KEGG   PATHWAY: plep04148
Entry
plep04148                   Pathway                                
Name
Efferocytosis - Plectropomus leopardus (leopard coralgrouper)
Class
Cellular Processes; Transport and catabolism
Pathway map
plep04148  Efferocytosis
plep04148

Organism
Plectropomus leopardus (leopard coralgrouper) [GN:plep]
Gene
121942065  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
121948074  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
121963193  caspase-3-like [KO:K02187] [EC:3.4.22.56]
121958571  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
121943038  caspase a-like [KO:K01370] [EC:3.4.22.36]
121942397  pannexin-1-like isoform X1 [KO:K03443]
121943504  pannexin-1-like [KO:K03443]
121943591  p2ry2.1; P2Y purinoceptor 2 isoform X1 [KO:K04269]
121943325  P2Y purinoceptor 3 isoform X1 [KO:K04272]
121943263  p2ry12; P2Y purinoceptor 12 [KO:K04298]
121942104  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
121945784  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121957167  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121940478  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
121942265  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
121965345  abca7; phospholipid-transporting ATPase ABCA1 [KO:K05641]
121941839  phospholipid-transporting ATPase ABCA1-like isoform X1 [KO:K05641]
121961901  phospholipid-transporting ATPase ABCA1-like [KO:K05641]
121955506  probable G-protein coupled receptor 132 isoform X1 [KO:K08426]
121962320  si:dkey-165a24.9; G-protein coupled receptor 4 [KO:K08426]
121953389  adam17a; disintegrin and metalloproteinase domain-containing protein 17a [KO:K06059] [EC:3.4.24.86]
121955712  disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
121947514  adam10a; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
121950293  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
121937813  si:ch1073-396h14.1; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
121946590  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
121956685  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
121946226  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
121957447  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
121960397  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
121951981  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
121953345  hif1aa; hypoxia inducible factor 1 subunit alpha a [KO:K08268]
121942843  hif1al; hypoxia inducible factor 1 subunit alpha, like isoform X1 [KO:K08268]
121945380  arnt; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
121962046  epoa; erythropoietin isoform X1 [KO:K05437]
121956701  epor; erythropoietin receptor [KO:K05079]
121959857  jak2a; tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
121943967  jak2b; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
121944320  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121956713  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121947282  cebpb; CCAAT/enhancer-binding protein beta [KO:K10048]
121957686  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
121959525  rxraa; retinoic acid receptor RXR-alpha-A isoform X1 [KO:K08524]
121945389  rxrbb; retinoic acid receptor RXR-beta-B isoform X1 [KO:K08524]
121942568  EGF-like repeat and discoidin I-like domain-containing protein 3 isoform X1 [KO:K17253]
121949824  mfge8b; milk fat globule EGF and factor V/VIII domain containing b isoform X1 [KO:K17253]
121947485  gas6; growth arrest-specific protein 6 [KO:K05464]
121954233  mertka; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
121961480  cd36; platelet glycoprotein 4 [KO:K06259]
121953263  thrombospondin-1-like [KO:K16857]
121955248  thbs1b; thrombospondin-1 [KO:K16857]
121950008  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121938842  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121951784  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
121965412  ptgs2b; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121963025  ptger2a; prostaglandin E receptor 2a (subtype EP2) [KO:K04259]
121963415  prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
121959902  ptger4b; prostaglandin E receptor 4 (subtype EP4) b [KO:K04261]
121943989  ptger4a; prostaglandin E receptor 4 (subtype EP4) a [KO:K04261]
121963277  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
121951667  ptger4c; prostaglandin E receptor 4 (subtype EP4) c [KO:K04261]
121953434  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
121955594  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
121948855  creb1b; cyclic AMP-responsive element-binding protein 1b [KO:K05870]
121962741  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
121943219  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
121952258  atp2a3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
121941478  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
121958455  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
121960238  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
121944904  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
121956760  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
121952163  camk2a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
121952669  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
121941940  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
121959037  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
121954606  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
121961873  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
121945071  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
121946583  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121946587  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
121952837  mapk14b; mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
121947552  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
121961086  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
121961232  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
121950748  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
121947328  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
121953644  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
121954568  LOW QUALITY PROTEIN: polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
121954569  LOW QUALITY PROTEIN: polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
121947315  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121942414  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121959574  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121944327  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121950166  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121961531  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121950363  dusp8a; LOW QUALITY PROTEIN: dual specificity protein phosphatase 8a [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121956075  si:ch211-195b15.8; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121957541  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121949673  ano3; anoctamin-3 isoform X1 [KO:K19498]
121961204  anoctamin-4-like [KO:K19499]
121943561  ano5b; anoctamin-5b [KO:K19480]
121949674  ano5a; anoctamin-5 isoform X1 [KO:K19480]
121946425  ano11; anoctamin-7 [KO:K19501]
121943350  ano7; anoctamin-7 [KO:K19501]
121950232  anoctamin-9 [KO:K19503]
121945876  ano9b; anoctamin-9 [KO:K19503]
121939188  bsg; basigin isoform X1 [KO:K06535]
121957866  XK-related protein 8-like [KO:K26813]
121958016  XK-related protein 8-like [KO:K26813]
121960812  xkr9; XK-related protein 9 [KO:K26814]
121946979  xkr5l; XK-related protein 7 [KO:K26811]
121947286  LOW QUALITY PROTEIN: XK-related protein 7-like [KO:K26811]
121951749  xkr4; XK-related protein 4 [KO:K26811]
121955919  xkr6b; XK-related protein 6b [KO:K26811]
121962639  XK-related protein 6 [KO:K26811]
121948516  atp8a1; probable phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
121960784  atp8a2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
121947715  atp11c; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
121948982  phospholipid-transporting ATPase IH-like isoform X1 [KO:K26934] [EC:7.6.2.1]
121962883  atp11a; phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
121963953  atp11b; phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
121953985  tmem30aa; transmembrane protein 30Aa [KO:K26935]
121955505  cell cycle control protein 50A-like [KO:K26935]
121947493  pros1; vitamin K-dependent protein S [KO:K03908]
121958498  itgb3b; integrin beta-3b [KO:K06493]
121956048  integrin beta-3-like [KO:K06493]
121948823  itgb5; integrin beta-5 [KO:K06588]
121943248  LOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO [KO:K05115] [EC:2.7.10.1]
121945976  adgrb1a; adhesion G protein-coupled receptor B1 [KO:K04596]
121960177  stab1; stabilin-1 [KO:K19020]
121941354  LOW QUALITY PROTEIN: stabilin-2-like [KO:K19013]
121945745  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
121957499  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
121939291  breast cancer anti-estrogen resistance protein 1-like [KO:K05726]
121952270  adapter molecule crk-like [KO:K04438]
121959826  crkl; crk-like protein [KO:K04438]
121943251  crk; adapter molecule crk [KO:K04438]
121963423  adapter molecule crk-like [KO:K04438]
121957416  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
121958875  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
121958494  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
121956256  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
121958835  zgc:174164; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
121962453  calr; calreticulin [KO:K08057]
121962666  calr3a; calreticulin 3a [KO:K08057]
121951568  calr3b; calreticulin 3b [KO:K08057]
121948547  c1qa; complement C1q subcomponent subunit A [KO:K03986]
121950809  c1qb; complement C1q subcomponent subunit B [KO:K03987]
121937684  collagen alpha-1(X) chain-like [KO:K03987]
121960418  complement C1q subcomponent subunit C-like [KO:K03988]
121946721  lrp1ab; low-density lipoprotein receptor-related protein 1 [KO:K04550]
121953052  low-density lipoprotein receptor-related protein 1-like [KO:K04550]
121960030  megf10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
121950327  megf11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
121943184  scarf1; scavenger receptor class F member 1 [KO:K24318]
121948925  gulp1a; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
121964398  PTB domain-containing engulfment adapter protein 1-like [KO:K23285]
121949375  ras-related protein Rab-17-like [KO:K07909]
121945795  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
121957446  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
121949491  rab5b; LOW QUALITY PROTEIN: ras-related protein Rab-5B [KO:K07888]
121958625  ras-related protein Rab-5C-like [KO:K07889]
121956656  rab5c; ras-related protein Rab-5C [KO:K07889]
121947406  tgfbrap1; transforming growth factor-beta receptor-associated protein 1 homolog [KO:K20177]
121953208  si:ch211-266g18.9; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
121954899  vps8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
121952876  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
121963047  vps16; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
121955639  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
121944920  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
121959782  rab14l; RAB14, member RAS oncogene family, like [KO:K07881]
121960730  ras-related protein Rab-14-like [KO:K07881]
121953600  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
121960859  vps41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
121955052  ras-related protein rab7 [KO:K07897]
121955485  si:dkey-13a21.4; ras-related protein rab7 [KO:K07897]
121955965  ras-related protein rab7-like [KO:K07897]
121947440  slc66a1; lysosomal amino acid transporter 1 homolog [KO:K23678]
121953409  arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
121959289  arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
121939552  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
121953921  odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
121956195  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
121956825  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
121958812  ch25h; cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
121959425  ch25hl2; cholesterol 25-hydroxylase-like protein 2 [KO:K10223] [EC:1.14.99.38]
121944851  ch25hl3; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
121950428  ch25hl1.2; cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
121950544  ch25hl1.1; cholesterol 25-hydroxylase-like protein 1, member 1 [KO:K10223] [EC:1.14.99.38]
121946124  nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
121958481  LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
121950010  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K08765] [EC:2.3.1.21]
121950678  cpt1ab; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
121957221  cpt1a2b; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
121942635  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
121950490  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
121954969  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
121941021  LOW QUALITY PROTEIN: pre-B-cell leukemia transcription factor 1-like [KO:K09355]
121951823  pbx1a; pre-B-cell leukemia homeobox 1a isoform X1 [KO:K09355]
121950263  il10; interleukin-10 [KO:K05443]
121939091  lipf; gastric triacylglycerol lipase isoform X1 [KO:K01052] [EC:3.1.1.13]
121950585  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
121946549  ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504]
121947150  LOW QUALITY PROTEIN: solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
121953794  solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
121959571  slc2a1b; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
121947247  monocarboxylate transporter 1-like [KO:K08179]
121950880  slc16a1a; monocarboxylate transporter 1a isoform X1 [KO:K08179]
121955154  sgk1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
121945541  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
121957512  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
121942007  platelet endothelial cell adhesion molecule-like [KO:K06471]
121957043  pecam1a; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
121945132  sialic acid-binding Ig-like lectin 16 [KO:K06749]
121945525  sialic acid-binding Ig-like lectin 10 isoform X1 [KO:K06749]
121946280  uncharacterized protein LOC121946280 [KO:K06551]
121945251  ptpn6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
121946887  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
121959592  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
plep00010  Glycolysis / Gluconeogenesis
plep04140  Autophagy - animal
plep04145  Phagosome
KO pathway
ko04148   
LinkDB

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