KEGG   PATHWAY: puc05146
Entry
puc05146                    Pathway                                
Name
Amoebiasis - Panthera uncia (snow leopard)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
puc05146  Amoebiasis
puc05146

Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125937410  interleukin-1 beta isoform X1 [KO:K04519]
125936904  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
125936912  interleukin-1 receptor type 2 [KO:K04387]
125923687  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125912163  transcription factor p65 [KO:K04735]
125928521  heat shock protein beta-1 [KO:K04455]
125929912  collagen alpha-2(I) chain [KO:K06236]
125926420  collagen alpha-1(I) chain isoform X1 [KO:K06236]
125931891  collagen alpha-6(IV) chain [KO:K06237]
125931892  collagen alpha-5(IV) chain [KO:K06237]
125933953  collagen alpha-2(IV) chain [KO:K06237]
125934049  collagen alpha-1(IV) chain [KO:K06237]
125911119  collagen alpha-4(IV) chain [KO:K06237]
125911120  collagen alpha-3(IV) chain [KO:K06237]
125911221  fibronectin isoform X1 [KO:K05717]
125914808  LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
125937984  laminin subunit alpha-2 [KO:K05637]
125914386  laminin subunit alpha-3 isoform X1 [KO:K06240]
125936426  laminin subunit alpha-5 [KO:K06240]
125937961  laminin subunit alpha-4 isoform X1 [KO:K06241]
125929828  laminin subunit beta-1 [KO:K05636]
125929332  laminin subunit beta-2 [KO:K06243]
125925325  laminin subunit beta-3 [KO:K06244]
125929830  laminin subunit beta-4 [KO:K06245]
125925244  laminin subunit gamma-1 [KO:K05635]
125925243  laminin subunit gamma-2 [KO:K06246]
125922657  laminin subunit gamma-3 [KO:K06247]
125923904  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125925154  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
125930520  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
125925185  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
125930519  guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
125931611  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
125909840  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
125935985  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
125936809  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125927372  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125927972  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125915497  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
125917302  neuroendocrine secretory protein 55 [KO:K04632]
125918189  neuroendocrine secretory protein 55 [KO:K04632]
125936451  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
125914842  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
125930396  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125912461  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
125929088  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
125921347  ras-related protein Rab-5A [KO:K07887]
125919212  ras-related protein Rab-5B [KO:K07888]
125926561  ras-related protein Rab-5C [KO:K07889]
125929690  ras-related protein Rab-7a [KO:K07897]
125925479  ras-related protein Rab-7b isoform X1 [KO:K07898]
125923764  toll-like receptor 2 [KO:K10159]
125920696  toll-like receptor 4 isoform X1 [KO:K10160]
125935594  monocyte differentiation antigen CD14 [KO:K04391]
125930836  interleukin-6 [KO:K05405]
125922824  growth-regulated alpha protein-like [KO:K05505]
125922825  growth-regulated alpha protein-like isoform X1 [KO:K05505]
125935135  granulocyte-macrophage colony-stimulating factor [KO:K05427]
125922826  interleukin-8 [KO:K10030]
125922827  interleukin-8-like [KO:K10030]
125938466  tumor necrosis factor [KO:K03156]
125921200  interleukin-12 subunit alpha [KO:K05406]
125934482  interleukin-12 subunit beta [KO:K05425]
125925568  T-cell surface glycoprotein CD1a-like [KO:K06448]
125925637  T-cell surface glycoprotein CD1a-like [KO:K06448]
125925638  T-cell surface glycoprotein CD1a-like [KO:K06448]
125925640  T-cell surface glycoprotein CD1c-like [KO:K06448]
125925642  antigen-presenting glycoprotein CD1d [KO:K06448]
125925645  T-cell surface glycoprotein CD1e, membrane-associated-like [KO:K06448]
125925647  T-cell surface glycoprotein CD1a-like [KO:K06448]
125925648  T-cell surface glycoprotein CD1b-like [KO:K06448]
125925836  T-cell surface glycoprotein CD1a-like [KO:K06448]
125919316  interferon gamma [KO:K04687]
125911481  collagen alpha-1(III) chain [KO:K19720]
125924709  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
125933295  vinculin isoform X1 [KO:K05700]
125915450  alpha-actinin-4 isoform X1 [KO:K05699]
125909407  alpha-actinin-1 isoform X1 [KO:K05699]
125938914  arginase-1 [KO:K01476] [EC:3.5.3.1]
125909422  arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
125927474  nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
125920659  integrin beta-2 [KO:K06464]
125928124  integrin alpha-M isoform X1 [KO:K06461]
125913493  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125935698  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125929237  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125921850  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125913143  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125921289  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125913511  peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
125908450  serpin B6 [KO:K13963]
125908451  serpin B9 [KO:K13963]
125914446  serpin B10 [KO:K13963]
125914450  serpin B3 isoform X1 [KO:K13963]
125914451  serpin B13 isoform X1 [KO:K13963]
125909632  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
125916760  interleukin-10 isoform X1 [KO:K05443]
125916763  interleukin-10 isoform X1 [KO:K05443]
125915432  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
125925521  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
125908676  transforming growth factor beta-3 proprotein [KO:K13377]
125912554  complement component C8 alpha chain [KO:K03997]
125912553  complement component C8 beta chain [KO:K03998]
125923551  complement component C8 gamma chain isoform X1 [KO:K03999]
125935032  complement component C9 isoform X1 [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
puc00330  Arginine and proline metabolism
puc00590  Arachidonic acid metabolism
puc04144  Endocytosis
puc04210  Apoptosis
puc04510  Focal adhesion
puc04610  Complement and coagulation cascades
puc04612  Antigen processing and presentation
puc04620  Toll-like receptor signaling pathway
puc04672  Intestinal immune network for IgA production
puc04810  Regulation of actin cytoskeleton
KO pathway
ko05146   
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