KEGG   PATHWAY: rbb04540
Entry
rbb04540                    Pathway                                
Name
Gap junction - Rhinopithecus bieti (black snub-nosed monkey)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
rbb04540  Gap junction
rbb04540

Other DBs
GO: 0005921
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108512087  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108512657  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
108513181  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
108513198  GJA1; LOW QUALITY PROTEIN: gap junction alpha-1 protein [KO:K07372]
108513636  SOS2; son of sevenless homolog 2 [KO:K03099]
108513979  [KO:K04289]
108514094  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
108514672  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108514696  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
108514761  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
108515747  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
108516255  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
108516767  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
108517033  [KO:K04157]
108517034  [KO:K04157]
108517114  [KO:K07372]
108517430  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
108517523  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
108517746  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108517986  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108518420  [KO:K07374]
108519632  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
108519844  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108520474  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
108520633  [KO:K07375]
108520869  SOS1; son of sevenless homolog 1 [KO:K03099]
108521967  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
108522039  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108522550  TUBB; tubulin beta chain [KO:K07375]
108522948  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
108523462  [KO:K04144]
108523468  [KO:K04144]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108523739  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
108523748  KRAS; GTPase KRas isoform X1 [KO:K07827]
108524752  [KO:K07375]
108525461  [KO:K07374]
108525726  [KO:K07374]
108526799  TJP1; LOW QUALITY PROTEIN: tight junction protein ZO-1 [KO:K05701]
108526885  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108526962  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
108527520  [KO:K12318] [EC:4.6.1.2]
108527553  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
108527564  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108527683  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108528122  NRAS; GTPase NRas [KO:K07828]
108528737  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108529019  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
108529025  GUCY1B3; LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
108529026  GUCY1A3; guanylate cyclase soluble subunit alpha-3 isoform X1 [KO:K12318] [EC:4.6.1.2]
108529080  TUBB3; LOW QUALITY PROTEIN: tubulin beta-3 chain [KO:K07375]
108529452  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108529896  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
108530264  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
108530715  [KO:K12319] [EC:4.6.1.2]
108532047  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108532059  [KO:K07375]
108533000  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
108533750  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
108534083  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
108534562  TUBB4A; tubulin beta-4A chain [KO:K07375]
108534757  PDGFD; platelet-derived growth factor D [KO:K05450]
108534793  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
108534866  GNAI1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108536354  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
108536960  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
108537414  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108538319  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
108538326  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
108538857  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
108539155  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
108540003  [KO:K04345] [EC:2.7.11.11]
108540946  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
108541026  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108541619  TUBB1; tubulin beta-1 chain [KO:K07375]
108541624  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
108541626  [KO:K04632]
108541714  TUBA8; tubulin alpha-8 chain [KO:K07374]
108542252  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108542315  PDGFA; LOW QUALITY PROTEIN: platelet-derived growth factor subunit A [KO:K04359]
108542470  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
108542641  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
108542832  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
108543021  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108543451  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
108543525  HRAS; GTPase HRas isoform X1 [KO:K02833]
108543665  GJD2; gap junction delta-2 protein [KO:K07373]
108543933  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
rbb04010  MAPK signaling pathway
rbb04020  Calcium signaling pathway
rbb04060  Cytokine-cytokine receptor interaction
rbb04070  Phosphatidylinositol signaling system
rbb04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   

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