KEGG   PATHWAY: pmua04814
Entry
pmua04814                   Pathway                                
Name
Motor proteins - Podarcis muralis (common wall lizard)
Class
Cellular Processes; Cell motility
Pathway map
pmua04814  Motor proteins
pmua04814

Organism
Podarcis muralis (common wall lizard) [GN:pmua]
Gene
114585359  DYNC1H1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
114595667  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
114607036  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
114607067  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
114601994  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
114607125  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
114594733  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
114587162  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
114585530  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
114604533  dynein light chain roadblock-type 2 isoform X1 [KO:K10419]
114599513  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
114593248  dynein light chain roadblock-type 2-like [KO:K10419]
114594298  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
114596179  DYNLT3; dynein light chain Tctex-type 3 isoform X1 [KO:K10420]
114594358  TCTE3; tctex1 domain-containing protein 3 [KO:K25419]
114598347  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
114598882  TCTEX1D1; LOW QUALITY PROTEIN: tctex1 domain-containing protein 1 [KO:K25421]
114587415  DNAH6; dynein heavy chain 6, axonemal isoform X1 [KO:K10408]
114589224  DNAH17; dynein heavy chain 17, axonemal isoform X1 [KO:K10408]
114607897  DNAH11; dynein heavy chain 11, axonemal isoform X1 [KO:K10408]
114591570  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
114601012  DNAH5; LOW QUALITY PROTEIN: dynein heavy chain 5, axonemal [KO:K10408]
114591702  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
114590758  DNAH9; LOW QUALITY PROTEIN: dynein heavy chain 9, axonemal [KO:K10408]
114593415  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
114584578  LOW QUALITY PROTEIN: dynein beta chain, ciliary-like [KO:K10408]
114581500  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
114607536  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
114594558  DNAH8; LOW QUALITY PROTEIN: dynein heavy chain 8, axonemal [KO:K10408]
114587198  DNAH10; dynein heavy chain 10, axonemal isoform X1 [KO:K10408]
114584907  DNAH3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
114606200  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
114588653  DNAI2; dynein intermediate chain 2, axonemal isoform X1 [KO:K11143]
114598801  WDR63; WD repeat-containing protein 63 isoform X1 [KO:K24722]
114598879  WDR78; WD repeat-containing protein 78 isoform X1 [KO:K24723]
114601745  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
114589959  axonemal dynein light intermediate polypeptide 1-like [KO:K10410]
114594504  DNAL1; dynein light chain 1, axonemal [KO:K10411]
114605513  DNAL4; dynein light chain 4, axonemal [KO:K10412]
114604464  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
114592939  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
114606596  DCTN3; dynactin subunit 3 [KO:K10425]
114591359  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
114584094  DCTN5; dynactin subunit 5 [KO:K10427]
114587901  DCTN6; dynactin subunit 6 [KO:K10428]
114597536  ACTR1A; alpha-centractin [KO:K16575]
114602424  beta-centractin [KO:K16575]
114596700  ACTR10; actin-related protein 10 [KO:K16576]
114605261  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
114605594  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
114599373  CAPZA1; F-actin-capping protein subunit alpha-1 isoform X1 [KO:K10364]
114602867  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
114586241  BICDL1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
114582302  BICDL2; BICD family-like cargo adapter 2 isoform X1 [KO:K16756]
114587789  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
114602742  tubulin alpha-1D chain [KO:K07374]
114602811  tubulin alpha-4A chain [KO:K07374]
114587623  tubulin alpha-1B chain [KO:K07374]
114587624  tubulin alpha-1A chain [KO:K07374]
114587625  tubulin alpha-1C chain-like [KO:K07374]
114587630  tubulin alpha-1C chain [KO:K07374]
114605478  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
114597763  tubulin alpha-3 chain isoform X1 [KO:K07374]
114597767  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
114599454  tubulin alpha-8 chain [KO:K07374]
114605600  tubulin alpha-4 chain-like [KO:K07374]
114605624  tubulin alpha-8 chain [KO:K07374]
114587477  TUBB4A; tubulin beta-4A chain [KO:K07375]
114600760  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
114599689  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
114602926  TUBB3; tubulin beta-3 chain [KO:K07375]
114600949  tubulin beta-1 chain-like [KO:K07375]
114600950  tubulin beta-1 chain-like [KO:K07375]
114600951  tubulin beta-2 chain isoform X1 [KO:K07375]
114600952  tubulin beta-1 chain-like [KO:K07375]
114591987  TUBB; tubulin beta chain [KO:K07375]
114583723  TUBG1; tubulin gamma-1 chain [KO:K10389]
114585226  TUBD1; tubulin delta chain [KO:K10390]
114594055  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
114604961  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
114607084  KIF5B; kinesin-1 heavy chain [KO:K10396]
114592940  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
114607821  KLC1; kinesin light chain 1 isoform X8 [KO:K10407]
114594770  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
114587156  KLC2; kinesin light chain 2 [KO:K10407]
114603136  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
114591243  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
114599842  KIF3B; kinesin-like protein KIF3B [KO:K20196]
114598602  KIFAP3; kinesin-associated protein 3 [KO:K25388]
114594990  KIF3C; kinesin-like protein KIF3C isoform X1 [KO:K20197]
114587801  KIF17; kinesin-like protein KIF17 isoform X1 [KO:K20198]
114582429  KIF1C; kinesin-like protein KIF1C isoform X1 [KO:K10392]
114597674  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
114602460  KIF1B; kinesin-like protein KIF1B isoform X1 [KO:K10392]
114600864  KIF13A; kinesin-like protein KIF13A isoform X1 [KO:K17914]
114594924  KIF13B; LOW QUALITY PROTEIN: kinesin-like protein KIF13B [KO:K17914]
114598661  KIF14; kinesin-like protein KIF14 isoform X1 [KO:K17915]
114593685  KIF16B; kinesin-like protein KIF16B isoform X1 [KO:K17916]
114594422  STARD9; stAR-related lipid transfer protein 9 isoform X1 [KO:K16491]
114582190  KIF4A; chromosome-associated kinesin KIF4A [KO:K10395]
114584978  KIF7; kinesin-like protein KIF7 [KO:K18806]
114605971  KIF21A; kinesin-like protein KIF21A isoform X1 [KO:K24185]
114599192  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
114606394  KIF27; LOW QUALITY PROTEIN: kinesin-like protein KIF27 [KO:K24186]
114597337  KIF11; kinesin-like protein KIF11 [KO:K10398]
114591470  KIF20A; kinesin-like protein KIF20A [KO:K10402]
114597307  KIF20B; kinesin-like protein KIF20B isoform X1 [KO:K10402]
114600594  LOW QUALITY PROTEIN: kinesin-like protein KIF20A [KO:K10402]
114584153  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
114603993  CENPE; centromere-associated protein E isoform X1 [KO:K11498]
114597212  KIF18A; kinesin-like protein KIF18A isoform X1 [KO:K10401]
114582187  KIF18B; kinesin-like protein KIF18B [KO:K26156]
114588686  KIF19; kinesin-like protein KIF19 isoform X1 [KO:K26157]
114584709  kinesin-like protein KIF19 [KO:K26157]
114607161  kinesin-like protein KIF9 isoform X1 [KO:K10397]
114594565  KIF6; kinesin-like protein KIF6 isoform X1 [KO:K10397]
114607603  KIF9; kinesin-like protein KIF9 [KO:K10397]
114582872  KIF22; kinesin-like protein KIF22 isoform X1 [KO:K10403]
114594453  KIF26B; kinesin-like protein KIF26B isoform X1 [KO:K10404]
114607020  KIF15; kinesin-like protein KIF15 [KO:K10400]
114606348  KIF24; kinesin-like protein KIF24 [KO:K10393]
114599100  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
114606252  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
114592820  KIF2B; kinesin-like protein KIF2B [KO:K10393]
114592558  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
114601830  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
114601243  kinesin-like protein KIFC2 [KO:K10406]
114600151  LOW QUALITY PROTEIN: kinesin-like protein KIFC3 [KO:K10406]
114594340  KIF25; kinesin-like protein KIF25 isoform X1 [KO:K18627]
114607764  unconventional myosin-Ig-like isoform X1 [KO:K10356]
114583733  MYO1H; unconventional myosin-Ih isoform X1 [KO:K10356]
114588531  MYO1F; unconventional myosin-If [KO:K10356]
114586429  unconventional myosin-Ie-like [KO:K10356]
114585426  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
114584633  MYO1B; unconventional myosin-Ib [KO:K10356]
114582781  MYO1D; unconventional myosin-Id isoform X1 [KO:K10356]
114584926  MYO1E; unconventional myosin-Ie [KO:K10356]
114586197  unconventional myosin-Ia-like [KO:K10356]
114584587  MYO3B; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
114607625  MYO3A; LOW QUALITY PROTEIN: myosin-IIIa [KO:K08834] [EC:2.7.11.1]
114606438  MYO5B; LOW QUALITY PROTEIN: unconventional myosin-Vb [KO:K10357]
114584474  MYO5C; unconventional myosin-Vc isoform X1 [KO:K10357]
114584743  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
114593888  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
114595563  MYO7A; unconventional myosin-VIIa isoform X1 [KO:K10359]
114597644  MYO7B; LOW QUALITY PROTEIN: unconventional myosin-VIIb [KO:K21868]
114583993  MYO9A; LOW QUALITY PROTEIN: unconventional myosin-IXa [KO:K10360]
114588708  MYO9B; LOW QUALITY PROTEIN: unconventional myosin-IXb [KO:K10360]
114601021  MYO10; unconventional myosin-X isoform X1 [KO:K12559]
114602469  unconventional myosin-X-like isoform X1 [KO:K12559]
114590615  unconventional myosin-XVB-like isoform X1 [KO:K10361]
114584415  MYO15A; unconventional myosin-XV isoform X1 [KO:K10361]
114585607  unconventional myosin-XVIIIa-like isoform X1 [KO:K10362]
114586127  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
114585711  MYO19; unconventional myosin-XIX isoform X1 [KO:K25838]
114590696  myosin-1B [KO:K24220]
114590694  myosin-3 [KO:K24220]
114599490  myosin-7B-like isoform X1 [KO:K24220]
114595899  MYH15; myosin-15 [KO:K24220]
114590697  myosin-4-like [KO:K24220]
114583613  myosin-6-like [KO:K17751]
114581469  myosin-7 isoform X1 [KO:K17751]
114583987  MYH11; myosin-11 isoform X1 [KO:K10352]
114590752  MYH10; myosin-10 isoform X1 [KO:K10352]
114605121  MYH9; myosin-9 [KO:K10352]
114607974  myosin-10-like isoform X1 [KO:K10352]
114583531  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
114607612  MYL3; myosin light chain 3 [KO:K12749]
114582326  myosin light chain 4 [KO:K12750]
114592950  myosin light polypeptide 6-like [KO:K12751]
114592951  myosin light polypeptide 6 isoform X1 [KO:K12751]
114602734  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
114587600  MYL5; myosin light chain 5 [KO:K12753]
114585940  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
114599524  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
114585755  MYL10; myosin regulatory light chain 10 [KO:K12756]
114600714  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
114582017  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
114594382  ACTA1; actin, alpha skeletal muscle [KO:K10354]
114597295  ACTA2; actin, aortic smooth muscle [KO:K12313]
114587228  actin, alpha cardiac muscle 1-like [KO:K12314]
114593238  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
114596644  actin, alpha cardiac muscle 1-like [KO:K12314]
114602657  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
114604348  actin, cytoplasmic 3-like [KO:K05692]
114588783  ACTG1; actin, cytoplasmic 2 [KO:K05692]
114584064  ACTB; actin, cytoplasmic 1 [KO:K05692]
114604489  actin, clone 302-like [KO:K05692]
114591584  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
114599416  TNNI1; LOW QUALITY PROTEIN: troponin I, slow skeletal muscle [KO:K10371]
114608041  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
114599883  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
114599296  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
114599142  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
114582228  TNNI3; troponin I, cardiac muscle [KO:K12044]
114599413  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
114584780  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
114606214  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
114586747  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
114588372  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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