KEGG   PATHWAY: ppad05167
Entry
ppad05167                   Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Panthera pardus (leopard)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05167

Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109261021  C3; complement C3 isoform X1 [KO:K03990]
109261022  complement C3-like [KO:K03990]
109250994  TLR3; toll-like receptor 3 [KO:K05401]
109255994  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
109274594  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
109257640  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
109270431  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
109259807  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
109247112  interferon alpha-2-like [KO:K05414]
109247120  interferon alpha-like [KO:K05414]
109247123  interferon alpha-like [KO:K05414]
109261306  interferon alpha-like [KO:K05414]
109261307  interferon alpha [KO:K05414]
109253050  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
109278438  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
109265617  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
109247124  IFNB1; interferon beta [KO:K05415]
109249714  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109249711  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109266731  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109254113  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
109274693  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109270329  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
109254992  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
109265829  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
109265257  MAPK11; LOW QUALITY PROTEIN: mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
109265767  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
109271512  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109271515  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
109250406  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
109277026  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
109256578  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
109263814  IL6; interleukin-6 isoform X1 [KO:K05405]
109250814  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
109247709  C-C chemokine receptor type 3-like [KO:K04178]
109247710  C-C chemokine receptor type 5-like [KO:K04180]
109247706  C-C chemokine receptor type 1-like [KO:K04176]
109248706  CCR4; C-C chemokine receptor type 4 [KO:K04179]
109248844  CCR8; C-C chemokine receptor type 8 [KO:K04183]
109255367  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109246999  FADD; FAS-associated death domain protein [KO:K02373]
109260762  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
109276279  BID; BH3-interacting domain death agonist [KO:K04726]
109253092  apoptosis regulator BAX isoform X1 [KO:K02159]
109253093  apoptosis regulator BAX isoform X1 [KO:K02159]
109253096  apoptosis regulator BAX-like [KO:K02159]
109271451  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
109269619  cytochrome c, testis-specific [KO:K08738]
109274153  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
109251018  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
109276143  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109270786  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109258781  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
109272766  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109262264  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109261148  IKBKG; NF-kappa-B essential modulator [KO:K07210]
109261721  NF-kappa-B essential modulator-like [KO:K07210]
109253320  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109247385  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109246747  RELA; transcription factor p65 isoform X1 [KO:K04735]
109245932  TP53; cellular tumor antigen p53 [KO:K04451]
109271531  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
109270390  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
109263689  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
109265951  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
109272548  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
109274297  E2F2; transcription factor E2F2 [KO:K09389]
109252691  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
109260547  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
109260633  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
109249533  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
109249536  HLA class I histocompatibility antigen, Cw-12 alpha chain-like [KO:K06751]
109261321  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
109261353  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109261485  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
109261493  HLA class I histocompatibility antigen, B-47 alpha chain-like [KO:K06751]
109261573  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
109249871  IFNGR1; interferon gamma receptor 1 [KO:K05132]
109254118  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
109266469  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
109259078  C-type lectin domain family 2 member B-like isoform X1 [KO:K10071]
109247632  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
109252147  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
109255456  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
109245820  UBB; polyubiquitin-B [KO:K04551]
109258570  BECN1; beclin-1 isoform X1 [KO:K08334]
109250249  BECN2; beclin-2 [KO:K08334]
109268435  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
109276389  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
109266388  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
109251424  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
109245565  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
109250512  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
109272536  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
109273949  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
109251301  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
109276106  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
109275164  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
109262977  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
109268480  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
109246597  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
109248876  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
109246185  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
109260809  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
109253189  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
109269978  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
109263699  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
109266704  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109254045  uncharacterized LOC105372280 homolog [KO:K04347]
109259658  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
109263698  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
109247331  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
109259759  GTPase HRas [KO:K02833]
109268745  KRAS; GTPase KRas isoform X1 [KO:K07827]
109272105  NRAS; GTPase NRas [KO:K07828]
109257492  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109262816  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109255967  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109259699  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109261343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109268360  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
109266785  JUN; transcription factor AP-1 [KO:K04448]
109253856  FOS; proto-oncogene c-Fos [KO:K04379]
109268077  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
109245881  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
109246080  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
109274075  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109275159  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109259912  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109266953  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109275060  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109247606  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109256570  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109251379  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109257810  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109274103  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109272309  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
109251192  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
109278973  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109276314  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109264550  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109266391  cell surface glycoprotein CD200 receptor 1-like isoform X1 [KO:K21668]
109266205  LOW QUALITY PROTEIN: cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
109275517  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
109272472  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109272582  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
109250302  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
109246076  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
109254200  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109245637  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
109272437  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
109254652  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
109268756  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
109271454  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
109273951  calmodulin-like protein 6 isoform X1 [KO:K02183]
109246761  CALM2; calmodulin [KO:K02183]
109253192  CALM3; calmodulin isoform X1 [KO:K02183]
109273783  calmodulin-like protein 3 [KO:K02183]
109273784  calmodulin-like [KO:K02183]
109273854  calmodulin-like protein 6 [KO:K02183]
109274449  CALM1; calmodulin [KO:K02183]
109262791  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
109257442  calmodulin-alpha-like [KO:K02183]
109262226  calmodulin-like [KO:K02183]
109247332  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109277349  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109262013  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
109270050  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
109251747  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109272263  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
109270732  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109254966  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
109277765  interleukin-8 [KO:K10030]
109253602  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
109277737  growth-regulated alpha protein-like isoform X1 [KO:K05505]
109249748  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
109246691  FGF2; fibroblast growth factor 2 [KO:K18497]
109271390  VEGFA; vascular endothelial growth factor A [KO:K05448]
109265580  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109254262  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
109246341  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
109275494  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109258518  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
109266441  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
109248805  CTNNB1; catenin beta-1 [KO:K02105]
109250863  TCF7; transcription factor 7 isoform X1 [KO:K02620]
109263707  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
109272915  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
109247814  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
109265159  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109246902  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
109273136  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
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J Virol 74:5300-9 (2000)
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
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Virology 428:112-20 (2012)
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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J Mol Med (Berl) 82:223-31 (2004)
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KSHV Genome Replication and Maintenance.
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Front Microbiol 7:54 (2016)
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Related
pathway
ppad04010  MAPK signaling pathway
ppad04064  NF-kappa B signaling pathway
ppad04110  Cell cycle
ppad04115  p53 signaling pathway
ppad04140  Autophagy - animal
ppad04144  Endocytosis
ppad04151  PI3K-Akt signaling pathway
ppad04210  Apoptosis
ppad04310  Wnt signaling pathway
ppad04610  Complement and coagulation cascades
ppad04620  Toll-like receptor signaling pathway
ppad04630  JAK-STAT signaling pathway
ppad04650  Natural killer cell mediated cytotoxicity
ppad04668  TNF signaling pathway
KO pathway
ko05167   
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