TUBB2B; LOW QUALITY PROTEIN: tubulin beta-2B chain [KO:K07375]
123813801  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
123814961  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
123823367  TUBB4B; tubulin beta-4B chain isoform X1 [KO:K07375]
123810347  TUBB; tubulin beta chain [KO:K07375]
123816927  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
123820943  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
123809588  tight junction protein ZO-1 isoform X1 [KO:K05701]
123829013  ADRB1; beta-1 adrenergic receptor [KO:K04141]
123806765  DRD1; D(1A) dopamine receptor [KO:K04144]
123815116  neuroendocrine secretory protein 55-like [KO:K04632]
123815292  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
123819804  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
123811468  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
123824963  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123822448  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
123820487  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123826843  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123812947  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
123805699  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123833093  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
123807136  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
123828245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123816440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123818951  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
123805153  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
123823218  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
123821691  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
123805619  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
123813822  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
123819693  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
123829335  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
123814755  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123814917  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123808665  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123830469  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
123812354  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
123815944  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
123817558  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
123825494  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123824140  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123813982  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
123818054  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
123814152  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
123828671  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
123831363  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
phas04010  MAPK signaling pathway
phas04020  Calcium signaling pathway
phas04060  Cytokine-cytokine receptor interaction
phas04070  Phosphatidylinositol signaling system
phas04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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