Entry Name Measles - Phocoena sinus (vaquita)
Description Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover, H protein expressed on viral particles and binding to SLAM or CD46, as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Ortholog table Organism Phocoena sinus (vaquita) [GN:
psiu ]
Gene 116741795 SLAMF1; LOW QUALITY PROTEIN: signaling lymphocytic activation molecule [KO:K06536 ]
116740220 MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648 ]
116754222 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
116761621 MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
116763460 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
116760425 LOW QUALITY PROTEIN: receptor of activated protein C kinase 1-like [KO:K14753 ]
116757187 STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
116760219 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
116748514 IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693 ]
116752723 LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx1-like [KO:K14754 ]
116764650 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195 ] [EC:2.7.11.1 ]
116748015 LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283 ]
116748530 LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283 ]
116756610 LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283 ]
116758770 HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283 ]
116742642 EIF3H; eukaryotic translation initiation factor 3 subunit H isoform X1 [KO:K03247 ]
116748072 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
116749321 LOW QUALITY PROTEIN: RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144 ] [EC:2.3.2.27 ]
116739025 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
116741753 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
116760585 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
116758073 CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450 ]
116760998 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
116747462 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
116750604 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
116742613 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
116751944 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
116752953 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116752990 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
116751286 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116745657 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
116745691 signal transducer and activator of transcription 5A isoform X1 [KO:K11223 ]
116745059 STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
116758779 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Schneider-Schaulies S, Schneider-Schaulies J
Title Measles virus-induced immunosuppression.
Journal Reference Authors Hahm B
Title Hostile communication of measles virus with host innate immunity and dendritic cells.
Journal Reference Authors Gerlier D, Valentin H
Title Measles virus interaction with host cells and impact on innate immunity.
Journal Reference Authors Schneider-Schaulies S, Dittmer U
Title Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
Journal Reference Authors Avota E, Gassert E, Schneider-Schaulies S
Title Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
Journal Reference Authors Jiang Y, Qin Y, Chen M
Title Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
Journal Reference Authors Pfaller CK, Conzelmann KK
Title Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
Journal Reference Authors Yokota S, Okabayashi T, Yokosawa N, Fujii N
Title Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
Journal Reference Authors Delpeut S, Noyce RS, Siu RW, Richardson CD
Title Host factors and measles virus replication.
Journal Reference Authors Shah M, Anwar MA, Kim JH, Choi S
Title Advances in Antiviral Therapies Targeting Toll-like Receptors.
Journal Reference Authors Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
Title Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
Journal Reference Authors Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
Title Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
Journal Reference Authors Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
Title STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
Journal Reference Authors Shaffer JA, Bellini WJ, Rota PA
Title The C protein of measles virus inhibits the type I interferon response.
Journal Reference Authors Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
Title hsp72, a host determinant of measles virus neurovirulence.
Journal Reference Authors Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
Title Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
Journal Reference Authors Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
Title Promotion of virus assembly and organization by the measles virus matrix protein.
Journal Reference Authors Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
Title Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
Journal Reference Authors Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
Title Measles virus N protein inhibits host translation by binding to eIF3-p40.
Journal Reference Authors Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
Title Measles virus: evidence for association with lung cancer.
Journal Reference Authors Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
Title Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
Journal Reference Authors Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
Title Measles virus V protein inhibits p53 family member p73.
Journal Reference Authors Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
Title Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
Journal Reference Authors Kushwah R, Hu J
Title Dendritic cell apoptosis: regulation of tolerance versus immunity.
Journal Reference Authors Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
Title Measles virus induces functional TRAIL production by human dendritic cells.
Journal Reference Authors Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
Title Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
Journal Reference Authors Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
Title Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
Journal Reference Authors Fan Y, Sanyal S, Bruzzone R
Title Breaking Bad: How Viruses Subvert the Cell Cycle.
Journal Reference Authors Griffin DE
Title Measles virus-induced suppression of immune responses.
Journal Reference Authors Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
Title Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
Journal Reference Authors Avota E, Muller N, Klett M, Schneider-Schaulies S
Title Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
Journal Reference Authors Yanagi Y, Takeda M, Ohno S
Title Measles virus: cellular receptors, tropism and pathogenesis.
Journal Reference Authors Kerdiles YM, Sellin CI, Druelle J, Horvat B
Title Immunosuppression caused by measles virus: role of viral proteins.
Journal Related psiu04620 Toll-like receptor signaling pathway
psiu04622 RIG-I-like receptor signaling pathway
KO pathway LinkDB All DBs
