Entry
Name
Rap1 signaling pathway - Rattus norvegicus (rat)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
171337 Rap1b; ras-related protein Rap-1b precursor [KO:K07836 ]
362799 Rapgef5; rap guanine nucleotide exchange factor 5 isoform 1 [KO:K08019 ]
24408 Grin1; glutamate receptor ionotropic, NMDA 1 isoform 1a precursor [KO:K05208 ]
24409 Grin2a; glutamate receptor ionotropic, NMDA 2A precursor [KO:K05209 ]
24410 Grin2b; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210 ]
25439 F2r; proteinase-activated receptor 1 precursor [KO:K03914 ]
66025 Lpar3; lysophosphatidic acid receptor 3 [KO:K04294 ]
24896 Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632 ]
59326 Rapgef3; rap guanine nucleotide exchange factor 3 [KO:K08014 ]
252857 Rapgef4; rap guanine nucleotide exchange factor 4 [KO:K04351 ]
81666 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
24654 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
29322 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
85240 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
25031 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
25313 Egf; pro-epidermal growth factor precursor [KO:K04357 ]
170633 Fgf3; fibroblast growth factor 3 precursor [KO:K04358 ]
116499 Fgf4; fibroblast growth factor 4 precursor [KO:K04358 ]
60662 Fgf5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358 ]
29348 Fgf7; fibroblast growth factor 7 precursor [KO:K04358 ]
25443 Fgf10; fibroblast growth factor 10 precursor [KO:K04358 ]
29368 Fgf17; fibroblast growth factor 17 isoform 1 precursor [KO:K04358 ]
29369 Fgf18; fibroblast growth factor 18 precursor [KO:K04358 ]
170579 Fgf22; fibroblast growth factor 22 precursor [KO:K04358 ]
29349 Fgf8; fibroblast growth factor 8 isoform 1 precursor [KO:K04358 ]
170582 Fgf19; fibroblast growth factor 19 precursor [KO:K22603 ]
170580 Fgf21; fibroblast growth factor 21 precursor [KO:K22429 ]
170583 Fgf23; fibroblast growth factor 23 precursor [KO:K22428 ]
24482 Igf1; insulin-like growth factor I isoform d preproprotein [KO:K05459 ]
25266 Pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359 ]
24628 Pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386 ]
79429 Pdgfc; platelet-derived growth factor C precursor [KO:K05450 ]
66018 Pdgfd; platelet-derived growth factor D precursor [KO:K05450 ]
78965 Csf1; macrophage colony-stimulating factor 1 precursor [KO:K05453 ]
60427 Kitlg; kit ligand isoform 1 precursor [KO:K05461 ]
83785 Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448 ]
89811 Vegfb; vascular endothelial growth factor B precursor [KO:K16858 ]
94203 Pgf; placenta growth factor precursor [KO:K16859 ]
114111 Vegfc; vascular endothelial growth factor C precursor [KO:K05449 ]
360457 Vegfd; vascular endothelial growth factor D precursor [KO:K05449 ]
24446 Hgf; hepatocyte growth factor preproprotein [KO:K05460 ]
24596 Ngfr; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583 ]
25718 Igf1r; insulin-like growth factor 1 receptor isoform 2 precursor [KO:K05087 ] [EC:2.7.10.1 ]
25267 Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363 ] [EC:2.7.10.1 ]
54251 Flt1; vascular endothelial growth factor receptor 1 isoform 2 precursor [KO:K05096 ] [EC:2.7.10.1 ]
63881 Rapgef1; rap guanine nucleotide exchange factor 1 isoform X25 [KO:K06277 ]
25414 Bcar1; breast cancer anti-estrogen resistance protein 1 isoform 3 [KO:K05726 ]
500261 Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 2 [KO:K05631 ]
113970 Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629 ]
245903 Magi3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 [KO:K06112 ]
310533 Rapgef2; rap guanine nucleotide exchange factor 2 [KO:K08018 ]
303141 Rapgef6; rap guanine nucleotide exchange factor 6 [KO:K08020 ]
81511 Lat; linker for activation of T-cells family member 1 [KO:K07362 ]
286975 Skap1; src kinase-associated phosphoprotein 1 [KO:K17699 ]
25738 Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116 ] [EC:3.1.4.11 ]
24318 Drd2; D(2) dopamine receptor isoform 1 [KO:K04145 ]
25686 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
25643 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
81664 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
50664 Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform B [KO:K04534 ]
313644 Rap1gap; rap1 GTPase-activating protein 1 isoform 1 [KO:K17700 ]
246212 Sipa1l1; signal-induced proliferation-associated 1-like protein 1 isoform 1 [KO:K17701 ]
361710 Sipa1; signal-induced proliferation-associated protein 1 [KO:K08013 ]
361442 Sipa1l2; signal-induced proliferation-associated 1-like protein 2 [KO:K17702 ]
25261 Id1; DNA-binding protein inhibitor ID-1 [KO:K04680 ]
445442 Thbs1; thrombospondin-1 isoform 1 precursor [KO:K16857 ]
29622 Ralgds; ral guanine nucleotide dissociation stimulator isoform 1 [KO:K08732 ]
363875 Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
366957 Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
688319 Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861 ]
307171 Apbb1ip; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704 ]
361517 Vasp; vasodilator-stimulated phosphoprotein [KO:K06274 ]
361314 Arap3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490 ]
297173 RSA-14-44; ras homolog gene family, member A [KO:K04513 ]
316639 Farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 [KO:K06082 ]
64465 Cdc42; cell division control protein 42 homolog [KO:K04393 ]
295378 Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730 ]
296603 Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730 ]
304109 Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731 ]
81918 Pard3; partitioning defective 3 homolog [KO:K04237 ]
307237 Pard6g; partitioning defective 6 homolog gamma [KO:K06093 ]
307799 Pard6a; partitioning defective 6 homolog alpha isoform 1 [KO:K06093 ]
362279 Pard6b; partitioning defective 6 homolog beta [KO:K06093 ]
362317 Krit1; krev interaction trapped protein 1 [KO:K17705 ]
114705 Rgs14; regulator of G-protein signaling 14 [KO:K17706 ]
54355 Rassf5; ras association domain-containing protein 5 [KO:K08015 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
134484121 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
114633 Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860 ] [EC:3.1.4.11 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
Compound
Reference
Authors
Kooistra MR, Dube N, Bos JL
Title
Rap1: a key regulator in cell-cell junction formation.
Journal
Reference
Authors
Bos JL, de Rooij J, Reedquist KA
Title
Rap1 signalling: adhering to new models.
Journal
Reference
Authors
Minato N, Kometani K, Hattori M
Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
Journal
Reference
Authors
Bos JL
Title
Linking Rap to cell adhesion.
Journal
Reference
Authors
Caron E
Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
Journal
Reference
Authors
Zwartkruis FJ, Bos JL
Title
Ras and Rap1: two highly related small GTPases with distinct function.
Journal
Reference
Authors
Hattori M, Minato N
Title
Rap1 GTPase: functions, regulation, and malignancy.
Journal
Reference
Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
Journal
Reference
Authors
Boettner B, Van Aelst L
Title
Control of cell adhesion dynamics by Rap1 signaling.
Journal
Reference
Authors
Xia Z, Storm DR.
Title
The role of calmodulin as a signal integrator for synaptic plasticity.
Journal
Reference
Authors
Mor A, Dustin ML, Philips MR
Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
Journal
Reference
Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
Title
T-cell receptor signaling to integrins.
Journal
Reference
Authors
Stork PJ
Title
Does Rap1 deserve a bad Rap?
Journal
Reference
Authors
Banihashemi B, Albert PR
Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
Journal
Reference
Authors
Banno A, Ginsberg MH
Title
Integrin activation.
Journal
Reference
Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
Journal
Reference
Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
Journal
Related pathway
rno04660 T cell receptor signaling pathway
rno04810 Regulation of actin cytoskeleton
KO pathway
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