Entry
Name
Human papillomavirus infection - Rattus norvegicus (rat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
83721 Dvl1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
303811 Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353 ]
303251 Dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
24205 Apc; adenomatous polyposis coli protein [KO:K02085 ]
299611 Apc2; adenomatous polyposis coli protein 2 [KO:K02085 ]
363328 Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842 ]
500261 Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 2 [KO:K05631 ]
81918 Pard3; partitioning defective 3 homolog [KO:K04237 ]
307237 Pard6g; partitioning defective 6 homolog gamma [KO:K06093 ]
307799 Pard6a; partitioning defective 6 homolog alpha isoform 1 [KO:K06093 ]
362279 Pard6b; partitioning defective 6 homolog beta [KO:K06093 ]
64465 Cdc42; cell division control protein 42 homolog [KO:K04393 ]
25252 Dlg1; disks large homolog 1 isoform 1 [KO:K12076 ]
54265 Llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094 ]
360661 Llgl2; LLGL scribble cell polarity complex component 2 [KO:K06094 ]
445442 Thbs1; thrombospondin-1 isoform 1 precursor [KO:K16857 ]
25304 Comp; cartilage oligomeric matrix protein precursor [KO:K04659 ]
84352 Col1a2; collagen alpha-2(I) chain precursor [KO:K06236 ]
29393 Col1a1; collagen alpha-1(I) chain precursor [KO:K06236 ]
25412 Col2a1; collagen alpha-1(II) chain isoform 2 precursor [KO:K19719 ]
290905 Col4a1; collagen alpha-1(IV) chain precursor [KO:K06237 ]
306628 Col4a2; collagen alpha-2(IV) chain precursor [KO:K06237 ]
363457 Col4a5; collagen alpha-5(IV) chain precursor [KO:K06237 ]
363265 Col4a3; collagen alpha-3(IV) chain precursor [KO:K06237 ]
363458 Col4a6; collagen type IV alpha 6 chain precursor [KO:K06237 ]
315981 Col6a4; collagen alpha-4(VI) chain precursor [KO:K06238 ]
361821 Col6a2; collagen alpha-2(VI) chain precursor [KO:K06238 ]
294337 Col6a1; collagen alpha-1(VI) chain precursor [KO:K06238 ]
315979 Col6a6; collagen alpha-6(VI) chain isoform X3 [KO:K06238 ]
367313 Col6a3; collagen alpha-3(VI) chain precursor [KO:K06238 ]
501047 Col6a5; collagen alpha-5(VI) chain isoform X3 [KO:K06238 ]
305104 Col9a1; collagen alpha-1(IX) chain precursor [KO:K08131 ]
362584 Col9a2; collagen alpha-2(IX) chain precursor [KO:K08131 ]
362285 Col9a3; collagen alpha-3(IX) chain precursor [KO:K08131 ]
307582 Lama3; laminin subunit alpha-3 isoform B precursor [KO:K06240 ]
25473 Lamb2; laminin subunit beta-2 precursor [KO:K06243 ]
296456 Itgav; integrin alpha-V isoform 1 precursor [KO:K06487 ]
25625 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
246756 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
25385 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
246097 Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
266610 Fadd; FAS-associated death domain protein [KO:K02373 ]
59114 Nherf1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365 ]
24672 Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
24673 Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382 ] [EC:3.1.3.16 ]
100362453 Ppp2cal1; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382 ] [EC:3.1.3.16 ]
117281 Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
315648 Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456 ]
246255 Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354 ]
60660 Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1 [KO:K04354 ]
117256 Ppp2r2c; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1 [KO:K04354 ]
117104 Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354 ]
682033 Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583 ]
362739 Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583 ]
363122 Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583 ]
309179 Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584 ]
691318 Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 4 [KO:K11584 ]
363193 Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584 ]
299147 Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584 ]
312754 Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584 ]
116636 Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
64639 Bad; bcl2-associated agonist of cell death [KO:K02158 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
134484121 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
83571 Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624 ]
114851 Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
24708 Rb1; retinoblastoma-associated protein [KO:K06618 ]
117263 Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062 ]
83785 Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
117535 Chd4; chromodomain-helicase-DNA-binding protein 4 [KO:K11643 ] [EC:5.6.2.-]
24747 RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751 ]
24973 RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751 ]
24974 RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751 ]
24988 RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751 ]
294213 RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751 ]
309600 RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751 ]
309603 RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751 ]
309607 RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751 ]
361787 RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751 ]
365527 RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751 ]
368153 RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751 ]
414779 RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751 ]
414783 RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751 ]
414784 RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751 ]
414785 RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751 ]
414786 RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751 ]
414789 RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751 ]
414790 RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751 ]
414791 RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751 ]
414792 RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751 ]
414793 RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751 ]
414819 RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751 ]
406194 RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751 ]
414788 RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751 ]
680842 RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751 ]
102546590 H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
499400 RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751 ]
293852 Bcap31; B-cell receptor-associated protein 31 [KO:K14009 ]
117596 Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
312488 Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
299971 Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148 ]
362802 Atp6v1c2; V-type proton ATPase subunit C 2 [KO:K02148 ]
297566 Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150 ]
366545 Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150 ]
289407 Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152 ]
298103 Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152 ]
368044 Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152 ]
501686 Atp6v1g1l1; V-type proton ATPase subunit G 1-like [KO:K02152 ]
297797 Atp6v1h; V-type proton ATPase subunit H isoform 1 [KO:K02144 ]
29757 Atp6v0a1; V-type proton ATPase 116 kDa subunit a 1 [KO:K02154 ]
296981 Atp6v0a4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154 ]
293650 Tcirg1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154 ]
116455 Atp6v0a2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154 ]
291969 Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146 ]
297932 Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146 ]
94170 Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153 ]
436582 Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153 ]
170667 Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155 ]
298451 Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661 ]
83615 Atp6ap1; V-type proton ATPase subunit S1 precursor [KO:K03662 ]
25313 Egf; pro-epidermal growth factor precursor [KO:K04357 ]
81504 Grb2; growth factor receptor-bound protein 2 [KO:K04364 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
84023 Ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261 ]
24896 Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632 ]
81646 Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870 ]
310616 Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1 [KO:K09048 ]
362165 Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
362339 Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
314638 Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048 ]
298400 Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
500131 Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047 ]
298213 Ifna2; interferon alpha family, gene 2 precursor [KO:K05414 ]
690894 Ifna1; interferon alpha family, gene 5 precursor [KO:K05414 ]
502961 Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414 ]
500491 Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414 ]
502959 Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414 ]
288264 Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130 ]
686326 Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131 ]
25124 Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220 ]
288774 Stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
54287 Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195 ] [EC:2.7.11.1 ]
304545 Oasl; 2'-5'-oligoadenylate synthase-like protein 1 [KO:K14608 ]
304549 Oasl2; 2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608 ]
286918 Mx2; interferon-induced GTP-binding protein Mx2 [KO:K14754 ]
24575 Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754 ]
25496 Notch1; neurogenic locus notch homolog protein 1 precursor [KO:K02599 ]
29492 Notch2; neurogenic locus notch homolog protein 2 precursor [KO:K20994 ]
56761 Notch3; neurogenic locus notch homolog protein 3 precursor [KO:K20995 ]
406162 Notch4; neurogenic locus notch homolog protein 4 precursor [KO:K20996 ]
170905 Lfng; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe precursor [KO:K05948 ] [EC:2.4.1.222 ]
689844 Maml2; mastermind-like protein 2 isoform X1 [KO:K06061 ]
362268 Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053 ]
679028 Rbpj; recombining binding protein suppressor of hairless isoform 1 [KO:K06053 ]
287423 Hes7; transcription factor HES-7 isoform 1 [KO:K09087 ]
313575 Heyl; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091 ]
155430 Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091 ]
155437 Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Moody CA, Laimins LA
Title
Human papillomavirus oncoproteins: pathways to transformation.
Journal
Reference
Authors
Chen J
Title
Signaling pathways in HPV-associated cancers and therapeutic implications.
Journal
Reference
Authors
Tummers B, Burg SH
Title
High-risk human papillomavirus targets crossroads in immune signaling.
Journal
Reference
Authors
Lehoux M, D'Abramo CM, Archambault J
Title
Molecular mechanisms of human papillomavirus-induced carcinogenesis.
Journal
Reference
Authors
Pang CL, Thierry F
Title
Human papillomavirus proteins as prospective therapeutic targets.
Journal
Reference
Authors
Yugawa T, Kiyono T
Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
Journal
Reference
Authors
Narisawa-Saito M, Kiyono T
Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
Journal
Reference
Authors
Wolf JK, Ramirez PT.
Title
The molecular biology of cervical cancer.
Journal
Reference
Authors
zur Hausen H
Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
Journal
Reference
Authors
Kim YT, Zhao M
Title
Aberrant cell cycle regulation in cervical carcinoma.
Journal
Reference
Authors
McCance DJ
Title
Human papillomaviruses and cell signaling.
Journal
Reference
Authors
Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
Journal
Kobe J Med Sci 50:9-19 (2004)
Reference
Authors
Tommasino M
Title
The human papillomavirus family and its role in carcinogenesis.
Journal
Reference
Authors
Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
Title
Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
Journal
Reference
Authors
Shah M, Anwar MA, Park S, Jafri SS, Choi S
Title
In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
Journal
Reference
Authors
James CD, Roberts S
Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
Journal
Reference
Authors
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
Journal
Reference
Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
Title
PDZ domains: the building blocks regulating tumorigenesis.
Journal
Reference
Authors
Banks L, Pim D, Thomas M
Title
Human tumour viruses and the deregulation of cell polarity in cancer.
Journal
Reference
Authors
Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
Title
Human papillomaviruses, cervical cancer and cell polarity.
Journal
Reference
Authors
Jayshree RS, Sreenivas A, Tessy M, Krishna S
Title
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
Journal
Indian J Med Res 130:286-95 (2009)
Reference
Authors
Garnett TO, Duerksen-Hughes PJ
Title
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
Journal
Reference
Authors
Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
Title
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
Journal
Reference
Authors
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
Title
Papillomavirus E5: the smallest oncoprotein with many functions.
Journal
Reference
Authors
DiMaio D, Mattoon D
Title
Mechanisms of cell transformation by papillomavirus E5 proteins.
Journal
Reference
Authors
Ganguly N
Title
Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
Journal
Reference
Authors
DiMaio D, Petti LM
Title
The E5 proteins.
Journal
Reference
Authors
De Marco F
Title
Oxidative stress and HPV carcinogenesis.
Journal
Reference
Authors
Wieringa HW, van der Zee AG, de Vries EG, van Vugt MA
Title
Breaking the DNA damage response to improve cervical cancer treatment.
Journal
Reference
Authors
Chung CH, Gillison ML
Title
Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
Journal
Reference
Authors
Koromilas AE, Li S, Matlashewski G
Title
Control of interferon signaling in human papillomavirus infection.
Journal
Reference
Authors
Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ
Title
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
Journal
Reference
Authors
Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
Title
Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
Journal
Reference
Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
Journal
Reference
Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
Journal
Reference
Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
Journal
Reference
Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
Journal
Related pathway
rno04612 Antigen processing and presentation
rno04620 Toll-like receptor signaling pathway
KO pathway
LinkDB
All DBs